Genomes and Genes
Experts and Doctors on mice in California, United States
Locale: California, United States
Publications940 found, 100 shown here
- Zhang F, Wang L, Brauner M, Liewald J, Kay K, Watzke N, et al. Multimodal fast optical interrogation of neural circuitry. Nature. 2007;446:633-9 pubmed..NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits. ..
- Sun A, Murray S, Simon R, Jawien J, Behnam K, Miller T, et al. Alanine-scanning mutations of the BMP-binding domain of recombinant secretory bovine spp24 affect cytokine binding. Connect Tissue Res. 2010;51:445-51 pubmed publisher..Thus, the ?-pleated sheets play a greater role in BMP-2 binding than the ?-helical turn. ..
- Sankaranarayanan J, Mahmoud E, Kim G, MORACHIS J, Almutairi A. Multiresponse strategies to modulate burst degradation and release from nanoparticles. ACS Nano. 2010;4:5930-6 pubmed publisher..4 and rapid degradation at pH 5. Our results indicate that the prepared logic gate nanoparticles may prove valuable in delivering therapeutics and diagnostics to cells and diseased tissue. ..
- Li S, Quarto N, Longaker M. Activation of FGF signaling mediates proliferative and osteogenic differences between neural crest derived frontal and mesoderm parietal derived bone. PLoS ONE. 2010;5:e14033 pubmed publisher..FGF signaling plays a key role in determining biological differences between the two types of osteoblasts. ..
- Gupta A, Yu X, Case T, Paul M, Shen M, Kaestner K, et al. Mash1 expression is induced in neuroendocrine prostate cancer upon the loss of Foxa2. Prostate. 2013;73:582-9 pubmed publisher..These studies suggest that the TRAMP NE tumors can form in the absence of Foxa2 by an up regulation of Mash1. ..
- Rieg T, Tang T, Uchida S, Hammond H, Fenton R, Vallon V. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Am J Pathol. 2013;182:96-106 pubmed publisher..Renal AC6 determines total NKCC2 expression and mediates vasopressin-induced NKCC2/NCC phosphorylation. These regulatory mechanisms, which are defective in AC knockout mice, are likely responsible for the observed mild Bartter syndrome. ..
- Keeney M, Ong S, Padilla A, Yao Z, Goodman S, Wu J, et al. Development of poly(?-amino ester)-based biodegradable nanoparticles for nonviral delivery of minicircle DNA. ACS Nano. 2013;7:7241-50 pubmed publisher..Together, our results highlight the promise of PBAE-based nanoparticles as promising nonviral gene carriers for MC delivery, which may provide a valuable tool for broad applications of MC DNA-based gene therapy. ..
- Kim K, Qiang L, Hayden M, Sparling D, Purcell N, Pajvani U. mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. Nat Commun. 2016;7:10255 pubmed publisher..These data suggest that the balance of free and mTORC1-associated Raptor governs hepatic lipid accumulation, and uncover the potentially therapeutic role of PHLPP2 activators in non-alcoholic fatty liver disease. ..
- KilpelÃ¤inen T, Carli J, Skowronski A, Sun Q, Kriebel J, Feitosa M, et al. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun. 2016;7:10494 pubmed publisher..Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health. ..
- Kim C, Monack D, Falkow S. Modulation of virulence by two acidified nitrite-responsive loci of Salmonella enterica serovar Typhimurium. Infect Immun. 2003;71:3196-205 pubmed..We conclude that these genes are regulated by physiological nitrogen oxides and that the absence of these bacterial genes in some way diminishes the ability of mice to clear a low dose infection. ..
- Koo S, Flechner L, Qi L, Zhang X, Screaton R, Jeffries S, et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 2005;437:1109-11 pubmed..Individuals with type 2 diabetes often exhibit fasting hyperglycaemia due to elevated gluconeogenesis; compounds that enhance TORC2 phosphorylation may offer therapeutic benefits in this setting. ..
