Experts and Doctors on moloney murine leukemia virus in New York, United States


Locale: New York, United States
Topic: moloney murine leukemia virus

Top Publications

  1. Gonsky J, Bacharach E, Goff S. Identification of residues of the Moloney murine leukemia virus nucleocapsid critical for viral DNA synthesis in vivo. J Virol. 2001;75:2616-26 pubmed
    ..Nonetheless, viruses possessing these NC mutations demonstrated significant defects in the synthesis and accumulation of viral DNA products in vivo. ..
  2. Lim D, Orlova M, Goff S. Mutations of the RNase H C helix of the Moloney murine leukemia virus reverse transcriptase reveal defects in polypurine tract recognition. J Virol. 2002;76:8360-73 pubmed
    ..The data also suggest that the C helix may play an important role in polypurine tract recognition and proper formation of the plus-strand DNA's 5' end. ..
  3. Lim D, Gregorio G, Bingman C, Martinez Hackert E, Hendrickson W, Goff S. Crystal structure of the moloney murine leukemia virus RNase H domain. J Virol. 2006;80:8379-89 pubmed
    ..coli, and HIV-1 revealed that a loop of the HIV-1 connection domain resides within the same region of the Mo-MLV and E. coli C-helix. The HIV-1 connection domain may serve to recognize and bind the RNA/DNA substrate major groove. ..
  4. Rambukkana A, Kunz S, Min J, Campbell K, Oldstone M. Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination. Proc Natl Acad Sci U S A. 2003;100:16071-6 pubmed
  5. Yuan B, Campbell S, Bacharach E, Rein A, Goff S. Infectivity of Moloney murine leukemia virus defective in late assembly events is restored by late assembly domains of other retroviruses. J Virol. 2000;74:7250-60 pubmed
    ..Remarkably, the PPPY deletion mutant formed chain structures composed of multiple viral particles linked on the cell surface. Many of the mutants with heterologous L-domains released virions with wild-type morphology. ..
  6. DeStefano J, Buiser R, Mallaber L, Myers T, Bambara R, Fay P. Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled. J Biol Chem. 1991;266:7423-31 pubmed
    ..Results demonstrate that the RNase H function is much less active than the polymerization function during processive DNA synthesis and that the activities are not strictly coupled. ..
  7. Thenin Houssier S, de Vera I, Pedro Rosa L, Brady A, Richard A, Konnick B, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016;60:2195-208 pubmed publisher
    ..This study reports the use of TR-FRET screening to successfully identify a novel capsid inhibitor, ebselen, validating HIV-1 capsid as a promising target for drug development. ..
  8. Pinter A, Kopelman R, Li Z, Kayman S, Sanders D. Localization of the labile disulfide bond between SU and TM of the murine leukemia virus envelope protein complex to a highly conserved CWLC motif in SU that resembles the active-site sequence of thiol-disulfide exchange enzymes. J Virol. 1997;71:8073-7 pubmed
    ..A model is proposed in which rearrangements of the SU-TM intersubunit disulfide linkage, mediated by the CWLC sequence, play roles in the assembly and function of the Env complex. ..
  9. Schlesinger S, Goff S. Silencing of proviruses in embryonic cells: efficiency, stability and chromatin modifications. EMBO Rep. 2013;14:73-9 pubmed publisher
    ..The results indicate that epigenetic mechanisms with different specificity and efficiency are used to silence the exogenous retroviral sequences in embryonic cells...

