Experts and Doctors on mitochondria in California, United States


Locale: California, United States
Topic: mitochondria

Top Publications

  1. Hsu M, Savas U, Griffin K, Johnson E. Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. J Biol Chem. 2001;276:27950-8 pubmed
    ..Additionally, no significant differences were seen for the expression of apolipoprotein AI, AII, or CIII; medium chain acyl-CoA dehydrogenase; or stearoyl-CoA desaturase mRNAs. ..
  2. Ju W, Liu Q, Kim K, Crowston J, Lindsey J, Agarwal N, et al. Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007;48:2145-51 pubmed
    ..Increased understanding of the molecular mechanisms that regulate the cellular response to elevated pressure including mitochondrial fission may provide new therapeutic targets for protecting RGCs from elevated hydrostatic pressure. ..
  3. Parone P, Da Cruz S, Han J, McAlonis Downes M, Vetto A, Lee S, et al. Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci. 2013;33:4657-71 pubmed publisher
  4. Yu F, Sugawara T, Nishi T, Liu J, Chan P. Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury. J Neurotrauma. 2006;23:595-603 pubmed
    ..An increased level of SOD1 in mitochondria conceivably reduces oxidative stress, thereby attenuating EndoG translocation, and resulting in reduction of caspase-independent apoptosis. ..
  5. Ramakrishna R, Edwards J, McCulloch A, Palsson B. Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints. Am J Physiol Regul Integr Comp Physiol. 2001;280:R695-704 pubmed
    ..The model provides a systemic perspective to characterize the effect of stoichiometric constraints and specific metabolic fluxes on mitochondrial function. ..
  6. Kartvelishvili E, Tworowski D, Vernon H, Moor N, Wang J, Wong L, et al. Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci. 2017;26:1505-1516 pubmed publisher
    ..Using steady-state kinetic measurements of phenylalanine activation and tRNAPhe aminoacylation, we gained insight into the structural and kinetic effects of mitochondrial disease-related mutations in FARS2 gene. ..
  7. Haun F, Nakamura T, Shiu A, Cho D, Tsunemi T, Holland E, et al. S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxid Redox Signal. 2013;19:1173-84 pubmed publisher
    ..Moreover, the SNO-Drp1 signaling pathway links mutHTT neurotoxicity to a malfunction in mitochondrial dynamics, resulting in neuronal synaptic damage in HD. ..
  8. Ubhi K, Lee P, Adame A, Inglis C, Mante M, Rockenstein E, et al. Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. J Neurosci Res. 2009;87:2728-39 pubmed publisher
    ..3NP administration also exaggerated neurological deficits in the MBP-halphasyn tg mice, resulting in widespread neuronal degeneration and behavioral impairment. ..
  9. Murriel C, Churchill E, Inagaki K, Szweda L, Mochly Rosen D. Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J Biol Chem. 2004;279:47985-91 pubmed
    ..Our data suggest that PKCdelta activation has a critical proapoptotic role in cardiac responses following ischemia and reperfusion. ..

More Information


  1. Sun X, Budas G, Xu L, Barreto G, Mochly Rosen D, Giffard R. Selective activation of protein kinase C? in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice. J Neurosci Res. 2013;91:799-807 pubmed publisher
  2. Wang X, Zhang C, Yan X, Lan B, Wang J, Wei C, et al. A Novel Bioavailable BH3 Mimetic Efficiently Inhibits Colon Cancer via Cascade Effects of Mitochondria. Clin Cancer Res. 2016;22:1445-58 pubmed publisher
    ..These findings provide a rational basis for clinical investigation of this highly promising BH3 mimetic in colon cancer. ..
  3. Wang Y, Zhang C, Yu R, Cho H, Nelson M, Bayuga Ocampo C, et al. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004;2:e294 pubmed
    ..These results demonstrate that complex physiologic properties such as fatigue, endurance, and running capacity can be molecularly analyzed and manipulated. ..
  4. Kao K, Schwartz K, Sherlock G. A genome-wide analysis reveals no nuclear dobzhansky-muller pairs of determinants of speciation between S. cerevisiae and S. paradoxus, but suggests more complex incompatibilities. PLoS Genet. 2010;6:e1001038 pubmed publisher
    ..After such a speciation event, it is possible that one or more D-M pairs might subsequently arise following isolation. ..
