Genomes and Genes
Experts and Doctors on neoplasm proteins in California, United States
Locale: California, United States
Topic: neoplasm proteins
- Sternsdorf T, Phan V, Maunakea M, Ocampo C, Sohal J, Silletto A, et al. Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. Cancer Cell. 2006;9:81-94 pubmed..These results demonstrate that the dimerization interface of RARalpha fusion partners is a critical element in APL pathogenesis while pointing to other features of PML for enhancing penetrance and progression. ..
- Arcinas A, Yen T, Kebebew E, Macher B. Cell surface and secreted protein profiles of human thyroid cancer cell lines reveal distinct glycoprotein patterns. J Proteome Res. 2009;8:3958-68 pubmed publisher..e., anaplastic). On the basis of the results obtained, a set of glycoprotein biomarker candidates for thyroid cancer is proposed. ..
- Krishnan A, Feldman D. Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment. Endocr Relat Cancer. 2010;17:R19-38 pubmed publisher..Calcitriol or its analogs may have utility as chemopreventive agents and should be evaluated in clinical trials in PCa patients with early or precancerous disease. ..
- Thompson M, Lapointe J, Choi Y, Ong D, Higgins J, Brooks J, et al. Identification of candidate prostate cancer genes through comparative expression-profiling of seminal vesicle. Prostate. 2008;68:1248-56 pubmed publisher..We hypothesized that gene-expression differences between prostate and seminal vesicle might inform mechanisms underlying the higher incidence of prostate cancer...
- Ferrari M, McNeal J, Malhotra S, Brooks J. Vascular invasion predicts recurrence after radical prostatectomy: stratification of risk based on pathologic variables. Urology. 2004;64:749-53 pubmed..In long-term follow-up, VI was a significant predictor of prostate cancer recurrence and death after radical prostatectomy. In patients with VI, high Gleason grade, EPE, and more than five foci of VI are associated with poor prognosis. ..
- Lin R, Sternsdorf T, Tini M, Evans R. Transcriptional regulation in acute promyelocytic leukemia. Oncogene. 2001;20:7204-15 pubmed..These studies have been instrumental in our understanding of the process of leukemogenesis in general and have laid the scientific foundation for the novel concept of transcription therapy in the treatment of human cancer. ..
- Kuo P, Morris J, Marks W, Lieberman J, Johnson D, Alfrey E, et al. Human syngeneic intestinal transplantation: evaluation of enterocyte viability with serum levels of intestinal fatty acid binding protein. Clin Transplant. 1996;10:282-6 pubmed..These observations suggest that (i) a clinical syndrome consistent with translocation may occur in the absence of rejection in intestinal transplantation, and (ii) I-FABP may serve as a clinically relevant marker for enterocyte injury. ..
- Richieri G, Ogata R, Kleinfeld A. Thermodynamic and kinetic properties of fatty acid interactions with rat liver fatty acid-binding protein. J Biol Chem. 1996;271:31068-74 pubmed
- Nguyen L, Erzberger J, Root J, Wilson D. The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers. J Biol Chem. 2000;275:25900-6 pubmed..The results presented within suggest a role for human Sfn in cellular nucleotide recycling. ..
- Schaner M, Ross D, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, et al. Gene expression patterns in ovarian carcinomas. Mol Biol Cell. 2003;14:4376-86 pubmed
- Leo C, Hsu S, Chun S, Bae H, Hsueh A. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Endocrinology. 1999;140:5469-77 pubmed..In conclusion, rat Mcl-1 was identified as an ovarian BAD-interacting protein and the message for the antiapoptotic Mcl-1 protein was induced after treatment with gonadotropins in granulosa and thecal cells of growing follicles. ..
- Higgins J, Montgomery K, Wang L, Domanay E, Warnke R, Brooks J, et al. Expression of FKBP12 in benign and malignant vascular endothelium: an immunohistochemical study on conventional sections and tissue microarrays. Am J Surg Pathol. 2003;27:58-64 pubmed..In addition, our findings may explain the toxic effects of FK506 on vascular endothelium of the kidney. ..
- Golubkov V, Chernov A, Strongin A. Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo. J Biol Chem. 2011;286:34215-23 pubmed publisher..Our results emphasize the importance of the intradomain cleavages resulting in the inactivation of the respective inhibitory prodomains not only for MT1-MMP but also for other MMP family members. ..
