Experts and Doctors on immunologic receptors in New York, United States


Locale: New York, United States
Topic: immunologic receptors

Top Publications

  1. Hudson B, Bucciarelli L, Wendt T, Sakaguchi T, Lalla E, Qu W, et al. Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders. Arch Biochem Biophys. 2003;419:80-8 pubmed
    ..Here, we will summarize the known consequences of RAGE activation in the tissues and highlight novel areas for therapeutic intervention in these disease states. ..
  2. Taylor M, Bezouska K, Drickamer K. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. J Biol Chem. 1992;267:1719-26 pubmed
    ..In the mannose receptor, these multiple weak interactions are achieved through several active CRDs in a single polypeptide chain rather than by oligomerization of polypeptides each containing a single CRD. ..
  3. Vyas Y, Selvakumar A, Steffens U, Dupont B. Multiple transcripts of the killer cell immunoglobulin-like receptor family, KIR3DL1 (NKB1), are expressed by natural killer cells of a single individual. Tissue Antigens. 1998;52:510-9 pubmed
    ..221 B-lymphoblastoid cell line expressing a HLA-B antigen with Bw4 epitope. All NK clones were, however, inhibited by 721.221 cells transfected with a HLA-B antigen carrying the Bw6 epitope. ..
  4. Yan S, Zhu H, Zhu A, Golabek A, Du H, Roher A, et al. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat Med. 2000;6:643-51 pubmed
    ..Antagonizing RAGE suppressed cell stress and amyloid deposition in mouse spleens. These data indicate that RAGE is a potential target for inhibiting accumulation of amyloid A and for limiting cellular dysfunction induced by amyloid A. ..
  5. Han J, Nicholson A, Zhou X, Feng J, Gotto A, Hajjar D. Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I. J Biol Chem. 2001;276:16567-72 pubmed
  6. Manavalan J, Rossi P, Vlad G, Piazza F, Yarilina A, Cortesini R, et al. High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol. 2003;11:245-58 pubmed
  7. Kalea A, See F, Harja E, Arriero M, Schmidt A, Hudson B. Alternatively spliced RAGEv1 inhibits tumorigenesis through suppression of JNK signaling. Cancer Res. 2010;70:5628-38 pubmed publisher
    ..Our results identify RAGEv1 as a novel suppressor, the study of which may offer new cancer therapeutic directions. ..
  8. Berg K, Carlberg K, Rohrschneider L, Siminovitch K, Stanley E. The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate. Oncogene. 1998;17:2535-41 pubmed
    ..These observations identify SHP-1 interactions with and regulation of p91/PIR-B as a potential mechanism for inhibiting the signaling cascades linking extracellular stimuli to macrophage activation and/or development. ..
  9. Cai W, He J, Zhu L, Lu C, Vlassara H. Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor. Proc Natl Acad Sci U S A. 2006;103:13801-6 pubmed
    ..AGER1 could serve as a model for developing therapeutic targets against vascular and kidney disorders related to diabetes and aging. ..

More Information

Publications122 found, 100 shown here

  1. Schmidt A, Vianna M, Gerlach M, Brett J, Ryan J, Kao J, et al. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem. 1992;267:14987-97 pubmed
    ..These polypeptides represent a novel class of cell surface acceptor molecules for glucose-modified proteins which may promote degradation and/or transcytosis of the ligand, and modulation of cellular function. ..
  2. Seo T, Velez Carrasco W, Qi K, Hall M, Worgall T, Johnson R, et al. Selective uptake from LDL is stimulated by unsaturated fatty acids and modulated by cholesterol content in the plasma membrane: role of plasma membrane composition in regulating non-SR-BI-mediated selective lipid transfer. Biochemistry. 2002;41:7885-94 pubmed
    ..Moreover, in conditions where elevated plasma FFA occur, SU from LDL can be an important mechanism for cholesterol delivery in vivo. ..
  3. Hsu K, Liu X, Selvakumar A, Mickelson E, O Reilly R, Dupont B. Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. J Immunol. 2002;169:5118-29 pubmed
    ..Additional rare haplotypes can be identified, and may have arisen by gene duplication, intergenic recombination, or deletions. ..
