Experts and Doctors on mice in Scotland, United Kingdom

Summary

Locale: Scotland, United Kingdom
Topic: mice

Top Publications

  1. Brewer J, Conacher M, Satoskar A, Bluethmann H, Alexander J. In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production. Eur J Immunol. 1996;26:2062-6 pubmed
    ..However, although production of the Th2 cytokine IL-5 was totally inhibited in IL-4-deficient mice inoculated with FCA/OVA, there was no significant difference in IL-5 production between the two strains when alum was used as adjuvant...
  2. Engelkamp D, Rashbass P, Seawright A, van Heyningen V. Role of Pax6 in development of the cerebellar system. Development. 1999;126:3585-96 pubmed
    ..Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3. ..
  3. March J, Clark J, Brodlie M. Characterization of strains of Mycoplasma mycoides subsp. mycoides small colony type isolated from recent outbreaks of contagious bovine pleuropneumonia in Botswana and Tanzania: evidence for a new biotype. J Clin Microbiol. 2000;38:1419-25 pubmed
    ..These findings have implications for the control of the current CBPP epidemic in Africa...
  4. Tee A, Proud C. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol Cell Biol. 2002;22:1674-83 pubmed
    ..This suggests that the N-terminal sequence of 4E-BP1 is required for optimal regulation of 4E-BPs by insulin. ..
  5. Bakirtzis G, Choudhry R, Aasen T, Shore L, Brown K, Bryson S, et al. Targeted epidermal expression of mutant Connexin 26(D66H) mimics true Vohwinkel syndrome and provides a model for the pathogenesis of dominant connexin disorders. Hum Mol Genet. 2003;12:1737-44 pubmed
  6. Weber M, Blair E, Simpson C, O Hara M, Blackburn P, Rot A, et al. The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines. Mol Biol Cell. 2004;15:2492-508 pubmed
    ..By this mechanism, D6 can target chemokines for degradation without the necessity for cell signaling, and without desensitizing the cell to subsequent chemokine exposure. ..
  7. Mora A, Lipina C, Tronche F, Sutherland C, Alessi D. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure. Biochem J. 2005;385:639-48 pubmed
    ..They suggest that a deficiency of the PDK1 pathway in the liver could contribute to development of diabetes, as well as to liver failure. ..
  8. Mullin M, Lightfoot K, Marklund U, Cantrell D. Differential requirement for RhoA GTPase depending on the cellular localization of protein kinase D. J Biol Chem. 2006;281:25089-96 pubmed
    ..These studies demonstrate that a Rho requirement for PKD activation is not ubiquitous. Moreover, links between PKD and Rho are determined by the cellular location of PKD. ..
  9. Gilbert N, Thomson I, Boyle S, Allan J, Ramsahoye B, Bickmore W. DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction. J Cell Biol. 2007;177:401-11 pubmed

More Information

Publications329 found, 100 shown here

  1. Calcraft P, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, et al. NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature. 2009;459:596-600 pubmed publisher
    ..TPCs therefore provide new insights into the regulation and organization of Ca(2+) signals in animal cells, and will advance our understanding of the physiological role of NAADP...
  2. Mowat A. Does TLR2 regulate intestinal inflammation?. Eur J Immunol. 2010;40:318-20 pubmed publisher
  3. Rafiqi F, Zuber A, Glover M, Richardson C, Fleming S, Jovanovic S, et al. Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med. 2010;2:63-75 pubmed publisher
    ..See accompanying Closeup by Maria Castañeda-Bueno and Gerald Gamba (DOI 10.1002/emmm.200900059). ..
  4. Gleason C, Ordureau A, Gourlay R, Arthur J, Cohen P. Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon ?. J Biol Chem. 2011;286:35663-74 pubmed publisher
    ..In conclusion, our results suggest that OPTN binds to polyubiquitylated species formed in response to LPS and poly(I:C), enhancing the activation of TBK1 that is required for optimal phosphorylation of IRF3 and production of IFN?. ..
