Experts and Doctors on gene expression regulation in New York, United States

Summary

Locale: New York, United States
Topic: gene expression regulation

Top Publications

  1. Don J, Wolgemuth D. Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle. Cell Growth Differ. 1992;3:495-505 pubmed
    ..These results suggest a role for meg1 during germ cell differentiation, possibly during meiotic prophase. ..
  2. Stavenhagen J, Robins D. An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene. Cell. 1988;55:247-54 pubmed
    ..The association of this transposable element with Slp regulation thus provides a long-sought example of an insertional mutation that has been maintained in evolution. ..
  3. Sparrow J, Barnstable C. A gradient molecule in developing rat retina: expression of 9-O-acetyl GD3 in relation to cell type, developmental age, and GD3 ganglioside. J Neurosci Res. 1988;21:398-409 pubmed
    ..abstract truncated at 400 words) ..
  4. Aletta J, Angeletti R, Liem R, Purcell C, Shelanski M, Greene L. Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin). J Neurochem. 1988;51:1317-20 pubmed
    ..Identification of the intermediate filament protein encoded by an NGF-induced message should facilitate studies of its regulation and function. ..
  5. Venkatesh T. Neuronal development in the Drosophila retina. J Neurobiol. 1993;24:740-56 pubmed
    ..Recent genetic and molecular studies have provided important clues regarding the nature of the molecules involved in cellular signalling and neuronal differentiation. ..
  6. Martinek S, Young M. Specific genetic interference with behavioral rhythms in Drosophila by expression of inverted repeats. Genetics. 2000;156:1717-25 pubmed
    ..As an example, we show that inverted-repeat-mediated interference with the period gene produces a hypomorphic period phenotype. A selective decrease of period RNA appears to be a component of the cellular response. ..
  7. Liang C, Tall A. Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver. J Biol Chem. 2001;276:49066-76 pubmed
    ..However, the regulation of genes involved in high density lipoprotein and bile salt metabolism shows complex kinetics and is likely to be mediated by novel transcription factors. ..
  8. Zhu C, Rao K, Xiong H, Gagnidze K, Li F, Horvath C, et al. Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP. J Biol Chem. 2003;278:39372-82 pubmed
    ..Three NFAT domains are required for ICSBP interaction. Finally, in LPS- and IFN-gamma-activated RAW-264.7 cells, the association between NFAT and ICSBP is abrogated by IL-10 priming. ..
  9. Cohen D, Brennwald P, Rodriguez Boulan E, Müsch A. Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol. 2004;164:717-27 pubmed
    ..Our experiments suggest that EMK1 primarily promotes reorganization of the MT network, consistent with the MT-regulating role of this gene product in other systems, which in turn controls lumen formation and position. ..

More Information

Publications471 found, 100 shown here

  1. Nakayama K, Frew I, Hagensen M, Skals M, Habelhah H, Bhoumik A, et al. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell. 2004;117:941-52 pubmed
    ..Thus, the control of PHD1/3 by Siah1a/2 constitutes another level of complexity in the regulation of HIF1alpha during hypoxia. ..
  2. Zhou D, Xue J, Gavrialov O, Haddad G. Na+/H+ exchanger 1 deficiency alters gene expression in mouse brain. Physiol Genomics. 2004;18:331-9 pubmed
  3. Morales M, Theunissen J, Kim C, Kitagawa R, Kastan M, Petrini J. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev. 2005;19:3043-54 pubmed
  4. Kuo T, Shaffer A, Haddad J, Choi Y, Staudt L, Calame K. Repression of BCL-6 is required for the formation of human memory B cells in vitro. J Exp Med. 2007;204:819-30 pubmed
    ..These studies establish new molecular criteria for defining the memory B cell stage in human B cells. ..
  5. Yao J, Taylor M, Davey F, Ren Y, Aiton J, Coote P, et al. Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model. Mol Cell Neurosci. 2007;35:377-82 pubmed
    ..Therefore this indicates the possibility of reversing changes observed in Alzheimer's disease and that the Abeta-ABAD interaction is a suitable drug target. ..
