Genomes and Genes
Experts and Doctors on lipoproteins in New York, United States
Locale: New York, United States
Publications104 found, 100 shown here
- Sturley S, Hussain M. Lipid droplet formation on opposing sides of the endoplasmic reticulum. J Lipid Res. 2012;53:1800-10 pubmed publisher..This default pathway directs droplets into the cytoplasm where they accumulate in many lipid disorders...
- Aliprantis A, Yang R, Mark M, Suggett S, Devaux B, Radolf J, et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science. 1999;285:736-9 pubmed..Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms. ..
- Goldberg I, Eckel R, McPherson R. Triglycerides and heart disease: still a hypothesis?. Arterioscler Thromb Vasc Biol. 2011;31:1716-25 pubmed publisher..The time is more than ripe for new and creative approaches to understanding the relationship of triglycerides and heart disease. ..
- Murphy A, Akhtari M, Tolani S, Pagler T, Bijl N, Kuo C, et al. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest. 2011;121:4138-49 pubmed publisher..Although endogenous apoA-I was ineffective, pharmacologic approaches to increasing cholesterol efflux suppressed stem cell proliferative responses...
- Liang J, Distler O, Cooper D, Jamil H, Deckelbaum R, Ginsberg H, et al. HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia. Nat Med. 2001;7:1327-31 pubmed..These findings suggest a molecular basis for protease-inhibitor-associated hyperlipidemia, a serious adverse effect of an otherwise efficacious treatment for HIV infection. ..
- Shachter N. Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism. Curr Opin Lipidol. 2001;12:297-304 pubmed..Variation in the expression of apoC-III has been credibly documented to have an important role in hypertriglyceridemia. Variation in the expression of apoC-I may also be important for hypertriglyceridemia under certain circumstances. ..
- Chahil T, Ginsberg H. Diabetic dyslipidemia. Endocrinol Metab Clin North Am. 2006;35:491-510, vii-viii pubmed..A number of physiologic and pharmacologic approaches are available and should be used aggressively to treat diabetic dyslipidemia. ..
- Kincaid E, Wolf A, Desvignes L, Mahapatra S, Crick D, Brennan P, et al. Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo. J Immunol. 2007;179:3187-95 pubmed..tuberculosis uses multiple pathways to abrogate the action of an important effector of adaptive immunity. This work was supported by National Institutes of Health Grants AI 065357-AI 020010. ..
- Barzilai N, Atzmon G, Schechter C, Schaefer E, Cupples A, Lipton R, et al. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA. 2003;290:2030-40 pubmed..These findings suggest that lipoprotein particle sizes are heritable and promote a healthy aging phenotype. ..
- Yvan Charvet L, Welch C, Pagler T, Ranalletta M, Lamkanfi M, Han S, et al. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation. 2008;118:1837-47 pubmed publisher..This study was undertaken to elucidate the mechanisms and consequences of enhanced inflammatory gene expression in ABC transporter-deficient macrophages...
- Hoehn G, Clark V. The major anaerobically induced outer membrane protein of Neisseria gonorrhoeae, Pan 1, is a lipoprotein. Infect Immun. 1992;60:4704-8 pubmed..3H]palmitic acid labeling of gonococci grown under oxygen-limited conditions demonstrated specific incorporation of label into Pan 1, suggesting further that Pan 1 is a lipoprotein...
- Xu H, Lee K, Goldfarb M. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. J Biol Chem. 1998;273:17987-90 pubmed..The SNT binding motif of FGFR-1 is distinct from previously described phosphotyrosine-binding domain recognition motifs, lacking both tyrosine and asparagine residues. ..
- Yvan Charvet L, Pagler T, Seimon T, Thorp E, Welch C, Witztum J, et al. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res. 2010;106:1861-9 pubmed publisher..The ATP-binding cassette transporters ABCA1 and ABCG1 have a major role in promoting cholesterol efflux from macrophages to apolipoprotein A-1 and HDL and are upregulated during the phagocytosis of apoptotic cells (efferocytosis)...
