Experts and Doctors on messenger rna in New York, United States

Summary

Locale: New York, United States
Topic: messenger rna

Top Publications

  1. Kelley K, Stamm S, Kozak C. Expression and chromosome localization of the murine cystic fibrosis transmembrane conductance regulator. Genomics. 1992;13:381-8 pubmed
  2. Maurel P, Rauch U, Flad M, Margolis R, Margolis R. Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase. Proc Natl Acad Sci U S A. 1994;91:2512-6 pubmed
  3. Burova E, Hung S, Sagitov V, Stitt B, Gottesman M. Escherichia coli NusG protein stimulates transcription elongation rates in vivo and in vitro. J Bacteriol. 1995;177:1388-92 pubmed
    ..In a purified in vitro system, NusG accelerated the transcription elongation rate. The stimulation of the rate of transcription elongation by NusG appears to result from the suppression of specific transcription pause sites. ..
  4. Winer M, Wadewitz A, Wolgemuth D. Members of the raf gene family exhibit segment-specific patterns of expression in mouse epididymis. Mol Reprod Dev. 1993;35:16-23 pubmed
    ..These studies indicate that each raf gene exhibits a characteristic pattern of expression in the epididymis; A-raf in particular may play a unique regulatory role in the regionalized functions of the epididymis. ..
  5. Mizuno T, Kleopoulos S, Bergen H, Roberts J, Priest C, Mobbs C. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes. 1998;47:294-7 pubmed
  6. Schwer B, Mao X, Shuman S. Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme. Nucleic Acids Res. 1998;26:2050-7 pubmed
    ..These findings provide genetic evidence for the long-held idea that the cap guanylate is critical for mRNA stability. The deadenylation-decapping-degradation pathway appears to be short-circuited when Ceg1 is inactivated. ..
  7. Takito J, Yan L, Ma J, Hikita C, Vijayakumar S, Warburton D, et al. Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am J Physiol. 1999;277:F277-89 pubmed
    ..The most likely interpretation of these data is that one gene produces at least three transcripts, namely, hensin, DMBT1, and CRP-ductin. Hensin may participate in determining the polarized phenotype of other epithelia and brain cells. ..
  8. Vilim F, Alexeeva V, Moroz L, Li L, Moroz T, Sweedler J, et al. Cloning, expression and processing of the CP2 neuropeptide precursor of Aplysia. Peptides. 2001;22:2027-38 pubmed
    ..MALDI-TOF MS is used to identify additional peptides derived from the CP2 precursor in neuronal somata and nerves, suggesting that the CP2 precursor may give rise to additional bioactive neuropeptides...
  9. Clancy R, Backer C, Yin X, Kapur R, Molad Y, Buyon J. Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block. J Immunol. 2003;171:3253-61 pubmed
    ..This profibrosing cytokine and its secretion/activation circuitry may provide a novel direction for evaluating fetal factors in the development of a robust animal model of CHB as well as therapeutic strategies in humans. ..

More Information

Publications396 found, 100 shown here

  1. Kamm C, Leung J, Joseph S, Dobyns W, Brashear A, Breakefield X, et al. Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene. Mov Disord. 2004;19:845-847 pubmed publisher
    ..9 cM interval flanked by markers D19S224 and D19S900. Evaluation of a positional candidate gene, the glutamate receptor subunit GRIK5, revealed no mutations. ..
  2. Salas M, John R, Saxena A, Barton S, Frank D, Fitzpatrick G, et al. Placental growth retardation due to loss of imprinting of Phlda2. Mech Dev. 2004;121:1199-210 pubmed
    ..Consistent with this conclusion, we observed significant placental stunting in BAC-transgenic mice that over-expressed Phlda2 and one flanking gene, Slc22a1l, but did not over-express Cdkn1c. ..