- Bilousova T, Rusakov D, Ethell D, Ethell I. Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation. J Neurochem. 2006;97:44-56 pubmed..These findings are the first direct evidence that MMPs can influence the morphology of mature dendritic spines, and hence synaptic stability. ..
- Maher P, Dargusch R, Ehren J, Okada S, Sharma K, Schubert D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS ONE. 2011;6:e21226 pubmed publisher..Therefore, fisetin or a synthetic derivative may have potential therapeutic use for the treatment of diabetic complications. ..
- Lin M, Rivera R, Chun J. Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain. J Biol Chem. 2012;287:17608-17 pubmed publisher..These data expand the influences of LPA signaling in neuropathic pain through a second LPA receptor subtype, LPA(5), involving a mechanistically distinct downstream signaling pathway compared with LPA(1). ..
- Gupta A, Wodziak D, Tun M, Bouley D, Lowe A. Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. J Biol Chem. 2013;288:4321-33 pubmed publisher..Similar effects of the Agr2 null on cell proliferation in the intestine were also observed. Agr2 consequently serves to maintain the balance between proliferating and differentiated epithelial cells. ..
- Reber L, Starkl P, Balbino B, Sibilano R, Gaudenzio N, Rogalla S, et al. The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice. PLoS ONE. 2017;12:e0185704 pubmed publisher..Altogether, these results raise the possibility that tyrosine kinase inhibitors might have utility in the treatment of acute gout in humans...
- Nauta A, Grova M, Montoro D, Zimmermann A, Tsai M, Gurtner G, et al. Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice. PLoS ONE. 2013;8:e59167 pubmed publisher..These data indicate that mast cells do not play a significant non-redundant role in these features of the healing of splinted full thickness excisional cutaneous wounds in mice. ..
- Horn F, Windle J, Barnhart K, Mellon P. Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotrope-specific protein. Mol Cell Biol. 1992;12:2143-53 pubmed
- Baumann M, Baumann H, Fey G. Molecular cloning, characterization and functional expression of the rat liver interleukin 6 receptor. J Biol Chem. 1990;265:19853-62 pubmed..Therefore, both IL6-R mRNA species code for functionally active receptor, depending on the target cell, but only the longer mRNA species coded for significant receptor levels in human hepatoma cell lines. ..
- Fisher R, Parisi M, Clayton D. Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Genes Dev. 1989;3:2202-17 pubmed..Flexible DNA sequence recognition by mtTF1, on the other hand, may be a principal facilitating mechanism for rapid control sequence evolution. ..
- Berg E, McEvoy L, Berlin C, Bargatze R, Butcher E. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature. 1993;366:695-8 pubmed..7), and may be uniquely adapted to support both selectin-mediated lymphocyte rolling and integrin-mediated adhesion and arrest in vivo. ..
- Stevens C, Tonegawa S, Wang Y. The role of calcium-calmodulin kinase II in three forms of synaptic plasticity. Curr Biol. 1994;4:687-93 pubmed..We propose that the activation of this enzyme is a common step in the induction of LTP and STP, and that alpha CaMKII activity is required for the normal production of LTD. ..
- Takayama S, Kochel K, Irie S, Inazawa J, Abe T, Sato T, et al. Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. Genomics. 1996;35:494-8 pubmed
- Takayama S, Krajewski S, Krajewska M, Kitada S, Zapata J, Kochel K, et al. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. Cancer Res. 1998;58:3116-31 pubmed
- Kamal A, Almenar Queralt A, Leblanc J, Roberts E, Goldstein L. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001;414:643-8 pubmed
- Malakhova O, Malakhov M, Hetherington C, Zhang D. Lipopolysaccharide activates the expression of ISG15-specific protease UBP43 via interferon regulatory factor 3. J Biol Chem. 2002;277:14703-11 pubmed..Coordinated induction of ISG15 and UBP43 suggests that ISG15 conjugation is a dynamic process and that a critical balance of ISG15-modification should be maintained during innate immune response. ..
- Bakre M, Zhu Y, Yin H, Burton D, Terkeltaub R, Deftos L, et al. Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor. Nat Med. 2002;8:995-1003 pubmed..These studies show that parathyroid hormone-related peptide is a naturally occurring angiogenesis inhibitor that functions by activation of protein kinase A. ..