  4. Manavalan J, Kim Schulze S, Scotto L, Naiyer A, Vlad G, Colombo P, et al. Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity. Int Immunol. 2004;16:1055-68 pubmed
    ..Modulation of endothelial cells in favor of promoting tolerance may be important for long-term survival of organ allografts. ..
  5. LOPEZ C, Moltedo B, Alexopoulou L, Bonifaz L, Flavell R, Moran T. TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses. J Immunol. 2004;173:6882-9 pubmed
    ..The revelation of this pathway should stimulate invigorating research into the mechanism for virus-induced DC maturation and immunity...
  6. Erskine L, Williams S, Brose K, Kidd T, Rachel R, Goodman C, et al. Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits. J Neurosci. 2000;20:4975-82 pubmed
  7. Soong G, Reddy B, Sokol S, Adamo R, Prince A. TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells. J Clin Invest. 2004;113:1482-9 pubmed
  8. Runko E, Kaprielian Z. Caenorhabditis elegans VEM-1, a novel membrane protein, regulates the guidance of ventral nerve cord-associated axons. J Neurosci. 2004;24:9015-26 pubmed
    ..Consistent with these genetic data, we also show that VEM-1 is capable of physically interacting with UNC-40 but not SAX-3. ..
  9. Hofmann M, Yang Q, Harja E, Kedia P, Gregersen P, Cupples L, et al. The RAGE Gly82Ser polymorphism is not associated with cardiovascular disease in the Framingham offspring study. Atherosclerosis. 2005;182:301-5 pubmed
    ..Further studies are required on other more prevalent genetic variants of RAGE and cardiovascular disease. ..
  10. Lalla E, Lamster I, Feit M, Huang L, Spessot A, Qu W, et al. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest. 2000;105:1117-24 pubmed
    ..These findings link RAGE and exaggerated inflammatory responses to the pathogenesis of destructive periodontal disease in diabetes. ..
  11. Shachter N. Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism. Curr Opin Lipidol. 2001;12:297-304 pubmed
    ..Variation in the expression of apoC-III has been credibly documented to have an important role in hypertriglyceridemia. Variation in the expression of apoC-I may also be important for hypertriglyceridemia under certain circumstances. ..
  12. Ma J, Takito J, Vijayakumar S, Peehl D, Olsson C, Al Awqati Q. Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation. Prostate. 2001;49:9-18 pubmed
    ..The localization of hensin/DMBT1 during maturation raises the possibility that hensin/DMBT1 is involved in terminal differentiation of the prostate and vas deferens. ..
  13. Han J, Parsons M, Zhou X, Nicholson A, Gotto A, Hajjar D. Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104). Circulation. 2004;110:3472-9 pubmed
  14. Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W, et al. RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol. 2008;294:H1823-32 pubmed publisher
  15. Ji J, Park Min K, Shen Z, Fajardo R, Goldring S, McHugh K, et al. Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors. J Immunol. 2009;183:7223-33 pubmed publisher
    ..Our findings identify a new mechanism of homeostatic regulation of osteoclastogenesis that targets RANK expression and limits bone resorption during infection and inflammation. ..
  16. Aliprantis A, Yang R, Weiss D, Godowski P, Zychlinsky A. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 2000;19:3325-36 pubmed
    ..These results indicate that caspase activation is an innate immune response to microbial pathogens, culminating in apoptosis and cytokine production. ..
  17. Shi S, Blumenthal A, Hickey C, Gandotra S, Levy D, Ehrt S. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol. 2005;175:3318-28 pubmed
  18. Marti F, Xu C, Selvakumar A, Brent R, Dupont B, King P. LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A. 1998;95:11810-5 pubmed
    ..Therefore, in addition to providing negative signals, KIR may also contribute positive signals for NK and T cell growth and/or survival. ..
  19. Chen W, Wang N, Tall A. A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes. J Biol Chem. 2005;280:29277-81 pubmed
  20. Ignatius R, Tenner Racz K, Messmer D, Gettie A, Blanchard J, Luckay A, et al. Increased macrophage infection upon subcutaneous inoculation of rhesus macaques with simian immunodeficiency virus-loaded dendritic cells or T cells but not with cell-free virus. J Virol. 2002;76:9787-97 pubmed
    ..This may have important implications for the subsequent dissemination of infection and/or induction of antiretroviral immunity. ..