  5. Noshita N, Sugawara T, Fujimura M, Morita Fujimura Y, Chan P. Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. J Cereb Blood Flow Metab. 2001;21:557-67 pubmed
    ..The current study revealed Mn-SOD might affect cytochrome c translocation and downstream caspase activation in the mitochondrial-dependent cell death pathway after transient FCI. ..
  6. Guo B, Zhai D, Cabezas E, Welsh K, Nouraini S, Satterthwait A, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003;423:456-61 pubmed
    ..We speculate therefore that HN arose from mitochondria and transferred to the nuclear genome, providing a mechanism for protecting these organelles from Bax. ..
  7. Chen V, Staub R, Baggett S, Chimmani R, Tagliaferri M, Cohen I, et al. Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle. PLoS ONE. 2012;7:e30107 pubmed publisher
    ..This indicates that the activity of total Bezielle extract might depend on a combination of several different compounds present within it. ..
  8. Ma C, Kesarwala A, Eggert T, Medina Echeverz J, Kleiner D, Jin P, et al. NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature. 2016;531:253-7 pubmed publisher
    ..In vivo blockade of ROS reversed NAFLD-induced hepatic CD4(+) T lymphocyte decrease and delayed NAFLD-promoted HCC. Our results provide an unexpected link between lipid dysregulation and impaired anti-tumour surveillance. ..
  9. Hock M, Kralli A. Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol. 2009;71:177-203 pubmed publisher
    ..Characterization of the transcriptional mechanisms that regulate mitochondrial biogenesis and function can offer insights into possible therapeutic interventions aimed at modulating mitochondrial function. ..
  10. Hayashi M, Imanaka Yoshida K, Yoshida T, Wood M, Fearns C, Tatake R, et al. A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy. Nat Med. 2006;12:128-32 pubmed
    ..These findings suggest that Dnaja3 is crucial for mitochondrial biogenesis, at least in part, through its chaperone activity on Polga and provide genetic evidence of the necessity for mitochondrial Hsp40 in preventing DCM. ..
  11. Zhai D, Yu E, Jin C, Welsh K, Shiau C, Chen L, et al. Vaccinia virus protein F1L is a caspase-9 inhibitor. J Biol Chem. 2010;285:5569-80 pubmed publisher
  12. Denko N. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer. 2008;8:705-13 pubmed publisher
    ..As discussed in this Perspective, new data suggests that this metabolic switch may provide a benefit to the tumour not by increasing glycolysis but by decreasing mitochondrial activity. ..
  13. Krajewski S, Tanaka S, Takayama S, Schibler M, Fenton W, Reed J. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 1993;53:4701-14 pubmed
  14. Takayama S, Krajewski S, Krajewska M, Kitada S, Zapata J, Kochel K, et al. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. Cancer Res. 1998;58:3116-31 pubmed
  15. Matsuyama S, Llopis J, Deveraux Q, Tsien R, Reed J. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol. 2000;2:318-25 pubmed
    ..These findings indicate that mitochondria-mediated alteration of intracellular pH may be an early event that regulates caspase activation in the mitochondrial pathway for apoptosis. ..
  16. Marella M, Seo B, Thomas B, Matsuno Yagi A, Yagi T. Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal model. PLoS ONE. 2010;5:e11472 pubmed publisher
    ..Our results indicate a window of opportunity for the gene therapy to be applied successfully after the onset of the disease symptoms. ..
  17. Teh P, Chen M, Engel J, Worby C, Manning G, Dixon J, et al. Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica. J Biol Chem. 2013;288:5176-85 pubmed publisher
    ..When ectopically expressed, this bacterial PGP phosphatase was localized in the mitochondria of yeast and mammalian cells. Together, our results demonstrate the conservation of function between bacterial and mammalian PTPMT1 orthologs. ..
  18. Ouyang Y, Voloboueva L, Xu L, Giffard R. Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia. J Neurosci. 2007;27:4253-60 pubmed
    ..We suggest that greater oxidative stress and loss of GLT-1 function selectively in CA1 astrocytes is central to the well known delayed death of CA1 neurons. ..
  19. Sellmyer M, Chen L, Egeler E, Rakhit R, Wandless T. Intracellular context affects levels of a chemically dependent destabilizing domain. PLoS ONE. 2012;7:e43297 pubmed publisher
    ..These data reinforce that DD is an effective tool for protein perturbation, show that the local QC machinery affects levels of the DD, and suggest that the DD may be a useful probe for monitoring protein quality control machinery. ..
