Genomes and Genes
Experts and Doctors on membrane proteins in New York, United States
Locale: New York, United States
Topic: membrane proteins
Publications493 found, 100 shown here
- Salman H, Libchaber A. A concentration-dependent switch in the bacterial response to temperature. Nat Cell Biol. 2007;9:1098-100 pubmed..Our findings indicate that the secreted intercellular signal, glycine, mediates this switch through methylation of Tsr receptors. At high bacterial concentration, the switch is reinforced by an inversion of the Tar/Tsr expression ratio. ..
- Shaw M, Stone K, Colangelo C, Gulcicek E, Palese P. Cellular proteins in influenza virus particles. PLoS Pathog. 2008;4:e1000085 pubmed publisher..While not all of the host proteins are necessarily incorporated specifically, those that are and are found to have an essential role represent novel targets for antiviral drugs and for attenuation of viruses for vaccine purposes. ..
- Chun J, Prince A. TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration. Cell Host Microbe. 2009;5:47-58 pubmed publisher..aeruginosa infection. Thus, TLR2 signaling in the airway not only induces chemokine expression to recruit PMNs, but also initiates cleavage of junctional proteins to accommodate transmigration of the recruited PMNs. ..
- Charpentier X, Gabay J, Reyes M, Zhu J, Weiss A, Shuman H. Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathog. 2009;5:e1000501 pubmed publisher..pneumophila lifestyle. Chemical genetic screening provides a novel approach to probe the host cell functions and factors involved in host-pathogen interactions. ..
- Worman H, Fong L, Muchir A, Young S. Laminopathies and the long strange trip from basic cell biology to therapy. J Clin Invest. 2009;119:1825-36 pubmed publisher..Here, we review the laminopathies and the long strange trip from basic cell biology to therapeutic approaches for these diseases. ..
- Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A. 2009;106:13439-44 pubmed publisher..Our findings highlight the significance of GARP both in dissecting duality of Treg/Th17 cell differentiation and as a marker to identify bona fide Tregs during diseases with chronic immune activation. ..
- Papeta N, Zheng Z, Schon E, Brosel S, Altintas M, Nasr S, et al. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest. 2010;120:4055-64 pubmed publisher..These findings implicate mtDNA damage in the development of ADR toxicity and identify Prkdc as a MDDS modifier gene and a component of the mitochondrial genome maintenance pathway. ..
- Lefort R, Pozueta J, Shelanski M. Cross-linking of cell surface amyloid precursor protein leads to increased ?-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease. J Neurosci. 2012;32:10674-85 pubmed publisher..Together, our data suggest the occurrence of a positive pathogenic feedback loop involving A? and APP in affected neurons possibly allowing A? to spread to nearby healthy neurons. ..
- Greenburg G, Shelness G, Blobel G. A subunit of mammalian signal peptidase is homologous to yeast SEC11 protein. J Biol Chem. 1989;264:15762-5 pubmed..C., Deshaies, R. J., and Schekman, R. W. (1988) J. Cell Biol. 106, 1035-1042). It is, therefore, likely that the 21-kDa subunit of signal peptidase complex is the structural and functional homologue of the yeast SEC11 gene product. ..
- Aderem A. The MARCKS family of protein kinase-C substrates. Biochem Soc Trans. 1995;23:587-91 pubmed
- Glerum D, Shtanko A, Tzagoloff A. SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. J Biol Chem. 1996;271:20531-5 pubmed..We interpret the ability of SCO2 to restore respiration in cox17, but not in sco1 mutants, to indicate that Sco1p and Sco2p have overlapping but not identical functions. ..
- Li Z, Rossi E, Hoheisel J, Kalderon D, Rubin C. Generation of a novel A kinase anchor protein and a myristoylated alanine-rich C kinase substrate-like analog from a single gene. J Biol Chem. 1999;274:27191-200 pubmed..Enhancement or suppression of exon 5 excision during DAKAP200 pre-mRNA processing provides potential mechanisms for regulating anchoring of PKAII and targeting of cAMP signals to effector sites in cytoskeleton and/or organelles. ..
