Experts and Doctors on liver in Vermont, United States
Locale: Vermont, United States
Sinclair P, Walton H, Gorman N, Jacobs J, Sinclair J. Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes. Toxicol Appl Pharmacol. 1997;147:171-9 pubmed
..We conclude that URO accumulation in chick hepatocyte cultures is limited not only by the induction of CYP1A, but also by the stimulation of intracellular UROGEN oxidation. ..
Jacobs J, Nichols C, Andrew A, Marek D, Wood S, Sinclair P, et al
. Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol. 1999;157:51-9 pubmed
..These results suggest that, in rat hepatocytes, elevated levels of HO alone are not responsible for arsenite-mediated decreases in CYP. ..
Sinclair P, Gorman N, Walton H, Bement W, Szakacs J, Gonzalez F, et al
. Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone. Arch Biochem Biophys. 2000;384:383-90 pubmed
..Acetone was not an inducer of hepatic CYP1A2 in the wild-type mice. Although acetone is an inducer of CYP2E1, CYP1A2 appears to have the essential role in acetone-enhancement of uroporphyria. ..