  5. Lek H, Morrison V, Conneely M, Campbell P, McGloin D, Kliche S, et al. The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow. J Biol Chem. 2013;288:14698-708 pubmed publisher
  6. Williams M, Clouston A, Forbes S. Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology. 2014;146:349-56 pubmed publisher
    ..Understanding the interactions between progenitor cells and matrix is critical for the development of novel regenerative and antifibrotic therapies. ..
  7. Wilson J, Ferguson M, Jenkins N, Lock L, Copeland N, Levine A. Transgenic mouse model of X-linked cleft palate. Cell Growth Differ. 1993;4:67-76 pubmed
    ..The disrupted cellular sequences have been mapped to the proximal region of the mouse X chromosome. The disrupted locus may represent the mouse counterpart to a human locus mutated in an X-linked cleft secondary palate syndrome. ..
  8. Barker V, Middleton G, Davey F, Davies A. TNFalpha contributes to the death of NGF-dependent neurons during development. Nat Neurosci. 2001;4:1194-8 pubmed
    ..These neurons coexpress TNFalpha and TNFR1 during this stage of development, suggesting that TNFalpha acts by an autocrine loop. ..
  9. Bom A, Bradley M, Cameron K, Clark J, Van Egmond J, Feilden H, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl. 2002;41:266-70 pubmed
  10. Morton N, Ramage L, Seckl J. Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease. Endocrinology. 2004;145:2707-12 pubmed
    ..Adaptive down-regulation of adipose 11beta-HSD-1 in response to chronic HF represents a novel mechanism that may counteract metabolic disease. ..
  11. Felmer R, Clark J. The gene suicide system Ntr/CB1954 causes ablation of differentiated 3T3L1 adipocytes by apoptosis. Biol Res. 2004;37:449-60 pubmed
  12. Ottersbach K, McLean J, Isaacs N, Graham G. A310 helical turn is essential for the proliferation-inhibiting properties of macrophage inflammatory protein-1 alpha (CCL3). Blood. 2006;107:1284-91 pubmed
    ..In addition, this study further attests to the alternative mechanisms of action used by MIP-1alpha in inhibition of hematopoietic progenitor-cell proliferation and regulation of leukocyte migration. ..
  13. Conway A, James A, Zang J, Morris B. Regulation of neuronal cdc20 (p55cdc) expression by the plasticity-related transcription factor zif268. Synapse. 2007;61:463-8 pubmed
  14. Windheim M, Stafford M, Peggie M, Cohen P. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase. Mol Cell Biol. 2008;28:1783-91 pubmed publisher
    ..Our data suggest a model in which the recruitment of the NEMO-IKK complex to K63-pUb-IRAK1 and the recruitment of the TAK1 complex to TRAF6 facilitate the TAK1-catalyzed activation of IKK by the TRAF6-IRAK1 complex. ..
  15. Chen L, Jeffries O, Rowe I, Liang Z, Knaus H, Ruth P, et al. Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. J Biol Chem. 2010;285:23265-75 pubmed publisher
    ..Thus alternative splicing of the intracellular RCK1-RCK2 linker plays a critical role in determining cell surface expression of BK channels by controlling the inclusion/exclusion of multiple trafficking motifs. ..
  16. Grainger J, Smith K, Hewitson J, McSorley H, Harcus Y, Filbey K, et al. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-? pathway. J Exp Med. 2010;207:2331-41 pubmed publisher
    ..We have therefore identified a novel pathway through which helminth parasites may stimulate T reg cells, which is likely to be a key part of the parasite's immunological relationship with the host...
  17. Hambly C, Duncan J, Archer Z, Moar K, Mercer J, Speakman J. Repletion of TNF? or leptin in calorically restricted mice suppresses post-restriction hyperphagia. Dis Model Mech. 2012;5:83-94 pubmed publisher
    ..Signals from adipose tissue, including but not limited to leptin and TNF?, regulate PRH and might be targets for therapies that support people engaged in CR to reduce obesity...