  20. Martin F, Xu X, von Löhneysen K, Gilmartin T, Friedman J. SOD2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolism. PLoS ONE. 2011;6:e16894 pubmed publisher
    ..SA is primarily an acquired, clonal marrow disorder occurring in individuals over 60 years of age with uncertain etiology...
  21. Santidrian A, Matsuno Yagi A, Ritland M, Seo B, LeBoeuf S, Gay L, et al. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest. 2013;123:1068-81 pubmed publisher
  22. Stary V, Puppala D, Scherrer Crosbie M, Dillmann W, Armoundas A. SERCA2a upregulation ameliorates cellular alternans induced by metabolic inhibition. J Appl Physiol (1985). 2016;120:865-75 pubmed publisher
  23. Gerber A, Herschlag D, Brown P. Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol. 2004;2:E79 pubmed
  24. Cornillez Ty C, Liao L, Yates J, Kuhn P, Buchmeier M. Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling. J Virol. 2009;83:10314-8 pubmed publisher
    ..For nsp2, we identified an interaction with two host proteins, prohibitin 1 (PHB1) and PHB2. Our results suggest that nsp2 may be involved in the disruption of intracellular host signaling during SARS-CoV infections. ..
  25. Xu X, Martin F, Friedman J. The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage. Blood Cells Mol Dis. 2010;45:227-32 pubmed publisher
    ..These results indicate that DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. ..
  26. Xu Y, Huang S, Liu Z, Han J. Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem. 2006;281:8788-95 pubmed
    ..Therefore, our study uncovers that RIP1, TRAF2, and JNK comprise a pathway to mediate the signaling from PARP-1 overactivation to mitochondrial dysfunction. ..
  27. Yagi T, Matsuno Yagi A. The proton-translocating NADH-quinone oxidoreductase in the respiratory chain: the secret unlocked. Biochemistry. 2003;42:2266-74 pubmed
  28. Lloyd S, Lauble H, Prasad G, Stout C. The mechanism of aconitase: 1.8 A resolution crystal structure of the S642a:citrate complex. Protein Sci. 1999;8:2655-62 pubmed
    ..Now, however, the structure revealing the citrate mode of binding provides direct support for the proposed enzyme mechanism. ..
  29. Voloboueva L, Suh S, Swanson R, Giffard R. Inhibition of mitochondrial function in astrocytes: implications for neuroprotection. J Neurochem. 2007;102:1383-94 pubmed
  30. Voloboueva L, Sun X, Xu L, Ouyang Y, Giffard R. Distinct Effects of miR-210 Reduction on Neurogenesis: Increased Neuronal Survival of Inflammation But Reduced Proliferation Associated with Mitochondrial Enhancement. J Neurosci. 2017;37:3072-3084 pubmed publisher
    ..This explains in part the contradictory published reports of the effects of miR-210 on neurogenesis. ..
  31. Li W, Bengtson M, Ulbrich A, Matsuda A, Reddy V, Orth A, et al. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS ONE. 2008;3:e1487 pubmed publisher
    ..These findings suggest the existence of a new, Ub-mediated mechanism responsible for integration of mitochondria into the cellular environment. ..
  32. Schmitt M, Clayton D. Characterization of a unique protein component of yeast RNase MRP: an RNA-binding protein with a zinc-cluster domain. Genes Dev. 1994;8:2617-28 pubmed
    ..We propose that the SNM1 protein is an essential and specific component of the RNase MRP ribonucleoprotein complex, the first unique protein of this complex to be identified. ..
  33. Li D, Dammer E, Sewer M. Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Endocrinology. 2012;153:3258-68 pubmed publisher
    ..Collectively, this study identifies a role for NAD(+)-dependent SIRT deacetylase activity in regulating the expression of mitochondrial steroidogenic P450. ..
  34. Margolin W, Bramhill D, Long S. The dnaA gene of Rhizobium meliloti lies within an unusual gene arrangement. J Bacteriol. 1995;177:2892-900 pubmed
    ..Downstream of dnaA, there are two open reading frames that are probably expressed but are not highly similar to any genes in the databases. These results show that R. meliloti dnaA is located within a novel gene arrangement. ..