- Xu L, Shen Y, Joseph T, Bryant A, Luo J, Frankel P, et al. Mitogenic phospholipase D activity is restricted to caveolin-enriched membrane microdomains. Biochem Biophys Res Commun. 2000;273:77-83 pubmed..These data indicate that mitogenic signals through PLD are initiated in CEMMs where many signaling molecules colocalize. ..
- Maher J, Brentjens R, Gunset G, Riviere I, Sadelain M. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor. Nat Biotechnol. 2002;20:70-5 pubmed..These findings have important implications for adoptive immunotherapy of cancer, especially in the context of tumor cells that fail to express major histocompatibility complex antigens and co-stimulatory molecules. ..
- Egawa T, Albrecht B, Favier B, Sunshine M, Mirchandani K, O BRIEN W, et al. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol. 2003;13:1252-8 pubmed..Together, these results show that CARMA1 has a central role in antigen receptor signaling that results in activation and proliferation of both B and T lymphocytes. ..
- Ehrlich I, Malinow R. Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity. J Neurosci. 2004;24:916-27 pubmed..We conclude that PSD-95 controls activity-dependent AMPAR incorporation at synapses via PDZ interactions not only during LTP in vitro but also during experience-driven synaptic strengthening by natural stimuli in vivo. ..
- Loria P, Hodgkin J, Hobert O. A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans. J Neurosci. 2004;24:2191-201 pubmed
- Chen C, Strapps W, Tomlinson A, Struhl G. Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless. Proc Natl Acad Sci U S A. 2004;101:15961-6 pubmed..Thus, we infer that signal transduction does not require binding of Wg to the CRD, but instead depends on interactions between Wg and other portions of the receptor, or other proteins of the receptor complex. ..
- Darwin A. Regulation of the phage-shock-protein stress response in Yersinia enterocolitica. Adv Exp Med Biol. 2007;603:167-77 pubmed..Finally, current ideas about how PspB/C might sense the inducing trigger(s) are briefly discussed, including a consideration of whether there might be any unidentified signal transduction components that communicate with the Psp system...
- Yount J, Karssemeijer R, Hang H. S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. J Biol Chem. 2012;287:19631-41 pubmed publisher..In sum, by characterizing S-palmitoylation and ubiquitination of IFITM3, we have gained a better understanding of the trafficking, activity, and intramembrane topology of this important IFN-induced effector protein. ..
- Argaw A, Asp L, Zhang J, Navrazhina K, Pham T, Mariani J, et al. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012;122:2454-68 pubmed publisher..Collectively, these data identify blockade of VEGF-A signaling as a protective strategy to treat inflammatory CNS disease. ..
- Wu J, Roman A, Carvajal Gonzalez J, Mlodzik M. Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila. Nat Cell Biol. 2013;15:1045-55 pubmed publisher..They affect PCP by modulating the intercellular interaction between Fz and Vang, which is thought to be a key step in setting up initial polarity, thus providing directionality to the PCP process. ..
- Lin R, Moss S, Rubin C. Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. J Biol Chem. 1995;270:27804-11 pubmed..Immunofluorescence analysis demonstrated that S-AKAP84 is co-localized with mitochondria in the flagellum. ..
- Jovanovic G, Model P. The RIB element in the goaG-pspF intergenic region of Escherichia coli. J Bacteriol. 1997;179:3095-102 pubmed..Thus, the pspF 3'-flanking region containing the RIB element has an important role in the stabilization of the pspF transcript. ..
- Krasnoperov V, Bittner M, Beavis R, Kuang Y, Salnikow K, Chepurny O, et al. alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron. 1997;18:925-37 pubmed..Interaction of CIRL with a specific presynaptic neurotoxin and with a component of the docking-fusion machinery suggests its role in regulation of neurosecretion. ..
- Guermah M, Malik S, Roeder R. Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1. Mol Cell Biol. 1998;18:3234-44 pubmed..Taken together, these data underscore the importance of both TAFs and specific USA-derived coactivators for optimal activation of the HIV-1 promoter, as well as certain parallels in their overall mechanisms of action. ..
