Experts and Doctors on intestinal mucosa in California, United States


Locale: California, United States
Topic: intestinal mucosa

Top Publications

  1. Davis C, Wahid R, Toapanta F, Simon J, Sztein M, Levy D. Applying mathematical tools to accelerate vaccine development: modeling Shigella immune dynamics. PLoS ONE. 2013;8:e59465 pubmed publisher
    ..It introduces mathematical models to the Shigella vaccine development effort and lays a foundation for joint theoretical/experimental/clinical approaches to Shigella vaccine design. ..
  2. Hartmann P, Haimerl M, Mazagova M, Brenner D, Schnabl B. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Gastroenterology. 2012;143:1330-1340.e1 pubmed publisher
    ..Therefore, enteric TNFRI is an important mediator of cholestatic liver fibrosis. ..
  3. Otsuka M, Kang Y, Ren J, Jiang H, Wang Y, Omata M, et al. Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology. 2010;138:1255-65, 1265.e1-9 pubmed publisher
    ..p38Alpha has distinct functions in mouse myeloid cells versus colonic epithelium; these differences should be taken into consideration in defining the role of p38alpha in inflammation and developing p38 inhibitors as therapeutics. ..
  4. Zeng R, Oderup C, Yuan R, Lee M, Habtezion A, Hadeiba H, et al. Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells. Mucosal Immunol. 2013;6:847-56 pubmed publisher
    ..The results define a novel vitamin A-dependent, RA-regulated developmental sequence for DCs and identify a targeted precursor for CD103? cDCs in the gut. ..
  5. Smith A, Contreras C, Ko K, Chow J, Dong X, Tuo B, et al. Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion. Endocrinology. 2008;149:4554-66 pubmed publisher
    ..Gender-associated differences in basal, acid- and E2-stimulated DMBS may have offered a reasonable explanation for the clinically observed lower incidence of duodenal ulcer in premenopausal women than age-matched men. ..
  6. Habtezion A, Nguyen L, Hadeiba H, Butcher E. Leukocyte Trafficking to the Small Intestine and Colon. Gastroenterology. 2016;150:340-54 pubmed publisher
    ..We review the mechanisms for innate and adaptive leukocyte localization to the intestinal tract and GALT, and discuss their relevance to human intestinal homeostasis and inflammation. ..
  7. Bethune M, Khosla C. Parallels between pathogens and gluten peptides in celiac sprue. PLoS Pathog. 2008;4:e34 pubmed publisher
  8. Bansal V, Costantini T, Ryu S, Peterson C, Loomis W, Putnam J, et al. Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma. 2010;68:1059-64 pubmed publisher
    ..Furthermore, vagal stimulation increased enteric glial activity and may represent the pathway for central nervous system regulation of intestinal permeability. ..
  9. Bird L, Sivagnanam M, Taylor S, Newbury R. A new syndrome of tufting enteropathy and choanal atresia, with ophthalmologic, hematologic and hair abnormalities. Clin Dysmorphol. 2007;16:211-21 pubmed
    ..We compare this syndrome with previously reported intractable diarrhea syndromes and speculate on the developmental mechanisms that could account for many of the features demonstrated by this sibship...

