Experts and Doctors on longevity in North Carolina, United States
Locale: North Carolina, United States
Chan P, Ramot Y, Malarkey D, Blackshear P, Kissling G, Travlos G, et al
. Fourteen-week toxicity study of green tea extract in rats and mice. Toxicol Pathol. 2010;38:1070-84 pubmed publisher
..The nose and liver are organs with high metabolic enzyme activity. The increased susceptibility of the nose and liver suggests a role for GTE metabolites in toxicity induction. ..
Ghanayem B, Nyska A, Haseman J, Bucher J. Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice. Toxicol Sci. 2002;68:59-68 pubmed
..This was also considered an equivocal result. In conclusion, these studies demonstrated that acrylonitrile causes multiple carcinogenic effects after gavage administration to male and female B6C3F1 mice for 2 years. ..
Ress N, Chou B, Renne R, Dill J, Miller R, Roycroft J, et al
. Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice. Toxicol Sci. 2003;74:287-96 pubmed
..5 mg/m3 (dust) (National Institute for Occupational Safety and Health, NIOSH Pocket Guide to Chemical Hazards, U.S. Department of Health and Human Services, Washington, DC, 1997, p. 328)...
Barlow N, McIntyre B, Foster P. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol. 2004;32:79-90 pubmed
..While the morphology and incidence of this DBP-induced testicular developmental lesion has been fully characterized by this study, the detailed pathogenesis warrants further investigation. ..
Howroyd P, Swanson C, Dunn C, Cattley R, Corton J. Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Toxicol Pathol. 2004;32:591-9 pubmed
..Our results imply that PPARalpha delays the development of some spontaneous lesions associated with aging in the liver, kidney, and heart of SV129 mice...
Tyl R, Myers C, Marr M, Sloan C, Castillo N, Veselica M, et al
. Two-generation reproductive toxicity evaluation of dietary 17beta-estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) mice. Toxicol Sci. 2008;102:392-412 pubmed publisher
..The no observable effect level was 0.005 ppm E2 ( approximately 1 mug/kg/day). Therefore, the mouse model is sensitive to E2 by oral administration, with effects on reproductive development at doses of 10- 100 mug/kg/day. ..
Hall J, McElwee M, Freedman J. Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. PLoS ONE. 2017;12:e0177432 pubmed publisher
..Identification of portions of the insulin signaling pathway as regulators of metallothionein expression supports the hypothesis that longevity is affected by the expression of this efficient ROS scavenger. ..