  35. Ribas de Pouplana L, Schimmel P. A view into the origin of life: aminoacyl-tRNA synthetases. Cell Mol Life Sci. 2000;57:865-70 pubmed
  36. Venter P, Marshall D, Schneemann A. Dual roles for an arginine-rich motif in specific genome recognition and localization of viral coat protein to RNA replication sites in flock house virus-infected cells. J Virol. 2009;83:2872-82 pubmed publisher
    ..Our results are compatible with a model in which recognition of RNA1 and RNA2 for encapsidation occurs sequentially and in distinct cellular microenvironments. ..
  37. Wang H, Rapp U, Reed J. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell. 1996;87:629-38 pubmed
    ..Bcl-2 can therefore target Raf-1 to mitochondrial membranes, allowing this kinase to phosphorylate BAD or possibly other protein substrates involved in apoptosis regulation. ..
  38. Fogal V, Richardson A, Karmali P, Scheffler I, Smith J, Ruoslahti E. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol. 2010;30:1303-18 pubmed publisher
  39. Chen V, Staub R, Fong S, Tagliaferri M, Cohen I, Shtivelman E. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. PLoS ONE. 2012;7:e30300 pubmed publisher
    ..This study provides a better understanding of the mechanism of Bezielle's cytotoxicity, and the basis of its selectivity towards cancer cells. ..
  40. Fisher R, Clayton D. Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol. 1988;8:3496-509 pubmed
  41. Yamaguchi R, Janssen E, Perkins G, Ellisman M, Kitada S, Reed J. Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. PLoS ONE. 2011;6:e24102 pubmed publisher
  42. Lam H, Baglini C, Lope A, Parkhitko A, Liu H, Alesi N, et al. p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer Res. 2017;77:3255-3267 pubmed publisher
    ..i>Cancer Res; 77(12); 3255-67. ©2017 AACR. ..
  43. Hales K, Fuller M. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell. 1997;90:121-9 pubmed
    ..Fzo has homologs of unknown function in mammals, nematodes, and yeast. ..
  44. Chu V, Bhattacharya S, Nomoto A, Lin J, Zaidi S, Oberley T, et al. Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells. PLoS ONE. 2011;6:e28551 pubmed publisher
    ..The population doubling time and cyclin D1 level were also comparable to that of control cells. Finally, the cytopathic effects of core protein appeared to focus on the mitochondria without remarkable disturbances in the cytosol...
  45. Gong X, Choi J, Franzin C, Zhai D, Reed J, Marassi F. Conformation of membrane-associated proapoptotic tBid. J Biol Chem. 2004;279:28954-60 pubmed
  46. Hartsock A, Nelson W. Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai-mediated ubiquitination. PLoS ONE. 2012;7:e37476 pubmed publisher
    ..Our results indicate that ubiquitination of the JMD inhibits p120-catenin binding, and targets E-cadherin for degradation. ..
  47. Matsuno Yagi A, Hatefi Y. Ubiquinol:cytochrome c oxidoreductase (complex III). Effect of inhibitors on cytochrome b reduction in submitochondrial particles and the role of ubiquinone in complex III. J Biol Chem. 2001;276:19006-11 pubmed
    ..It was also shown that antimycin did not inhibit electron transfer from b (b(H)) to Q, in clear contrast to the assumption of the Q-cycle hypothesis regarding the site of antimycin inhibition. ..
  48. Endo H, Kamada H, Nito C, Nishi T, Chan P. Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. J Neurosci. 2006;26:7974-83 pubmed
    ..These results suggest that the mitochondrial p53 pathway is one of the novel mechanisms mediating delayed death of vulnerable hippocampal CA1 neurons after tGCI. ..
  49. Kim G, Gasche Y, Grzeschik S, Copin J, Maier C, Chan P. Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?. J Neurosci. 2003;23:8733-42 pubmed
    ..65 +/- 17; p < or = 0.05). We conclude that early expression and activation of MMP-9 by ROS may be involved in early BBB disruption and progressive striatal damage after 3-NP treatment. ..
  50. Miyamoto S, Howes A, Adams J, Dorn G, Brown J. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. J Biol Chem. 2005;280:38505-12 pubmed
  51. Masters B, Stohl L, Clayton D. Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell. 1987;51:89-99 pubmed
    ..Interestingly, the mitochondrial enzyme is highly homologous to the DNA-directed RNA polymerases of bacteriophages T3 and T7, especially in regions most highly conserved between the T3 and T7 enzymes themselves...
  52. Zhang L, Zambon A, Vranizan K, Pothula K, Conklin B, Insel P. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J Biol Chem. 2008;283:4304-13 pubmed
    ..The findings indicate that cAMP/PKA-promoted apoptosis of lymphoid cells occurs via mitochondrial-mediated events and imply that such apoptosis involves gene networks in multiple biochemical pathways. ..