- Seimon T, Nadolski M, Liao X, Magallon J, Nguyen M, Feric N, et al. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 2010;12:467-82 pubmed publisher..These findings provide insight into how atherogenic lipoproteins trigger macrophage apoptosis in the setting of ER stress and how TLR activation might promote macrophage apoptosis and plaque necrosis in advanced atherosclerosis. ..
- Zhang J, Hashmi S, Cheema F, Al Nasser N, Bakheet R, Parhar R, et al. Regulation of lipoprotein assembly, secretion and fatty acid ?-oxidation by Krüppel-like transcription factor, klf-3. J Mol Biol. 2013;425:2641-55 pubmed publisher..Genetic interactions between klf-3 and dsc-4, as well as vit-5 genes, suggest that klf-3 may have an important role in regulating lipid assembly and secretion. ..
- Colantonio L, Bittner V, Reynolds K, Levitan E, Rosenson R, Banach M, et al. Association of Serum Lipids and Coronary Heart Disease in Contemporary Observational Studies. Circulation. 2016;133:256-64 pubmed publisher..81-1.92) in REGARDS, and 1.49 (95% confidence interval, 1.38-1.61) in KPSC. The association between lipids and CHD in contemporary studies may be attenuated by the preferential use of statins by high-risk individuals. ..
- Aliprantis A, Weiss D, Radolf J, Zychlinsky A. Release of Toll-like receptor-2-activating bacterial lipoproteins in Shigella flexneri culture supernatants. Infect Immun. 2001;69:6248-55 pubmed..The activation of apoptosis by BLP shed from S. flexneri is discussed as a novel aspect of the interaction of bacteria with the host. ..
- Mousa S, Mohamed S. Inhibition of endothelial cell tube formation by the low molecular weight heparin, tinzaparin, is mediated by tissue factor pathway inhibitor. Thromb Haemost. 2004;92:627-33 pubmed..These results suggest that the inhibitory effect of the LMWH tinzaparin on endothelial tube formation is associated with stimulation of the release of TFPI, but not to anti-Factor Xa activity. ..
- Kim J, van de Wall E, Laplante M, Azzara A, Trujillo M, Hofmann S, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest. 2007;117:2621-37 pubmed..These mice therefore represent what we believe is a novel model of morbid obesity associated with an improved metabolic profile. ..
- Zhou X, He W, Huang Z, Gotto A, Hajjar D, Han J. Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism. J Biol Chem. 2008;283:2129-38 pubmed
- Steinhauer J, Treisman J. Lipid-modified morphogens: functions of fats. Curr Opin Genet Dev. 2009;19:308-14 pubmed publisher..Additionally, secretion of lipid-modified morphogens of the Wnt and Hh families requires dedicated accessory proteins and may involve their packaging into lipoprotein particles for long-range transport. ..
- Westerterp M, Koetsveld J, Yu S, Han S, Li R, Goldberg I, et al. Increased atherosclerosis in mice with vascular ATP-binding cassette transporter G1 deficiency--brief report. Arterioscler Thromb Vasc Biol. 2010;30:2103-5 pubmed publisher..ABCG1 is highly expressed in macrophages and endothelial cells. ABCG1 preserves endothelial function by maintaining endothelial NO synthase activity and by reducing adhesion molecule expression and monocyte adhesion...
- Bao L, Li Y, Deng S, Landry D, Tabas I. Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages. J Biol Chem. 2006;281:33635-49 pubmed..Pending future in vivo studies, this concept may provide at least one mechanism for accelerated plaque necrosis and atherothrombotic disease in patients with sitosterolemia. ..
- Yang Q, Tinsley C, Gotschlich E. Novel lipoprotein expressed by Neisseria meningitidis but not by Neisseria gonorrhoeae. Infect Immun. 1995;63:1631-6 pubmed..The significance of the remarkable conservation of these gonococcal genes is discussed. ..