  21. Fujii S, Shimizu K, Smith C, Bonifaz L, Steinman R. Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med. 2003;198:267-79 pubmed
    ..Therefore a single dose of alphaGalCer i.v. rapidly stimulates the full maturation of DCs in situ, and this accounts for the induction of combined Th1 CD4+ and CD8+ T cell immunity to a coadministered protein. ..
  22. Zhou J, Cai B, Jang Y, Pachydaki S, Schmidt A, Sparrow J. Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells. Exp Eye Res. 2005;80:567-80 pubmed
  23. Chang J, Wendt T, Qu W, Kong L, Zou Y, Schmidt A, et al. Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ Res. 2008;102:905-13 pubmed publisher
    ..These findings identify RAGE as a master regulator of tissue stress elicited by hypoxia and highlight this receptor as a central therapeutic target to suppress the tissue injury-provoking effects of oxygen deprivation. ..
  24. Filbin M. PirB, a second receptor for the myelin inhibitors of axonal regeneration Nogo66, MAG, and OMgp: implications for regeneration in vivo. Neuron. 2008;60:740-2 pubmed publisher
    ..In a recent issue of Science, a second receptor for these myelin inhibitors was described, PirB, a receptor first described in the immune system. Will PirB be the answer to CST regeneration in vivo? ..
  25. Silver D, Wang N, Vogel S. Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. J Biol Chem. 2003;278:28528-32 pubmed
    ..Thus, SPAP may be an endogenous regulator of cellular PDZK1 levels by regulating PDZK1 turnover. ..
  26. Papanikolaou N, Vasilescu E, Suciu Foca N. Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4. Hum Immunol. 2004;65:700-5 pubmed
    ..Domain 1 is part of the distal membrane portion of ILT4, which is engaged in protein-protein interactions between APC and T cells. ..
  27. Liu J, Liu Z, Witkowski P, Vlad G, Manavalan J, Scotto L, et al. Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection. Transpl Immunol. 2004;13:239-47 pubmed
    ..This study focuses attention on the need to develop agents that act directly on graft EC in order to achieve tolerance. ..
  28. Cai W, He J, Zhu L, Chen X, Striker G, Vlassara H. AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation. Am J Physiol Cell Physiol. 2008;294:C145-52 pubmed
    ..This represents a key mechanism by which AGER1 maintains cellular resistance against OS. Thus the decrease of AGER1 noted in aging and diabetes may further enhance OS and reduce innate antioxidant defenses. ..
  29. Vlassara H, Uribarri J, Ferrucci L, Cai W, Torreggiani M, Post J, et al. Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in elderly persons. Semin Nephrol. 2009;29:594-603 pubmed publisher
    ..These data suggest that the changes in renal function in normal aging may be subject to control and this subject deserves renewed attention. ..
  30. Kim S, Ruiz N, Bezouska K, Drickamer K. Organization of the gene encoding the human macrophage mannose receptor (MRC1). Genomics. 1992;14:721-7 pubmed
    ..The pattern of intron positions as well as comparison of the sequences of the carbohydrate-recognition domains suggests that the duplication of these domains was an evolutionarily ancient event. ..
  31. Silver D, Wang N, Xiao X, Tall A. High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion. J Biol Chem. 2001;276:25287-93 pubmed
    ..A distinct process not mediated by SR-BI is involved in uptake and degradation of apoE-free HDL in hepatocytes. ..
  32. Vargesson N, Luria V, Messina I, Erskine L, Laufer E. Expression patterns of Slit and Robo family members during vertebrate limb development. Mech Dev. 2001;106:175-80 pubmed
    ..We also compare the expression patterns of Robo1 and Robo2 in developing chick and mouse hindlimbs. These genes are expressed in regions of muscle development, chrondrogenesis, and axon guidance. ..
  33. Bucciarelli L, Wendt T, Qu W, Lu Y, Lalla E, Rong L, et al. RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice. Circulation. 2002;106:2827-35 pubmed
    ..Blockade of RAGE may be a novel strategy to stabilize atherosclerosis and vascular inflammation in established diabetes. ..
  34. Zang X, Sullivan P, Soslow R, Waitz R, Reuter V, Wilton A, et al. Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 2010;23:1104-12 pubmed publisher
    ..B7-H3 expression in tumor vasculature may be a reflection of tumor aggressiveness and has diagnostic and immunotherapeutic implications in ovarian carcinomas. ..