More Information


  1. Wolf D, Goff S. TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells. Cell. 2007;131:46-57 pubmed
    ..The identification of TRIM28 as a retroviral silencer adds to the growing body of evidence that many TRIM family proteins are involved in retroviral restriction. ..
  2. Auerbach M, Brown K, Singh I. Mutational analysis of the N-terminal domain of Moloney murine leukemia virus capsid protein. J Virol. 2007;81:12337-47 pubmed
    ..Future studies are needed to understand the mechanism of these blocks and to target these regions pharmacologically to inhibit retroviral infection at additional stages...
  3. Leung J, Yueh A, Appah F, Yuan B, De los Santos K, Goff S. Interaction of Moloney murine leukemia virus matrix protein with IQGAP. EMBO J. 2006;25:2155-66 pubmed
    ..Virus replication was potently inhibited by a C-terminal fragment of IQGAP1, and impaired by RNAi knockdown of IQGAP1 and 2. We suggest that the IQGAPs link the virus to the cytoskeleton for trafficking both into and out of the cell...
  4. Arriagada G, Muntean L, Goff S. SUMO-interacting motifs of human TRIM5? are important for antiviral activity. PLoS Pathog. 2011;7:e1002019 pubmed publisher
    ..We propose that at least a portion of the antiviral activity of TRIM5? is mediated through the binding of its SIMs to SUMO-conjugated CA. ..
  5. Liberatore R, Mastrocola E, Powell C, Bieniasz P. Tetherin Inhibits Cell-Free Virus Dissemination and Retards Murine Leukemia Virus Pathogenesis. J Virol. 2017;91: pubmed publisher
    ..The delay in disease associated with this scenario suggests a role for cell-free virus in retroviral disease progression. ..
  6. Rodriguez J, Goff S. Xenotropic murine leukemia virus-related virus establishes an efficient spreading infection and exhibits enhanced transcriptional activity in prostate carcinoma cells. J Virol. 2010;84:2556-62 pubmed publisher
    ..These data suggest that XMRV may replicate more efficiently in LNCaP cells in part due to the transcriptional environment in LNCaP cells...
  7. Yueh A, Leung J, Bhattacharyya S, Perrone L, De los Santos K, Pu S, et al. Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection. J Virol. 2006;80:342-52 pubmed
    ..The results suggest that the SUMOylation of CA mediated by an interaction with Ubc9 and PIASy is required for early events of infection, after reverse transcription and before nuclear entry and viral DNA integration...
  8. Schlesinger S, Lee A, Wang G, Green L, Goff S. Proviral silencing in embryonic cells is regulated by Yin Yang 1. Cell Rep. 2013;4:50-8 pubmed publisher
    ..Finally, we report an embryonic cell-specific interaction between YY1 and Trim28. Our results suggest a major role for YY1 in the silencing of both exogenous retroviruses and ERVs in embryonic cells. ..
  9. Wang G, Wolf D, Goff S. EBP1, a novel host factor involved in primer binding site-dependent restriction of moloney murine leukemia virus in embryonic cells. J Virol. 2014;88:1825-9 pubmed publisher
    ..Here, we identified ErbB3-binding protein 1 (EBP1) to be a novel component of the ZFP809-TRIM28 silencing complex and show that EBP1 depletion reduces PBS-mediated retroviral silencing. ..
  10. Studamire B, Goff S. Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors. Retrovirology. 2008;5:48 pubmed publisher
    ..Significant questions remain regarding the influence of host proteins on the selection of target sites, on the repair of integration intermediates, and on the efficiency of integration...
  11. Wang M, Kim W, Gao G, Torrey T, Morse H, De Camilli P, et al. Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production. J Biol. 2003;3:4 pubmed
    ..This study shows that endophilins interact with Mo-MuLV Gag and affect virion production. The findings imply that endophilin is another component of the large complex that is hijacked by retroviruses to promote virion production. ..
  12. Orlova M, Yueh A, Leung J, Goff S. Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination. Cell. 2003;115:319-31 pubmed
    ..These results suggest that RT enhances suppression of termination and that the interaction of RT with eRF1 is required for an appropriate level of translational readthrough. ..
  13. Auerbach M, Shu C, Kaplan A, Singh I. Functional characterization of a portion of the Moloney murine leukemia virus gag gene by genetic footprinting. Proc Natl Acad Sci U S A. 2003;100:11678-83 pubmed
    ..In addition to providing the most comprehensive functional map of a retroviral gag gene, our study demonstrates the abundance of information that can be gleaned by genetic footprinting of viral sequences...
  14. Yueh A, Goff S. Phosphorylated serine residues and an arginine-rich domain of the moloney murine leukemia virus p12 protein are required for early events of viral infection. J Virol. 2003;77:1820-9 pubmed
    ..The restored function of S(61,65)A mutant virus by second or third site mutations may result from a structural change or the addition of positively charged residues in the arginine-rich region...
  15. Yuan B, Fassati A, Yueh A, Goff S. Characterization of Moloney murine leukemia virus p12 mutants blocked during early events of infection. J Virol. 2002;76:10801-10 pubmed
  16. Koehne C, Lazo P, Alves K, Lee J, Tsichlis P, O Donnell P. The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical. J Virol. 1989;63:2366-9 pubmed
    ..This finding demonstrates the need for rigorous characterization of any newly identified common regions of integration in retrovirus-induced neoplasms. ..
  17. Buiser R, DeStefano J, Mallaber L, Fay P, Bambara R. Requirements for the catalysis of strand transfer synthesis by retroviral DNA polymerases. J Biol Chem. 1991;266:13103-9 pubmed
    ..These results suggest that strand transfer synthesis relies on an unidentified functional activity present in RTs...
  18. Green L, Houck Loomis B, Yueh A, Goff S. Large ribosomal protein 4 increases efficiency of viral recoding sequences. J Virol. 2012;86:8949-58 pubmed publisher