- Gordon B, Parker T, Levine D, Saal S, Wang J, Sloan B, et al. Low lipid concentrations in critical illness: implications for preventing and treating endotoxemia. Crit Care Med. 1996;24:584-9 pubmed..Correction of the hypolipidemia by a reconstituted high-density lipoprotein preparation offers a new strategy for the prevention and treatment of endotoxemia. ..
- Leventhal A, Leslie C, Tabas I. Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking. J Biol Chem. 2004;279:8084-92 pubmed
- Park T, Yamashita H, Blaner W, Goldberg I. Lipids in the heart: a source of fuel and a source of toxins. Curr Opin Lipidol. 2007;18:277-82 pubmed..This information is likely to lead to new diagnostic categories of cardiomyopathy and more pathophysiologically appropriate treatments. ..
- Scheinfeld N. A review of the new antifungals: posaconazole, micafungin, and anidulafungin. J Drugs Dermatol. 2007;6:1249-51 pubmed..The exciting new agents have extended the armamentarium against antifungal pathogens, but have yet to find their place in the dermatologic practice. ..
- Blumenthal A, Kobayashi T, Pierini L, Banaei N, Ernst J, Miyake K, et al. RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins. Cell Host Microbe. 2009;5:35-46 pubmed publisher..Our data identify RP105 as an accessory molecule for TLR2, forming part of the receptor complex for innate immune recognition of mycobacterial lipoproteins. ..
- Westerterp M, Gourion Arsiquaud S, Murphy A, Shih A, Cremers S, Levine R, et al. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell. 2012;11:195-206 pubmed publisher..Our data identify a role of cholesterol efflux pathways in the control of HSPC mobilization. This may translate into therapeutic strategies for atherosclerosis and hematologic malignancies...
- Skoura A, Michaud J, Im D, Thangada S, Xiong Y, Smith J, et al. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol. 2011;31:81-5 pubmed publisher..These data suggest that S1PR2 signaling in the plaque macrophage regulates macrophage retention and inflammatory cytokine secretion, thereby promoting atherosclerosis. ..
- Weinstock P, Bisgaier C, Hayek T, Aalto Setala K, Sehayek E, Wu L, et al. Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice. J Lipid Res. 1997;38:1782-94 pubmed
- Liu J, Cao W, Lu M. Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants. J Mol Biol. 2002;318:877-88 pubmed..Thus, specific side-chain packing in the hydrophobic core of coiled coils are important determinants of protein main-chain conformation and stability. ..
- Rayner K, Suarez Y, Davalos A, Parathath S, Fitzgerald M, Tamehiro N, et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science. 2010;328:1570-3 pubmed publisher..Conversely, silencing of miR-33 in vivo increases hepatic expression of ABCA1 and plasma HDL levels. Thus, miR-33 appears to regulate both HDL biogenesis in the liver and cellular cholesterol efflux...
- Plump A, Breslow J. Apolipoprotein E and the apolipoprotein E-deficient mouse. Annu Rev Nutr. 1995;15:495-518 pubmed..This review briefly discussed the biological and clinical importance of this protein and describes the early experiments performed in the apoE-deficient mouse. ..
- Jiang X, Bruce C, Mar J, Lin M, Ji Y, Francone O, et al. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest. 1999;103:907-14 pubmed..Vesicular lipoproteins accumulating in PLTP-/- mice on a high-fat diet could influence the development of atherosclerosis. ..
- Zhang Y, Hernandez Ono A, Ko C, Yasunaga K, Huang L, Ginsberg H. Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids. I. Differential response to the delivery of fatty acids via albumin or remnant-like emulsion particles. J Biol Chem. 2004;279:19362-74 pubmed
- Augustus A, Yagyu H, Haemmerle G, Bensadoun A, Vikramadithyan R, Park S, et al. Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression. J Biol Chem. 2004;279:25050-7 pubmed..Thus, the loss of LpL in the heart leads to defective plasma metabolism of TG. Moreover, fatty acids derived from lipoprotein TG and not just albumin-associated fatty acids are important for cardiac lipid metabolism and gene regulation. ..