- Reed J. Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol Oncol Clin North Am. 1995;9:451-73 pubmed
- Labhart P. Transcript cleavage in an RNA polymerase I elongation complex. Evidence for a dissociable activity similar to but distinct from TFIIS. J Biol Chem. 1997;272:9055-61 pubmed..The predicted amino acid sequences of the present and previously identified Xenopus TFIIS are less than 65% conserved. Thus, like mammalian species, Xenopus has at least two highly divergent forms of TFIIS. ..
- Suzuki Anekoji M, Suzuki M, Kobayashi T, Sato Y, Nakayama J, Suzuki A, et al. HNK-1 glycan functions as a tumor suppressor for astrocytic tumor. J Biol Chem. 2011;286:32824-33 pubmed publisher..Overall, these results indicate that HNK-1 glycan functions as a tumor suppressor. ..
- Mitra S, Duggineni S, Koolpe M, Zhu X, Huang Z, Pasquale E. Structure-activity relationship analysis of peptides targeting the EphA2 receptor. Biochemistry. 2010;49:6687-95 pubmed publisher..The two peptides and derivatives are quite stable in conditioned cell culture medium and show promise for delivering drugs and imaging agents to EphA2-expressing tumors. ..
- Ayton P, Cleary M. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 2003;17:2298-307 pubmed
- Richieri G, Ogata R, Kleinfeld A. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J Biol Chem. 1994;269:23918-30 pubmed..These results provide a framework with which to understand better the biological function of FABPs and the FA-FABP interaction. ..
- Loviscach M, Rehman N, Carter L, Mudaliar S, Mohadeen P, Ciaraldi T, et al. Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action. Diabetologia. 2000;43:304-11 pubmed..The PPAR gamma protein is abundant in skeletal muscle as well as adipose tissue. The altered expression of skeletal muscle PPAR gamma is consistent with a role for this nuclear protein in the impaired insulin action of Type II diabetes. ..
- Han K, Jeng E, Hess G, Morgens D, Li A, Bassik M. Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. Nat Biotechnol. 2017;35:463-474 pubmed publisher..This work provides an effective strategy to screen synergistic drug combinations in high-throughput and a CRISPR-based tool to dissect functional GI networks. ..
- Gomez Cabrero A, Wrasidlo W, Reisfeld R. IMD-0354 targets breast cancer stem cells: a novel approach for an adjuvant to chemotherapy to prevent multidrug resistance in a murine model. PLoS ONE. 2013;8:e73607 pubmed publisher..Targeting both bulk tumor cells with a chemotherapeutic agent and CSCs with IMD-0354 should be able to reduce MDR. This could eventually result in decreasing tumor recurrences and/or improve the outcome of metastatic disease. ..
- Vang R, Kempson R. Perivascular epithelioid cell tumor ('PEComa') of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors. Am J Surg Pathol. 2002;26:1-13 pubmed
- Sundram U, Harvell J, Rouse R, Natkunam Y. Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA. Mod Pathol. 2003;16:802-10 pubmed..With the exception of desmoplastic and spindle cell melanomas, MUM1 appears to be a sensitive and specific immunohistochemical stain for melanocytic lesions and may prove to be a useful addition to the current panel of melanoma markers. ..
- Zhang X, Xiong Z, Wu Y, Cai W, Tseng J, Gambhir S, et al. Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2. J Nucl Med. 2006;47:113-21 pubmed..The binding potential calculated from simplified tracer kinetic modeling such as the Logan plot appears to be an excellent indicator of tumor integrin density. ..
- Martin J, Halenbeck R, Kaufmann J. Human transcription factor hTAF(II)150 (CIF150) is involved in transcriptional regulation of cell cycle progression. Mol Cell Biol. 1999;19:5548-56 pubmed..These results suggest that one function of CIF150 (hTAF(II)150) is to select specific RNA polymerase II core promoter elements involved in cell cycle progression. ..
- Salim A, Nacamuli R, Morgan E, Giaccia A, Longaker M. Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J Biol Chem. 2004;279:40007-16 pubmed
- Hsu S, Lin P, Hsueh A. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol Endocrinol. 1998;12:1432-40 pubmed..Identification of BOD expands the group of proapoptotic Bcl-2 proteins that only contains the BH3 domain and allows future elucidation of the intracellular mechanism for apoptosis regulation in ovary and other tissues. ..