  3. Sarkar D, Park E, Emdad L, Randolph A, Valerie K, Fisher P. Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence. Mol Cell Biol. 2005;25:7333-43 pubmed
  4. Cai H, Del Priore L. Bruch membrane aging alters the gene expression profile of human retinal pigment epithelium. Curr Eye Res. 2006;31:181-9 pubmed
    ..The role of these changes in the pathogenesis of age-related diseases such as macular degeneration remains to be elucidated...
  5. Silvera D, Formenti S, Schneider R. Translational control in cancer. Nat Rev Cancer. 2010;10:254-66 pubmed publisher
    ..Several clinical efforts are underway to target specific components of the translation apparatus or unique mRNA translation elements for cancer therapeutics. ..
  6. Johnson M, Housey G, Kirschmeier P, Weinstein I. Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C. Mol Cell Biol. 1987;7:2821-9 pubmed
    ..6 X 10(3) that exhibits homology with sequences representing a protein with human erythroid-potentiating activity and protease inhibitory activity. ..
  7. Stebbins C, Borukhov S, Orlova M, Polyakov A, Goldfarb A, Darst S. Crystal structure of the GreA transcript cleavage factor from Escherichia coli. Nature. 1995;373:636-40 pubmed
    ..The structure exhibits an unusual asymmetric charge distribution which indicates the manner in which GreA interacts with the RNA polymerase elongation complex. ..
  8. Chen M, Achkar C, Gudas L. Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenases. Mol Pharmacol. 1994;46:88-96 pubmed
    ..AHD-2 is more active than AHD-M1 in this conversion, but AHD-2 is not the enzyme responsible for this conversion in F9 embryonic stem cells. ..
  9. Price J, Blau J, Rothenfluh A, Abodeely M, Kloss B, Young M. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell. 1998;94:83-95 pubmed
    ..This would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity. ..
  10. Goldberg M, Peshkovsky C, Shifteh A, Al Awqati Q. mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains. J Biol Chem. 2000;275:24622-9 pubmed
    ..The cytoplasmic domain contains four proline-rich regions, similar to SH3 binding regions. Thus, it is likely that adhesive interactions mediated by mu-protocadherin induce signaling events that regulate branching morphogenesis. ..
  11. Chen J, Li Z, Pan H, Murphy D, Tamir H, Koepsell H, et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci. 2001;21:6348-61 pubmed
    ..The watery diarrhea is probably attributable to the potentiation of serotonergic signaling in SERT -/- mice, whereas the transient constipation may be caused by episodes of enhanced 5-HT release leading to 5-HT receptor desensitization. ..
  12. Angelastro J, Torocsik B, Greene L. Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins. BMC Neurosci. 2002;3:3 pubmed
  13. Mantsch J, Yuferov V, Mathieu Kia A, Ho A, Kreek M. Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology (Berl). 2004;175:26-36 pubmed
    ..The characterization of neurobiological alterations that accompany escalated SA should facilitate the identification of mechanisms underlying the onset of human addiction. ..
  14. Lu J, Bergman N, Sadri N, Schneider R. Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay. RNA. 2006;12:883-93 pubmed
    ..Based on these and other data, we propose a model for the molecular interactions of AUF1 that involves translation-dependent displacement of AUF1-PABP complexes from ARE-mRNAs with possible unmasking of the poly(A) tail. ..
  15. Subbaramaiah K, Dannenberg A. Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange. Cancer Res. 2007;67:3976-85 pubmed
    ..To our knowledge, this study also provides the first evidence that NCoR can function as a repressor of COX-2 gene expression. ..
  16. Lauriat T, Shiue L, Haroutunian V, Verbitsky M, Ares M, Ospina L, et al. Developmental expression profile of quaking, a candidate gene for schizophrenia, and its target genes in human prefrontal cortex and hippocampus shows regional specificity. J Neurosci Res. 2008;86:785-96 pubmed
    ..We also suggest that OMR transcripts might be processed by different splicing proteins in different tissues. ..
