Experts and Doctors on guanine nucleotide exchange factors in England, United Kingdom


Locale: England, United Kingdom
Topic: guanine nucleotide exchange factors

Top Publications

  1. Barr F. Review series: Rab GTPases and membrane identity: causal or inconsequential?. J Cell Biol. 2013;202:191-9 pubmed publisher
    ..Such systems can promote the rapid membrane accumulation and removal of Rabs to create time-limited membrane domains with a unique composition, and can explain how Rabs define the identity of vesicle and organelle membranes. ..
  2. Wachten S, Masada N, Ayling L, Ciruela A, Nikolaev V, Lohse M, et al. Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells. J Cell Sci. 2010;123:95-106 pubmed publisher
    ..These findings demonstrate the existence of distinct adenylyl-cyclase-centered cAMP microdomains in live cells and open the door to their molecular micro-dissection. ..
  3. Yoshimura S, Gerondopoulos A, Linford A, Rigden D, Barr F. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. J Cell Biol. 2010;191:367-81 pubmed publisher
    ..DENND1C, DENND3, DENND5A/5B, MTMR5/13, and MADD activate Rab13, Rab12, Rab39, Rab28, and Rab27A/27B, respectively. Together, these findings provide a basis for future studies on Rab regulation and function. ..
  4. Geymonat M, Spanos A, de Bettignies G, Sedgwick S. Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1. J Cell Biol. 2009;187:497-511 pubmed publisher
    ..We observed that lte1 mutants display aberrant localization of the polarity cap, which is the organizer of the actin cytoskeleton. We propose that Lte1's role in cell polarization underlies its contribution to mitotic regulation. ..
  5. Geymonat M, Spanos A, Jensen S, Sedgwick S. Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae. J Cell Biol. 2010;191:1097-112 pubmed publisher
    ..Thus, Lte1 has dual functions for regulation of mitotic progression: it both induces mitotic exit and prevents polarized growth during mitotic arrest, thereby coupling cell cycle progression and morphological development. ..
  6. Christis C, Munro S. The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. J Cell Biol. 2012;196:327-35 pubmed publisher
    ..We show that in mammalian cells, Arl1 is necessary for Golgi recruitment of BIG1 and BIG2 but not GBF1. Thus, Arl1 acts to direct a trans-Golgi-specific Arf1 GEF, and hence active Arf1, to the trans side of the Golgi. ..
  7. Bastos R, PeƱate X, Bates M, Hammond D, Barr F. CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis. J Cell Biol. 2012;198:865-80 pubmed publisher
    ..Based on these findings, we propose that CYK4 GAP activity is required during anaphase to inhibit Rac1-dependent effector pathways associated with control of cell spreading and adhesion. ..
  8. Zihni C, Munro P, Elbediwy A, Keep N, Terry S, Harris J, et al. Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. J Cell Biol. 2014;204:111-27 pubmed publisher
    ..Thus, Dbl3 drives Cdc42 signaling at the apical margin to regulate morphogenesis, apical-lateral border positioning, and apical differentiation. ..
  9. Gerondopoulos A, Bastos R, Yoshimura S, Anderson R, Carpanini S, Aligianis I, et al. Rab18 and a Rab18 GEF complex are required for normal ER structure. J Cell Biol. 2014;205:707-20 pubmed publisher
    ..Micro syndrome is therefore a disease characterized by direct loss of Rab18 function or loss of Rab18 activation at the ER by its GEF Rab3GAP. ..

More Information


  1. Graziano B, Gong D, Anderson K, Pipathsouk A, Goldberg A, Weiner O. A module for Rac temporal signal integration revealed with optogenetics. J Cell Biol. 2017;216:2515-2531 pubmed publisher
    ..This circuit is masked by feedback and redundancy when chemoattractant is used as the input, highlighting the value of probing signaling networks at intermediate nodes to deconvolve complex signaling cascades. ..