  18. Mah L, O Prey J, Baudot A, Hoekstra A, Ryan K. DRAM-1 encodes multiple isoforms that regulate autophagy. Autophagy. 2012;8:18-28 pubmed publisher
    ..In summary, these findings identify new autophagy regulators that provide insight into the control of autophagy downstream of p53. ..
  19. Cook P, Jones L, Jenkins S, Wynn T, Allen J, MacDonald A. Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo. Proc Natl Acad Sci U S A. 2012;109:9977-82 pubmed publisher
    ..Together, these data highlight the significant impact that IL-4 and RELMα can have on DC activation and function in the context of either bacterial or helminth pathogens. ..
  20. Kent J, Coriat A, Sharpe P, Hastie N, van Heyningen V. The evolution of WT1 sequence and expression pattern in the vertebrates. Oncogene. 1995;11:1781-92 pubmed
    ..A wider role in mesodermal differentiation is suggested by expression in some paraxial and lateral mesoderm derivatives...
  21. Mountford P, Zevnik B, Duwel A, Nichols J, Li M, Dani C, et al. Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci U S A. 1994;91:4303-7 pubmed
    ..This has allowed visualization of putative "stem-cell niches" in which sources of elevated expression of differentiation-inhibiting activity were localized to the differentiated cells surrounding colonies of stem cells. ..
  22. Stacey A, Schnieke A, McWhir J, Cooper J, Colman A, Melton D. Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice. Mol Cell Biol. 1994;14:1009-16 pubmed
    ..A typical strategy for future use would be to generate a null mutation which could then be used to produce multiple second-step alterations at the same locus. ..
  23. Pinon L, Minichiello L, Klein R, Davies A. Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling. Development. 1996;122:3255-61 pubmed
    ..These results demonstrate that TrkB signalling is required for the in vivo survival of many trigeminal neurons during the early stages of target field innervation before they become NGF-dependent. ..
  24. Macleod K, Jacks T. Insights into cancer from transgenic mouse models. J Pathol. 1999;187:43-60 pubmed
    ..Several exising mouse strains have already been used to develop and test new therapies and conditional mutagenesis will undoubtedly increase the potential use of transgenic mice in understanding and treating cancer. ..
  25. Porter R, Jahoda C, Lunny D, Henderson G, Ross J, McLean W, et al. Defolliculated (dfl): a dominant mouse mutation leading to poor sebaceous gland differentiation and total elimination of pelage follicles. J Invest Dermatol. 2002;119:32-7 pubmed
    ..Defolliculated may be a useful model for determining further functions of the sebaceous gland, and for understanding the regulation of catagen and hair follicle immunology. ..
  26. Milburn C, Boudeau J, Deak M, Alessi D, van Aalten D. Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. Nat Struct Mol Biol. 2004;11:193-200 pubmed
  27. Edgar J, McLaughlin M, Yool D, Zhang S, Fowler J, Montague P, et al. Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. J Cell Biol. 2004;166:121-31 pubmed
    ..Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis...
  28. Chambers I, Smith A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene. 2004;23:7150-60 pubmed
    ..Nanog function also requires Oct4. Here, we review recent progress in ES cell self-renewal, relate this to the biology of teratocarcinomas and offer testable hypotheses to expose the mechanics of ES cell self-renewal...
  29. Wallace D, Johnston L, Huston E, MacMaster D, Houslay T, Cheung Y, et al. Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. Mol Pharmacol. 2005;67:1920-34 pubmed
  30. Rousseau S, Peggie M, Campbell D, Nebreda A, Cohen P. Nogo-B is a new physiological substrate for MAPKAP-K2. Biochem J. 2005;391:433-40 pubmed
    ..The anisomycin-induced phosphorylation of Ser107 in HeLa cells can be prevented by 'knockdown' of MAPKAP-K2 using siRNA (small interfering RNA). Taken together, our results identify Nogo-B as a new physiological substrate of MAPKAP-K2. ..
