Experts and Doctors on heart transplantation in California, United States


Locale: California, United States
Topic: heart transplantation

Top Publications

  1. Chin J, Troke J, Kimura N, Itoh S, Wang X, Palmer O, et al. A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection. Yale J Biol Med. 2011;84:423-32 pubmed
    ..Our findings suggest novel therapeutic strategies for minimizing chronic cardiac rejection via the use of metformin- and AMPK-mediated pathways to suppress acute I-R injury. ..
  2. Kutschka I, Kofidis T, Chen I, von Degenfeld G, Zwierzchoniewska M, Hoyt G, et al. Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts. Circulation. 2006;114:I174-80 pubmed
    ..Transduction of mH9c2 cardiomyoblasts with AdCMVhBcl-2 increased graft survival in ischemic rat myocardium without causing malignancies. Both AdCMVhBcl-2/mH9c2 and mH9c2 grafts improved LV function. ..
  3. Kimura N, Nakae S, Itoh S, Merk D, Wang X, Gong Y, et al. Potential role of ?? T cell-derived IL-17 in acute cardiac allograft rejection. Ann Thorac Surg. 2012;94:542-8 pubmed publisher
    ..The ?? T cells promote acute cardiac allograft rejection, presumably by producing IL-17. The ?? T cell depletion may prove beneficial in prolonging allograft survival by suppressing IL-17 production. ..
  4. Ginwalla M, Pando M, Khush K. Pregnancy-related human leukocyte antigen sensitization leading to cardiac allograft vasculopathy and graft failure in a heart transplant recipient: a case report. Transplant Proc. 2013;45:800-2 pubmed publisher
    ..This resulted in acute heart failure and ventricular arrhythmias requiring repeat heart transplantation. ..
  5. Chin C, Chen G, Sequeria F, Berry G, Siehr S, Bernstein D, et al. Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients. J Heart Lung Transplant. 2011;30:158-63 pubmed publisher
    ..Avoiding only the donor antigens that would be recognized by the C1q assay may accelerate time to transplant by expansion of the donor pool and potentially allows transplantation of previously "incompatible" organs. ..
  6. Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, et al. Prevention of transplant coronary artery disease by prenylation inhibitors. J Heart Lung Transplant. 2011;30:761-9 pubmed publisher
    ..FPT and GGPT-2 (inhibition) are the key enzymes in the HGM-CoA reductase pathway and most influential in TCAD prevention. TCAD reduction is most closely related to smooth muscle cell migration, but not its anti-inflammatory properties. ..
  7. Tremmel J, Ng M, Ikeno F, Hunt S, Lee D, Yeung A, et al. Comparison of drug-eluting versus bare metal stents in cardiac allograft vasculopathy. Am J Cardiol. 2011;108:665-8 pubmed publisher
  8. Balsam L, Mokhtari G, Jones S, Peterson S, Hoyt E, Kofidis T, et al. Early inhibition of caspase-3 activity lessens the development of graft coronary artery disease. J Heart Lung Transplant. 2005;24:827-32 pubmed
    ..Early inhibition of caspase-3 activity with cell-permeable DEVD-CHO lessens the development of GCAD. Caspase-3 inhibition may be a useful strategy for prevention of GCAD in clinical transplantation. ..
  9. Kutschka I, Chen I, Kofidis T, von Degenfeld G, Sheikh A, Hendry S, et al. In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts. J Heart Lung Transplant. 2007;26:273-80 pubmed
    ..Optical bioluminescence is a powerful method for assessment of cardiac cell graft survival in vivo. Collagen matrices support early survival of cardiomyoblasts after transplantation into injured musculature. ..

