Genomes and Genes
Experts and Doctors on intestinal mucosa in California, United States
Locale: California, United States
Topic: intestinal mucosa
- Watchmaker P, Lahl K, Lee M, Baumjohann D, Morton J, Kim S, et al. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol. 2014;15:98-108 pubmed publisher..Our results highlight evolutionarily conserved and divergent programming of intestinal DCs. ..
- Krause P, Zahner S, Kim G, Shaikh R, Steinberg M, Kronenberg M. The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice. Gastroenterology. 2014;146:1752-62.e4 pubmed publisher..Tnfsf14(-/-) mice develop more severe colitis than control mice. LIGHT signals through the lymphotoxin ? receptor in the colon to regulate the innate immune response and mediate recovery from intestinal inflammation. ..
- Kang Y, Otsuka M, van den Berg A, Hong L, Huang Z, Wu X, et al. Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. PLoS Pathog. 2010;6:e1000934 pubmed publisher..Thus, p38alpha in IECs contributes to the host immune responses against enteric bacteria by the recruitment of immune cells. ..
- Fergusson J, Hühn M, Swadling L, Walker L, Kurioka A, Llibre A, et al. CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut. Mucosal Immunol. 2016;9:401-13 pubmed publisher..As induction of such responses represents a major aim of T-cell prophylactic and therapeutic vaccines in viral disease and cancer, analysis of these populations could be of value in the future. ..
- Chang M, Kistler E, Schmid Schonbein G. Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall. Shock. 2012;37:297-305 pubmed publisher..This study demonstrates that disruption of the mucosal epithelial barrier within minutes of intestinal ischemia allows entry of fully activated pancreatic digestive proteases across the intestinal barrier triggering autodigestion. ..
- Múnera J, Cecena G, Jedlicka P, Wankell M, Oshima R. Ets2 regulates colonic stem cells and sensitivity to tumorigenesis. Stem Cells. 2011;29:430-9 pubmed publisher..Ets2-dependent, epithelial cell-autonomous repression of intestinal tumors may contribute to protection from colon cancer of persons with increased dosage of chromosome 21. ..
- Ng K, Ferreyra J, Higginbottom S, Lynch J, Kashyap P, Gopinath S, et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature. 2013;502:96-9 pubmed publisher..This insight suggests new therapeutic approaches for preventing diseases caused by antibiotic-associated pathogens. ..
- Lee P, Kuhl W, Gelbart T, Kamimura T, West C, Beutler E. Homology between a human protein and a protein of the green garden pea. Genomics. 1994;21:371-8 pubmed..Attempts to induce the mRNA by heat-shock, dehydration, ionizing irradiation, or treatment with iron, t-butylhydroperoxide, or glucocorticoids were unsuccessful. The function of the protein remains unknown. ..
- Sivagnanam M, Mueller J, Lee H, Chen Z, Nelson S, Turner D, et al. Identification of EpCAM as the gene for congenital tufting enteropathy. Gastroenterology. 2008;135:429-37 pubmed publisher..Mutations in the gene for EpCAM are responsible for CTE. This information will be used to gain further insight into the molecular mechanisms of this disease. ..
- Bode L, Salvestrini C, Park P, Li J, Esko J, Yamaguchi Y, et al. Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest. 2008;118:229-38 pubmed..We demonstrate here that non-anticoagulant 2,3-de-O-sulfated heparin could prevent intestinal protein leakage in syndecan-deficient mice, suggesting that this may be a safe and effective therapy for PLE patients. ..
- Rey O, Zhukova E, Sinnett Smith J, Rozengurt E. Vasopressin-induced intracellular redistribution of protein kinase D in intestinal epithelial cells. J Cell Physiol. 2003;196:483-92 pubmed..These findings provide evidence for a mechanism by which PKC coordinates in intestinal epithelial cells the translocation and activation of PKD in response to vasopressin-induced GPCR activation. ..
- Easwaran V, Lee S, Inge L, Guo L, Goldbeck C, Garrett E, et al. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res. 2003;63:3145-53 pubmed..Taken together, our observations indicate a close link between beta-catenin signaling and the regulation of VEGF-A expression in colon cancer. ..
- Akama T, Misra A, Hindsgaul O, Fukuda M. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. J Biol Chem. 2002;277:42505-13 pubmed..Based on these results, we propose a biosynthetic pathway for N-linked keratan sulfate on corneal proteoglycans. ..
- Kunkel E, Campbell J, Haraldsen G, Pan J, Boisvert J, Roberts A, et al. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J Exp Med. 2000;192:761-8 pubmed..Selective expression of chemokines by differentiated epithelium may represent an important mechanism for targeting and specialization of immune responses. ..
- Meehan T, Witherden D, Kim C, Sendaydiego K, Ye I, Garijo O, et al. Protection against colitis by CD100-dependent modulation of intraepithelial ?? T lymphocyte function. Mucosal Immunol. 2014;7:134-42 pubmed publisher..These results demonstrate that CD100-mediated signals are critical for effective activation of ?? IEL to produce growth factors, including KGF-1, that are required for healing of the colon epithelium during colitis. ..