  17. Luan Y, Kong L, Howell D, Ilalov K, Fajardo M, Bai X, et al. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis Cartilage. 2008;16:1413-20 pubmed publisher
    ..Furthermore, a(2)M is a novel substrate for ADAMTS-7 and ADAMTS-12. More significantly, a(2)M represents the first endogenous inhibitor of ADAMTS-7 and ADAMTS-12. ..
  18. Litton C, Stone J, Eddleman K, Lee M. Noninvasive prenatal diagnosis: past, present, and future. Mt Sinai J Med. 2009;76:521-8 pubmed publisher
    ..These biomarkers, the result of inherent placental dysfunction or the byproducts of placental trophoblastic apoptosis, may allow for improvements in the diagnosis and management of high-risk pregnancies. ..
  19. Ward S, Morrison S. Spontaneous deletions in Ig heavy chain genes: flanking sequences influence splice site selection. Nucleic Acids Res. 1991;19:6475-80 pubmed
    ..Analysis of these events provides some interesting insights into the mechanism of splice site selection and the evolution of introns and exons. ..
  20. Ebihara L, Beyer E, Swenson K, Paul D, Goodenough D. Cloning and expression of a Xenopus embryonic gap junction protein. Science. 1989;243:1194-5 pubmed
    ..Pairs of RNA-injected oocytes formed many more time- and voltage-sensitive cell-cell channels than water-injected pairs. ..
  21. Yamashita M, Krystal M, Palese P. Evidence that the matrix protein of influenza C virus is coded for by a spliced mRNA. J Virol. 1988;62:3348-55 pubmed
    ..Despite the difference in coding strategies, there are sequence homologies among the M proteins of influenza A, B, and C viruses which confirm the evolutionary relationship of the three influenza virus types. ..
  22. Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen J, et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem. 1995;270:25752-61 pubmed
  23. Georgieff I, Liem R, Couchie D, Mavilia C, Nunez J, Shelanski M. Expression of high molecular weight tau in the central and peripheral nervous systems. J Cell Sci. 1993;105 ( Pt 3):729-37 pubmed
  24. Zagzag D, Friedlander D, Dosik J, Chikramane S, Chan W, Greco M, et al. Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro. Cancer Res. 1996;56:182-9 pubmed
    ..Furthermore, our results suggest that TN expression may be associated with endothelial cell activation and may play an important role in angiogenesis. ..
  25. Komissarova N, Kashlev M. RNA polymerase switches between inactivated and activated states By translocating back and forth along the DNA and the RNA. J Biol Chem. 1997;272:15329-38 pubmed
    ..These oscillations of RNA polymerase can explain its apparent discontinuous advancement, which had been interpreted as indicating flexibility within the enzyme. ..
  26. Wu G, Mochizuki T, Le T, Cai Y, Hayashi T, Reynolds D, et al. Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2. Genomics. 1997;45:220-3 pubmed
    ..Pkd2 mRNA is widely expressed in mouse tissues. Pkd2 maps to mouse Chromosome 5 and is excluded as a candidate gene for previously mapped mouse mutations resulting in a polycystic kidney phenotype. ..
  27. Ho C, Gong C, Shuman S. RNA triphosphatase component of the mRNA capping apparatus of Paramecium bursaria Chlorella virus 1. J Virol. 2001;75:1744-50 pubmed
    ..Indeed, PBCV-1 is unique among DNA viruses in that the triphosphatase and guanylyltransferase steps of cap formation are catalyzed by separate viral enzymes instead of a single viral polypeptide with multiple catalytic domains...