- Prados Rosales R, Baena A, Martinez L, Luque Garcia J, Kalscheuer R, Veeraraghavan U, et al. Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice. J Clin Invest. 2011;121:1471-83 pubmed publisher..These findings may open up new horizons for understanding the pathogenesis of tuberculosis and developing vaccines...
- Ouimet M. Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems. Biochim Biophys Acta. 2013;1831:1124-33 pubmed publisher..The manipulation of autophagic activity represents a new possible therapeutic approach for the treatment complex metabolic disorders such as obesity and the metabolic syndrome. ..
- Hsieh J, Koseki M, Molusky M, Yakushiji E, Ichi I, Westerterp M, et al. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. 2016;535:303-7 pubmed publisher..T39 inhibition could be an effective strategy for reducing both steatohepatitis and atherosclerosis. ..
- Shachter N, Ebara T, Ramakrishnan R, Steiner G, Breslow J, Ginsberg H, et al. Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein Cl. J Clin Invest. 1996;98:846-55 pubmed
- Yagyu H, Lutz E, Kako Y, Marks S, Hu Y, Choi S, et al. Very low density lipoprotein (VLDL) receptor-deficient mice have reduced lipoprotein lipase activity. Possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiency. J Biol Chem. 2002;277:10037-43 pubmed..Therefore, the VLDLr is required for normal LpL regulation in vivo, and the disruption of VLDLr results in hypertriglyceridemia associated with decreased LpL activity. ..
- Ravindranath T, Goto M, Iqbal O, Florian Kujawski M, Hoppensteadt D, Hammadeh R, et al. Plasma thrombin activatable fibrinolysis inhibitor and tissue factor pathway inhibitor changes following sepsis. Clin Appl Thromb Hemost. 2007;13:362-8 pubmed..These results suggest that plasma TAFI and TFPI levels differ depending on the type of bacteria involved in the septic process. ..
- Yvan Charvet L, Pagler T, Wang N, Senokuchi T, Brundert M, Li H, et al. SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL. J Lipid Res. 2008;49:107-14 pubmed..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
- Wang N, Yvan Charvet L, Lutjohann D, Mulder M, Vanmierlo T, Kim T, et al. ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J. 2008;22:1073-82 pubmed
- Plump A, Smith J, Hayek T, Aalto Setala K, Walsh A, Verstuyft J, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343-53 pubmed..apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis. ..
- Sehayek E, Duncan E, Lutjohann D, von Bergmann K, Ono J, Batta A, et al. Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross. Proc Natl Acad Sci U S A. 2002;99:16215-9 pubmed..Therefore, other genes besides ABCG5ABCG8 influence plasma plant sterol levels and now become candidates to explain differences in plasma plant sterol levels between humans...
- Sehayek E, Yu H, von Bergmann K, Lutjohann D, Stoffel M, Duncan E, et al. Phytosterolemia on the island of Kosrae: founder effect for a novel ABCG8 mutation results in high carrier rate and increased plasma plant sterol levels. J Lipid Res. 2004;45:1608-13 pubmed..The latter finding suggests that heterozygosity for a mutated ABCG8 allele results in a modest increase in dietary cholesterol absorption and a decrease in cholesterol biosynthesis...
- Roth G, Aumayr K, Giacona M, Papapanou P, Schmidt A, Lalla E. Porphyromonas gingivalis infection and prothrombotic effects in human aortic smooth muscle cells. Thromb Res. 2009;123:780-4 pubmed publisher..These data demonstrate for the first time that infection with a periodontal pathogen induces a prothrombotic response in HASMC. ..