  35. Parathath S, Connelly M, Rieger R, Klein S, Abumrad N, de la Llera Moya M, et al. Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36. J Biol Chem. 2004;279:41310-8 pubmed
    ..Scavenger receptor-mediated changes in membrane phosphatidylcholine may contribute to the increased flux of cholesterol and other lipids elicited by these receptors. ..
  36. Paietta E, Stockert R, Racevskis J. Alternatively spliced variants of the human hepatic asialoglycoprotein receptor, H2, differ in cellular trafficking and regulation of phosphorylation. J Biol Chem. 1992;267:11078-84 pubmed
    ..Since the 57-nucleotide region does not encode for serine residues, it per se cannot be the site of phosphorylation but rather constitutes a regulatory element for post-translational modification. ..
  37. Coraci I, Husemann J, Berman J, Hulette C, Dufour J, Campanella G, et al. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol. 2002;160:101-12 pubmed
    ..We propose that similar to their role in the interaction of macrophages with oxLDL, class A scavenger receptors and CD36 play complimentary roles in the interactions of microglia with fibrillar beta-amyloid. ..
  38. Greene L, Angelastro J. You can't go home again: transcriptionally driven alteration of cell signaling by NGF. Neurochem Res. 2005;30:1347-52 pubmed
    ..We discuss specific examples based on reports in the literature as well as on data derived from a serial analysis of gene expression (SAGE) study of NGF-promoted transcriptional changes in PC12 pheochromocytoma cells. ..
  39. Brentjens R, Santos E, Nikhamin Y, Yeh R, Matsushita M, La Perle K, et al. Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res. 2007;13:5426-35 pubmed
    ..The finding that modifications in CAR design as well as T-cell dosing allowed for the complete eradication of systemic disease affects the design of clinical trials using this treatment strategy. ..
  40. Reiniger N, Lau K, McCalla D, Eby B, Cheng B, Lu Y, et al. Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse. Diabetes. 2010;59:2043-54 pubmed publisher
    ..These data provide compelling evidence for critical roles for RAGE in the pathogenesis of diabetic nephropathy and suggest that strategies targeting RAGE in long-term diabetes may prevent loss of renal function. ..
  41. Zang X, Thompson R, Al Ahmadie H, Serio A, Reuter V, Eastham J, et al. B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci U S A. 2007;104:19458-63 pubmed
    ..Given the proposed immune-inhibitory mechanisms of B7-H3 and B7x, these molecules represent attractive targets for therapeutic manipulation in prostate cancer. ..
  42. Cai W, He J, Zhu L, Chen X, Zheng F, Striker G, et al. Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan. Am J Pathol. 2008;173:327-36 pubmed publisher
    ..Therefore, the beneficial effects of a CR diet may be partly related to reduced oxidant intake, a principal determinant of oxidant status in aging mice, rather than decreased energy intake. ..
  43. Rosas Ballina M, Goldstein R, Gallowitsch Puerta M, Yang L, Vald├ęs Ferrer S, Patel N, et al. The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol Med. 2009;15:195-202 pubmed publisher
    ..These findings establish the immunoregulatory effect of GTS-21 on human monocytes, and indicate the potential benefits of further exploration of GTS-21's therapeutic uses in human inflammatory disease. ..
  44. Mellow T, Halberg D, Drickamer K. Endocytosis of N-acetylglucosamine-containing glycoproteins by rat fibroblasts expressing a single species of chicken liver glycoprotein receptor. J Biol Chem. 1988;263:5468-73 pubmed
  45. Berger M, Budhu S, Lu E, Li Y, Loike D, Silverstein S, et al. Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. J Leukoc Biol. 2002;71:798-806 pubmed
    ..We propose that the qualitative differences in effector functions signaled by different chemoattractants reflect qualitative differences in using G-protein beta and/or gamma subunits or other factors by their cognate receptors. ..
  46. Runko E, Kaprielian Z. Expression of Vema in the developing mouse spinal cord and optic chiasm. J Comp Neurol. 2002;451:289-99 pubmed
    ..The expression of Vema at two key choice points for pathfinding axons suggests an important role for this protein in regulating axon guidance at the midline of the developing mouse central nervous system. ..
