Genomes and Genes
Experts and Doctors on molecular sequence data in Massachusetts, United States
Locale: Massachusetts, United States
Topic: molecular sequence data
Publications186 found, 100 shown here
- Zhang Y, Fox J, Ho Y, Zhang L, Stills H, Smith T. Comparison of the major outer-membrane protein (MOMP) gene of mouse pneumonitis (MoPn) and hamster SFPD strains of Chlamydia trachomatis with other Chlamydia strains. Mol Biol Evol. 1993;10:1327-42 pubmed publisher..The branching pattern of this evolutionary tree is generally consistent with current classification based on serological, morphological, and other biological characteristics...
- Hinkle G, Sogin M. The evolution of the Vahlkampfiidae as deduced from 16S-like ribosomal RNA analysis. J Eukaryot Microbiol. 1993;40:599-603 pubmed..The Vahlkampfiidae lineage is monophyletic, branches early along the eukaryotic line of descent, and is not a close relative of the multicellular amoebae that also reversibly transform from amoebae to flagellates...
- Holtz K, Stec B, Myers J, Antonelli S, Widlanski T, Kantrowitz E. Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes. Protein Sci. 2000;9:907-15 pubmed..Both enzyme-inhibitor complexes exhibit close contacts, one of which has the chemical and geometrical potential to be considered an unconventional hydrogen bond of the type C-H...X. ..
- Tori K, Cheriyan M, Pedamallu C, Contreras M, Perler F. The Thermococcus kodakaraensis Tko CDC21-1 intein activates its N-terminal splice junction in the absence of a conserved histidine by a compensatory mechanism. Biochemistry. 2012;51:2496-505 pubmed publisher..Consequently, inteins have more flexibility to sample catalytic mechanisms, providing insight into various strategies that enzymes use to accomplish catalysis...
- Reitter J, Means R, Desrosiers R. A role for carbohydrates in immune evasion in AIDS. Nat Med. 1998;4:679-84 pubmed..These results demonstrate a role for N-linked glycosylation in limiting the neutralizing antibody response to SIV and in shielding the virus from immune recognition. ..
- Yang F, Vought B, Satterlee J, Walker A, Jim Sun Z, Watts J, et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006;442:700-4 pubmed..Taken together, our findings demonstrate that ARC105 is a key effector of SREBP-dependent gene regulation and control of lipid homeostasis in metazoans. ..
- Christianson C, Montavon T, Van Lanen S, Shen B, Bruner S. The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry. 2007;46:7205-14 pubmed..The amino acid determinants for substrate recognition and catalysis can be predicted from the structure, setting the framework for detailed mechanistic investigations. ..
- Murthy S, Trimble J, Desrosiers R. Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation. J Virol. 1989;63:3307-14 pubmed..5 kilobases). Although some analogies can be drawn between STP and LMP (lymphocyte membrane protein) of Epstein-Barr virus, STP is not related in sequence to LMP...
- Chan S, Opitz L, Higgins L, O loane D, Xu S. Cofactor requirement of HpyAV restriction endonuclease. PLoS ONE. 2010;5:e9071 pubmed publisher..A survey of sequenced microbial genomes uncovered 10 putative R-M systems that show high sequence similarity to the HpyAV system, suggesting lateral transfer of a prototypic HpyAV-like R-M system among these microorganisms. ..
- Tzertzinis G, Egana A, Palli S, Robinson Rechavi M, Gissendanner C, Liu C, et al. Molecular evidence for a functional ecdysone signaling system in Brugia malayi. PLoS Negl Trop Dis. 2010;4:e625 pubmed publisher..Furthermore, our study proposes that existing compounds targeting the insect ecdysone signaling pathway should be considered as potential pharmacological agents against filarial parasites. ..