- Contractor A, Sailer A, Darstein M, Maron C, Xu J, Swanson G, et al. Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice. J Neurosci. 2003;23:422-9 pubmed..These results identify the KA2 subunit as a determinant of kainate receptor function at presynaptic and postsynaptic mossy-fiber kainate receptors. ..
- Myers C, Lewcock J, Hanson M, Gosgnach S, Aimone J, Gage F, et al. Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 2005;46:37-49 pubmed..These findings suggest that the cholinergic neurotransmitter pathway is involved in configuring the CPG during a transient period of development. ..
- Bowen T, Yakushiji H, Montagna C, Jain S, Ried T, Wynshaw Boris A. Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching. Cancer Res. 2005;65:8736-46 pubmed
- Kaelin C, Gong L, Xu A, Yao F, Hockman K, Morton G, et al. Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid. Mol Endocrinol. 2006;20:2591-602 pubmed
- Shinde R, Perkins J, Contag C. Luciferin derivatives for enhanced in vitro and in vivo bioluminescence assays. Biochemistry. 2006;45:11103-12 pubmed..The ability to assay luciferase in vitro and in vivo using these substrates, which exhibit different pharmacokinetic and pharmacodynamic properties, will provide flexibility and improve current imaging capabilities. ..
- April C, Barsh G. Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation. PLoS Genet. 2007;3:e9 pubmed
- Ray P, Tsien R, Gambhir S. Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects. Cancer Res. 2007;67:3085-93 pubmed..This improved triple fusion reporter vector will enable high sensitivity detection of lower numbers of cells from living animals using the combined bioluminescence, fluorescence, and microPET imaging techniques. ..
- Kupfer R, Swanson L, Chow S, Staub R, Zhang Y, Cohen I, et al. Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101. Drug Metab Dispos. 2008;36:2261-9 pubmed publisher..4-32.2 nmol/g protein/min). An estrogen receptor luciferase assay indicated that the metabolite was a 3-fold more potent activator of the estrogen receptor beta than the parent compound and did not activate the estrogen receptor alpha. ..
- Fazilleau N, McHeyzer Williams L, Rosen H, McHeyzer Williams M. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat Immunol. 2009;10:375-84 pubmed publisher..Our studies demonstrate a central function for differences in the binding strength of the T cell antigen receptor in the antigen-specific mechanisms that 'program' specialized effector T(FH) function in vivo. ..
- Manglik A, Kruse A, Kobilka T, Thian F, Mathiesen J, Sunahara R, et al. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012;485:321-6 pubmed publisher..These high-resolution insights into opioid receptor structure will enable the application of structure-based approaches to develop better drugs for the management of pain and addiction. ..
- Schlosburg J, Radanova L, Di Marzo V, Imming P, Lichtman A. Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice. Behav Pharmacol. 2012;23:722-6 pubmed publisher..These findings indicate that FAAH-dependent arachidonoyl metabolites and cannabinoid receptors are not requisites by which dipyrone exerts these pharmacological effects under noninflammatory conditions. ..
- Mosher K, Andres R, Fukuhara T, Bieri G, Hasegawa Moriyama M, He Y, et al. Neural progenitor cells regulate microglia functions and activity. Nat Neurosci. 2012;15:1485-7 pubmed publisher..Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity. ..
- Hanson J, La H, Plise E, Chen Y, Ding X, Hanania T, et al. SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition. PLoS ONE. 2013;8:e69964 pubmed publisher..These results do not predict CNS effects of SAHA during clinical use and also emphasize the importance of analyzing brain drug levels when interpreting preclinical behavioral pharmacology. ..
- Verdoes M, Oresic Bender K, Segal E, van der Linden W, Syed S, Withana N, et al. Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc. 2013;135:14726-30 pubmed publisher..These reagents show enhanced in vivo properties and broad reactivity resulting in dramatically improved labeling and tumor imaging properties compared to those of previously reported ABPs. ..