- Weng W, Li L, Van Bennekum A, Potter S, Harrison E, Blaner W, et al. Intestinal absorption of dietary cholesteryl ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase knockout mice. Biochemistry. 1999;38:4143-9 pubmed..Overall, the data indicate that in the mouse, other enzymes besides CEL participate in the hydrolysis of dietary cholesteryl esters, retinyl esters, and triglycerides. ..
- Fournier E, Isakoff S, Ko K, Cardinale C, Inghirami G, Li Z, et al. The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responses. Curr Biol. 2003;13:1858-66 pubmed
- Terasaka N, Wang N, Yvan Charvet L, Tall A. High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. Proc Natl Acad Sci U S A. 2007;104:15093-8 pubmed..These findings indicate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and related oxysterols from macrophages onto HDL and in protecting these cells from oxysterol-induced cytotoxicity...
- Devlin C, Leventhal A, Kuriakose G, Schuchman E, Williams K, Tabas I. Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Arterioscler Thromb Vasc Biol. 2008;28:1723-30 pubmed publisher..0005). These findings support a causal role for acid SMase in lipoprotein retention and lesion progression and provides further support for the response-to-retention model of atherogenesis. ..
- Rosenson R, Brewer H, Rader D. Lipoproteins as biomarkers and therapeutic targets in the setting of acute coronary syndrome. Circ Res. 2014;114:1880-9 pubmed publisher..Here, we review the relationship of lipoproteins as biomarkers to cardiovascular risk after ACS, the evidence for lipid-targeted interventions, and the potential for novel therapeutic approaches in this arena. ..
- Buxbaum J, Choi E, Luo Y, Lilliehook C, Crowley A, Merriam D, et al. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998;4:1177-81 pubmed..Further characterization of calsenilin may lead to an understanding of the normal role of the presenilins and of the role of the presenilins in Alzheimer disease. ..
- Arni S, Keilbaugh S, Ostermeyer A, Brown D. Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residues. J Biol Chem. 1998;273:28478-85 pubmed..Targeting of GAP-43 to rafts may function to facilitate signaling through Go. In addition, raft association may aid in sorting of GAP-43 into axonally directed vesicles in the trans-Golgi network. ..
- Liang C, Tall A. Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver. J Biol Chem. 2001;276:49066-76 pubmed..However, the regulation of genes involved in high density lipoprotein and bile salt metabolism shows complex kinetics and is likely to be mediated by novel transcription factors. ..
- Banaiee N, Kincaid E, Buchwald U, Jacobs W, Ernst J. Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol. 2006;176:3019-27 pubmed..These results establish that M. tuberculosis possesses multiple mechanisms of inhibiting responses to IFN-gamma. ..
- Wang N, Ranalletta M, Matsuura F, Peng F, Tall A. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL. Arterioscler Thromb Vasc Biol. 2006;26:1310-6 pubmed..This study examines the ABCG1-mediated cholesterol efflux and intracellular cholesterol transport by studying the ABCG1 localization and function in macrophages...
- Banaei N, Kincaid E, Lin S, Desmond E, Jacobs W, Ernst J. Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green. Antimicrob Agents Chemother. 2009;53:3799-802 pubmed publisher..In summary, lipoprotein processing by LspA is essential for resistance of M. tuberculosis to malachite green. A cell wall permeability defect is likely responsible for the hypersensitivity of lspA mutant to malachite green...
- Yvan Charvet L, Pagler T, Gautier E, Avagyan S, Siry R, Han S, et al. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science. 2010;328:1689-93 pubmed publisher..The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis. ..
- Richer L, Brisson D, Melo R, Ostfeld R, Zeidner N, Gomes Solecki M. Reservoir targeted vaccine against Borrelia burgdorferi: a new strategy to prevent Lyme disease transmission. J Infect Dis. 2014;209:1972-80 pubmed publisher..Significant decreases in tick infection prevalence were observed within 3 years of vaccine deployment. Implementation of such a long-term public health measure could substantially reduce the risk of human exposure to Lyme disease. ..