- Wray L, Atkinson M, Fisher S. The nitrogen-regulated Bacillus subtilis nrgAB operon encodes a membrane protein and a protein highly similar to the Escherichia coli glnB-encoded PII protein. J Bacteriol. 1994;176:108-14 pubmed..The nucleotide sequence of this promoter has significant similarity with the -10 region, but not the -35 region, of the consensus sequence for Bacillus subtilis sigma A-dependent promoters. ..
- Reilly K, Melton D. Short-range signaling by candidate morphogens of the TGF beta family and evidence for a relay mechanism of induction. Cell. 1996;86:743-54 pubmed..These results suggest that if a localized cellular source of an inducer acts to pattern mesodermal cells at a distance in Xenopus embryos, it does so by a relay mechanism. ..
- Newman R, Hall L, Kirmaier A, Pozzi L, Pery E, Farzan M, et al. Evolution of a TRIM5-CypA splice isoform in old world monkeys. PLoS Pathog. 2008;4:e1000003 pubmed publisher..Whether the formation of novel genes through alternative splicing has played a wider role in the evolution of the TRIM family remains to be investigated...
- Sano T, Pandori M, Chen X, Smith C, Cantor C. Recombinant core streptavidins. A minimum-sized core streptavidin has enhanced structural stability and higher accessibility to biotinylated macromolecules. J Biol Chem. 1995;270:28204-9 pubmed..Apparently, the terminal regions, present on the surface of natural core streptavidin, spatially hinder biotinylated macromolecules from approaching the biotin binding sites. ..
- Zambonelli C, Roberts M. Non-HKD phospholipase D enzymes: new players in phosphatidic acid signaling?. Prog Nucleic Acid Res Mol Biol. 2005;79:133-81 pubmed
- Goldrick D, Yu G, Jiang S, Hong J. Nucleotide sequence and transcription start point of the phosphoglycerate transporter gene of Salmonella typhimurium. J Bacteriol. 1988;170:3421-6 pubmed
- Martin S, Heinrich G, Sandell J. Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish. J Comp Neurol. 1998;396:253-66 pubmed..The zebrafish GAD65 and GAD67 are present in identified neurons in the forebrain, midbrain, hindbrain, and spinal cord, and they catalyze the production of GABA in the developing embryo. ..
- Xu X, Meiler S, Zhong T, Mohideen M, Crossley D, Burggren W, et al. Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nat Genet. 2002;30:205-9 pubmed..Absence of Titin function thus results in blockage of sarcomere assembly and causes a functional disorder resembling human dilated cardiomyopathies, one form of which is described in another paper in this issue. ..
- Zhu B, Ramachandran B, Gulick T. Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain. J Biol Chem. 2005;280:28749-60 pubmed..Thus, a conserved pattern of alternative splicing in vertebrate MEF2 genes generates an acidic activation domain in MEF2 proteins selectively in tissues where MEF2 target genes are highly expressed. ..
- Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S. Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase. J Biol Chem. 2001;276:21737-44 pubmed..However, PKK itself may be phosphorylated by PKCbeta. PKK represents a developmentally regulated protein kinase that can associate with membranes. The functional significance of its association with PKCbeta remains to be ascertained. ..
- Hudson N, Ding F, Bucay I, O Brien E, Gorkun O, Superfine R, et al. Submillisecond elastic recoil reveals molecular origins of fibrin fiber mechanics. Biophys J. 2013;104:2671-80 pubmed publisher..Our results point to the unstructured ?C regions of the otherwise structured fibrin molecule as being responsible for the elastic recoil of the fibers. ..
- Shen B, Tai P, Pritchard A, Vasil M. Nucleotide sequences and expression in Escherichia coli of the in-phase overlapping Pseudomonas aeruginosa plcR genes. J Bacteriol. 1987;169:4602-7 pubmed..These results indicate the expression of Pseudomonas in-phase overlapping genes in E. coli. ..
- Wang S, Miura M, Jung Y, Zhu H, Gagliardini V, Shi L, et al. Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem. 1996;271:20580-7 pubmed..Ich-3 does not process proIL-1beta directly but does promote proIL-1beta processing by ICE. These results suggest that Ich-3 may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE. ..