- Mantuano E, Lam M, Gonias S. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem. 2013;288:34009-18 pubmed publisher..Proteins that activate cell signaling by binding to LRP1 assemble different co-receptor systems. Ligand-specific co-receptor recruitment provides a mechanism by which one receptor, LRP1, may trigger different signaling responses. ..
- Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, et al. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet. 2014;46:245-52 pubmed publisher..These data identify a key role for Lis1 in hematopoietic stem cells and mark its directed control of asymmetric division as a critical regulator of normal and malignant hematopoietic development. ..
- Mathews L, Vale W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell. 1991;65:973-82 pubmed..elegans daf-1 gene product, a putative transmembrane serine/threonine-specific protein kinase for which the ligand is not known. ..
- Oyler G, Higgins G, Hart R, Battenberg E, Billingsley M, Bloom F, et al. The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. J Cell Biol. 1989;109:3039-52 pubmed..The distribution of the SNAP-25 mRNA and the association of the protein with presynaptic elements suggest that SNAP-25 may play an important role in the synaptic function of specific neuronal systems. ..
- Yang X, Sytwu H, McDevitt H, Michie S. Involvement of beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in obese diabetic mice. Diabetes. 1997;46:1542-7 pubmed..Moreover, the results suggest that treatment of humans with antibodies against tissue-selective lymphocyte or endothelial adhesion molecules may selectively inhibit the development of autoimmune diseases such as diabetes. ..
- Baumgarth N, Herman O, Jager G, Brown L, Herzenberg L, Chen J. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med. 2000;192:271-80 pubmed
- Augustine K, Rossi R, Silbiger S, Bucay N, Duryea D, Marshall W, et al. Evidence that the protein tyrosine phosphatase (PC12,Br7,Sl) gamma (-) isoform modulates chondrogenic patterning and growth. Int J Dev Biol. 2000;44:361-71 pubmed..These studies provide evidence that in early skeletal development, PTPPBS gamma may regulate the rate of chondroblast proliferation in the cartilaginous skeleton. ..
- Valdivia R, Cirillo D, Lee A, Bouley D, Falkow S. mig-14 is a horizontally acquired, host-induced gene required for salmonella enterica lethal infection in the murine model of typhoid fever. Infect Immun. 2000;68:7126-31 pubmed..We hypothesize that the mig-14 gene product may repress immune system functions by interfering with normal cytokine expression in response to bacterial infections. ..
- Eto K, Huet C, Tarui T, Kupriyanov S, Liu H, Puzon McLaughlin W, et al. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem. 2002;277:17804-10 pubmed..As alpha(9)beta(1) is a receptor for many ADAM disintegrins and alpha(9)beta(1) and ADAMs are widely expressed, alpha(9)beta(1)-ADAM interaction may be of a broad biological importance. ..
- Huang C, Zhou Q, Liang P, Hollander M, Sheikh F, Li X, et al. Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem. 2003;278:7360-5 pubmed..Although surviving mice exhibit muscle pathology, these results suggest that either isoform is sufficient to rescue the lethality associated with the absence of Cypher. ..
- McIntire J, Umetsu S, Macaubas C, Hoyte E, Cinnioglu C, Cavalli Sforza L, et al. Immunology: hepatitis A virus link to atopic disease. Nature. 2003;425:576 pubmed
- Flodstrom Tullberg M, Yadav D, Hägerkvist R, Tsai D, Secrest P, Stotland A, et al. Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse. Diabetes. 2003;52:2696-700 pubmed..Importantly, given that the SOCS-1-expressing mouse maintain normal blood glucose levels throughout life, this study also showed that SOCS-1 expression by beta-cells can represent a promising strategy to prevent type 1 diabetes. ..
- Lu X, Borchers A, Jolicoeur C, Rayburn H, Baker J, Tessier Lavigne M. PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature. 2004;430:93-8 pubmed..These results identify PTK7 as a novel regulator of PCP in vertebrates. ..