- Devlin C, Kuriakose G, Hirsch E, Tabas I. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size. Proc Natl Acad Sci U S A. 2002;99:6280-5 pubmed..These data demonstrate that in selected models of murine atherosclerosis, chronic IL-1ra depletion or overexpression has potentially important effects on lipoprotein metabolism and foam-cell lesion development. ..
- Niemetz J, Fallon J, Harrington E, Hathcock J. Rapid generation of thrombin by atheroma and platelets. J Thromb Haemost. 2004;2:321-6 pubmed..A FXa inhibitor, DX 9065a, was very effective in preventing prothrombinase generation. These findings may explain the rapid occlusion that has been observed after angioplasty and point to avenues of prevention. ..
- Becker M, Bunikis J, Lade B, Dunn J, Barbour A, Lawson C. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005;280:17363-70 pubmed publisher..OspB structure, stability, and possible mechanisms of killing by H6831 and other bactericidal Fabs are discussed in light of the structural data...
- Ranalletta M, Wang N, Han S, Yvan Charvet L, Welch C, Tall A. Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol. 2006;26:2308-15 pubmed..Recent studies indicate that the ATP-binding cassette transporter ABCG1 can promote cholesterol efflux from macrophages to high-density lipoprotein. This study was designed to assess the in vivo role of macrophage ABCG1 in atherosclerosis...
- Terasaka N, Yu S, Yvan Charvet L, Wang N, Mzhavia N, Langlois R, et al. ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest. 2008;118:3701-13 pubmed publisher..Our data suggest that ABCG1 and HDL maintain EC function in HCD-fed mice by promoting efflux of cholesterol and 7-oxysterols and preserving active eNOS dimer levels...
- Khetarpal S, Zeng X, Millar J, Vitali C, Somasundara A, Zanoni P, et al. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nat Med. 2017;23:1086-1094 pubmed publisher..This protective mechanism has the potential to be exploited as a new therapeutic approach to reduce apoC-III levels and circulating TRL burden. ..
- Choi S, Sivaram P, Walker D, Curtiss L, Gretch D, Sturley S, et al. Lipoprotein lipase association with lipoproteins involves protein-protein interaction with apolipoprotein B. J Biol Chem. 1995;270:8081-6 pubmed..Thus, we conclude that a specific interaction between LPL and the amino-terminal region of apoB may facilitate LPL association with circulating lipoproteins. ..
- Kako Y, Huang L, Yang J, Katopodis T, Ramakrishnan R, Goldberg I. Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice. Effects on lipoproteins and atherosclerosis. J Lipid Res. 1999;40:2185-94 pubmed..LpL activity was not decreased in these animals. However, additional LpL expression eliminated the diabetic lipoprotein changes. These mice did not have more atherosclerosis with diabetes. ..
- Jiang X, Tall A, Qin S, Lin M, Schneider M, Lalanne F, et al. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem. 2002;277:31850-6 pubmed
- Wang N, Lan D, Chen W, Matsuura F, Tall A. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A. 2004;101:9774-9 pubmed..ABCG1 is highly expressed in macrophages and probably mediates cholesterol efflux from macrophage foam cells to the major HDL fractions, providing a mechanism to explain the relationship between HDL levels and atherosclerosis risk...
- Qiu W, Schutzer S, Bruno J, Attie O, Xu Y, Dunn J, et al. Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing. Proc Natl Acad Sci U S A. 2004;101:14150-5 pubmed..Frequent recombination implies a potential for rapid adaptive evolution and a possible polygenic basis of B. burgdorferi pathogenicity. ..
- Westerterp M, Murphy A, Wang M, Pagler T, Vengrenyuk Y, Kappus M, et al. Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Circ Res. 2013;112:1456-65 pubmed publisher..Although it is widely assumed that this is attributable to the ability of high-density lipoprotein to promote cholesterol efflux from macrophage foam cells, direct experimental support for this hypothesis is lacking...
