Experts and Doctors on molecular evolution in Illinois, United States


Locale: Illinois, United States
Topic: molecular evolution

Top Publications

  1. Brennan C, Bodelle P, Coffey R, Harris B, Holzmayer V, Luk K, et al. HIV global surveillance: foundation for retroviral discovery and assay development. J Med Virol. 2006;78 Suppl 1:S24-9 pubmed
  2. Palopoli M, Davis A, Wu C. Discord between the phylogenies inferred from molecular versus functional data: uneven rates of functional evolution or low levels of gene flow?. Genetics. 1996;144:1321-8 pubmed
    ..We propose tests that will allow us to discriminate between these hypotheses...
  3. Tsaur S, Ting C, Wu C. Positive selection driving the evolution of a gene of male reproduction, Acp26Aa, of Drosophila: II. Divergence versus polymorphism. Mol Biol Evol. 1998;15:1040-6 pubmed publisher
    ..We suggest that positive selection is active, but may be weak, for each amino acid change in the Acp26Aa gene...
  4. Wyckoff G, Wang W, Wu C. Rapid evolution of male reproductive genes in the descent of man. Nature. 2000;403:304-9 pubmed publisher
    ..These results open up opportunities to test the hypothesis that sexual selection plays some role in the molecular evolution of higher primates...
  5. Ludwig M, Bergman C, Patel N, Kreitman M. Evidence for stabilizing selection in a eukaryotic enhancer element. Nature. 2000;403:564-7 pubmed
    ..Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences. ..
  6. Ludwig M. Functional evolution of noncoding DNA. Curr Opin Genet Dev. 2002;12:634-9 pubmed
    ..Several experimentally characterized regulatory elements have failed to show sequence similarity even between closely related species. ..
  7. Zhang R, Grembecka J, Vinokour E, Collart F, Dementieva I, Minor W, et al. Structure of Bacillus subtilis YXKO--a member of the UPF0031 family and a putative kinase. J Struct Biol. 2002;139:161-70 pubmed
    ..The crystal structure provides valuable information about the YXKO protein's tertiary and quaternary structure, the biochemical function of YXKO and its homologues, and the evolution of its ribokinase-like superfamily. ..
  8. Ludwig M, Palsson A, Alekseeva E, Bergman C, Nathan J, Kreitman M. Functional evolution of a cis-regulatory module. PLoS Biol. 2005;3:e93 pubmed
    ..Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules. ..
  9. Kim I, Zhou Y, Ramakrishna S, Hughes D, Solway J, Costa R, et al. Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus. J Biol Chem. 2005;280:37908-16 pubmed
    ..3-kb Foxf1 promoter in cotransfection assays. These studies demonstrated that the conserved Foxf1 3'RE region is essential for proper tissue-specific regulation of the Foxf1 promoter region during mouse embryogenesis. ..

More Information


  1. Grasberger H, Refetoff S. Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent. J Biol Chem. 2006;281:18269-72 pubmed
    ..The identification of DUOXA genes has important implications for studies of the molecular mechanisms controlling DUOX expression and the molecular genetics of congenital hypothyroidism. ..
  2. Pritchard J, Di Rienzo A. Adaptation - not by sweeps alone. Nat Rev Genet. 2010;11:665-7 pubmed publisher
    ..Jonathan Pritchard and Anna Di Rienzo argue that many adaptive events in natural populations may occur by polygenic adaptation, which would largely go undetected by conventional methods for detecting selection. ..
  3. Bettencourt B, Feder M. Hsp70 duplication in the Drosophila melanogaster species group: how and when did two become five?. Mol Biol Evol. 2001;18:1272-82 pubmed publisher
    ..The proliferation, concerted evolution, and maintenance of functionality in the D. melanogaster hsp70 genes is consistent with the action of natural selection in this species...