  53. Sonoda J, Laganiere J, Mehl I, Barish G, Chong L, Li X, et al. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev. 2007;21:1909-20 pubmed
    ..Thus, ERR alpha and PGC-1 beta act together as a key effector of IFN-gamma-induced mitochondrial ROS production and host defense. ..
  54. Parisi M, Xu B, Clayton D. A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol Cell Biol. 1993;13:1951-61 pubmed
    ..Both human and yeast proteins affect yeast mitochondrial transcription initiation in vitro, suggesting that the two proteins may have a common role in this fundamental process. ..
  55. Reed J. Bcl-2 family proteins. Oncogene. 1998;17:3225-36 pubmed
  56. Vats D, Mukundan L, Odegaard J, Zhang L, Smith K, Morel C, et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006;4:13-24 pubmed
  57. Zhai D, Luciano F, Zhu X, Guo B, Satterthwait A, Reed J. Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak. J Biol Chem. 2005;280:15815-24 pubmed
    ..We conclude that Bid represents an additional cellular target of HN, and we propose that HN-mediated suppression of Bid contributes to the antiapoptotic activity of this endogenous peptide. ..
  58. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed publisher
    ..These defects impair antigen recognition and T cell function and are correlated with sepsis severity. Pharmacological targeting of these defects may improve T cell function and reduce the risk of sepsis. ..
  59. Kekenes Huskey P, Liao T, Gillette A, Hake J, Zhang Y, Michailova A, et al. Molecular and subcellular-scale modeling of nucleotide diffusion in the cardiac myofilament lattice. Biophys J. 2013;105:2130-40 pubmed publisher
    ..A reaction-diffusion model of the half-sarcomere further suggests that diffusional anisotropy may lead to modest adenine nucleotide gradients in the myoplasm under physiological conditions. ..
  60. Nakanishi N, Ryan S, Zhang X, Khan A, Holland T, Cho E, et al. Synaptic protein ?1-takusan mitigates amyloid-?-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J Neurosci. 2013;33:14170-83 pubmed publisher
    ..In summary, ?1-takusan protects synapses from A?-induced insult via interaction with PSD-95 and tau. Thus, takusan-based protein sequences from either mouse or human may be of potential therapeutic benefit in AD. ..
  61. Yogalingam G, Hwang S, Ferreira J, Mochly Rosen D. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase C? (PKC?) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury. J Biol Chem. 2013;288:18947-60 pubmed publisher
    ..Taken together, we identified a GAPDH/PKC? signaling switch, which is activated during oxidative stress to regulate the balance between cell survival by mitophagy and cell death due to accumulation of damaged mitochondria. ..
  62. Varsano T, Lau E, Feng Y, Garrido M, Milan L, Heynen Genel S, et al. Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2. Clin Cancer Res. 2013;19:2710-22 pubmed publisher
  63. Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, et al. Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance. Genes Dev. 2013;27:157-62 pubmed publisher
    ..Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals. ..
  64. Sano R, Hou Y, Hedvat M, Correa R, Shu C, Krajewska M, et al. Endoplasmic reticulum protein BI-1 regulates Ca²?-mediated bioenergetics to promote autophagy. Genes Dev. 2012;26:1041-54 pubmed publisher
    ..The results reveal BI-1 as a novel autophagy regulator that bridges Ca²? signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress. ..
  65. Wenger J, Piotrowski J, Nagarajan S, Chiotti K, Sherlock G, Rosenzweig F. Hunger artists: yeast adapted to carbon limitation show trade-offs under carbon sufficiency. PLoS Genet. 2011;7:e1002202 pubmed publisher
    ..We conclude that yeasts that evolve high fitness under one resource-limiting condition also become more fit under other resource-limiting conditions, but may pay a fitness cost when those same resources are abundant. ..
  66. Zhao H, Ali S, Haddad G. Does hyperoxia selection cause adaptive alterations of mitochondrial electron transport chain activity leading to a reduction of superoxide production?. Antioxid Redox Signal. 2012;16:1071-6 pubmed publisher
    ..Our observations lead to the hypothesis that decreased complex activity results in a decreased ROS production, which might be a major potential adaptive mechanism of hyperoxia tolerance. ..