- Hadari Y, Kouhara H, Lax I, Schlessinger J. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol Cell Biol. 1998;18:3966-73 pubmed..These experiments demonstrate that FRS2 recruits Grb2 molecules both directly and indirectly via complex formation with Shp2 and that Shp2 plays an important role in FGF-induced PC12 cell differentiation. ..
- Refolo L, Pappolla M, LaFrancois J, Malester B, Schmidt S, Thomas Bryant T, et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2001;8:890-9 pubmed..This study demonstrates that hypocholesterolemia is associated with reduced Abeta accumulation suggesting that lowering cholesterol by pharmacological means may be an effective approach for reducing the risk of developing AD. ..
- Staleva L, Manga P, Orlow S. Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism. Mol Biol Cell. 2002;13:4206-20 pubmed..Our data demonstrate that the pink-eyed dilution protein increases cellular sensitivity to arsenicals and other metalloids and can modulate intracellular glutathione metabolism. ..
- Wilson P. The genes and proteins associated with poly-cystic kidney diseases. Minerva Urol Nefrol. 2002;54:201-11 pubmed..It is suggested that the function of the polycystin complex is to act as a key developmental regulator of renal tubule morphogenesis. ..
- Ule J, Jensen K, Ruggiu M, Mele A, Ule A, Darnell R. CLIP identifies Nova-regulated RNA networks in the brain. Science. 2003;302:1212-5 pubmed..Thus, CLIP reveals that Nova coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA. ..
- Chang M, Arevalo J, Chao M. Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein. J Neurosci Res. 2004;78:186-92 pubmed..These findings thus suggest that Kidins220/ARMS plays an important role in regulating interactions between Trk and p75 neurotrophin receptors. ..
- Anthony T, Mason H, Gridley T, Fishell G, Heintz N. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev. 2005;19:1028-33 pubmed..These results identify Blbp as the first predominantly CNS-specific Notch target gene and suggest that it mediates some aspects of Notch signaling in radial glia. ..
- Racaniello V. One hundred years of poliovirus pathogenesis. Virology. 2006;344:9-16 pubmed..The dilemma is not how to answer the remaining questions, but whether there will be sufficient time to do so before global eradication of poliomyelitis leads to cessation of research on the disease. ..
- Diefenbach C, Gnjatic S, Sabbatini P, Aghajanian C, Hensley M, Spriggs D, et al. Safety and immunogenicity study of NY-ESO-1b peptide and montanide ISA-51 vaccination of patients with epithelial ovarian cancer in high-risk first remission. Clin Cancer Res. 2008;14:2740-8 pubmed publisher..Additional study is warranted. ..
- Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, et al. VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. Circ Res. 2008;103:916-8 pubmed publisher..Targeting the sheddases of VEGFR2 or NRP-1 might offer new opportunities to modulate VEGF-A signaling, an already-established target for treatment of pathological neovascularization. ..
- Guaiquil V, Swendeman S, Yoshida T, Chavala S, Campochiaro P, Blobel C. ADAM9 is involved in pathological retinal neovascularization. Mol Cell Biol. 2009;29:2694-703 pubmed publisher..Collectively, these results suggest that ADAM9 could be an attractive target for the prevention of proliferative retinopathies, CNV, and cancer. ..
- Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, et al. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature. 2010;464:1043-7 pubmed publisher..As APCDD1 is expressed in a broad repertoire of cell types, our findings indicate that APCDD1 may regulate a diversity of biological processes controlled by Wnt signalling...
- Dahan S, Rabinowitz K, Martin A, Berin M, Unkeless J, Mayer L. Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans. Gastroenterology. 2011;140:550-9 pubmed publisher..LPLs maintain intestinal homeostasis by inducing intestinal epithelial cell differentiation, polarization, and barrier function. ..
- Trivedi S, Uhlemann A, Herman Bausier P, Sullivan S, Sowash M, Flores E, et al. The Surface Protein SdrF Mediates Staphylococcus epidermidis Adherence to Keratin. J Infect Dis. 2017;215:1846-1854 pubmed publisher..These studies demonstrate that SdrF mediates adherence to human keratin and suggest that SdrF may facilitate S. epidermidis colonization of the skin. ..