  47. Guan F, Villegas G, Teichman J, Mundel P, Tufro A. Autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival. Kidney Int. 2006;69:1564-9 pubmed
  48. Pichiule P, Chavez J, Schmidt A, Vannucci S. Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia. J Biol Chem. 2007;282:36330-40 pubmed
    ..Specific binding of HIF-1 to this putative HRE in hypoxic cells was detected by chromatin immunoprecipitation assay. ..
  49. Xu H, Cheung I, Guo H, Cheung N. MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors. Cancer Res. 2009;69:6275-81 pubmed publisher
    ..Differential modulation of this key immunoinhibitory molecule in tumor versus normal tissues may advance both cell-mediated immunotherapy and antibody-based targeted strategies using the B7-H3-specific mAb 8H9. ..
  50. Kalliolias G, Zhao B, Triantafyllopoulou A, Park Min K, Ivashkiv L. Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling. Arthritis Rheum. 2010;62:402-13 pubmed publisher
    ..This homeostatic function is compromised under conditions of chronic inflammation such as in RA synovitis. ..
  51. Li J, Qu X, Schmidt A. Sp1-binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells. J Biol Chem. 1998;273:30870-8 pubmed
    ..These results point to Sp1-dependent mechanisms underlying amphoterin-mediated increases in RAGE expression in neuroblastoma cells and further link amphoterin-RAGE interaction to development of the nervous system. ..
  52. Hsu H, Hajjar D, Khan K, Falcone D. Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway. J Biol Chem. 1998;273:1240-6 pubmed
    ..These findings establish for the first time a signaling pathway induced by ligand binding to MSR-A and suggest a molecular model for the regulation of macrophage uPA expression by specific ligands of the MSR-A. ..
  53. Suciu Foca N, Cortesini R. Central role of ILT3 in the T suppressor cell cascade. Cell Immunol. 2007;248:59-67 pubmed
    ..Both membrane and soluble ILT3 are proteins with potent immunosuppressive activity which are of importance for treatment of rejection, autoimmunity and cancer. ..
  54. Bu D, Rai V, Shen X, Rosario R, Lu Y, D AGATI V, et al. Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice. Circ Res. 2010;106:1040-51 pubmed publisher
  55. Febbraio M, Podrez E, Smith J, Hajjar D, Hazen S, Hoff H, et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J Clin Invest. 2000;105:1049-56 pubmed
    ..These results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances. ..
  56. Husemann J, Silverstein S. Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain. Am J Pathol. 2001;158:825-32 pubmed
    ..They suggest that SR-BI expression also is developmentally regulated in human microglia. ..
  57. Doubrovina E, Doubrovin M, Vider E, Sisson R, O Reilly R, Dupont B, et al. Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. J Immunol. 2003;171:6891-9 pubmed
    ..These results suggest that circulating sMIC in the cancer patients deactivates NK immunity by down-modulating important activating and chemokine receptors. ..
  58. Hassid B, Nair M, Ducruet A, Otten M, Komotar R, Pinsky D, et al. Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia. J Clin Neurosci. 2009;16:302-6 pubmed publisher
    ..These results indicate that RAGE signaling directly contributes to pathology in cerebral ischemia. ..
  59. Kalea A, Reiniger N, Yang H, Arriero M, Schmidt A, Hudson B. Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene. FASEB J. 2009;23:1766-74 pubmed publisher
    ..These differences in RAGE splicing in both physiological and pathogenic states further expand our understanding of the biological repertoire of this receptor in health and disease. ..
  60. Yokoyama W. Hybrid resistance and the Ly-49 family of natural killer cell receptors. J Exp Med. 1995;182:273-7 pubmed
  61. Idris A, Iizuka K, Smith H, Scalzo A, Yokoyama W. Genetic control of natural killing and in vivo tumor elimination by the Chok locus. J Exp Med. 1998;188:2243-56 pubmed
    ..Our genetic analysis suggests Chok is a single locus that affects NK cell-mediated cytotoxicity similar to other NKC loci that also regulate the complex activity of NK cells. ..
  62. Silver D. A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver. J Biol Chem. 2002;277:34042-7 pubmed
  63. Huang W, Ochs H, Dupont B, Vyas Y. The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement. J Immunol. 2005;174:2602-11 pubmed
    ..Our results indicate that WASp independently regulates its dual functions, i.e., actin cytoskeletal remodeling and transcription in NK cells. ..