- Roelink H, Nusse R. Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube. Genes Dev. 1991;5:381-8 pubmed..Characteristic expression patterns of these two closely related genes suggest that Wnt-3 and Wnt-3A play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. ..
- Harvell J, Bastian B, LeBoit P. Persistent (recurrent) Spitz nevi: a histopathologic, immunohistochemical, and molecular pathologic study of 22 cases. Am J Surg Pathol. 2002;26:654-61 pubmed..Although ancillary molecular techniques such as CGH are of great help in distinguishing these from melanoma, until such techniques become widely available we advocate complete but conservative excision of any recurrent Spitz nevus...
- Johnson K, van Etten D, Nanda N, Graham R, Terkeltaub R. Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy. J Biol Chem. 2003;278:18824-32 pubmed..TG2 is a potential site for intervention in pathologic calcification promoted by IL-1 beta and ATRA. ..
- Heeb M, Cabral K, Ruan L. Down-regulation of factor IXa in the factor Xase complex by protein Z-dependent protease inhibitor. J Biol Chem. 2005;280:33819-25 pubmed..ZPI may be an unusual physiologic regulator of both the intrinsic FXase and the prothrombinase complexes. ..
- Reed J, Bischoff J. BIRinging chromosomes through cell division--and survivin' the experience. Cell. 2000;102:545-8 pubmed
- Verdecia M, Huang H, Dutil E, Kaiser D, Hunter T, Noel J. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol. 2000;7:602-8 pubmed
- Sun Z, Pan J, Hope W, Cohen S, Balk S. Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300. Cancer. 1999;86:689-96 pubmed
- McCurdy D, Tai L, Nguyen J, Wang Z, Yang H, Udar N, et al. MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera. Mol Genet Metab. 1998;63:3-13 pubmed..MAGE gene expression may be important not only for tumor recognition and cancer therapy, but, because it is the apparent target of autoantibodies in SLE sera, it may also play a role in autoimmune diseases. ..
- D Osualdo A, Weichenberger C, Wagner R, Godzik A, Wooley J, Reed J. CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain. PLoS ONE. 2011;6:e27396 pubmed publisher..Altogether, these results identify a function for the FIIND and show that CARD8 and NLRP1 are ZU5-UPA domain-containing autoproteolytic proteins, thus suggesting a novel mechanism for regulating innate immune responses. ..
- Kahner B, Kato H, Banno A, Ginsberg M, Shattil S, Ye F. Kindlins, integrin activation and the regulation of talin recruitment to ?IIb?3. PLoS ONE. 2012;7:e34056 pubmed publisher..Thus, kindlins do not promote initial talin recruitment to ?IIb?3, suggesting that they co-activate integrin through a mechanism independent of recruitment. ..
- Fukuchi K, Steiniger S, Deryugina E, Liu Y, Lowery C, Gloeckner C, et al. Inhibition of tumor metastasis: functional immune modulation of the CUB domain containing protein 1. Mol Pharm. 2010;7:245-53 pubmed publisher..Our findings indicate a functional role for CDCP1 in human cancer and underscore the therapeutic potential of function-blocking anti-CDCP1 antibodies targeting both primary and metastatic carcinoma cells. ..
- Zheng X, Soroush F, Long J, Hall E, Adishesha P, Bhattacharya S, et al. Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy. PLoS ONE. 2017;12:e0185250 pubmed publisher..Esm-1 inversely correlates with disease susceptibility and inhibits leukocyte infiltration, a critical factor in protecting the kidney from DN. ..
- Kuo S, Mellentin J, Copeland N, Gilbert D, Jenkins N, Cleary M. Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. Oncogene. 1991;6:961-8 pubmed..We conclude that LYL1 has the properties of a lineage- and differentiation-specific HLH protein that contributes to T-cell neoplasia through its deregulated expression following chromosomal translocation. ..
- Niethammer A, Xiang R, Ruehlmann J, Lode H, Dolman C, Gillies S, et al. Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma. Cancer Res. 2001;61:6178-84 pubmed
- Feierbach B, Nogales E, Downing K, Stearns T. Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin. J Cell Biol. 1999;144:113-24 pubmed..The phenotype of overexpression of ALF1 suggests that Alf1p can act to sequester alpha-tubulin from interaction with beta-tubulin, raising the possibility that it plays a regulatory role in the formation of the tubulin heterodimer. ..