  6. Homma Y, Cao S, Shi X, Ma X. The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation. J Interferon Cytokine Res. 2007;27:799-808 pubmed
  7. Cohen J, Larson J, Killeen E, Love D, Takemaru K. CFTR and Wnt/beta-catenin signaling in lung development. BMC Dev Biol. 2008;8:70 pubmed publisher
    ..These data are consistent with CFTR participating in the mechanicosensory process essential to regulate Wnt/beta-Catenin signaling required for lung organogenesis. ..
  8. Egawa T, Taniuchi I. Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytes. Blood Cells Mol Dis. 2009;43:27-9 pubmed publisher
    ..Recent studies have revealed that a reciprocal antagonistic interplay between Runx3 and ThPOK is a central component in the transcription factor network governing the helper versus cytotoxic-lineage decision. ..
  9. Silva J, von Meyenn F, Howell J, Thorens B, Wolfrum C, Stoffel M. Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature. 2009;462:646-50 pubmed publisher
    ..Our results demonstrate that Foxa2 can act as a metabolic sensor in neurons of the lateral hypothalamic area to integrate metabolic signals, adaptive behaviour and physiological responses. ..
  10. Calixto A, Chelur D, Topalidou I, Chen X, Chalfie M. Enhanced neuronal RNAi in C. elegans using SID-1. Nat Methods. 2010;7:554-9 pubmed publisher
    ..Expression of sid-1(+) from cell-specific promoters in sid-1 mutants results in cell-specific feeding RNAi. We used these strains to identify a role for integrin signaling genes in mechanosensation. ..
  11. Dorado B, Area E, Akman H, Hirano M. Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation. Hum Mol Genet. 2011;20:155-64 pubmed publisher
    ..Understanding the molecular mechanisms that allow Tk2 mutant organs to be spared may help design therapies for Tk2 deficiency. ..
  12. Ouyang W, Liao W, Luo C, Yin N, Huse M, Kim M, et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 2012;491:554-9 pubmed publisher
    ..These findings show that the evolutionarily ancient Akt-Foxo1 signalling module controls a novel genetic program indispensable for T(reg) cell function. ..
  13. Goedeke L, Vales Lara F, Fenstermaker M, Cirera Salinas D, Chamorro Jorganes A, Ramírez C, et al. A regulatory role for microRNA 33* in controlling lipid metabolism gene expression. Mol Cell Biol. 2013;33:2339-52 pubmed publisher
    ..Altogether, these data support a regulatory role for the miRNA* species and suggest that miR-33 regulates lipid metabolism through both arms of the miR-33/miR-33* duplex. ..
  14. Hussey K, Chen H, Yang C, Park E, Hah N, Erdjument Bromage H, et al. The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1. Mol Cell Biol. 2014;34:2437-49 pubmed publisher
    ..MacroH2A1 specifically recruits PELP1 to the promoters of macroH2A1 target genes, but macroH2A1 occupancy occurs independent of PELP1. This recruitment allows macroH2A1 and PELP1 to cooperatively regulate gene expression outcomes. ..
  15. Manohar S, Jamesdaniel S, Ding D, Salvi R, Seigel G, Roth J. Quantitative PCR analysis and protein distribution of drug transporter genes in the rat cochlea. Hear Res. 2016;332:46-54 pubmed publisher
    ..Identification and characterization of these membrane transporters in the inner ear have clinical implications for both therapeutic and cytotoxic mechanisms that may aid in the preservation of auditory function. ..
  16. Sterling M, Chang G, Karatayev O, Chang S, Leibowitz S. Effects of embryonic ethanol exposure at low doses on neuronal development, voluntary ethanol consumption and related behaviors in larval and adult zebrafish: Role of hypothalamic orexigenic peptides. Behav Brain Res. 2016;304:125-38 pubmed publisher
    ..These results, similar to those obtained in rats, suggest that the ethanol-induced increase in genesis and expression of these hypothalamic peptide neurons contribute to the behavioral changes induced by embryonic exposure to ethanol. ..
  17. Ohtsuki M, Tomic Canic M, Freedberg I, Blumenberg M. Regulation of epidermal keratin expression by retinoic acid and thyroid hormone. J Dermatol. 1992;19:774-80 pubmed
    ..Furthermore, our recent results concerning the regulation of K5 and K14 expression by the RA receptor are also shown; these confirm our predictions regarding the location of the RAREs in epidermal keratin genes. ..