  31. MacKay G, West J. Fate of tetraploid cells in 4n<-->2n chimeric mouse blastocysts. Mech Dev. 2005;122:1266-81 pubmed
    ..Relevance of these results to the aetiology of human confined placental mosaicism and possible implications for the interpretation of mouse tetraploid complementation studies of the site of gene action are discussed. ..
  32. Clarke M, Ewart M, Santy L, Prekeris R, Gould G. ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Biochem Biophys Res Commun. 2006;342:1361-7 pubmed
    ..Collectively, these data implicate both Arf6 and Rab11 as crucial mediators of constitutive and insulin-stimulated secretion of ACRP30 and further suggest that recycling endosomes may play a central role in this process. ..
  33. Long G, Chan B, Allen J, Read A, Graham A. Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections. Parasitology. 2006;133:673-84 pubmed
    ..Thus, during P.c.c. infection, TNF-alpha is a key mediator of weight loss, independent of parasite load and across parasite genotypes. ..
  34. Richmond G, Smith T. The role and characterization of phospholipase A1 in mediating lysophosphatidylcholine synthesis in Trypanosoma brucei. Biochem J. 2007;405:319-29 pubmed publisher
  35. Nakamura R, Nakamoto C, Obama H, Durward E, Nakamoto M. Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions. J Biol Chem. 2012;287:3282-91 pubmed publisher
    ..These results suggest that Nel interacts with a range of molecules through its different domains and exerts distinct functions...
  36. Sterratt D, Lyngholm D, Willshaw D, Thompson I. Standard anatomical and visual space for the mouse retina: computational reconstruction and transformation of flattened retinae with the Retistruct package. PLoS Comput Biol. 2013;9:e1002921 pubmed publisher
    ..Moreover, using these coordinates, the dorsoventral boundary for S-opsin expressing cones closely matches the horizontal meridian...
  37. Vitalis T, Fouquet C, Alvarez C, Seif I, Price D, Gaspar P, et al. Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse. J Comp Neurol. 2002;442:331-47 pubmed
    ..These localizations are of importance for understanding the effects of monoaminergic transmission during development. ..
  38. Miranda Saavedra D, Barton G. Classification and functional annotation of eukaryotic protein kinases. Proteins. 2007;68:893-914 pubmed
    ..The application of the Library facilitates the annotation of kinomes and has provided novel insights on the early evolution and subsequent adaptations of the various protein kinase families in eukaryotes. ..
  39. Forgie A, Kuehnel F, Wyatt S, Davies A. In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor. Eur J Neurosci. 2000;12:670-6 pubmed
  40. Ruggiu M, Saunders P, Cooke H. Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells. J Androl. 2000;21:470-7 pubmed
    ..Variations in location seem to be independent of the presence of the DAZ protein are species specific and, as in Drosophila, may not have great functional significance. ..
  41. Smith D, Mitchell S, Nash T, Rhind S. Gamma interferon influences intestinal epithelial hyperplasia caused by Lawsonia intracellularis infection in mice. Infect Immun. 2000;68:6737-43 pubmed
  42. Lipina C, Huang X, Finlay D, McManus E, Alessi D, Sutherland C. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. Biochem J. 2005;392:633-9 pubmed
    ..We suggest for the first time that although pharmacological inhibition of GSK3 reduces hepatic glucose production even in insulin-resistant states, feeding can repress the gluconeogenic genes without inhibiting GSK3. ..
  43. Menachery A, Kremer C, Wong P, Carlsson A, Neale S, Barrett M, et al. Counterflow dielectrophoresis for trypanosome enrichment and detection in blood. Sci Rep. 2012;2:775 pubmed publisher
    ..We combine this enrichment technique with an automated image analysis detection algorithm, negating the need for a human operator. ..
  44. Brown K, Day J, Huston E, Zimmermann B, Hampel K, Christian F, et al. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A. 2013;110:E1533-42 pubmed publisher
    ..Similarly, PDE8 deletion in Drosophila melanogaster reduced basal ERK activation and sensitized flies to stress-induced death. We propose that PDE8A is a physiological regulator of Raf-1 signaling in some cells. ..