- Dong A, Gupta A, Pai R, Tun M, Lowe A. The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation. J Biol Chem. 2011;286:18301-10 pubmed publisher..Additional experiments demonstrate that AGR2 induction of AREG is mediated by activation of the Hippo signaling pathway co-activator, YAP1. Thus AGR2 promotes growth by regulating the Hippo and EGF receptor signaling pathways. ..
- Deng G, Bell I, Crawley S, Gum J, Terdiman J, Allen B, et al. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res. 2004;10:191-5 pubmed..This discrepancy of BRAF mutations between sporadic MSI+ cancer and HNPCC might be used in a strategy for the detection of HNPCC families. ..
- Yamaguchi Y, Du X, Zhao L, Morser J, Leung L. Proteolytic cleavage of chemerin protein is necessary for activation to the active form, Chem157S, which functions as a signaling molecule in glioblastoma. J Biol Chem. 2011;286:39510-9 pubmed publisher..This study emphasized the necessity of appropriate C-terminal proteolytic processing to generate the likely physiologic form of active chemerin, chem157S, and suggested a possible role in malignant GBM. ..
- Adamson E, Minchiotti G, Salomon D. Cripto: a tumor growth factor and more. J Cell Physiol. 2002;190:267-78 pubmed..Meanwhile some speculations on possible receptor complexes for Cripto signaling in mammary cells are offered here as a spur to further discoveries. ..
- Miyamoto A, Cui X, Naumovski L, Cleary M. Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Mol Cell Biol. 1996;16:2394-401 pubmed
- Lin C, Shen W, Chen Z, Tu Y, Matsudaira P. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Mol Cell Biol. 1994;14:2457-67 pubmed..Immunofluorescence microscopy detected I-plastin in the brush border of the small intestine and colon. These results identify I-plastin as the human homolog of chicken intestine fimbrin and as a third plastin isoform in humans. ..
- Partridge J, Madsen M, Ardi V, Papagiannakopoulos T, Kupriyanova T, Quigley J, et al. Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis. J Biol Chem. 2007;282:35964-77 pubmed..Collectively, these findings demonstrate that tumor-derived MMPs may have protective functions in cancer cell intravasation, i.e. not promoting but rather catalytically interfering with the early stages of cancer dissemination. ..
- Xiao Y, Woo W, Nagao K, Li W, Terunuma A, Mukouyama Y, et al. Perivascular hair follicle stem cells associate with a venule annulus. J Invest Dermatol. 2013;133:2324-2331 pubmed publisher..Together, these findings demonstrate that the upper bulge is associated with a perivascular niche during the establishment and maintenance of this specialized region of hair follicle stem cells. ..
- Zhang J, Chan E, Peng X, Lu M, Wang X, Mueller F, et al. Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies. Clin Immunol. 2001;100:149-56 pubmed..The immune responses might be related to overexpression or dysregulation of p62 and Koc in some tumors. ..
- Stuart R, Pavlova A, Beier D, Li Z, Krijanovski Y, Nigam S. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. Am J Physiol Renal Physiol. 2001;281:F1148-56 pubmed..The data raise the possibility that EEG1 and POV1 may define a new family of transport proteins involved in the transport of nutrients or metabolites in rapidly growing and/or developing tissues...
- Apgar J. Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization. Mol Biol Cell. 1995;6:97-108 pubmed
- Cui H, Bansal V, Grunert M, Malecova B, Dall Agnese A, Latella L, et al. Muscle-relevant genes marked by stable H3K4me2/3 profiles and enriched MyoD binding during myogenic differentiation. PLoS ONE. 2017;12:e0179464 pubmed publisher..These results point to the importance of integrating histone modifications and MyoD chromatin binding for coordinated gene activation and repression during myogenic differentiation. ..
- Fitzpatrick P, Shattil S, Ablooglu A. C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein. J Biol Chem. 2014;289:11183-93 pubmed publisher..Thus, by employing zebrafish as an in situ physiological tool to correlate protein structure and function, we have discovered an unexpected association chemistry between an integrin and a key adapter involved in integrin signaling. ..
- Wang G, Pasillas M, Kamps M. Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes. Mol Cell Biol. 2006;26:3902-16 pubmed..Chromatin immunoprecipitation confirmed co-occupancy of Hoxa9 and Meis1 on the Flt3 promoter. ..