- Zhang D, Johnson R. Molecular cloning and comparative analysis of the rhesus macaque costimulatory molecules CD80 (B7-1) and CD86 (B7-2). Cell Immunol. 1997;177:9-17 pubmed..The high degree of homology between the rhesus and the human CD80 and CD86 molecules should facilitate analysis of therapeutic interventions directed at this costimulatory pathway in nonhuman primates. ..
- Longmore G, Lodish H. An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: a cytokine receptor superfamily oncogene. Cell. 1991;67:1089-102 pubmed..The activated erythropoietin receptor does not transform cultured fibroblasts, suggesting why oncogenic mutations in other members of this receptor superfamily have not been detected. ..
- Claffey K, Herrera V, Brecher P, Ruiz Opazo N. Cloning and tissue distribution of rat heart fatty acid binding protein mRNA: identical forms in heart and skeletal muscle. Biochemistry. 1987;26:7900-4 pubmed..The structural differences between heart FABP and other members of this multigene family may be related to the functional requirements of oxidative muscle for fatty acids as a fuel source. ..
- Gibbs J, Regier D, Desrosiers R. Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes. AIDS Res Hum Retroviruses. 1994;10:343-50 pubmed..This collection of HIV-1 deletion mutants will be useful for elucidating the functions of these genes and for investigating antiviral immunity in animal models. ..
- Lee H, Choi J, Li M, Kaye K, Kieff E, Jung J. Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP. J Virol. 1999;73:3913-9 pubmed..Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts. ..
- Elion E, Grisafi P, Fink G. FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation. Cell. 1990;60:649-64 pubmed..The predicted FUS3 protein is 35% identical to the cdc2+/CDC28 kinases and 52% identical to the KSS1 predicted kinase. ..
- Brooks C, Tolan D. A partially active mutant aldolase B from a patient with hereditary fructose intolerance. FASEB J. 1994;8:107-13 pubmed
- Sharon J, Kao C, Sompuram S. Oligonucleotide-directed mutagenesis of antibody combining sites. Int Rev Immunol. 1993;10:113-27 pubmed
- White D, Gilmore T. Temperature-sensitive transforming mutants of the v-rel oncogene. J Virol. 1993;67:6876-81 pubmed..5 degrees C but rapidly senesced at 41.5 degrees C. Both mutant v-Rel proteins were also ts for DNA binding in vitro. These mutants may be valuable for identifying genes directly regulated by v-rel. ..
- Koch M, Olson P, Albus A, Jin W, Hunter D, Brunken W, et al. Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain. J Cell Biol. 1999;145:605-18 pubmed..It seems likely that these apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. ..
- Gómez del Arco P, Maki K, Georgopoulos K. Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition. Mol Cell Biol. 2004;24:2797-807 pubmed..We thus propose that Ikaros's activity as a regulator of the G(1)-S transition is controlled by phosphorylation in response to signaling events that down-modulate its DNA binding activity. ..
- Mauris J, Evans T. Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity. PLoS ONE. 2009;4:e7175 pubmed publisher..Finally, the C-terminal 123 amino acid residues of Aae MutL were sufficient to display Mn(++) induced nicking activity. ..
- Panchenko M, Williams M, Brody J, Yu Q. Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels. Am J Physiol. 1996;270:L547-58 pubmed..The differential expression of multiple type I receptors within different cell lineages may therefore define cell specific responses to TGF-beta. ..
- Bolcato Bellemin A, Mattei M, Fenton M, Amar S. Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression. J Endotoxin Res. 2004;10:15-23 pubmed..Taken together, these results highlight the important role of LITAF in the regulation of TNF-alpha gene expression and suggest a potential role of LITAF in mouse organogenesis. ..