  18. Brooks D, Qiu W, Luster A, Ravetch J. Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med. 1989;170:1369-85 pubmed
    ..Expression of these cDNA molecules by transfection results in the appearance of IgG binding molecules that bear the epitopes defined by the FcRII(CD32) mAbs previously described. ..
  19. Blum M, Wong G, Higgins K, Sunshine M, Lacy E. Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. J Exp Med. 1993;177:1343-58 pubmed
  20. Vosshall L, Amrein H, Morozov P, Rzhetsky A, Axel R. A spatial map of olfactory receptor expression in the Drosophila antenna. Cell. 1999;96:725-36 pubmed
    ..The isolation of candidate odorant receptor genes along with a genetic analysis of olfactory-driven behavior in insects may ultimately afford a system to understand the mechanistic link between odor recognition and behavior. ..
  21. Lee E, Trepicchio W, Oestreicher J, Pittman D, Wang F, Chamian F, et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med. 2004;199:125-30 pubmed
    ..Our data suggest that IL-23 is playing a more dominant role than IL-12 in psoriasis, a Th1 type of human inflammatory disease. ..
  22. Lee P, Shabbir A, Cardozo C, Caplan A. Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase. Mol Biol Cell. 2004;15:1785-92 pubmed
    ..These data suggest that Cdc37 and Sti1 have functional overlap in stabilizing Hsp90:client complexes. Finally, we show that Cns1 functions in MAP kinase signaling in association with Cpr7. ..
  23. Chang G, Karatayev O, Davydova Z, Leibowitz S. Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus. Endocrinology. 2004;145:3904-12 pubmed
  24. Peterson J, Burmeister M, Tian X, Zhou Y, Guruju M, Stupinski J, et al. Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II. Hypertension. 2009;54:1106-14 pubmed publisher
  25. Green N, Barral S. Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease. Pediatr Blood Cancer. 2011;56:177-81 pubmed publisher
    ..We review these methods and findings, and speculate on applying pharmaco-genetics to optimize hydroxyurea therapy aimed at increasing HbF. ..
  26. Yadav V, Oury F, Tanaka K, Tanaka K, Thomas T, Wang Y, et al. Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications. J Exp Med. 2011;208:41-52 pubmed publisher
  27. Baquie M, St Onge L, Kerr Conte J, Cobo Vuilleumier N, Lorenzo P, Jimenez Moreno C, et al. The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis. Hum Mol Genet. 2011;20:2823-33 pubmed publisher
    ..We postulate that this effect is mediated through increased glucocorticoid production that blunts the pro-inflammatory response of islets. ..
  28. Suh H, Choi N, Tarassishin L, Lee S. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE. 2012;7:e35115 pubmed publisher
    ..Microglial PGRN appears to function as an endogenous modulator of innate immune responses. ..
  29. Yang J, Liao W, Ma Y. Role of SALL4 in hematopoiesis. Curr Opin Hematol. 2012;19:287-91 pubmed publisher
    ..The emerging knowledge about how SALL4 regulates HSC behavior may be used in the near future to develop advanced cell therapies, for example, through large-scale stem cell expansion ex vivo. ..
  30. de Nooij J, Doobar S, Jessell T. Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets. Neuron. 2013;77:1055-68 pubmed publisher
    ..Our findings support a model in which the specification of aspects of pSN subtype character is controlled by variation in the level of muscle NT3 expression and signaling. ..
  31. Ren H, Lu T, McGraw T, Accili D. Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons. Diabetes. 2015;64:405-17 pubmed publisher
    ..We conclude that Glut4 neurons integrate hormonal and nutritional cues and mediate CNS actions of insulin on energy balance and peripheral metabolism. ..
  32. Cheloufi S, Elling U, Hopfgartner B, Jung Y, Murn J, Ninova M, et al. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 2015;528:218-24 pubmed publisher
  33. Tarafder S, Chen E, Jun Y, Kao K, Sim K, Back J, et al. Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling. FASEB J. 2017;31:3991-3998 pubmed publisher
    ..Tarafder, S., Chen, E., Jun, Y., Kao, K., Sim, K. H., Back, J., Lee, F. Y., Lee, C. H. Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling. ..
  34. Oh H, Grinberg Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, et al. An NF-?B Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. 2017;47:450-465.e5 pubmed publisher
    ..These dual roles of canonical NF-?B in Tconv and Treg cells highlight the functional plasticity of the NF-?B signaling pathway and underscores the need for more selective strategies to therapeutically target NF-?B. ..
