Experts and Doctors on insulin in North Carolina, United States


Locale: North Carolina, United States
Topic: insulin

Top Publications

  1. Pettis R, Hirsch L, Kapitza C, Nosek L, Hövelmann U, Kurth H, et al. Microneedle-based intradermal versus subcutaneous administration of regular human insulin or insulin lispro: pharmacokinetics and postprandial glycemic excursions in patients with type 1 diabetes. Diabetes Technol Ther. 2011;13:443-50 pubmed publisher
    ..ID RHI provided similar control of PPG as SC IL immediately premeal. Further studies of ID insulin delivery via steel microneedles are warranted. ..
  2. Fu J, Woods C, Yehuda Shnaidman E, Zhang Q, Wong V, Collins S, et al. Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress. Environ Health Perspect. 2010;118:864-70 pubmed publisher
    ..Our studies suggest that low levels of arsenic provoke a cellular adaptive oxidative stress response that increases antioxidant levels, dampens ROS signaling involved in GSIS, and thus disturbs beta-cell function. ..
  3. Bowers R, Tunney R, Kelly K, Mills B, Trotta K, Wheeless C, et al. Impact of Standardized Simulated Patients on First-Year Pharmacy Students' Knowledge Retention of Insulin Injection Technique and Counseling Skills. Am J Pharm Educ. 2017;81:113 pubmed publisher
    ..b>Conclusion. Simulated patient interactions, when added to traditional coursework within a P1 skills lab, improve student counseling aptitude and knowledge retention scores...
  4. Zeruth G, Takeda Y, Jetten A. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Mol Endocrinol. 2013;27:1692-705 pubmed publisher
    ..Taken together, these results indicate that Glis3 plays a pivotal role in the transcriptional regulation of insulin and may serve as an important therapeutic target for the treatment of diabetes. ..
  5. Vasanth S, Zeruth G, Kang H, Jetten A. Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2). J Biol Chem. 2011;286:4749-59 pubmed publisher
    ..This control may play a critical role in the Glis2-dependent regulation of target genes and renal function. ..
  6. Harvey A, Kaestner S, Sutter D, Harvey N, Mikszta J, Pettis R. Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs. Pharm Res. 2011;28:107-16 pubmed publisher
  7. Dukes I, Philipson L. K+ channels: generating excitement in pancreatic beta-cells. Diabetes. 1996;45:845-53 pubmed
    ..These discoveries have identified new pharmacological targets for possible therapeutic intervention in the treatment of diabetes...
  8. Ghanayem B, Bai R, Kissling G, Travlos G, Hoffler U. Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod. 2010;82:96-104 pubmed publisher
    ..This work demonstrated that diet-induced obesity in mice caused a significant reduction in male fertility and exacerbated AA-induced reproductive toxicity and germ cell mutagenicity...
  9. Scott G, Ray M, Ward T, McCann K, Peddada S, Jiang F, et al. Abnormal glucose metabolism in heterozygous mutant mice for a type I receptor required for BMP signaling. Genesis. 2009;47:385-91 pubmed publisher
    ..Together, our data suggest that BMP signaling through BMPRIA plays an important role in glucose metabolism and possibly working through the GSIS pathway. ..

More Information


  1. Liu H, Yehuda Shnaidman E, Hong T, Han J, Pi J, Liu Z, et al. Prolonged exposure to insulin suppresses mitochondrial production in primary hepatocytes. J Biol Chem. 2009;284:14087-95 pubmed publisher
    ..Together, our results show prolonged exposure of isolated hepatocytes to insulin suppresses mitochondrial production and function through the classical Akt-dependent insulin signaling pathway. ..
  2. Way J, Harrington W, Brown K, Gottschalk W, Sundseth S, Mansfield T, et al. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology. 2001;142:1269-77 pubmed
  3. Bailey S, Zacher C, Mittleman K. Effect of menstrual cycle phase on carbohydrate supplementation during prolonged exercise to fatigue. J Appl Physiol (1985). 2000;88:690-7 pubmed
    ..These results indicate that the menstrual cycle phase does not alter the effects of CHO supplementation on performance and plasma levels of related substrates during prolonged exercise...
  4. Dukes I, Sreenan S, Roe M, Levisetti M, Zhou Y, Ostrega D, et al. Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice. J Biol Chem. 1998;273:24457-64 pubmed
    ..We conclude that hepatocyte nuclear factor-1alpha diabetes results from defective beta-cell glycolytic signaling, which is potentially correctable using substrates that bypass the defect. ..
  5. Pi J, Bai Y, Daniel K, Liu D, Lyght O, Edelstein D, et al. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology. 2009;150:3040-8 pubmed publisher
    ..These data show that the chronic absence of UCP2 causes oxidative stress, including in islets, and is accompanied by impaired glucose-stimulated insulin secretion. ..
  6. Liu H, Wen G, Han J, Hong T, Zhuo D, Liu Z, et al. Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway. J Biol Chem. 2008;283:30642-9 pubmed publisher
    ..Together, our results demonstrate that SDF-1 is capable of inhibiting gluconeogenesis in primary hepatocytes through a signaling pathway distinct from the insulin signaling. ..
  7. Collins Q, Liu H, Pi J, Liu Z, Quon M, Cao W. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase. J Biol Chem. 2007;282:30143-9 pubmed
    ..Together, our results demonstrate an inhibitory role for EGCG in hepatic gluconeogenesis and shed new light on the mechanism by which EGCG suppresses gluconeogenesis. ..
  8. Ning J, Hong T, Ward A, Pi J, Liu Z, Liu H, et al. Constitutive role for IRE1?-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program. Endocrinology. 2011;152:2247-55 pubmed publisher
    ..Besides, the insulin-mediated protein synthesis is tightly connected with the insulin-mediated lipogenic program. ..
  9. Zeruth G, Yang X, Jetten A. Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused. J Biol Chem. 2011;286:22077-89 pubmed publisher
  10. Hannas B, Lambright C, Furr J, Howdeshell K, Wilson V, Gray L. Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate. Toxicol Sci. 2011;123:206-16 pubmed publisher
  11. Hall J, McElwee M, Freedman J. Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. PLoS ONE. 2017;12:e0177432 pubmed publisher
    ..Identification of portions of the insulin signaling pathway as regulators of metallothionein expression supports the hypothesis that longevity is affected by the expression of this efficient ROS scavenger. ..