- Capobianco A, Chang D, Mosialos G, Gilmore T. p105, the NF-kappa B p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells. J Virol. 1992;66:3758-67 pubmed..However, in vitro association with p105 by v-Rel does not necessarily correlate with transformation, since one nontransforming v-Rel mutant can associate with p105 in vitro. ..
- Li C, Nelson L, Kim K, Nathoo A, Hart A. Neuropeptide gene families in the nematode Caenorhabditis elegans. Ann N Y Acad Sci. 1999;897:239-52 pubmed..Cellular expression patterns and genetic analysis of flp and nlp genes suggest that neuropeptides in nematodes also have widespread and varied roles in nervous system function. ..
- Brown M, Begley G, Czerwiec E, Stenberg L, Jacobs M, Kalume D, et al. Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation. Biochemistry. 2005;44:9150-9 pubmed..It also provides the first formal evidence to prove that gamma-carboxylation occurs as a post-translational rather than a cotranslational process. ..
- Tong S, Li J, Wands J. Interaction between duck hepatitis B virus and a 170-kilodalton cellular protein is mediated through a neutralizing epitope of the pre-S region and occurs during viral infection. J Virol. 1995;69:7106-12 pubmed..Two peptides showed significant similarities to human and animal carboxypeptides H, M, and N. Taken together, these results raise the possibility that the p170 binding protein is important during the replication cycle of DHBV. ..
- Gunderson J, Goss S, Sogin M. The sequence of the Hartmannella vermiformis small subunit rRNA coding region. J Eukaryot Microbiol. 1994;41:481-2 pubmed..The coding region is 1,840 nucleotides long, and is typical of eukaryotic rRNA genes in both size and composition. Different clones contained different nucleotides at three positions...
- Koch M, Murrell J, Hunter D, Olson P, Jin W, Keene D, et al. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization. J Cell Biol. 2000;151:221-34 pubmed..Functional studies were performed and show that beta-netrin promotes neurite elongation from olfactory bulb explants. Together, these data suggest that beta-netrin is important in neural, kidney, and vascular development. ..
- Sweadner K, Wetzel R, Arystarkhova E. Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase. Biochem Biophys Res Commun. 2000;279:196-201 pubmed..FXYD2 is on chromosome 11q23 close to a site of tumorigenic chromosomal translocations, and has a number of repeat elements. ..
- Herrera V, Ruiz Opazo N. Identification of a novel V1-type AVP receptor based on the molecular recognition theory. Mol Med. 2001;7:499-506 pubmed
- Xu S, Nugent R, Kasamkattil J, Fomenkov A, Gupta Y, Aggarwal A, et al. Characterization of type II and III restriction-modification systems from Bacillus cereus strains ATCC 10987 and ATCC 14579. J Bacteriol. 2012;194:49-60 pubmed publisher..A survey of type II and III restriction-modification (R-M) system genes is presented from sequenced B. cereus, Bacillus anthracis, and Bacillus thuringiensis strains. ..
- Reyon D, Tsai S, Khayter C, Foden J, Sander J, Joung J. FLASH assembly of TALENs for high-throughput genome editing. Nat Biotechnol. 2012;30:460-5 pubmed publisher..Our results establish the robustness of TALEN technology and demonstrate that FLASH facilitates high-throughput genome editing at a scale not currently possible with other genome modification technologies. ..
- Arystarkhova E, Sweadner K. Isoform-specific monoclonal antibodies to Na,K-ATPase alpha subunits. Evidence for a tissue-specific post-translational modification of the alpha subunit. J Biol Chem. 1996;271:23407-17 pubmed..A new alpha1-specific antibody, 6F, was characterized and mapped to another site near the N terminus; this antibody has broader species specificity than the other well-characterized alpha1 antibody, McK1. ..
- Christmas P, Ursino S, Fox J, Soberman R. Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase. J Biol Chem. 1999;274:21191-9 pubmed..The data indicate that the tissue-specific expression of functionally distinct CYP4F3 isoforms is regulated by alternative promoter usage and mutually exclusive exon splicing. ..
