Experts and Doctors on intracellular signaling peptides and proteins in New Jersey, United States
Locale: New Jersey, United States
Topic: intracellular signaling peptides and proteins
Yamada K, Levell J, Yoon T, Kohls D, Yowe D, Rigel D, et al
. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017;60:7099-7107 pubmed publisher
Pilder S, Decker C, Islam S, Buck C, Cebra Thomas J, Silver L. Concerted evolution of the mouse Tcp-10 gene family: implications for the functional basis of t haplotype transmission ratio distortion. Genomics. 1992;12:35-41 pubmed
..The data are consistent with the hypothesis that the effector of mutant Tcr activity is a second, alternatively spliced product that is expressed in a haploid- and allele-specific manner. ..
Mancoll R, Snyder L, Silver L. Delineation of the t complex on mouse chromosome 17 by in situ hybridization. Mamm Genome. 1992;2:201-5 pubmed
Garrett S, Broach J. Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase. Genes Dev. 1989;3:1336-48 pubmed
..Finally, the coding region predicts a protein with significant homology to the family of protein kinases, suggesting that loss of cAMP-dependent protein kinase function can be suppressed by the loss of a second protein kinase. ..
Bibbins K, Tsai J, Schimenti J, Sarvetnick N, Zoghbi H, Goodfellow P, et al
. Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6. Genomics. 1989;5:139-43 pubmed
..The mapping of large portions of the mouse t haplotype to unlinked regions on human chromosome 6 rules out the possibility that a t-haplotype-like chromosome could exist in humans. ..
Johnston S, Rauskolb C, Wilson R, Prabhakaran B, Irvine K, Vogt T. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997;124:2245-54 pubmed
..When misexpressed in the developing Drosophila wing imaginal disc the mouse Fringe genes exhibit conserved and differential effects on boundary determination. ..
Chai J, Du C, Wu J, Kyin S, Wang X, Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 2000;406:855-62 pubmed
..These results establish an evolutionarily conserved structural and biochemical basis for the activation of apoptosis by Smac/DIABLO. ..
Wu G, Chai J, Suber T, Wu J, Du C, Wang X, et al
. Structural basis of IAP recognition by Smac/DIABLO. Nature. 2000;408:1008-12 pubmed
..In addition to explaining a number of biological observations, our structural analysis identifies potential targets for drug screening. ..
Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al
. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
..In combination our results support a model where the meiotic central spindle and associated proteins are essential for acentrosomal chromosome segregation. ..