  45. Stacey A, Schnieke A, Kerr M, Scott A, McKee C, Cottingham I, et al. Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice. Proc Natl Acad Sci U S A. 1995;92:2835-9 pubmed
    ..These variations demonstrated that alpha-lac expression in mice is gene dosage dependent. ..
  46. Wu C, Melton D. Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. Nat Genet. 1993;3:235-40 pubmed
    ..This combined genetic and biochemical model will facilitate the study of Lesch-Nyhan syndrome and the evaluation of novel therapies. ..
  47. Singh G, Johnston J, Ma W, Lozanoff S. Cleft palate formation in fetal Br mice with midfacial retrusion: tenascin, fibronectin, laminin, and type IV collagen immunolocalization. Cleft Palate Craniofac J. 1998;35:65-76 pubmed
    ..At E15 and E18 in cleft Br/Br mutants, TN stained beneath the MEE. Although the distributions of ECM molecules are similar during normal and cleft palatogenesis, differences in TN expression are associated with cleft palate formation. ..
  48. Slee R, Grimes B, Speed R, Taggart M, Maguire S, Ross A, et al. A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype. Proc Natl Acad Sci U S A. 1999;96:8040-5 pubmed
  49. Balmer P, Devaney E. NK T cells are a source of early interleukin-4 following infection with third-stage larvae of the filarial nematode Brugia pahangi. Infect Immun. 2002;70:2215-9 pubmed
    ..1(+) T cells in the spleen and draining lymph nodes. NK T cells produced interleukin-4 in the spleen within 24 h of infection, and these cells were CD4(-). ..
  50. Fillatreau S, Gray D. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med. 2003;197:195-206 pubmed
    ..Crucially, the up-regulation of OX40L (on antigen-presenting cells) and CXCR-5 (on T cells) are CD40-dependent events and we show that T cells do not migrate to follicles in immunized OX40-deficient mice. ..
  51. Felmer R, Horvat S, Clinton M, Clark A. Overexpression of Raidd cDNA inhibits differentiation of mouse preadipocytes. Cell Prolif. 2003;36:45-54 pubmed
  52. McBride M, Carr F, Graham D, Anderson N, Clark J, Lee W, et al. Microarray analysis of rat chromosome 2 congenic strains. Hypertension. 2003;41:847-53 pubmed
    ..8 x 10(-3); P=0.0034) and WKY 4.03 x 10(-3)+/-5.1 x 10(-4); (95% CI -5.4 x 10(-3) to -8.9 x 10(-4); P=0.027). We also identified regions of conserved synteny, each containing the Gstm2 gene, on mouse chromosome 3 and human chromosome 1. ..
  53. Eblaghie M, Song S, Kim J, Akita K, Tickle C, Jung H. Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos. J Anat. 2004;205:1-13 pubmed
    ..These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1. ..
  54. Smith J, Paton I, Hughes D, Burt D. Isolation and mapping the chicken zona pellucida genes: an insight into the evolution of orthologous genes in different species. Mol Reprod Dev. 2005;70:133-45 pubmed
    ..The presence of the ZPAX gene in the chicken has highlighted a pattern of probable gene loss by deletion in mouse and gene inactivation by deletion, and base substitution in human. ..
  55. Grove M, Komiyama N, Nave K, Grant S, Sherman D, Brophy P. FAK is required for axonal sorting by Schwann cells. J Cell Biol. 2007;176:277-82 pubmed
    ..These findings demonstrate the vital relationship between axon defasciculation and Schwann cell number and show the importance of FAK in regulating cell proliferation in the developing nervous system. ..
  56. Theil T, Dominguez Frutos E, Schimmang T. Differential requirements for Fgf3 and Fgf8 during mouse forebrain development. Dev Dyn. 2008;237:3417-23 pubmed publisher
    ..Therefore unlike in zebrafish, Fgf3 is not required for mouse forebrain development whereas Fgf8 has a central role during this process. ..