  28. Hirschhorn R, Huie M, Kasper J. Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31. Proc Natl Acad Sci U S A. 2002;99:13642-6 pubmed
  29. Zavolan M, Kondo S, Schonbach C, Adachi J, Hume D, Hayashizaki Y, et al. Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Res. 2003;13:1290-300 pubmed
  30. Maxwell K, Soccio R, Duncan E, Sehayek E, Breslow J. Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J Lipid Res. 2003;44:2109-19 pubmed
  31. Wu K, Tobias M, Kelley D. Estrogen receptor expression in laryngeal muscle in relation to estrogen-dependent increases in synapse strength. Neuroendocrinology. 2003;78:72-80 pubmed
    ..Taken together, these experiments strongly suggest that the ER is expressed by laryngeal muscle; this receptor could mediate estrogen-dependent changes in synaptic strength via retrograde signaling. ..
  32. Wang G, O Shaughnessy P, Chubb C, Robaire B, Hardy M. Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse leydig cells. Endocrinology. 2003;144:5058-64 pubmed
    ..These results show that in the absence of IGF-I, there is a failure of adult Leydig cells to mature, and that the reduced capacity for T production is caused by disproportionate expression of T biosynthetic and metabolizing enzymes. ..
  33. Chen Y, Guo X, Deng F, Liang F, Sun W, Ren M, et al. Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proc Natl Acad Sci U S A. 2003;100:14012-7 pubmed
    ..The association of Rab27b with fusiform vesicles and its differentiation-dependent expression suggest that this Rab protein plays a role in regulating the delivery of fusiform vesicles to the apical plasma membrane of umbrella cells. ..
  34. Weisberg S, McCann D, Desai M, Rosenbaum M, Leibel R, Ferrante A. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796-808 pubmed
    ..Adipose tissue macrophage numbers increase in obesity and participate in inflammatory pathways that are activated in adipose tissues of obese individuals. ..
  35. Lin Y, Berg A, Iyengar P, Lam T, Giacca A, Combs T, et al. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem. 2005;280:4617-26 pubmed
    ..Combined, these results highlight the importance ROS production in adipocytes and the associated insulin resistance and inflammatory response. ..
  36. Zhang F, Cheng J, Lam G, Jin D, Vincent L, Hackett N, et al. Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways. Circ Res. 2005;96:950-7 pubmed
    ..Taken together, these results suggest that AdE4+ may play an important role in the regulation of Cx expression in ECs, and that these effects are mediated by both the PKA/CREB and PI3K signaling pathways. ..
  37. Valdez G, Akmentin W, Philippidou P, Kuruvilla R, Ginty D, Halegoua S. Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. J Neurosci. 2005;25:5236-47 pubmed
    ..Pincher is the first distinguishing molecular component of a novel mechanistic pathway for endosomal signaling in neurons. ..
  38. Sun D, Ding A. MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA. Nat Immunol. 2006;7:375-81 pubmed
    ..These results demonstrate a MyD88-dependent post-transcriptional mechanism through which IFN-gamma can enhance the expression of genes encoding proinflammatory molecules. ..
  39. Boothroyd C, Wijnen H, Naef F, Saez L, Young M. Integration of light and temperature in the regulation of circadian gene expression in Drosophila. PLoS Genet. 2007;3:e54 pubmed
    ..Taken together, these findings suggest that information from both light and temperature is integrated by the transcriptional clock mechanism in the adult fly head. ..
  40. Qiu A, Min S, Jansen M, Malhotra U, Tsai E, Cabelof D, et al. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. Am J Physiol Cell Physiol. 2007;293:C1669-78 pubmed
    ..MmPCFT mRNA levels increased approximately 13-fold in the proximal small intestine in mice fed a folate-deficient vesus folate-replete diet, consistent with the critical role that PCFT plays in intestinal folate absorption. ..
  41. Rai A, Flores R, MATHEW A, Gonzalez Espinoza R, Bott M, Ladanyi M, et al. Soluble mesothelin related peptides (SMRP) and osteopontin as protein biomarkers for malignant mesothelioma: analytical validation of ELISA based assays and characterization at mRNA and protein levels. Clin Chem Lab Med. 2010;48:271-8 pubmed publisher
    ..Our results further characterize these markers, establish assay performance characteristics, and lay the groundwork for further studies to measure these markers in blood. ..
