Experts and Doctors on glucuronosyltransferase in California, United States


Locale: California, United States
Topic: glucuronosyltransferase

Top Publications

  1. Pratt V, Everts R, Aggarwal P, Beyer B, Broeckel U, EPSTEIN BAAK R, et al. Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project. J Mol Diagn. 2016;18:109-23 pubmed publisher
    ..These publicly available samples will help ensure the accuracy of pharmacogenetic testing. ..
  2. Watanabe K, Yamaguchi Y. Molecular identification of a putative human hyaluronan synthase. J Biol Chem. 1996;271:22945-8 pubmed
    ..These results suggest that the Has2 protein is a crucial component of the human hyaluronan synthase system. ..
  3. Wei G, Bai X, Sarkar A, Esko J. Formation of HNK-1 determinants and the glycosaminoglycan tetrasaccharide linkage region by UDP-GlcUA:Galactose beta1, 3-glucuronosyltransferases. J Biol Chem. 1999;274:7857-64 pubmed
    ..These findings suggest that, in neural tissues, GlcUAT-P may participate in both HNK-1 and glycosaminoglycan production. ..
  4. Yueh M, Huang Y, Hiller A, Chen S, Nguyen N, Tukey R. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 2003;278:15001-6 pubmed
    ..These observations reveal that the Ah receptor is involved in human UGT1A1 induction. ..
  5. Oikawa A, Joshi H, Rennie E, Ebert B, Manisseri C, Heazlewood J, et al. An integrative approach to the identification of Arabidopsis and rice genes involved in xylan and secondary wall development. PLoS ONE. 2010;5:e15481 pubmed publisher
  6. Yueh M, Mellon P, Tukey R. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol. 2011;79:1053-60 pubmed publisher
    ..These results suggest that HNF4? plays an important role in the constitutive expression of hepatic UGT2B7, and CAR acts as a negative regulator by interfering with HNF4? binding activity. ..
  7. Yueh M, Chen S, Nguyen N, Tukey R. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 2014;289:4699-709 pubmed publisher
    ..1%) in hUGT1/Tlr2(-/-) mice was observed when compared with hUGT1 mice (8.7%). These results suggest that TLR2 signaling and microglia neuroinflammation are linked to a repair and/or protection mode against BIND. ..
  8. Ouyang X, Panetta N, Talbott M, Payumo A, Halluin C, Longaker M, et al. Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. PLoS ONE. 2017;12:e0171898 pubmed publisher
    ..Our findings demonstrate a role for HA biosynthesis in zebrafish tail regeneration and delineate its epistatic relationships with other regenerative processes. ..
  9. Fujiwara R, Chen S, Karin M, Tukey R. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-?B leads to hyperbilirubinemia. Gastroenterology. 2012;142:109-118.e2 pubmed publisher
    ..Hyperbilirubinemia can be reduced by activation of pregnane X receptor, constitutive androstane receptor, or nuclear factor-?B. ..

More Information


  1. Rennie E, Hansen S, Baidoo E, Hadi M, Keasling J, Scheller H. Three members of the Arabidopsis glycosyltransferase family 8 are xylan glucuronosyltransferases. Plant Physiol. 2012;159:1408-17 pubmed publisher
    ..We also show that several related proteins, GUX2 to GUX5 and Plant Glycogenin-like Starch Initiation Protein6, are Golgi localized and that only two of these proteins, GUX2 and GUX4, have activity as xylan ?-glucuronosyltransferases. ..
  2. Gesteira T, Sun M, Coulson Thomas Y, Yamaguchi Y, Yeh L, Hascall V, et al. Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation. Invest Ophthalmol Vis Sci. 2017;58:4407-4421 pubmed publisher
    ..Finally, our findings suggest that HA has a major role in maintaining the LSC phenotype. ..