  57. Speakman J. FTO effect on energy demand versus food intake. Nature. 2010;464:E1; discussion E2 pubmed publisher
    ..The apparent contrasting effects of the gene in humans and mice is worthy of closer investigation. ..
  58. Drummond R, Brown G. The role of Dectin-1 in the host defence against fungal infections. Curr Opin Microbiol. 2011;14:392-9 pubmed publisher
    ..This review aims to provide an update on Dectin-1 and its role within antifungal immune responses, focussing on progress made in the last two years...
  59. Pattison M, MacKenzie K, Arthur J. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback. J Immunol. 2012;189:2784-92 pubmed publisher
    ..In addition to IL-10, IFN-? also helped sustain IL-6 and IL-12 transcription. Overall, these results suggest that inhibition of JAKs may increase the inflammatory potential of macrophages stimulated with TLR4 agonists. ..
  60. Blundell R, Harrison D, O Dea S. p21(Waf1/Cip1) regulates proliferation and apoptosis in airway epithelial cells and alternative forms have altered binding activities. Exp Lung Res. 2004;30:447-64 pubmed
    ..In conclusion, p21 regulates proliferation and protects against apoptosis in AECs. In addition, different forms of p21 are present in AECs and the subcellular localization of these forms reflects differences in p21 activity. ..
  61. Hing B, Davidson S, Lear M, Breen G, Quinn J, McGuffin P, et al. A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity. Biol Psychiatry. 2012;71:618-26 pubmed publisher
    ..The relevance of these findings to the role of BDNF misexpression in mood disorders and cognitive decline is discussed. ..
  62. McLaughlin M, Hunter D, Thomson C, Yool D, Kirkham D, Freer A, et al. Evidence for possible interactions between PLP and DM20 within the myelin sheath. Glia. 2002;39:31-6 pubmed
    ..We suggest that PLP and DM20 may form a hetero-oligomeric complex within the myelin sheath, probably in association with specific lipids and that this arrangement is essential for the normal structure of myelin and axons. ..
  63. Pall G, Johnson K, Smith G. Abnormal contractile activity and calcium cycling in cardiac myocytes isolated from DMPK knockout mice. Physiol Genomics. 2003;13:139-46 pubmed
    ..These observations suggest dmpk has a modulatory role in the control of intracellular Ca(2+) concentration in mouse ventricular cardiomyocytes, loss of which may contribute to cardiac dysfunction in DM1. ..
  64. Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003;113:643-55 pubmed
    ..These findings establish a central role for Nanog in the transcription factor hierarchy that defines ES cell identity. ..
  65. Plowman S, Williamson D, O Sullivan M, Doig J, Ritchie A, Harrison D, et al. While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. Mol Cell Biol. 2003;23:9245-50 pubmed
    ..The results demonstrate that K-Ras 4A, like H- and N-Ras, is dispensable for normal mouse development, at least in the presence of functional K-Ras 4B. ..
  66. Meehan R, Speed R, Gosden J, Rout D, Hutton J, Taylor B, et al. Chromosomal organization of the cytochrome P450-2C gene family in the mouse: a locus associated with constitutive aryl hydrocarbon hydroxylase. Proc Natl Acad Sci U S A. 1988;85:2662-6 pubmed
    ..These results are discussed in relation to the physiological roles of this P-450 family in foreign compound metabolism and steroid oxidations. ..
  67. Chambers I, Cozens A, Broadbent J, Robertson M, Lee M, Li M, et al. Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5' untranslated region. Biochem J. 1997;328 ( Pt 3):879-88 pubmed
  68. Wyatt S, Middleton G, Doxakis E, Davies A. Selective regulation of trkC expression by NT3 in the developing peripheral nervous system. J Neurosci. 1999;19:6559-70 pubmed
    ..In summary, our findings provide the first clear evidence that the expression of a trk receptor, tyrosine kinase, is regulated by physiological levels of its ligand in vivo and show that regulation by NT3 is cell type-specific. ..