- Lopez Casillas F, Cheifetz S, Doody J, Andres J, Lane W, Massague J. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Cell. 1991;67:785-95 pubmed..The unique features of betaglycan suggest important roles in cell interaction with TGF-beta. ..
- Chen Q, Lin R, Rubin C. Organelle-specific targeting of protein kinase AII (PKAII). Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria. J Biol Chem. 1997;272:15247-57 pubmed..Properties established for S-AKAP84 in vitro and in situ strongly suggest that a physiological function of this protein is to concentrate and immobilize RII (PKAII) isoforms at the cytoplasmic face of a phospholipid bilayer. ..
- Tomlinson A, Strapps W, Heemskerk J. Linking Frizzled and Wnt signaling in Drosophila development. Development. 1997;124:4515-21 pubmed..Taken together our results significantly strengthen the case for Fz acting in a Wnt signaling pathway in Drosophila. ..
- Wu G, Hubbard E, Kitajewski J, Greenwald I. Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin. Proc Natl Acad Sci U S A. 1998;95:15787-91 pubmed..The functional and physical interaction between sel-10 and sel-12 therefore offers an approach to understanding how presenilin levels are normally regulated. ..
- Mohler J, Seecoomar M, Agarwal S, Bier E, Hsai J. Activation of knot (kn) specifies the 3-4 intervein region in the Drosophila wing. Development. 2000;127:55-63 pubmed..The primordia for veins 3 and 4 are laid down adjacent to the kn-imposed vein-free zone, presumably by a signalling factor (such as Vn) also synthesized in the medial region of the wing. ..
- Treisman J. Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development. 2001;128:603-15 pubmed..These novel and specific phenotypes suggest that TRAP240 and TRAP230 act in concert to mediate an unknown developmental signal or a combination of signals. ..
- Faust P, Su H, Moser A, Moser H. The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction. J Mol Neurosci. 2001;16:289-97; discussion 317-21 pubmed..All tissues examined in postnatal mutant mice had reduced DHA. The combined use of morphologic and biochemical analyses in these mice will be essential to elucidate the pathogenesis of this complex peroxisomal disease. ..
- Do R, Chen Kiang S. Mechanism of BLyS action in B cell immunity. Cytokine Growth Factor Rev. 2002;13:19-25 pubmed
- Mueller S, Cao X, Welker R, Wimmer E. Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. J Biol Chem. 2002;277:7897-904 pubmed..Association with Tctex-1 and, hence, with the dynein motor complex may offer an explanation for how poliovirus hijacks the cellular transport machinery to retrogradely ascend along the axon to the neuronal cell body. ..
- Bristow C, Mercatante D, Kole R. HIV-1 preferentially binds receptors copatched with cell-surface elastase. Blood. 2003;102:4479-86 pubmed
- Raucci A, Laplantine E, Mansukhani A, Basilico C. Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes. J Biol Chem. 2004;279:1747-56 pubmed..These results indicate that inhibition of chondrocyte proliferation by FGF requires both ERK1/2 and p38 MAPK signaling and also suggest that sustained activation of these pathways is required to achieve growth inhibition. ..
- Mongini P, Jackson A, Tolani S, Fattah R, Inman J. Role of complement-binding CD21/CD19/CD81 in enhancing human B cell protection from Fas-mediated apoptosis. J Immunol. 2003;171:5244-54 pubmed
- Min K, Kovall R, Hendrickson W. Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency. Proc Natl Acad Sci U S A. 2003;100:14713-8 pubmed..We propose that this positively charged surface may serve to orient an interacting protein, which might function to regulate the release of alpha-T through an induced change in conformation of ATTP. ..
- Takahashi S, McConnell M, Harigae H, Kaku M, Sasaki T, Melnick A, et al. The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT. Blood. 2004;103:4650-8 pubmed..These data suggest that activating mutations of Flt3 may disrupt transcriptional repressor function resulting in aberrant gene regulation and abnormal leukemia cell growth. ..