  67. Dai Y, Weinreb R, Kim K, Nguyen D, Park S, Sun X, et al. Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. Invest Ophthalmol Vis Sci. 2011;52:2468-76 pubmed publisher
    ..These findings suggest that mitochondrial preservation after inhibition of NOS-2 may be useful for protecting RGCs against glaucomatous damage. ..
  68. Luciano F, Zhai D, Zhu X, Bailly Maitre B, Ricci J, Satterthwait A, et al. Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL. J Biol Chem. 2005;280:15825-35 pubmed
    ..Taken together, our results indicate that the inhibition of BimEL may contribute to the antiapoptotic properties of the HN peptide. ..
  69. Johnson X, Alric J. Central carbon metabolism and electron transport in Chlamydomonas reinhardtii: metabolic constraints for carbon partitioning between oil and starch. Eukaryot Cell. 2013;12:776-93 pubmed publisher
    ..As microalgae are now considered a potential renewable feedstock, we examine current work on the subject and also explore the possibility of rerouting metabolism toward lipid production...
  70. Ju W, Kim K, Lindsey J, Angert M, Duong Polk K, Scott R, et al. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008;49:4903-11 pubmed publisher
    ..Thus, interventions to preserve mitochondria may be useful for protecting against ON degeneration in glaucoma. ..
  71. Del Re D, Miyamoto S, Brown J. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem. 2007;282:8069-78 pubmed
    ..The dominant negative p53 also prevents RhoA-induced apoptosis. We conclude that RhoA/Rho kinase activation up-regulates Bax through p53 to induce a mitochondrial death pathway and cardiomyocyte apoptosis. ..
  72. Guan Y, Hickey M, Borgstahl G, Hallewell R, Lepock J, O Connor D, et al. Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34. Biochemistry. 1998;37:4722-30 pubmed
  73. Maslyar D, Aoki M, Vogt P. The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3. Oncogene. 2001;20:5087-92 pubmed
    ..These results suggest that phosphorylated Bad promotes cell growth and in oncogenic transformation may contribute to the neoplastic phenotype of the cell. ..
  74. Voloboueva L, Lee S, Emery J, Palmer T, Giffard R. Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo. J Neurosci. 2010;30:12242-51 pubmed publisher
    ..Our findings highlight mitochondrial mechanisms involved in neurogenesis and indicate mitochondria as a potential target for protective strategies to prevent the impairment of neurogenesis by inflammation...
  75. Ouyang Y, Xu L, Lu Y, Sun X, Yue S, Xiong X, et al. Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia. Glia. 2013;61:1784-94 pubmed publisher
    ..Our data suggest that by targeting a pro-apoptotic BCL2 family member, increasing levels of miR-29a might emerge as a strategy for protection against ischemia-reperfusion injury. ..
  76. Voloboueva L, Duan M, Ouyang Y, Emery J, Stoy C, Giffard R. Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro. J Cereb Blood Flow Metab. 2008;28:1009-16 pubmed
    ..These findings indicate that Hsp75 can provide protection against ischemia-like in vitro injury and suggest that it should be further studied as a potential candidate for protection against ischemic injury. ..
  77. Chihara T, Luginbuhl D, Luo L. Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization. Nat Neurosci. 2007;10:828-37 pubmed
    ..Our study highlights different demands of protein translation for the development and maintenance of axons and dendrites. ..
  78. Ju W, Kim K, Angert M, Duong Polk K, Lindsey J, Ellisman M, et al. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci. 2009;50:707-16 pubmed publisher
  79. Okuno S, Saito A, Hayashi T, Chan P. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J Neurosci. 2004;24:7879-87 pubmed
  80. Masta S, Boore J. The complete mitochondrial genome sequence of the spider Habronattus oregonensis reveals rearranged and extremely truncated tRNAs. Mol Biol Evol. 2004;21:893-902 pubmed publisher
    ..Such mechanisms may have allowed for the minimization of the spider mitochondrial genome...
  81. Turner R, Lovato M, Schimmel P. One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions. J Biol Chem. 2000;275:27681-8 pubmed
    ..Phylogenetic analysis shows that GlyRS2 is a predecessor of all yeast GlyRS homologues. Thus, GRS1 appears to be the result of a duplication of GRS2, which itself is pseudogene-like. ..
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    ..Thus SynCAM1 and SynCAM2 could be heterophilic partners. MiniSOG may do for EM what Green Fluorescent Protein did for fluorescence microscopy. ..