  35. Kang K, Lawrence B, Gao X, Luo Y, Zhou Q, Liu A, et al. Micro- and Nanoscale Topographies on Silk Regulate Gene Expression of Human Corneal Epithelial Cells. Invest Ophthalmol Vis Sci. 2017;58:6388-6398 pubmed publisher
  36. Colbert M, Ciejek Baez E. The proximal promoter of the aldolase A gene remains active during myogenesis in vitro and muscle development in vivo. Dev Biol. 1992;149:66-79 pubmed
    ..Furthermore, the M promoter shows no fiber-type restriction until 1 to 3 weeks postnatally, coincident with muscle maturation, while the H promoter remains transcriptionally active at all stages of development and in all fiber types. ..
  37. Mendelsohn C, Wimmer E, Racaniello V. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell. 1989;56:855-65 pubmed
  38. Sehgal A, Price J, Man B, Young M. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science. 1994;263:1603-6 pubmed
    ..Genetic mapping places tim on the left arm of the second chromosome between dumpy (dp) and decapentaplegic (dpp). ..
  39. Kaang B, Kandel E, Grant S. Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron. 1993;10:427-35 pubmed
    ..These data provide direct evidence for CREB-modulated transcriptional activation with long-term facilitation. ..
  40. Colgan J, Wampler S, Manley J. Interaction between a transcriptional activator and transcription factor IIB in vivo. Nature. 1993;362:549-53 pubmed
    ..Here we show that the activity of the glutamine-rich fushi tarazu activation domain is indeed blocked by truncated TFIIB derivatives in Drosophila Schneider L2 cells, suggesting that it is mediated by interactions with TFIIB. ..
  41. Lamprecht S, Lipkin M. Cellular mechanisms of calcium and vitamin D in the inhibition of colorectal carcinogenesis. Ann N Y Acad Sci. 2001;952:73-87 pubmed
    ..These consist of complex series of signaling events induced by the chemopreventive agents acting at various tiers of colonic cell organization. ..
  42. Jarriault S, Greenwald I. Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Genes Dev. 2002;16:2713-28 pubmed
  43. Ryu E, Harding H, Angelastro J, Vitolo O, Ron D, Greene L. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci. 2002;22:10690-8 pubmed
    ..Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease. ..
  44. Hedvat C, Yao J, Sokolic R, Nimer S. Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells. J Biol Chem. 2004;279:6395-400 pubmed
    ..These data demonstrates that MEF is an important regulator of IL-8 expression. ..
  45. Yang Y, Ochando J, Yopp A, Bromberg J, Ding Y. IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation. J Immunol. 2005;174:2720-9 pubmed
    ..Our findings suggest that IL-6 plays a unique role in initiating c-Maf expression after TCR engagement, and may subsequently regulate early IL-4 production and Th2 commitment. ..
  46. Wang J, Liu Y, Hande M, Wong A, Jin Y, Yin Y. TAp73 is a downstream target of p53 in controlling the cellular defense against stress. J Biol Chem. 2007;282:29152-62 pubmed
    ..Our data reveal a new pathway for cellular protection against oxidative damage and provide evidence that TAp73 is a stress-response gene and a downstream effector in the p53 pathway. ..
  47. Ries V, Silva R, Oo T, Cheng H, Rzhetskaya M, Kholodilov N, et al. JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. J Neurochem. 2008;107:1578-88 pubmed publisher
  48. Nadler E, Li X, Onyedika E, Greco M. Differential expression of hepatic fibrosis mediators in sick and spontaneously recovered mice with experimental biliary atresia. J Surg Res. 2010;159:611-7 pubmed publisher
    ..These data further support the notion that inhibition of ECM breakdown alone is sufficient to induce hepatic fibrosis. Modulation of this process may be a putative target for preventing liver injury in patients with BA. ..
  49. Wolfrum S, Rodriguez J, Tan M, Chen K, Teupser D, Breslow J. The mouse atherosclerosis locus at chromosome 10 (Ath11) acts early in lesion formation with subcongenic strains delineating 2 narrowed regions. Arterioscler Thromb Vasc Biol. 2010;30:1583-90 pubmed publisher
    ..This quantitative trait locus is genetically complex, containing a female-specific region 10a from 0 to 7.3 megabases (21 genes) and a gender-independent region 10b from 20.1 to 21.9 megabases (7 genes). ..