- Pack Chung E, Meyers M, Pettingell W, Moir R, Brownawell A, Cheng I, et al. Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J Biol Chem. 2000;275:14440-5 pubmed..Our findings reveal a molecular link between PS2 and intracellular Ca(2+) channels (i.e. ryanodine receptor) and substantiate normal and/or pathological roles of PS2 in intracellular Ca(2+) homeostasis. ..
- Chen T, Ueda Y, Xie S, Li E. A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem. 2002;277:38746-54 pubmed..These findings suggest that Dnmt3a and Dnmt3a2 may have distinct DNA targets and different functions in development. ..
- Herbeck J, Funk D, Degnan P, Wernegreen J. A conservative test of genetic drift in the endosymbiotic bacterium Buchnera: slightly deleterious mutations in the chaperonin groEL. Genetics. 2003;165:1651-60 pubmed..Rather, they further support the hypothesis that drift is an important force driving accelerated protein evolution in this obligate mutualist...
- Akiyoshi D, Weiss L, Feng X, Williams B, Keeling P, Zhang Q, et al. Analysis of the beta-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque. J Eukaryot Microbiol. 2007;54:38-41 pubmed..The beta-tubulin of E. bieneusi has a substitution at Glu(198), which is one of six amino acids reported to be associated with benzimidazole sensitivity...
- Samia J, Alexander S, Horton K, Auron P, Byers M, Shows T, et al. Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. Genomics. 1990;6:159-67 pubmed..A promoter "TATAAAbox" is located 30 bp upstream of the "cap" site.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Gong B, Mabuchi K, Takahashi K, Nadal Ginard B, Tao T. Characterization of wild type and mutant chicken gizzard alpha calponin expressed in E. coli. J Biochem. 1993;114:453-6 pubmed
- Wen D, Laursen R. A model for binding of an antifreeze polypeptide to ice. Biophys J. 1992;63:1659-62 pubmed
- Mazzarelli J, Rajur S, Iadarola P, McLaughlin L. Interactions between the trp repressor and its operator sequence as studied by base analogue substitution. Biochemistry. 1992;31:5925-36 pubmed
- Marchionni M, Goodearl A, Chen M, Bermingham McDonogh O, Kirk C, Hendricks M, et al. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature. 1993;362:312-8 pubmed..These factors are probably important in the development and regeneration of the nervous system. ..
- Denhez F, Wilcox Adelman S, Baciu P, Saoncella S, Lee S, French B, et al. Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5. J Biol Chem. 2002;277:12270-4 pubmed
- Dick F, Dyson N. Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins. J Virol. 2002;76:6224-34 pubmed..These residues most likely form ionic interactions with conserved acidic amino acids on E7 since a stable pRB/E7 interaction was restored when the lysine residues on pRB and the acidic residues on E7 were interchanged. ..
- Dinauer M, Curnutte J, Rosen H, Orkin S. A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. J Clin Invest. 1989;84:2012-6 pubmed..The mechanism by which the Pro 415----His mutation renders the oxidase nonfunctional is unknown, but may involve an impaired interaction with other components of the oxidase. ..
- Wirsen C, Sievert S, Cavanaugh C, Molyneaux S, Ahmad A, Taylor L, et al. Characterization of an autotrophic sulfide-oxidizing marine Arcobacter sp. that produces filamentous sulfur. Appl Environ Microbiol. 2002;68:316-25 pubmed..Filamentous sulfur formation by "Candidatus Arcobacter sulfidicus" or similar strains may be an ecologically important process, contributing significantly to primary production in such environments. ..
- Kegel K, Sapp E, Yoder J, Cuiffo B, Sobin L, Kim Y, et al. Huntingtin associates with acidic phospholipids at the plasma membrane. J Biol Chem. 2005;280:36464-73 pubmed..Our data support a new model in which huntingtin directly binds membranes through electrostatic interactions with acidic phospholipids. ..