  64. Torreggiani M, Liu H, Wu J, Zheng F, Cai W, Striker G, et al. Advanced glycation end product receptor-1 transgenic mice are resistant to inflammation, oxidative stress, and post-injury intimal hyperplasia. Am J Pathol. 2009;175:1722-32 pubmed publisher
  65. Vlassara H, Cai W, Goodman S, Pyzik R, Yong A, Chen X, et al. Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1. J Clin Endocrinol Metab. 2009;94:4483-91 pubmed publisher
    ..Whereas AGE receptor-1 (AGER1) reduces OS/infl in animals, this has not been assessed in normal humans...
  66. Ferrero E, Hsieh C, Francke U, Goyert S. CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes. J Immunol. 1990;145:331-6 pubmed
    ..The inclusion of CD14 in the family of leucine-rich proteins, its expression profile and the murine chromosomal localization support the hypothesis that CD14 may function as a receptor. ..
  67. Han J, Hajjar D, Tauras J, Nicholson A. Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. J Lipid Res. 1999;40:830-8 pubmed
  68. Sousa M, Du Yan S, Fernandes R, Guimaraes A, Stern D, Saraiva M. Familial amyloid polyneuropathy: receptor for advanced glycation end products-dependent triggering of neuronal inflammatory and apoptotic pathways. J Neurosci. 2001;21:7576-86 pubmed
    ..We propose that the interaction of TTR fibrils with RAGE may contribute to cellular stress and toxicity in FAP. Furthermore, there is an apparent lack of responsiveness of Schwann cells in FAP nerve to provide neurotrophic factors...
  69. Gourzi P, Leonova T, Papavasiliou F. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Immunity. 2006;24:779-86 pubmed
    ..Hence, in addition to its known function in immunoglobulin diversification, AID is active in innate defense against a transforming retrovirus...
  70. Zeng S, Dun H, Ippagunta N, Rosario R, Zhang Q, Lefkowitch J, et al. Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury. J Hepatol. 2009;50:929-36 pubmed publisher
    ..Suppression of Egr-1 may contribute to the protective mechanisms underlying the beneficial impact of RAGE blockade or deletion. ..
  71. Selvakumar A, Steffens U, Palanisamy N, Chaganti R, Dupont B. Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103. Tissue Antigens. 1997;49:564-73 pubmed
    ..KIR103 is localized to the KIR genetic region on chromosome 19q13.4. ..
  72. Hofmann M, Drury S, Fu C, Qu W, Taguchi A, Lu Y, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999;97:889-901 pubmed
    ..These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury. ..
  73. Wendt T, Tanji N, Guo J, Kislinger T, Qu W, Lu Y, et al. RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol. 2003;162:1123-37 pubmed
  74. Connelly M, de la Llera Moya M, Peng Y, Drazul Schrader D, Rothblat G, Williams D. Separation of lipid transport functions by mutations in the extracellular domain of scavenger receptor class B, type I. J Biol Chem. 2003;278:25773-82 pubmed
    ..The loss of the cholesterol oxidase-sensitive FC pool and FC efflux to small unilamellar vesicle acceptors in Class 4 mutants suggests that these activities may be mechanistically related. ..
  75. Colovai A, Tsao L, Wang S, Lin H, Wang C, Seki T, et al. Expression of inhibitory receptor ILT3 on neoplastic B cells is associated with lymphoid tissue involvement in chronic lymphocytic leukemia. Cytometry B Clin Cytom. 2007;72:354-62 pubmed
    ..Our findings indicate that expression of ILT3 and ILT4 on CLL B cells represents a phenotypic abnormality that may play a role in tolerization of tumor-specific T cells. ..
  76. Ivashkiv L. Cross-regulation of signaling by ITAM-associated receptors. Nat Immunol. 2009;10:340-7 pubmed publisher
  77. Ip N, Nye S, Boulton T, Davis S, Taga T, Li Y, et al. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell. 1992;69:1121-32 pubmed
    ..Thus, the receptor system for CNTF is surprisingly unlike those used by the nerve growth factor family of neurotrophic factors, but is instead related to those used by a subclass of hematopoietic cytokines. ..