  42. Hunter R, Bloss E, McCarthy K, McEwen B. Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids. Brain Res. 2010;1325:141-6 pubmed publisher
    ..While the mechanism behind these observations is as yet unclear, they may be neuroprotective against the damaging effects of CRS or an example of adaptation to the allostatic load produced by CRS. ..
  43. Masiakowski P, Carroll R. A novel family of cell surface receptors with tyrosine kinase-like domain. J Biol Chem. 1992;267:26181-90 pubmed
    ..Based on these data, Ror1 and Ror2 appear to define a new developmentally regulated family of cell surface receptors for unidentified ligands. ..
  44. Fakhrai H, Maines M. Expression and characterization of a cDNA for rat kidney biliverdin reductase. Evidence suggesting the liver and kidney enzymes are the same transcript product. J Biol Chem. 1992;267:4023-9 pubmed
    ..7-6.9 range and NADPH at pH 8.5-8.7. The findings suggest that the liver and kidney enzymes are the products of the same transcript(s) and that their microheterogeneity may reflect tissue-specific post-translational modifications. ..
  45. Brooks D, Qiu W, Luster A, Ravetch J. Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med. 1989;170:1369-85 pubmed
    ..Expression of these cDNA molecules by transfection results in the appearance of IgG binding molecules that bear the epitopes defined by the FcRII(CD32) mAbs previously described. ..
  46. Nitsche E, Moquin A, Adams P, Guenette R, Lakins J, Sinnecker G, et al. Differential display RT PCR of total RNA from human foreskin fibroblasts for investigation of androgen-dependent gene expression. Am J Med Genet. 1996;63:231-8 pubmed
    ..The results of this study are of interest in further investigation of normal and disturbed androgen-dependent gene expression. ..
  47. Tam W, Ben Yehuda D, Hayward W. bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA. Mol Cell Biol. 1997;17:1490-502 pubmed
    ..The possible role of bic in cell growth and differentiation is discussed in view of the emerging evidence that untranslated RNAs play a role in growth control. ..
  48. Kingsley P, Whitin J, Cohen H, Palis J. Developmental expression of extracellular glutathione peroxidase suggests antioxidant roles in deciduum, visceral yolk sac, and skin. Mol Reprod Dev. 1998;49:343-55 pubmed
    ..These findings suggest that EGPx may serve a wider antioxidant role than previously recognized in the interstitium of multiple localized tissues, particularly those associated with the active transport of lipids. ..
  49. Schmidt V, Nierman W, Maglott D, Cupit L, Moskowitz K, Wainer J, et al. The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets. J Biol Chem. 1998;273:15061-8 pubmed
    ..Rather, given its disparately greater expression in megakaryocytes (and megakaryocyte-like human erythroleukemia cells), a regulatory role in cellular development (by protease activation) could be postulated. ..
  50. Szabo P, Zhao K, Kirman I, Le Maoult J, Dyall R, Cruikshank W, et al. Maturation of B cell precursors is impaired in thymic-deprived nude and old mice. J Immunol. 1998;161:2248-53 pubmed
    ..We conclude that the impaired development of B cells within the bone marrow of thymic-deprived nude and old mice can be reversed, at least in part, by the administration of rIL-16. ..
  51. Li B, Ishii T, Tan C, Soh J, Goff S. Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. J Biol Chem. 2002;277:12418-22 pubmed
  52. Huang D, Chen S, Gudas L. Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice. Dev Dyn. 2002;223:353-70 pubmed
  53. Kao H, Song H, Porton B, Ming G, Hoh J, Abraham M, et al. A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. Nat Neurosci. 2002;5:431-7 pubmed
    ..These results provide a potential molecular approach for stimulating neuron regeneration, after injury and in neurodegenerative diseases. ..