  69. Balendran A, Biondi R, Cheung P, Casamayor A, Deak M, Alessi D. A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1. J Biol Chem. 2000;275:20806-13 pubmed
    ..These findings indicate that the hydrophobic motif of PRK2 and PKCzeta acts as a "docking site" enabling the recruitment of PDK1 to these substrates. This is essential for their phosphorylation by PDK1 in cells. ..
  70. Elliott D, Bourgeois C, Klink A, Stevenin J, Cooke H. A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. Proc Natl Acad Sci U S A. 2000;97:5717-22 pubmed
    ..Our results suggest that RBM protein is an evolutionarily conserved mammalian splicing regulator which operates as a germ cell-specific cofactor for more ubiquitously expressed pre-mRNA splicing activators. ..
  71. Pertwee R, Ross R, Craib S, Thomas A. (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. Eur J Pharmacol. 2002;456:99-106 pubmed
    ..We conclude that cannabidiol antagonizes R-(+)-WIN55212 and CP55940 by acting at prejunctional sites that are unlikely to be cannabinoid CB(1) or CB(2) receptors. ..
  72. Johnston J, Messager S, Barrett P, Hazlerigg D. Melatonin action in the pituitary: neuroendocrine synchronizer and developmental modulator?. J Neuroendocrinol. 2003;15:405-8 pubmed
  73. Daneshvar H, Hagan P, Phillips R. Leishmania mexicana H-line attenuated under pressure of gentamicin, potentiates a Th1 response and control of cutaneous leishmaniasis in BALB/c mice. Parasite Immunol. 2003;25:589-96 pubmed
  74. Bell J, McQueen D, Rees J. Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. Br J Pharmacol. 2004;142:374-80 pubmed
    ..Histamine H(4) receptor antagonists therefore merit investigation as antipruritic agents. ..
  75. Beattie J, Phillips K, Shand J, Szymanowska M, Flint D, Allan G. Molecular recognition characteristics in the insulin-like growth factor (IGF)-insulin-like growth factor binding protein -3/5 (IGFBP-3/5) heparin axis. J Mol Endocrinol. 2005;34:163-75 pubmed
    ..The potential biological significance of our data is highlighted by the demonstration that IGF-I and IGF-II can displace endogenous IGFBP-5 from monolayer cultures of the mouse mammary epithelial cell line HC11. ..
  76. Song C, Appleyard V, Murray K, Frank T, Sibbett W, Cuschieri A, et al. Thermographic assessment of tumor growth in mouse xenografts. Int J Cancer. 2007;121:1055-8 pubmed
    ..The findings of the study indicate that thermographic imaging might have considerable potential in monitoring human tumor xenografts and their response to anticancer drugs. ..
  77. Perona Wright G, Jenkins S, O Connor R, Zienkiewicz D, McSorley H, Maizels R, et al. A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. J Immunol. 2009;182:2808-15 pubmed publisher
    ..Our data delineate sequential requirements for DC expression of CD40 and production of IL-6 during Th17 polarization in vitro and in vivo, and reveal distinct costimulatory requirements for Th1 vs Th17 generation. ..
  78. Hamill K, Langbein L, Jones J, McLean W. Identification of a novel family of laminin N-terminal alternate splice isoforms: structural and functional characterization. J Biol Chem. 2009;284:35588-96 pubmed publisher
    ..Keratinocytes exhibiting specific knockdown of LaNt alpha3 displayed impaired adhesion, stress resistance, and reduced ability to close scratch wounds in vitro. ..
  79. Scott C, Walker D, Cwiklinski E, Tait C, Tee A, Land S. Control of HIF-1{alpha} and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock. Am J Physiol Lung Cell Mol Physiol. 2010;299:L455-71 pubmed publisher
    ..Thus, mTORC1 links HIF-1?-driven vasculogenesis with the FGF-10/FGFR2b/Spry2 airway branching periodicity regulator. ..