  50. Avagyan S, Aguilo F, Kamezaki K, Snoeck H. Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-?2 and FLT3 in hematopoiesis. Blood. 2011;118:6078-86 pubmed publisher
    ..We furthermore show that PPAR? agonists play a FLT3-dependent role in stress responses of progenitor cells. These observations identify a novel regulatory axis that includes PPARs, Prdm16, and TGF-?2 in hematopoiesis. ..
  51. Sawai C, Sisirak V, Ghosh H, Hou E, Ceribelli M, Staudt L, et al. Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells. J Exp Med. 2013;210:2151-9 pubmed publisher
    ..Thus, Runx2 is required for the emergence of mature BM pDCs into the periphery, in a process that is partially dependent on Ccr5. These results establish Runx2 as a lineage-specific regulator of immune system development. ..
  52. Sahu S, Williams L, Perez A, Philip F, Caso G, Zurawsky W, et al. Regulation of the activity of the promoter of RNA-induced silencing, C3PO. Protein Sci. 2017;26:1807-1818 pubmed publisher
    ..Taken together, this study allows predictions of the genes whose post-transcriptional regulation is responsive to the G protein/phospholipase C?/calcium signaling pathway. ..
  53. Heller D, Gianola K, Leinwand L. A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988;8:2797-803 pubmed
    ..This gene shows extremely high sequence conservation, extending to chicken, amphibian, and nematode genomes. Surprisingly, the gene appears to exist in only one copy in these organisms. ..
  54. Stoffel M, Duncan S. The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism. Proc Natl Acad Sci U S A. 1997;94:13209-14 pubmed
    ..These data provide direct evidence that HNF4alpha is critical for regulating glucose transport and glycolysis and in doing so is crucial for maintaining glucose homeostasis. ..
  55. Harding H, Novoa I, Bertolotti A, Zeng H, Zhang Y, Urano F, et al. Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum. Cold Spring Harb Symp Quant Biol. 2001;66:499-508 pubmed
  56. Pineda Torra I, Freedman L, Garabedian M. Identification of DRIP205 as a coactivator for the Farnesoid X receptor. J Biol Chem. 2004;279:36184-91 pubmed
    ..Together, these results demonstrate that DRIP205 acts as a bona fide coactivator of FXR and underscore the importance of DRIP205 in modulating the bile acid response of FXR target genes. ..
  57. Wu L, Belasco J. Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs. Mol Cell. 2008;29:1-7 pubmed publisher
    ..Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved. ..
  58. Hao S, Zhao H, Darzynkiewicz Z, Battula S, Ferreri N. Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells. Am J Physiol Renal Physiol. 2011;300:F966-75 pubmed publisher
    ..These findings suggest that NKCC2A and NKCC2F exhibit differential effects on NFAT5 expression and transcriptional activity in response to hypertonicity produced by high NaCl concentration. ..
  59. Di Giammartino D, Nishida K, Manley J. Mechanisms and consequences of alternative polyadenylation. Mol Cell. 2011;43:853-66 pubmed publisher
    ..The mechanisms governing both global and gene-specific APA are only starting to be deciphered. Here we review what is known about these mechanisms and the functional consequences of alternative polyadenylation. ..
  60. Galfalvy H, Zalsman G, Huang Y, Murphy L, Rosoklija G, Dwork A, et al. A pilot genome wide association and gene expression array study of suicide with and without major depression. World J Biol Psychiatry. 2013;14:574-82 pubmed publisher
    ..Results highlight a role for neuroimmunological effects in suicidal behaviour. ..
  61. González Sancho J, Greer Y, Abrahams C, Takigawa Y, Baljinnyam B, Lee K, et al. Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem. 2013;288:9428-37 pubmed publisher
    ..Our results indicate that phosphorylation at the WIP sites reduces Dvl accumulation in puncta and attenuates ?-catenin signaling, whereas it enables noncanonical signaling that is required for neurite outgrowth. ..