- Kelly K, Hutchinson G, Nebenius Oosthuizen D, Smith A, Bartsch J, Horiuchi K, et al. Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. Dev Dyn. 2005;232:221-31 pubmed..Examination of Adam8-/- mice, however, revealed no major defects in these or other structures during development or in adult tissues and no evident pathological phenotypes. ..
- Gade T, Hassen W, Santos E, Gunset G, Saudemont A, Gong M, et al. Targeted elimination of prostate cancer by genetically directed human T lymphocytes. Cancer Res. 2005;65:9080-8 pubmed..These results thus provide a strong rationale for undertaking phase I clinical studies to assess PSMA-targeted T cells in patients with metastatic prostate cancer. ..
- Du X, Edelstein D, Obici S, Higham N, Zou M, Brownlee M. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest. 2006;116:1071-80 pubmed..These studies identify what we believe to be a novel mechanism contributing to the accelerated atherogenesis and increased cardiovascular disease risk occurring in people with insulin resistance. ..
- He B, Qiao X, Klasse P, Chiu A, Chadburn A, Knowles D, et al. HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors. J Immunol. 2006;176:3931-41 pubmed..Chronic activation of B cells through this CD40-independent pathway could impair protective T cell-dependent Ab responses by inducing immune exhaustion. ..
- Prabhakaran J, Underwood M, Parsey R, Arango V, Majo V, Simpson N, et al. Synthesis and in vivo evaluation of [18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expression. Bioorg Med Chem. 2007;15:1802-7 pubmed..A radiolabeling method that can generate consistent high specific activity is needed for routine human use. ..
- Silverman J, Restituito S, Lu W, Lee Edwards L, Khatri L, Ziff E. Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes. J Neurosci. 2007;27:8505-16 pubmed..Thus, the interaction of scaffolding proteins with cadherin-NPRAP complexes may anchor diverse signaling and adhesion molecules at cadherins. ..
- Oresic K, Mueller B, Tortorella D. Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Biosci Rep. 2009;29:173-81 pubmed publisher..The results implicate ER quality control in the instability of the Cln variants that probably contributes to the development of NCL. ..
- Sathaliyawala T, O Gorman W, Greter M, Bogunovic M, Konjufca V, Hou Z, et al. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity. 2010;33:597-606 pubmed publisher..Thus, PI3K-mTOR signaling downstream of Flt3L controls DC development, and its restriction by Pten ensures optimal DC pool size and subset composition. ..
- Kinnebrew M, Buffie C, Diehl G, Zenewicz L, Leiner I, Hohl T, et al. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 2012;36:276-87 pubmed publisher..Thus, CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria. ..
- Sun L, Li X, Shi Y. Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to Î³-secretase. Curr Opin Struct Biol. 2016;37:97-107 pubmed publisher..In this review, we discuss the shared as well as unique features of these intramembrane proteases, with a focus on presenilin-the catalytic component of Î³-secretase. ..
- Lee M, Russell D, D Alesandro P, Van der Ploeg L. Identification of membrane-associated proteins in Trypanosoma brucei encoding an internal, EARLRAEE amino acid repeat. J Biol Chem. 1994;269:8408-15 pubmed..The subcellular distribution of Tb-29 proteins suggests that these proteins may provide a constituent associated with the cell's vesicular transport system...
- Ma H, Blitzer R, Healy E, Premont R, Landau E, Iyengar R. Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. J Biol Chem. 1993;268:19915-8 pubmed..Since the receptor responses are pertussis toxin-sensitive, we conclude that we have isolated a new form of PLC-beta involved in the pertussis toxin-sensitive receptor stimulation of the Ca2+ activated Cl- current in Xenopus oocytes. ..
- Beers J, Glerum D, Tzagoloff A. Purification, characterization, and localization of yeast Cox17p, a mitochondrial copper shuttle. J Biol Chem. 1997;272:33191-6 pubmed..These results are consistent with the previously proposed function of Cox17p, namely in providing cytoplasmic copper for mitochondrial utilization. ..