- Liou J, Kim M, Heo W, Jones J, Myers J, Ferrell J, et al. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol. 2005;15:1235-41 pubmed..Our study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(2+) store depletion to Ca(2+) influx. ..
- Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, et al. TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. J Biol Chem. 2001;276:32220-9 pubmed..Thus, TUCAN represents a new member of the CARD family that selectively suppresses apoptosis induced via the mitochondrial pathway for caspase activation. ..
- Stracker T, Lee D, Carson C, Araujo F, Ornelles D, Weitzman M. Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol. 2005;79:6664-73 pubmed..These results reveal surprising differences among the highly conserved E4orf3 proteins from different serotypes in the ability to disrupt the Mre11 complex. ..
- Wong P, Iwasaki M, Somervaille T, So C, So C, Cleary M. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev. 2007;21:2762-74 pubmed..Thus, TALE proteins are critical downstream effectors within an essential homeoprotein network that serves a rate-limiting regulatory role in MLL leukemogenesis. ..
- Ghosh M, Thompson D, Weigel R. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Cancer Res. 2000;60:6367-75 pubmed..GREB1 was also induced by beta-estradiol in the ER-positive endometrial cell line ECC-1. The pattern of expression suggests a critical role for these two genes in the response of tissues and tumors to beta-estradiol. ..
- Xiao B, Coste B, Mathur J, Patapoutian A. Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression. Nat Chem Biol. 2011;7:351-8 pubmed publisher..Additionally, physiologically relevant temperature shifts modulate STIM1-dependent gene expression in Jurkat T cells. Therefore, temperature is an important regulator of STIM1 function. ..
- Buss J, Der C, Solski P. The six amino-terminal amino acids of p60src are sufficient to cause myristylation of p21v-ras. Mol Cell Biol. 1988;8:3960-3 pubmed..This defines the minimum framework of the p60v-src myristylation signal (glycine 2 and serine 6) and identifies serine 6 as a crucial part of that signal for myristylation of a protein in vivo...
- Ji Q, Chen P, Aoyoma C, Liu P. Increased expression of human luteinizing hormone/human chorionic gonadotropin receptor mRNA in human endometrial cancer. Mol Cell Probes. 2002;16:269-75 pubmed..Quantitative real-time PCR also reveals increased expressions of LH/hCG receptor in endometrial cancerous tissues compared with surrounding microscopically normal tissues. ..
- Kenney N, Huang R, Johnson G, Wu J, Okamura D, Matheny W, et al. Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland. Mol Reprod Dev. 1995;41:277-86 pubmed..These results imply that together with EGF and transforming growth factor alpha (TGF alpha), Ar and Cr-1 may play salient roles as modifiers in the morphogenesis and differentiation of the mammary gland. ..
- Calvo K, Sykes D, Pasillas M, Kamps M. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. Oncogene. 2002;21:4247-56 pubmed..Rapid leukaemogenesis by Nup98-HoxA9 may therefore result from both the intrinsic functions of Nup98-HoxA9, as well as of those of coexpressed HOX and MEIS1 genes. ..
- Callahan C, Ofstad T, Horng L, Wang J, Zhen H, Coulombe P, et al. MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev. 2004;18:2724-9 pubmed..These data define MIM as both a Shh-responsive gene and a new member of the pathway that modulates Gli responses during growth and tumorigenesis. ..
- Leo C, Pisarska M, Hsueh A. DNA array analysis of changes in preovulatory gene expression in the rat ovary. Biol Reprod. 2001;65:269-76 pubmed..These results demonstrate that DNA arrays can be used to identify genes regulated during the periovulatory period, thus contributing to a more detailed understanding of the molecular mechanisms of ovulation. ..
- Kelber J, Shani G, Booker E, Vale W, Gray P. Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal. J Biol Chem. 2008;283:4490-500 pubmed..Together, our data indicate that Cripto facilitates Nodal signaling and inhibits activin signaling by forming receptor complexes with these ligands that are structurally and functionally similar. ..
- Huang L, Ichimaru E, Pestonjamasp K, Cui X, Nakamura H, Lo G, et al. Merlin differs from moesin in binding to F-actin and in its intra- and intermolecular interactions. Biochem Biophys Res Commun. 1998;248:548-53 pubmed..Merlin 1 function in cells may thus depend on intra- and intermolecular interactions and their modulation, which include interactions with other members of this protein family. ..