  54. Rydkina E, Sahni A, Silverman D, Sahni S. Rickettsia rickettsii infection of cultured human endothelial cells induces heme oxygenase 1 expression. Infect Immun. 2002;70:4045-52 pubmed
    ..rickettsii infection induces HO-1 expression in host endothelial cells and suggest an important role for this enzyme in cellular response to infection, possibly by serving a protective function against oxidative injury...
  55. Crowley T, Kaine E, Yoshida M, Nandi A, Wolgemuth D. Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. Mol Endocrinol. 2002;16:1727-37 pubmed
    ..Localization of Fsrg1 on euchromatin, the transcribed portion of the chromosomes, is consistent with its hypothesized function as a transcription regulator. ..
  56. Rajala M, Lin Y, Ranalletta M, Yang X, Qian H, Gingerich R, et al. Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue. Mol Endocrinol. 2002;16:1920-30 pubmed
    ..Additionally, we show that resistin and RELMalpha levels are not subject to regulation by proinflammatory stimuli. Finally, acute hyperglycemia leads to up-regulation of resistin and RELMalpha transcription in various adipose depots. ..
  57. Hazelrigg T. Lost in translation gets an oskar. Dev Cell. 2004;6:611-3 pubmed
    ..New results show that the Drosophila heterogeneous nuclear ribonucleoprotein (hnRNP) Hrp48 contributes to coordinated RNA localization and translational control in oocytes. ..
  58. Mo L, Huang H, Zhu X, Shapiro E, Hasty D, Wu X. Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation. Kidney Int. 2004;66:1159-66 pubmed
  59. Kentsis A, Topisirovic I, Culjkovic B, Shao L, Borden K. Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci U S A. 2004;101:18105-10 pubmed
    ..In all, ribavirin's association with eIF4E may provide a pharmacologic means for the interruption of posttranscriptional networks of oncogenes that maintain and enhance neoplasia and malignancy in human cancer. ..
  60. Elder G, Cho J, English D, Franciosi S, Schmeidler J, Sosa M, et al. Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor. J Neurochem. 2007;102:1220-31 pubmed
    ..ApoE protein levels in brain were, however, elevated, in LDLR-/- mice by post-transcriptional mechanisms. Collectively, these studies argue that plasma cholesterol levels do not normally regulate production of brain Abeta. ..
  61. Yang R, Kolb E, Qin J, Chou A, Sowers R, Hoang B, et al. The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Clin Cancer Res. 2007;13:2557-67 pubmed
    ..FR alpha overexpression is unlikely secondary to the decreased RFC expression in osteosarcoma. ..
  62. Harding H, Lackey J, Hsu H, Zhang Y, Deng J, Xu R, et al. An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. RNA. 2008;14:225-32 pubmed
    ..These observations argue against the presence of a 2'-PO4(2-) at the splice junction of ligated RNA molecules in Trpt1-/- cells, and suggest that Xbp-1 and tRNA ligation proceed by distinct pathways in yeast and mammals. ..
  63. Lee H, Chen S, DOETSCHMAN T, Deng C, D Agati V, Kim M. Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-beta1 pathway. Am J Physiol Renal Physiol. 2008;295:F128-36 pubmed publisher
    ..Therefore, we demonstrate in this study that sevoflurane-mediated renal protection in vivo requires the TGF-beta1-->SMAD3 signaling pathway. ..
  64. Ambrosetti D, Holmes G, Mansukhani A, Basilico C. Fibroblast growth factor signaling uses multiple mechanisms to inhibit Wnt-induced transcription in osteoblasts. Mol Cell Biol. 2008;28:4759-71 pubmed publisher
    ..Our results show that FGF antagonizes Wnt signaling by inhibiting Wnt-induced transcription and suggest that multiple mechanisms, including downregulation of TCFs and Wnt receptors, contribute to this effect. ..
  65. Pomerantz R, O Donnell M. The replisome uses mRNA as a primer after colliding with RNA polymerase. Nature. 2008;456:762-6 pubmed publisher
    ..These findings underscore the notable plasticity by which the replisome operates to circumvent obstacles in its path and may explain why the leading strand is synthesized discontinuously in vivo. ..