- Charron G, Li M, Macdonald M, Hang H. Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform. Proc Natl Acad Sci U S A. 2013;110:11085-90 pubmed publisher..These studies demonstrate the utility of isoprenoid chemical reporters for proteomic analysis of prenylated proteins and reveal a role for protein prenylation in host defense against viral infections. ..
- Watanabe K, Watson E, Cremona M, Millings E, Lefkowitch J, Fischer S, et al. ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis. PLoS ONE. 2013;8:e67234 pubmed publisher..Given these reciprocal interactions, and the relatively extended time-course over which these studies were conducted, we cannot assign causal primacy to either the effects on hepatic lipid homeostasis or ER stress responses. ..
- Tabas I, Lichtman A. Monocyte-Macrophages and T Cells in Atherosclerosis. Immunity. 2017;47:621-634 pubmed publisher..Herein, we review select topics that shed light on these processes and suggest new treatment strategies. ..
- Masucci Magoulas L, Goldberg I, Bisgaier C, Serajuddin H, Francone O, Breslow J, et al. A mouse model with features of familial combined hyperlipidemia. Science. 1997;275:391-4 pubmed..This mouse model may provide clues to the origin of human FCHL. ..
- Ramirez M, Tomasz A. Molecular characterization of the complete 23F capsular polysaccharide locus of Streptococcus pneumoniae. J Bacteriol. 1998;180:5273-8 pubmed..The 18.6-kb cps23f locus is composed of 18 open reading frames flanked at the 5' and 3' ends by the genes dexB and aliA, an arrangement similar to those of some of the other identified cps loci. ..
- Yamaguchi J, Gamble M, Conlon D, Liang J, Ginsberg H. The conversion of apoB100 low density lipoprotein/high density lipoprotein particles to apoB100 very low density lipoproteins in response to oleic acid occurs in the endoplasmic reticulum and not in the Golgi in McA RH7777 cells. J Biol Chem. 2003;278:42643-51 pubmed..In conclusion, apoB100 bulk lipidation, resulting in conversion of LDL/HDL to VLDL, can occur in the ER, but not in the Golgi, in McA RH7777 cells. ..
- Han A, Saijo K, Mecklenbrauker I, Tarakhovsky A, Nussenzweig M. Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. Immunity. 2003;19:621-32 pubmed
- Liang J, Oelkers P, Guo C, Chu P, Dixon J, Ginsberg H, et al. Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells. J Biol Chem. 2004;279:44938-44 pubmed
- Devlin C, Lee S, Kuriakose G, Spencer C, Becker L, Grosskopf I, et al. An apolipoprotein(a) peptide delays chylomicron remnant clearance and increases plasma remnant lipoproteins and atherosclerosis in vivo. Arterioscler Thromb Vasc Biol. 2005;25:1704-10 pubmed
- Yvan Charvet L, Ranalletta M, Wang N, Han S, Terasaka N, Li R, et al. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest. 2007;117:3900-8 pubmed..These results suggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central to the antiatherogenic properties of HDL...
- Li L, Weng W, Harrison E, Fisher E. Plasma carboxyl ester lipase activity modulates apolipoprotein B-containing lipoprotein metabolism in a transgenic mouse model. Metabolism. 2008;57:1361-8 pubmed publisher..In summary, our results demonstrate that plasma CEL modulates apo B-Lp metabolism in vivo, resulting in reduced VLDL clearance and elevated plasma cholesterol levels. ..
- Thorp E, Li G, Seimon T, Kuriakose G, Ron D, Tabas I. Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab. 2009;9:474-81 pubmed publisher..These data provide direct evidence for a causal link between the ER stress effector CHOP and plaque necrosis and suggest that interventions weakening this arm of the UPR may lessen plaque progression. ..
- Delihas N. Stem loop sequences specific to transposable element IS605 are found linked to lipoprotein genes in Borrelia plasmids. PLoS ONE. 2009;4:e7941 pubmed publisher..The findings show that IS605 stem loop sequences are multifaceted and are selectively conserved during evolution when the transposable element dissipates. ..