Experts and Doctors on mutagenesis in New Jersey, United States


Locale: New Jersey, United States
Topic: mutagenesis

Top Publications

  1. Webber A, Ingram R, Levorse J, Tilghman S. Location of enhancers is essential for the imprinting of H19 and Igf2 genes. Nature. 1998;391:711-5 pubmed
    ..Thus, the location of the enhancers determines the outcome of competition in liver, and the strength of the H19 promoter is not sufficient to silence Igf2. ..
  2. Welte M, Gross S, Postner M, Block S, Wieschaus E. Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics. Cell. 1998;92:547-57 pubmed
    ..Mutations in klar also affect nuclear migration during eye development, suggesting multiple roles for klar-based transport. ..
  3. Roof D, Meluh P, Rose M. Kinesin-related proteins required for assembly of the mitotic spindle. J Cell Biol. 1992;118:95-108 pubmed
    ..Consistent with this role, KIP1 protein was found to colocalize with the mitotic spindle. ..
  4. Levitan D, Greenwald I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature. 1995;377:351-4 pubmed
    ..The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved. ..
  5. Danese P, Murphy C, Silhavy T. Multicopy suppression of cold-sensitive sec mutations in Escherichia coli. J Bacteriol. 1995;177:4969-73 pubmed
    ..In all cases, the mechanism of suppression is unrelated to the process of protein export. We suggest that the multicopy plasmids also suppress the sec mutations by compromising protein synthesis. ..
  6. Neuman Silberberg F, Schupbach T. The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein. Cell. 1993;75:165-74 pubmed
    ..We propose that the dorsal localization of grk RNA results in a spatially restricted ligand that asymmetrically activates the receptor. ..
  7. Irvine K, Wieschaus E. fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell. 1994;79:595-606 pubmed
    ..These observations suggest that fringe encodes a boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development. ..
  8. Ohta N, Ninfa A, Allaire A, Kulick L, Newton A. Identification, characterization, and chromosomal organization of cell division cycle genes in Caulobacter crescentus. J Bacteriol. 1997;179:2169-80 pubmed
    ..On the basis of these results, we suggest that the C. crescentus divA-divB-divE(ftsA)-ftsZ gene cluster corresponds to the 2-min fts gene cluster of Escherichia coli...
  9. Bhat K, Schedl P. Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis. Development. 1997;124:1675-88 pubmed
    ..Our results also indicate that Hh is not the only ligand for Ptc and similarly Ptc is not the only receptor for Hh. ..

More Information


  1. Ozturk S, Vishnu M, Olarewaju O, Starita L, Masison D, Kinzy T. Unique classes of mutations in the Saccharomyces cerevisiae G-protein translation elongation factor 1A suppress the requirement for guanine nucleotide exchange. Genetics. 2006;174:651-63 pubmed
    ..The location of the mutations on the eEF1A-eEF1Balpha structure suggests that their mechanism of suppression may depend on effects on the conserved G-protein elements: the P-loop and NKXD nucleotide-binding element. ..
  2. Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
    ..In combination our results support a model where the meiotic central spindle and associated proteins are essential for acentrosomal chromosome segregation. ..