- Baker N, Yu S. The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose. Mech Dev. 1998;74:3-14 pubmed..Our data argue that other signals may be responsible for the pattern of R8 cell fate allocation by N. Potential relevance to other neurogenic regions is discussed. ..
- Stevens L. Twin peaks: Spitz and Argos star in patterning of the Drosophila egg. Cell. 1998;95:291-4 pubmed
- Gu W, Malik S, Ito M, Yuan C, Fondell J, Zhang X, et al. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell. 1999;3:97-108 pubmed..These findings demonstrate both positive and negative functional capabilities for the human complex, emphasize novel (CTD-independent) regulatory mechanisms, and link the complex to other human coactivator complexes. ..
- Tsai S, Fero J, Bartelmez S. Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Blood. 2000;96:950-7 pubmed..Taken together, these findings indicate that both c-kit(+) hematopoietic progenitors and endothelial cells express Jagged2 and that exogenous, full-length Jagged2 promotes the survival and proliferation of hematopoietic progenitors. ..
- Starz Gaiano M, Cho N, Forbes A, Lehmann R. Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells. Development. 2001;128:983-91 pubmed..We propose that spatially restricted phospholipid hydrolysis creates a gradient of signal necessary and specific for the migration and survival of germ cells. ..
- Abramova N, Sertil O, Mehta S, Lowry C. Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene expression in Saccharomyces cerevisiae. J Bacteriol. 2001;183:2881-7 pubmed
- Ong S, Hadari Y, Gotoh N, Guy G, Schlessinger J, Lax I. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A. 2001;98:6074-9 pubmed
- Liu J, Rost B. Comparing function and structure between entire proteomes. Protein Sci. 2001;10:1970-9 pubmed..These numbers may or may not suggest that there are 1200-2600 folds in the universe of protein structures. All predictions are available at http://cubic.bioc.columbia.edu/genomes...
- Wang J, Gambhir A, Hangyás Mihályné G, Murray D, Golebiewska U, McLaughlin S. Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C kinase substrate is due to nonspecific electrostatic interactions. J Biol Chem. 2002;277:34401-12 pubmed..This electrostatic sequestration was observed experimentally using a phospholipase C assay. Our results are consistent with the hypothesis that MARCKS could reversibly sequester much of the PIP(2) in the plasma membrane. ..
- Yan Q, Lennarz W. Studies on the function of oligosaccharyl transferase subunits. Stt3p is directly involved in the glycosylation process. J Biol Chem. 2002;277:47692-700 pubmed..From all of these results, we conclude that the sequence from residues 516 to 520, WWDYG in Stt3p, plays a central role in glycosylatable peptide recognition and/or the catalytic glycosylation process. ..
- Huangfu D, Liu A, Rakeman A, Murcia N, Niswander L, Anderson K. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003;426:83-7 pubmed..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction. ..
- Snoeck H. Serum of youth?. Nat Biotechnol. 2005;23:434-5 pubmed
- Li D, Yea S, Li S, Chen Z, Narla G, Banck M, et al. Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J Biol Chem. 2005;280:26941-52 pubmed
- Domeniconi M, Zampieri N, Spencer T, Hilaire M, Mellado W, Chao M, et al. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron. 2005;46:849-55 pubmed
- Mocco J, Mack W, Ducruet A, Sosunov S, Sughrue M, Hassid B, et al. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res. 2006;99:209-17 pubmed..05). Together, these results establish C3 activation as the key constituent in complement-related inflammatory tissue injury following stroke and suggest a C3a anaphylatoxin-mediated mechanism. ..
- Biswas S, Buteau J, Greene L. Glucagon-like peptide-1 (GLP-1) diminishes neuronal degeneration and death caused by NGF deprivation by suppressing Bim induction. Neurochem Res. 2008;33:1845-51 pubmed publisher..Thus, GLP-1 may protect neurons, at least in part, by suppressing Bim induction. Our findings support the idea that drugs that mimic or elevate GLP-1 represent potential therapeutics for neurodegenerative diseases. ..