  80. Zhang Y, Ahn Y, Benjamin I, Honda T, Hicks R, Calabrese V, et al. HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Chem Biol. 2011;18:1355-61 pubmed publisher
    ..This uncovered duality undoubtedly contributes to the cytoprotective effects of such molecules in models of carcinogenesis, cardiovascular disease, and neurodegeneration. ..
  81. Dixon M, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, et al. IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. J Biol Chem. 2012;287:22483-96 pubmed publisher
  82. Ghimire T, Benson R, Garside P, Brewer J. Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro. Immunol Lett. 2012;147:55-62 pubmed publisher
    ..These studies demonstrate the dynamic alterations in antigen processing and presentation induced by alum that underlie enhanced DC function in response to this adjuvant. ..
  83. Festuccia N, Osorno R, Halbritter F, Karwacki Neisius V, Navarro P, Colby D, et al. Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Cell Stem Cell. 2012;11:477-90 pubmed publisher
    ..Finally, Esrrb deletion abolishes the defining ability of Nanog to confer LIF-independent ESC self-renewal. These findings are consistent with the functional placement of Esrrb downstream of Nanog...
  84. Pattison M, MacKenzie K, Elcombe S, Arthur J. IFN? autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages. FEBS Lett. 2013;587:1496-503 pubmed publisher
    ..Overall, these results show the importance of the balance between IFN? and IL-10 in the regulation of MCP-1. ..
  85. Huesa C, Helfrich M, Aspden R. Parallel-plate fluid flow systems for bone cell stimulation. J Biomech. 2010;43:1182-9 pubmed publisher
    ..We present details of the new systems and of experiments with osteoblasts to illustrate the effects of fluid flow with and without additional pressure on the translocation of beta-catenin to the nucleus. ..
  86. Dzamko N, Deak M, Hentati F, Reith A, Prescott A, Alessi D, et al. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization. Biochem J. 2010;430:405-13 pubmed publisher
    ..They will also stimulate further research to understand how phosphorylation of Ser910 and Ser935 is controlled by LRRK2, and establish any relationship to development of Parkinson's disease. ..
  87. Lyons S, Kapoor A, Sharp C, Schneider B, Wolfe N, Culshaw G, et al. Nonprimate hepaciviruses in domestic horses, United kingdom. Emerg Infect Dis. 2012;18:1976-82 pubmed publisher
    ..Disease associations and host range of nonprimate hepaciviruses warrant further investigation...
  88. Inglis J, Lee M, Davidson D, Hill R. Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin-like proteins in a murine chondrocytic cell line. Gene. 1991;106:213-20 pubmed
    ..At least one of the sequences appears to be expressed at sites of skeletal deposition during the later stages of mouse foetal development, indicating a role for serpins during development. ..
  89. McCallion A, Guenet J, Montague P, Griffiths I, Savioz A, Davies R. The mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein maps to distal chromosome 9. Mamm Genome. 1996;7:847-9 pubmed
  90. Prost S, Bellamy C, Cunningham D, Harrison D. Altered DNA repair and dysregulation of p53 in IRF-1 null hepatocytes. FASEB J. 1998;12:181-8 pubmed
    ..Hence, in hepatocytes, IRF-1 is not required for growth arrest or apoptosis after DNA damage, but the results suggest for the first time a role in DNA repair regulation. ..
  91. Kotelevtsev Y, Brown R, Fleming S, Kenyon C, Edwards C, Seckl J, et al. Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. J Clin Invest. 1999;103:683-9 pubmed
    ..Thus, 11beta-HSD2(-/-) mice demonstrate the major features of SAME, providing a unique rodent model to study the molecular mechanisms of kidney resetting leading to hypertension. ..
  92. Hamanoue M, Middleton G, Wyatt S, Jaffray E, Hay R, Davies A. p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor. Mol Cell Neurosci. 1999;14:28-40 pubmed