  78. Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen J, et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem. 1995;270:25752-61 pubmed
  79. Borca M, Kutish G, Afonso C, Irusta P, Carrillo C, Brun A, et al. An African swine fever virus gene with similarity to the T-lymphocyte surface antigen CD2 mediates hemadsorption. Virology. 1994;199:463-8 pubmed
    ..The structural and functional similarities of LMW8-DR to CD2, a protein that is involved in cell-cell adhesion and immune response modulation, suggest a possible role in the pathogenesis of ASFV infection. ..
  80. Grumet M. Nr-CAM: a cell adhesion molecule with ligand and receptor functions. Cell Tissue Res. 1997;290:423-8 pubmed
    ..This review summarizes the structure and expression of Nr-CAM and discusses its potential functions as a ligand and as a receptor during neural development. ..
  81. Ji Y, Wang N, Ramakrishnan R, Sehayek E, Huszar D, Breslow J, et al. Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J Biol Chem. 1999;274:33398-402 pubmed
    ..Thus, in the mouse, a major portion of the clearance of HDL FC from plasma is mediated by SR-BI. ..
  82. Peng Y, Akmentin W, Connelly M, Lund Katz S, Phillips M, Williams D. Scavenger receptor BI (SR-BI) clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells and high-density lipoprotein. Mol Biol Cell. 2004;15:384-96 pubmed
    ..We speculate that SR-BI is in a more fluid membrane domain that will favor rapid cholesterol flux between the membrane and HDL. ..
  83. Weiss D, Raupach B, Takeda K, Akira S, Zychlinsky A. Toll-like receptors are temporally involved in host defense. J Immunol. 2004;172:4463-9 pubmed
    ..We propose a model where the sequential activation of TLRs tailors the immune response to different microbes. ..
  84. Parathath S, Sahoo D, Darlington Y, Peng Y, Collins H, Rothblat G, et al. Glycine 420 near the C-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of high density lipoprotein cholesteryl ester. J Biol Chem. 2004;279:24976-85 pubmed
    ..These observations have important implications regarding SR-BI function as related to its structure near the C-terminal transmembrane domain. ..
  85. Park Min K, Ji J, Antoniv T, Reid A, Silver R, Humphrey M, et al. IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression. J Immunol. 2009;183:2444-55 pubmed publisher
    ..The results also yield insights into crosstalk between ITAM-coupled receptors and heterologous receptors such as RANK, and they identify a mechanism by which IL-10 can suppress cellular responses to TNFR family members. ..
  86. Ayello J, van de Ven C, Cairo E, Hochberg J, Baxi L, Satwani P, et al. Characterization of natural killer and natural killer-like T cells derived from ex vivo expanded and activated cord blood mononuclear cells: implications for adoptive cellular immunotherapy. Exp Hematol. 2009;37:1216-29 pubmed publisher
  87. Wang L, Gordon R, Huynh L, Su X, Park Min K, Han J, et al. Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity. 2010;32:518-30 pubmed publisher
    ..These results provide an indirect mechanism of cross-inhibition of TLRs and delineate a signaling pathway important for deactivation of macrophages. ..
  88. Taylor M, Conary J, Lennartz M, Stahl P, Drickamer K. Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. J Biol Chem. 1990;265:12156-62 pubmed
    ..This structure suggests that the receptor may contain multiple ligand-binding domains thus accounting for its tight binding to highly multivalent ligands. ..
  89. Yan S, Chen X, Fu J, Chen M, Zhu H, Roher A, et al. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature. 1996;382:685-91 pubmed
    ..Increased expressing of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death. ..
  90. Chang C, Ciubotariu R, Manavalan J, Yuan J, Colovai A, Piazza F, et al. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol. 2002;3:237-43 pubmed
    ..These findings demonstrate an important mechanism of immune regulation. ..
  91. Yan S, Wu Z, Zhang H, Furtado G, Chen X, Yan S, et al. Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med. 2003;9:287-93 pubmed
    ..These data reinforce the importance of RAGE-ligand interactions in modulating properties of CD4+ T cells that infiltrate the CNS. ..
  92. Tian W, Nunez R, Cheng S, Ding Y, Tumang J, Lyddane C, et al. C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production. Cell Immunol. 2005;234:39-53 pubmed
    ..Our studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo. ..