Experts and Doctors on islets of langerhans in Connecticut, United States


Locale: Connecticut, United States
Topic: islets of langerhans

Top Publications

  1. Zawalich W, Zawalich K. Glucose-induced insulin secretion from islets of fasted rats: modulation by alternate fuel and neurohumoral agonists. J Endocrinol. 2000;166:111-20 pubmed
    ..These results also demonstrate that free fatty acids are not essential for glucose to evoke secretion from isolated islets of fasted donors. ..
  2. Padrick S, Miranker A. Islet amyloid: phase partitioning and secondary nucleation are central to the mechanism of fibrillogenesis. Biochemistry. 2002;41:4694-703 pubmed
    ..Marked acceleration of this reaction by hexafluoro-2-propanol reinforces this view by altering the relative solubility of the two phases and/or by stabilizing hydrogen-bonded structures in the transition states of the reaction pathway. ..
  3. Herold K, Brooks Worrell B, Palmer J, Dosch H, Peakman M, Gottlieb P, et al. Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes. 2009;58:2588-95 pubmed publisher
    ..The limited reproducibility of the measurements overall and of responses to individual analytes may reflect the difficulty in detection of low frequency of antigen-specific T-cells or variability in their appearance in peripheral blood. ..
  4. Dirkx R, Thomas A, Li L, Lernmark A, Sherwin R, De Camilli P, et al. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. J Biol Chem. 1995;270:2241-6 pubmed
    ..Taken together, our results indicate that GAD65-GAD67 association occurs in vivo and is required for the targeting of GAD67 to membranes. ..
  5. Wong S, Guerder S, Visintin I, Reich E, Swenson K, Flavell R, et al. Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse. Diabetes. 1995;44:326-9 pubmed
    ..This illustrates that B7-1 is a very potent co-stimulatory molecule in vivo and that its presence on the surface of tissue cells can potentiate the autoimmune process. ..
  6. Carty M, Lillquist J, Peshavaria M, Stein R, Soeller W. Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells. J Biol Chem. 1997;272:11986-93 pubmed
    ..Since PDX-1 is highly enriched in beta and delta cells, these results suggest that this factor plays a principal role in defining islet beta cell- and delta cell-specific expression of the IAPP gene. ..
  7. Ort T, Maksimova E, Dirkx R, Kachinsky A, Berghs S, Froehner S, et al. The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. Eur J Cell Biol. 2000;79:621-30 pubmed
    ..Thus, we propose that ICA512, through beta2-syntrophin and nNOS, links secretory granules with the actin cytoskeleton and signaling pathways involving nitric oxide...
  8. Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel J, et al. betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system. J Cell Biol. 2000;151:985-1002 pubmed
    ..Thus, we suggest that betaIVSigma1 spectrin interacts with ankyrin(G) 480/270-kD and participates in the clustering of voltage-gated Na(+) channels and cell-adhesion molecules at initial segments and nodes of Ranvier. ..
  9. Zawalich W, Zawalich K, Tesz G, Sterpka J, Philbrick W. Insulin secretion and IP levels in two distant lineages of the genus Mus: comparisons with rat islets. Am J Physiol Endocrinol Metab. 2001;280:E720-8 pubmed
    ..The divergence in 20 mM glucose-induced insulin release between these species may be attributable to differences in phospholipase C-mediated IP accumulation in islets...

More Information


  1. Paranjape S, Chan O, Zhu W, Horblitt A, Grillo C, Wilson S, et al. Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain. Am J Physiol Endocrinol Metab. 2011;301:E978-83 pubmed publisher
    ..These data suggest that insulin resistance within the VMH may be a significant contributor to the development of type 2 diabetes. ..
  2. Jurczak M, Lee H, Birkenfeld A, Jornayvaz F, Frederick D, Pongratz R, et al. SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes. 2011;60:890-8 pubmed publisher
    ..Taken together, these data support SGLT2 inhibition as a viable insulin-independent treatment of type 2 diabetes. ..
  3. Wen L, Ley R, Volchkov P, Stranges P, Avanesyan L, Stonebraker A, et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature. 2008;455:1109-13 pubmed publisher
    ..Together, these findings indicate that interaction of the intestinal microbes with the innate immune system is a critical epigenetic factor modifying T1D predisposition. ..
  4. Stark R, Pasquel F, Turcu A, Pongratz R, Roden M, Cline G, et al. Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion. J Biol Chem. 2009;284:26578-90 pubmed publisher
    ..Given that mtGTP synthesized by SCS-GTP is an indicator of TCA flux that is crucial for GSIS, PEPCK-M is a strong candidate to link mtGTP synthesis with insulin release through anaplerotic PEP cycling. ..
  5. Shao L, Zhou H, Zhang H, Qin L, Hwa J, Yun Z, et al. SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nat Commun. 2015;6:8917 pubmed publisher
    ..Our study reveals previously unrecognized mechanism regulating the onset and progression of T1DM associated with adipocyte dysfunction. ..
  6. Pongratz R, Kibbey R, Kirkpatrick C, Zhao X, Pontoglio M, Yaniv M, et al. Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets. J Biol Chem. 2009;284:16808-21 pubmed publisher
  7. Du W, Wong F, Li M, Peng J, Qi H, Flavell R, et al. TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. J Clin Invest. 2006;116:1360-70 pubmed
  8. Garofalo R, Orena S, Rafidi K, Torchia A, Stock J, Hildebrandt A, et al. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest. 2003;112:197-208 pubmed
  9. Vasavada R, Cavaliere C, D Ercole A, Dann P, Burtis W, Madlener A, et al. Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia. J Biol Chem. 1996;271:1200-8 pubmed
    ..PTHrP appears to regulate insulin secretion either directly or indirectly, through developmental or growth effects on islet mass. PTHrP may have a role as an agent that enhances islet mass and/or enhances insulin secretion. ..