  66. Xu H, Cheung I, Guo H, Cheung N. MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors. Cancer Res. 2009;69:6275-81 pubmed publisher
    ..Differential modulation of this key immunoinhibitory molecule in tumor versus normal tissues may advance both cell-mediated immunotherapy and antibody-based targeted strategies using the B7-H3-specific mAb 8H9. ..
  67. Gavarini S, Cayrol C, Fuchs T, Lyons N, Ehrlich M, Girard J, et al. Direct interaction between causative genes of DYT1 and DYT6 primary dystonia. Ann Neurol. 2010;68:549-53 pubmed publisher
    ..Our findings provide the first evidence that causative genes for primary dystonia intersect in a common pathway and raise the possibility of developing novel therapies targeting this pathway. ..
  68. Raabe T, Bollum F, Manley J. Primary structure and expression of bovine poly(A) polymerase. Nature. 1991;353:229-34 pubmed
    ..Poly(A) polymerase expressed from a cloned cDNA is fully functional in in vitro assays, and mutational analyses have identified a putative regulatory domain that enhances, but is not essential for, activity. ..
  69. Janne O, Crozat A, Palvimo J, Eisenberg L. Androgen-regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase genes. J Steroid Biochem Mol Biol. 1991;40:307-15 pubmed
  70. Rotenberg M, Maines M. Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2. J Biol Chem. 1990;265:7501-6 pubmed
    ..Finally, computer analysis of the heme oxygenase-2 cDNA sequence indicates that the predicted amino acid sequence and hydropathy profile of the heme oxygenase-2 protein exhibit similarity with heme oxygenase-1. ..
  71. Streit A, Lee K, Woo I, Roberts C, Jessell T, Stern C. Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. Development. 1998;125:507-19 pubmed
    ..These results suggest that the regulation of BMP signalling by chordin plays a role in primitive streak formation and that chordin is not sufficient to induce neural tissue. ..
  72. Thompson J, Chen S, Ho L, Langston A, Gudas L. An evolutionary conserved element is essential for somite and adjacent mesenchymal expression of the Hoxa1 gene. Dev Dyn. 1998;211:97-108 pubmed
    ..These results indicate that in transgenic animals, the evolutionary conserved CE2 element is a somite and adjacent mesenchymal enhancer of Hoxa1 expression. ..
  73. Kohtz J, Baker D, Corte G, Fishell G. Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. Development. 1998;125:5079-89 pubmed
    ..This is the embryonic structure from which the striatum is derived. These results suggest that temporally regulated changes in Sonic Hedgehog responsiveness are integral in the sequential induction of basal telencephalic structures. ..
  74. Jiang X, Bruce C, Mar J, Lin M, Ji Y, Francone O, et al. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest. 1999;103:907-14 pubmed
    ..Vesicular lipoproteins accumulating in PLTP-/- mice on a high-fat diet could influence the development of atherosclerosis. ..
  75. Almer G, Vukosavic S, Romero N, Przedborski S. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem. 1999;72:2415-25 pubmed
    ..This observation also suggests that iNOS may represent a valuable target for the development of new therapeutic avenues for ALS. ..
  76. Elder G, Friedrich V, Pereira D, Tu P, Zhang B, Lee V, et al. Mice with disrupted midsized and heavy neurofilament genes lack axonal neurofilaments but have unaltered numbers of axonal microtubules. J Neurosci Res. 1999;57:23-32 pubmed
    ..Thus in vivo rodent neurofilaments are obligate heteropolymers requiring NF-L plus either NF-M or NF-H to form a filamentous network. ..
  77. Runko E, Wideman C, Kaprielian Z. Cloning and expression of VEMA: a novel ventral midline antigen in the rat CNS. Mol Cell Neurosci. 1999;14:428-43 pubmed
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