- Yang Y, Goldrick D, Hong J. Identification of the products and nucleotide sequences of two regulatory genes involved in the exogenous induction of phosphoglycerate transport in Salmonella typhimurium. J Bacteriol. 1988;170:4299-303 pubmed..In the accompanying paper, we present genetic evidence that pgtB and pgtC genes are involved in the induction of the pgtP expression by modulating derepressor activity. ..
- Feschenko M, Donnet C, Wetzel R, Asinovski N, Jones L, Sweadner K. Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus. J Neurosci. 2003;23:2161-9 pubmed..At least two other FXYD family members have been detected in the CNS, suggesting that additional complexity of sodium pump regulation will be found. ..
- Wilson D, Wilson M. Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. J Clin Invest. 1992;89:996-1005 pubmed..Indirect immunofluorescence and subcellular fractionation showed that rab5b localizes to the plasma membrane. We speculate that rab5b plays a role in vesicular trafficking at the plasma membrane in various cell types. ..
- Russek S, Farb D. Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform. Genomics. 1994;23:528-33 pubmed..This organization of GABAAR gene clusters may have been preserved as linkage provides a mechanism for facilitating coordinate gene expression. ..
- Lucero H, Lebeche D, Kaminer B. ERcalcistorin/protein disulfide isomerase (PDI). Sequence determination and expression of a cDNA clone encoding a calcium storage protein with PDI activity from endoplasmic reticulum of the sea urchin egg. J Biol Chem. 1994;269:23112-9 pubmed..This molecule appears to have a dual function of calcium storage and PDI activity within the ER. We hence redesignate it ERcalcistorin/PDI (ECaSt/PDI), a protein that is distinct from calsequestrin and calreticulin...
- Maheswaran S, Englert C, Zheng G, Lee S, Wong J, Harkin D, et al. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev. 1998;12:1108-20 pubmed..These observations indicate that Hsp70 is an important cofactor for the function of WT1, and suggest a potential role for this chaperone during kidney differentiation. ..
- Sullivan B, Harrison Lavoie K, Marshansky V, Lin H, Kehrl J, Ausiello D, et al. RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. Mol Biol Cell. 2000;11:3155-68 pubmed..Thus, these data support the hypothesis that these RGS proteins sequester coatomer in the cytoplasm and inhibit its recruitment onto Golgi membranes, which may in turn modulate Golgi-plasma membrane or intra-Golgi transport. ..
- Phelps A, Schobert C, Wohlrab H. Cloning and characterization of the mitochondrial phosphate transport protein gene from the yeast Saccharomyces cerevisiae. Biochemistry. 1991;30:248-52 pubmed..Mersalyl sensitivity has been retained and must be due to one of its three cysteines. Among these three cysteines, only Cys-28, located in the first hydrophobic segment, is conserved between the yeast and the beef protein. ..
- Wang Z, Morris D, Rothstein T. Constitutive and inducible levels of egr-1 and c-myc early growth response gene expression in self-renewing B-1 lymphocytes. Cell Immunol. 1995;162:309-14 pubmed
- Maranto A. Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium. J Biol Chem. 1994;269:1222-30 pubmed..The subcellular distribution and appearance of staining is consistent with localization on the endoplasmic reticulum, with the highest concentration of staining occurring adjacent to the apical brush border of villus cells. ..
- Bogden C, Fass D, Bergman N, Nichols M, Berger J. The structural basis for terminator recognition by the Rho transcription termination factor. Mol Cell. 1999;3:487-93 pubmed..Dimerization of symmetric subunits on an asymmetric ligand is developed as a model for allosteric control in the action of the intact Rho hexamer...