More Information


  1. Watchmaker P, Lahl K, Lee M, Baumjohann D, Morton J, Kim S, et al. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol. 2014;15:98-108 pubmed publisher
    ..Our results highlight evolutionarily conserved and divergent programming of intestinal DCs. ..
  2. Krause P, Zahner S, Kim G, Shaikh R, Steinberg M, Kronenberg M. The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice. Gastroenterology. 2014;146:1752-62.e4 pubmed publisher
    ..Tnfsf14(-/-) mice develop more severe colitis than control mice. LIGHT signals through the lymphotoxin ? receptor in the colon to regulate the innate immune response and mediate recovery from intestinal inflammation. ..
  3. Kang Y, Otsuka M, van den Berg A, Hong L, Huang Z, Wu X, et al. Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. PLoS Pathog. 2010;6:e1000934 pubmed publisher
    ..Thus, p38alpha in IECs contributes to the host immune responses against enteric bacteria by the recruitment of immune cells. ..
  4. Fergusson J, Hühn M, Swadling L, Walker L, Kurioka A, Llibre A, et al. CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut. Mucosal Immunol. 2016;9:401-13 pubmed publisher
    ..As induction of such responses represents a major aim of T-cell prophylactic and therapeutic vaccines in viral disease and cancer, analysis of these populations could be of value in the future. ..
  5. Chang M, Kistler E, Schmid Schonbein G. Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall. Shock. 2012;37:297-305 pubmed publisher
    ..This study demonstrates that disruption of the mucosal epithelial barrier within minutes of intestinal ischemia allows entry of fully activated pancreatic digestive proteases across the intestinal barrier triggering autodigestion. ..
  6. Lickwar C, Camp J, Weiser M, Cocchiaro J, Kingsley D, Furey T, et al. Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. PLoS Biol. 2017;15:e2002054 pubmed publisher
  7. Múnera J, Cecena G, Jedlicka P, Wankell M, Oshima R. Ets2 regulates colonic stem cells and sensitivity to tumorigenesis. Stem Cells. 2011;29:430-9 pubmed publisher
    ..Ets2-dependent, epithelial cell-autonomous repression of intestinal tumors may contribute to protection from colon cancer of persons with increased dosage of chromosome 21. ..
  8. Ng K, Ferreyra J, Higginbottom S, Lynch J, Kashyap P, Gopinath S, et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature. 2013;502:96-9 pubmed publisher
    ..This insight suggests new therapeutic approaches for preventing diseases caused by antibiotic-associated pathogens. ..
  9. Chang M, Alsaigh T, Kistler E, Schmid Schonbein G. Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. PLoS ONE. 2012;7:e40087 pubmed publisher
  10. Lee P, Kuhl W, Gelbart T, Kamimura T, West C, Beutler E. Homology between a human protein and a protein of the green garden pea. Genomics. 1994;21:371-8 pubmed
    ..Attempts to induce the mRNA by heat-shock, dehydration, ionizing irradiation, or treatment with iron, t-butylhydroperoxide, or glucocorticoids were unsuccessful. The function of the protein remains unknown. ..
  11. Sivagnanam M, Mueller J, Lee H, Chen Z, Nelson S, Turner D, et al. Identification of EpCAM as the gene for congenital tufting enteropathy. Gastroenterology. 2008;135:429-37 pubmed publisher
    ..Mutations in the gene for EpCAM are responsible for CTE. This information will be used to gain further insight into the molecular mechanisms of this disease. ..
  12. Bode L, Salvestrini C, Park P, Li J, Esko J, Yamaguchi Y, et al. Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest. 2008;118:229-38 pubmed
    ..We demonstrate here that non-anticoagulant 2,3-de-O-sulfated heparin could prevent intestinal protein leakage in syndecan-deficient mice, suggesting that this may be a safe and effective therapy for PLE patients. ..
  13. Rey O, Zhukova E, Sinnett Smith J, Rozengurt E. Vasopressin-induced intracellular redistribution of protein kinase D in intestinal epithelial cells. J Cell Physiol. 2003;196:483-92 pubmed
    ..These findings provide evidence for a mechanism by which PKC coordinates in intestinal epithelial cells the translocation and activation of PKD in response to vasopressin-induced GPCR activation. ..
  14. Easwaran V, Lee S, Inge L, Guo L, Goldbeck C, Garrett E, et al. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res. 2003;63:3145-53 pubmed
    ..Taken together, our observations indicate a close link between beta-catenin signaling and the regulation of VEGF-A expression in colon cancer. ..
  15. Akama T, Misra A, Hindsgaul O, Fukuda M. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. J Biol Chem. 2002;277:42505-13 pubmed
    ..Based on these results, we propose a biosynthetic pathway for N-linked keratan sulfate on corneal proteoglycans. ..
  16. Kunkel E, Campbell J, Haraldsen G, Pan J, Boisvert J, Roberts A, et al. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J Exp Med. 2000;192:761-8 pubmed
    ..Selective expression of chemokines by differentiated epithelium may represent an important mechanism for targeting and specialization of immune responses. ..
  17. Meehan T, Witherden D, Kim C, Sendaydiego K, Ye I, Garijo O, et al. Protection against colitis by CD100-dependent modulation of intraepithelial ?? T lymphocyte function. Mucosal Immunol. 2014;7:134-42 pubmed publisher
    ..These results demonstrate that CD100-mediated signals are critical for effective activation of ?? IEL to produce growth factors, including KGF-1, that are required for healing of the colon epithelium during colitis. ..