- Li W, Bengtson M, Ulbrich A, Matsuda A, Reddy V, Orth A, et al. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS ONE. 2008;3:e1487 pubmed publisher..These findings suggest the existence of a new, Ub-mediated mechanism responsible for integration of mitochondria into the cellular environment. ..
- Holland L, Albalat R, Azumi K, Benito Gutiérrez E, Blow M, Bronner Fraser M, et al. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res. 2008;18:1100-11 pubmed publisher..Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates...
- Lindquist J, Cheresh D, Snyder E. Derivation of vasculature from embryonic stem cells. Curr Protoc Stem Cell Biol. 2010;Chapter 1:Unit 1F.9 pubmed publisher..This unit describes a system that allows human embryonic stem cells to differentiate and spontaneously form vascular networks via both vasculogenesis and angiogenesis in the context of the three germ layers. ..
- DeQuach J, Mezzano V, Miglani A, Lange S, Keller G, Sheikh F, et al. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS ONE. 2010;5:e13039 pubmed publisher..This versatile method can create tissue-specific ECM coatings, which offer a promising platform for cell culture to more closely mimic the mature in vivo ECM microenvironment. ..
- Akahoshi M, Song C, Piliponsky A, Metz M, Guzzetta A, Abrink M, et al. Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest. 2011;121:4180-91 pubmed publisher..Our findings support the notion that mast cells can enhance innate defense by degradation of diverse animal toxins and that release of MCPT4, in addition to CPA3, can contribute to this mast cell function. ..
- Swami S, Krishnan A, Wang J, Jensen K, Horst R, Albertelli M, et al. Dietary vitamin D? and 1,25-dihydroxyvitamin D? (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer. Endocrinology. 2012;153:2576-87 pubmed publisher..These preclinical data demonstrate the potential utility of dietary vitamin D(3) supplementation in cancer prevention and therapy. ..
- Chen W, Kawasaki N, Nycholat C, Han S, Pilotte J, Crocker P, et al. Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169. PLoS ONE. 2012;7:e39039 pubmed publisher..Together, these data provide insights into the potential of cell-specific targeting and delivery of antigens to intracellular organelles of macrophages using Sn-ligand decorated liposomal nanoparticles...
- Fujita A, Bonnavion P, Wilson M, Mickelsen L, Bloit J, de Lecea L, et al. Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability. J Neurosci. 2017;37:9574-9592 pubmed publisher..This work furthers our understanding of HA-mediated mechanisms that regulate behavioral arousal. ..
- Lagasse E, Weissman I. bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med. 1994;179:1047-52 pubmed..This transgenic model indicates that the mechanism that triggers phagocytosis of aging neutrophils operates independently of the process of apoptosis regulated by bcl-2. ..
- Sim B, Aftahi N, Reilly C, Bogen B, Schwartz R, Gascoigne N, et al. Thymic skewing of the CD4/CD8 ratio maps with the T-cell receptor alpha-chain locus. Curr Biol. 1998;8:701-4 pubmed..Thus, while it has been suggested that the TCR genes have been selected by evolution for MHC binding, our results further indicate selection for class II MHC preference. ..
- Chen A, Perrin M, Brar B, Li C, Jamieson P, Digruccio M, et al. Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids. Mol Endocrinol. 2005;19:441-58 pubmed
- King J, Ferrara R, Tabibiazar R, Spin J, Chen M, Kuchinsky A, et al. Pathway analysis of coronary atherosclerosis. Physiol Genomics. 2005;23:103-18 pubmed
- Fraikin J, Teesalu T, McKenney C, Ruoslahti E, Cleland A. A high-throughput label-free nanoparticle analyser. Nat Nanotechnol. 2011;6:308-13 pubmed publisher..The high-throughput detection capability, scalable fabrication and simple electronics of this instrument make it well suited for diverse applications. ..
- Xu Y, Chang E, Liu H, Jiang H, Gambhir S, Cheng Z. Proof-of-concept study of monitoring cancer drug therapy with cerenkov luminescence imaging. J Nucl Med. 2012;53:312-317 pubmed publisher..The findings warrant further exploration and optimization of CLI as an alternative to PET in preclinical therapeutic monitoring and drug screening. ..