- Xu Q, Buckley D, Guan C, Guo H. Structural insights into the mechanism of intramolecular proteolysis. Cell. 1999;98:651-61 pubmed
- Bixby J, Laur O, Johnson W, Desrosiers R. Diversity of envelope genes from an uncloned stock of SIVmac251. AIDS Res Hum Retroviruses. 2010;26:1115-31 pubmed publisher..These new SIV clones are being contributed to the NIH AIDS Reagent Repository and are available to the scientific community. ..
- Tong K, Keller T, Hoffman C, Annunziato A. Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. Eukaryot Cell. 2012;11:1095-103 pubmed publisher..These results point to a direct link between Hat1, H4 acetylation, and the establishment of repressed telomeric chromatin in fission yeast. ..
- Fenner M, Parrish J, Boyd Y, Reed V, Macdonald M, Nelson D, et al. MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis. Genomics. 1998;51:401-7 pubmed
- Osborn L, Hession C, Tizard R, Vassallo C, Luhowskyj S, Chi Rosso G, et al. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989;59:1203-11 pubmed..VCAM-1, which belongs to the immunoglobulin gene super-family, may be central to recruitment of mononuclear leukocytes into inflammatory sites in vivo. ..
- Wu Z, Bucher N, Farmer S. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids. Mol Cell Biol. 1996;16:4128-36 pubmed..C/EBPdelta may function by synergizing with C/EBPbeta to enhance the level of PPARgamma expression. ..
- Chadwick B, Mull J, Helbling L, Gill S, Leyne M, Robbins C, et al. Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31. Genomics. 1999;58:302-9 pubmed..No coding sequence mutations, genomic rearrangements, or differences in expression were detected for either gene in familial dysautonomia patients...
- Lorson M, Horvitz H, van den Heuvel S. LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans. J Cell Biol. 2000;148:73-86 pubmed..Our results show that LIN-5 is a novel component of the spindle apparatus required for chromosome and spindle movements, cytoplasmic cleavage, and correct alternation of the S and M phases of the cell cycle. ..
- Boston Howes W, Gibb S, Williams E, Pasinelli P, Brown R, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J Biol Chem. 2006;281:14076-84 pubmed..Taken together, our findings suggest that caspase-3 cleavage of EAAT2 is one mechanism responsible for the impairment of glutamate uptake in mutant SOD1-linked ALS. ..
- Sievert S, Scott K, Klotz M, Chain P, Hauser L, Hemp J, et al. Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas denitrificans. Appl Environ Microbiol. 2008;74:1145-56 pubmed..An elaborate arsenal of sensory and regulatory protein-encoding genes is in place, as are genes necessary to prevent and respond to oxidative stress...
- Min C, Yu Z, Kirsch K, Zhao Y, Vora S, Trackman P, et al. A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer. Cancer Res. 2009;69:6685-93 pubmed publisher..Thus, these findings identify for the first time genetic polymorphism as a mechanism of impaired tumor suppressor function of LOX-PP and suggest that it may play an etiologic role in ER-negative breast cancer. ..
- Berry M, Banu L, Larsen P. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature. 1991;349:438-40 pubmed..This explains why conversion of T4 to T3 is impaired in experimental selenium deficiency and identifies an essential role for this trace element in thyroid hormone action. ..
- Rishi A, Joyce Brady M, Fisher J, Dobbs L, Floros J, vanderSpek J, et al. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives. Dev Biol. 1995;167:294-306 pubmed..5 onward, but is detected by in situ hybridization earlier in lung, brain and neural derivatives, and foregut. Expression is down-regulated in all but lung tissues as development proceeds. ..
- Nocero M, Isshiki T, Yamamoto M, Hoffman C. Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8). Genetics. 1994;138:39-45 pubmed..Therefore, git3 and git5 appear to act either in concert with or independently from gpa2 (git8) to regulate adenylate cyclase activity. ..
- Papastoitsis G, Siman R, Scott R, Abraham C. Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. Biochemistry. 1994;33:192-9 pubmed..Sequence analysis reveals high homology to the rat metallopeptidase EC 220.127.116.11, a protease involved in neuropeptide processing. ..
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