- Scobie H, Wigelsworth D, Marlett J, Thomas D, Rainey G, Lacy D, et al. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog. 2006;2:e111 pubmed..Moreover, a D683K mutant form of PA that bound specifically to human and rat ANTXR2 mediated killing of rats by anthrax lethal toxin, providing strong evidence for the physiological importance of ANTXR2 in anthrax disease pathogenesis. ..
- Garcia J, Faca V, Jarzembowski J, Zhang Q, Park J, Hanash S. Comprehensive profiling of the cell surface proteome of Sy5Y neuroblastoma cells yields a subset of proteins associated with tumor differentiation. J Proteome Res. 2009;8:3791-6 pubmed publisher..This comprehensive neuroblastoma cell surface profile has identified novel potential markers for neuroblastoma classification and novel potential targets for therapy. ..
- Chang C, Jacobs Y, Nakamura T, Jenkins N, Copeland N, Cleary M. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol Cell Biol. 1997;17:5679-87 pubmed..We conclude that Meis proteins are preferred in vivo DNA binding partners for wild-type Pbx1, a relationship that is circumvented by its oncogenic counterpart E2a-Pbx1. ..
- Sun Y, Perera J, Rubin B, Huang J. SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein. J Biol Chem. 2011;286:18623-32 pubmed publisher..Such a mechanistic finding provides an opportunity to design specific therapeutic interventions to treat synovial sarcoma. ..
- West L, Roy S, Lachmi Weiner K, Hayashi R, Shi X, Appella E, et al. The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. J Biol Chem. 2010;285:37725-32 pubmed publisher..Together, we identify L3MBTL1 as the second known methyl-p53 effector protein, and provide a molecular explanation for the mechanism by which p53K382me1 is transduced to regulate p53 activity. ..
- Xu C, Liguori G, Adamson E, Persico M. Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. Dev Biol. 1998;196:237-47 pubmed..Differentiation into other cell types including skeletal muscle is not disrupted. These results suggest that Cr-1 is essential for contractile cardiomyocyte formation in vitro. ..
- Udani V, Santarelli J, Yung Y, Cheshier S, Andrews A, Kasad Z, et al. Differential expression of angiopoietin-1 and angiopoietin-2 may enhance recruitment of bone-marrow-derived endothelial precursor cells into brain tumors. Neurol Res. 2005;27:801-6 pubmed
- Bae J, Donigian J, Hsueh A. Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis. J Biol Chem. 2003;278:5195-204 pubmed..Thus, interaction of Mcl-1L and Mcl-1S with tankyrase 1 could serve as a unique mechanism to decrease the expression of these Bcl-2 family proteins, thereby leading to the modulation of the apoptosis pathway. ..
- Lin R, Nagy L, Inoue S, Shao W, Miller W, Evans R. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature. 1998;391:811-4 pubmed..Our findings suggest that oncogenic RARs mediate leukaemogenesis through aberrant chromatin acetylation, and that pharmacological manipulation of nuclear receptor co-factors may be a useful approach in the treatment of human disease. ..
- Wakasugi K, Schimmel P. Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase. J Biol Chem. 1999;274:23155-9 pubmed..Peptides based on these sequences are inactive as cytokines. Thus, the cytokine activities of split human TyrRS depend on highly differentiated motifs that are idiosyncratic to the mammalian system. ..
- Chen G, Duran G, Steger K, Lacayo N, Jaffrezou J, Dumontet C, et al. Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins. J Biol Chem. 1997;272:5974-82 pubmed..These data suggest that Phe335 is an important binding site on P-glycoprotein for substrates such as dactinomycin and vinblastine and for inhibitors such as cyclosporine and PSC 833. ..
- Jacobs Y, Schnabel C, Cleary M. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol. 1999;19:5134-42 pubmed..As a consequence, Hoxb1 employs Pbx and Meis-related proteins, as a pair of essential cofactors in a higher-order molecular complex, to mediate its transcriptional effects on an endogenous Hox response element. ..
- Onda M, Li D, Suzuki S, Nakamura I, Takenoshita S, Brogren C, et al. Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer. Clin Cancer Res. 2002;8:2870-4 pubmed..Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite. ..