- Milatovich A, Francke U. Human cyclin B1 gene (CCNB1) assigned to chromosome 5 (q13-qter). Somat Cell Mol Genet. 1992;18:303-7 pubmed..Based on our mapping of human CCNB1 and known evolutionary conservation of chromosomal regions, we propose that the homologous cyclin B1 locus, Cycb-4, on mouse chromosome 13 is a functional gene. ..
- Shannon M, Stubbs L. Analysis of homologous XRCC1-linked zinc-finger gene families in human and mouse: evidence for orthologous genes. Genomics. 1998;49:112-21 pubmed
- Corzett M, Kramer C, Blacher R, Mazrimas J, Balhorn R. Analysis of hamster protamines: primary sequence and species distribution. Mol Reprod Dev. 1999;54:273-82 pubmed publisher..Mol. Reprod. Dev. 54:273-282, 1999. Published 1999 Wiley-Liss, Inc...
- Ashburner M, Ball C, Blake J, Botstein D, Butler H, Cherry J, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25:25-9 pubmed
- Ke N, Godzik A, Reed J. Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. J Biol Chem. 2001;276:12481-4 pubmed..Bcl-B thus displays a unique pattern of selectivity for binding and regulating the function of other members of the Bcl-2 family. ..
- Smith K, Rhee J, Cleary M. Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2. Mol Cell Biol. 2002;22:7678-87 pubmed
- Warren S, Brunet L, Harland R, Economides A, Longaker M. The BMP antagonist noggin regulates cranial suture fusion. Nature. 2003;422:625-9 pubmed..Since noggin misexpression prevents cranial suture fusion in vitro and in vivo, we suggest that syndromic fgfr-mediated craniosynostoses may be the result of inappropriate downregulation of noggin expression...
- Nobrega M, Zhu Y, Plajzer Frick I, Afzal V, Rubin E. Megabase deletions of gene deserts result in viable mice. Nature. 2004;431:988-93 pubmed..Some of the deleted sequences might encode for functions unidentified in our screen; nonetheless, these studies further support the existence of potentially 'disposable DNA' in the genomes of mammals. ..
- Lee C, Arai M, Martinez Yamout M, Dyson H, Wright P. Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. Biochemistry. 2009;48:2115-24 pubmed publisher..The p53 TAD simultaneously occupies the two distinct sites that have been identified on the CBP KIX domain and efficiently competes for these sites with other known KIX-binding transcription factors. ..
- Airan R, Thompson K, Fenno L, Bernstein H, Deisseroth K. Temporally precise in vivo control of intracellular signalling. Nature. 2009;458:1025-9 pubmed publisher..The optoXR approach allows testing of hypotheses regarding the causal impact of biochemical signalling in behaving mammals, in a targetable and temporally precise manner. ..
- Burkhart D, Wirt S, Zmoos A, Kareta M, Sage J. Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet. 2010;6:e1001003 pubmed publisher..These experiments also suggest novel therapeutic strategies to increase the p107 levels in tumor cells. ..
- Xu X, Martin F, Friedman J. The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage. Blood Cells Mol Dis. 2010;45:227-32 pubmed publisher..These results indicate that DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. ..
- Perry S, Buck M, Lada S, Schindler C, Shresta S. STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor. PLoS Pathog. 2011;7:e1001297 pubmed publisher..Collectively, these results help elucidate the nature of the poorly understood STAT1-independent host defense mechanism against viruses by identifying a functional type I IFN/STAT2 signaling pathway following DENV infection in vivo. ..
- Lisowski L, Lau A, Wang Z, Zhang Y, Zhang F, Grompe M, et al. Ribosomal DNA integrating rAAV-rDNA vectors allow for stable transgene expression. Mol Ther. 2012;20:1912-23 pubmed publisher..Because of the relative safety of integration in the rDNA locus, these vectors expand the usage of rAAV for therapeutics requiring long-term gene transfer into dividing cells...