More Information


  1. Kown M, van der Steenhoven T, Jahncke C, Mari C, Lijkwan M, Koransky M, et al. Zinc chloride-mediated reduction of apoptosis as an adjunct immunosuppressive modality in cardiac transplantation. J Heart Lung Transplant. 2002;21:360-5 pubmed
    ..Simultaneous treatment of rat recipients of heterotopic heart transplants with zinc chloride (ZnCl(2)) thus may allow lower doses of CsA for immunosuppression...
  2. Parikh R, Khush K, Luikart H, Pargaonkar V, Kobayashi Y, Lee J, et al. Impact of Asymmetric Dimethylarginine on Coronary Physiology Early After Heart Transplantation. Am J Cardiol. 2017;120:1020-1025 pubmed publisher
    ..In conclusion, baseline ADMA was a strong independent predictor of FFR <0.90, suggesting that elevated ADMA levels are associated with abnormal epicardial function soon after heart transplantation. ..
  3. Chan M, Stalder M, Lam T, Tye T, Borie D, Morris R. Use of echocardiography to assess function of hDAF-transgenic pig cardiac xenografts. Transplant Proc. 2005;37:1923-5 pubmed
    ..Echocardiography has, therefore, the potential to detect and treat early rejection episodes of heterotopic heart xenografts in nonhuman primates. This may help to achieve longer graft survival. ..
  4. Tanaka M, Mokhtari G, Terry R, Gunawan F, Balsam L, Hoyt G, et al. Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. J Heart Lung Transplant. 2005;24:1906-14 pubmed
    ..More important, that prolonged cold ischemia correlates with increased GCAD. ..
  5. Al Khaldi A, Reitz B, Zhu H, Rosenthal D. Heterotopic heart transplant combined with postoperative Sildenafil use for the treatment of restrictive cardiomyopathy. Ann Thorac Surg. 2006;81:1505-7 pubmed
    ..Additional lessons learned from postoperative management, including the novel use of Sildenafil (Viagra, Pfizer, NY) for controlling pulmonary arterial pressure are described. ..
  6. Mainwaring R, Reddy V, Reinhartz O, Petrossian E, MacDonald M, Nasirov T, et al. Anomalous aortic origin of a coronary artery: medium-term results after surgical repair in 50 patients. Ann Thorac Surg. 2011;92:691-7 pubmed publisher
    ..Controversies exist regarding the diagnosis, treatment, and long-term recommendations for patients with AAOCA. The purpose of this study is to evaluate the medium-term results of surgical repair for AAOCA...
  7. Fearon W, Okada K, Kobashigawa J, Kobayashi Y, Luikart H, Sana S, et al. Angiotensin-Converting Enzyme Inhibition Early After Heart Transplantation. J Am Coll Cardiol. 2017;69:2832-2841 pubmed publisher
    ..Angiotensin Converting Enzyme [ACE] Inhibition and Cardiac Allograft Vasculopathy; NCT01078363). ..
  8. van der Starre P, Deuse T, Pritts C, Brun C, Vogel H, Oyer P. Late profound muscle weakness following heart transplantation due to Danon disease. Muscle Nerve. 2013;47:135-7 pubmed publisher
    ..This report underlines the need for early availability of pathology results from the explanted heart, which showed the same disorder. ..
  9. Bernstein D, Williams G, Eisen H, Mital S, Wohlgemuth J, Klingler T, et al. Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients. J Heart Lung Transplant. 2007;26:1270-80 pubmed
    ..The clinical relevance of these data remains to be defined. ..
  10. Kutschka I, Chen I, Kofidis T, Arai T, von Degenfeld G, Sheikh A, et al. Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts. Circulation. 2006;114:I167-73 pubmed
    ..Further optimization of the graft design should make restoration of large myocardial infarctions by tissue engineering approaches effective. ..
  11. Kofidis T, de Bruin J, Hoyt G, Ho Y, Tanaka M, Yamane T, et al. Myocardial restoration with embryonic stem cell bioartificial tissue transplantation. J Heart Lung Transplant. 2005;24:737-44 pubmed
    ..The present study utilizes embryonic stem cells as the substrate of bioartificial myocardial tissue and evaluates engraftment in, and functional recovery of, the recipient heart...
  12. Perlroth M, Miller J. Pseudoallescheria boydii pneumonia and empyema: a rare complication of heart transplantation cured with voriconazole. J Heart Lung Transplant. 2004;23:647-9 pubmed
    ..Pseudoallescheria boydii pneumonia is a rare occurrence, usually resistant to amphotericin B and other anti-fungal agents. We report a complete response to voriconazole in an immunosuppressed host...
  13. Chin C, Hunt S, Robbins R, Hoppe R, Reitz B, Bernstein D. Long-term follow-up after total lymphoid irradiation in pediatric heart transplant recipients. J Heart Lung Transplant. 2002;21:667-73 pubmed
    ..Total lymphoid irradiation is an effective treatment for recurrent rejection and has short- and long-term efficacy. Morbid events may include cancer, graft coronary artery disease, and restrictive cardiomyopathy. ..