  62. Zhang J, Hashmi S, Cheema F, Al Nasser N, Bakheet R, Parhar R, et al. Regulation of lipoprotein assembly, secretion and fatty acid ?-oxidation by Krüppel-like transcription factor, klf-3. J Mol Biol. 2013;425:2641-55 pubmed publisher
    ..Genetic interactions between klf-3 and dsc-4, as well as vit-5 genes, suggest that klf-3 may have an important role in regulating lipid assembly and secretion. ..
  63. Cohen D, Piekarz R, Hsu S, DePinho R, Carrasco N, Horwitz S. Structural and functional analysis of the mouse mdr1b gene promoter. J Biol Chem. 1991;266:2239-44 pubmed
    ..The studies indicate the presence of cis-acting elements in the 5'-flanking region of the mdr1b gene. The implications of these findings for expression and regulation of the mdr1b gene are discussed. ..
  64. Seykora J, Ravetch J, Aderem A. Cloning and molecular characterization of the murine macrophage "68-kDa" protein kinase C substrate and its regulation by bacterial lipopolysaccharide. Proc Natl Acad Sci U S A. 1991;88:2505-9 pubmed
    ..Multiple MARCKS transcripts were observed and could be accounted for by differential polyadenylylation and incomplete processing. Genomic Southern blot analysis suggested a single MARCKS gene per haploid genome. ..
  65. Warrior R, Levine M. Dose-dependent regulation of pair-rule stripes by gap proteins and the initiation of segment polarity. Development. 1990;110:759-67 pubmed
    ..We propose that the relative placement of the eve and hairy stripes may be an important factor in the initiation of segment polarity. ..
  66. Li W, Ohlmeyer J, Lane M, Kalderon D. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell. 1995;80:553-62 pubmed
    ..PKA therefore appears to be an integral component of the mechanism by which hh regulates the expression of key patterning molecules in imaginal discs. ..
  67. Ge H, Roeder R. The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein. J Biol Chem. 1994;269:17136-40 pubmed
  68. Siu G, Wurster A, Duncan D, Soliman T, Hedrick S. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 1994;13:3570-9 pubmed
  69. Issack P, Ziff E. Genetic elements regulating HES-1 induction in Wnt-1-transformed PC12 cells. Cell Growth Differ. 1998;9:827-36 pubmed
    ..One element binds Wnt-1-induced protein complexes in a sequence-specific manner. Identification of Wnt-1 responsive elements in potential target genes may provide clues to nuclear pathways regulated by Wnt-1. ..
  70. Mani S, Besharse J, Knox B. Immediate upstream sequence of arrestin directs rod-specific expression in Xenopus. J Biol Chem. 1999;274:15590-7 pubmed
    ..These results suggest that the Crx and Nrl binding sites in the proximal promoter are the primary cis-acting sequences regulating arrestin gene expression in rods. ..
  71. O Neill D, Schoetz S, Lopez R, Castle M, Rabinowitz L, Shor E, et al. An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol Cell Biol. 2000;20:7572-82 pubmed
    ..At the time of the switch from fetal to adult globin production, the PYR complex is assembled and may function to repress gamma-globin gene expression and facilitate gamma- to beta-globin switching. ..
  72. Eichinger D. Encystation in parasitic protozoa. Curr Opin Microbiol. 2001;4:421-6 pubmed
  73. Niu H, Cattoretti G, Dalla Favera R. BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells. J Exp Med. 2003;198:211-21 pubmed
    ..In addition, these findings imply that T-B cell interactions may be disrupted in B cell lymphoma expressing deregulated BCL6 genes. ..
  74. Blagden C, Fromm L, Burden S. Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87. Mol Cell Biol. 2004;24:1983-9 pubmed
  75. Chaudhry H, Dashoush N, Tang H, Zhang L, Wang X, Wu E, et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem. 2004;279:35858-66 pubmed
    ..These results reveal a previously unrecognized critical role for cyclin A2 in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium. ..
  76. Colby G, Sung Y, Ambron R. mRNAs encoding the Aplysia homologues of fasciclin-I and beta-thymosin are expressed only in the second phase of nerve injury and are differentially segregated in axons regenerating in vitro and in vivo. J Neurosci Res. 2005;82:484-98 pubmed
    ..However, only the mRNA for apbetaT was present in regenerating axons in vivo. This implies that the membrane protein apFasP is supplied by rapid transport from the soma, whereas the soluble apbetaT is synthesized locally. ..
  77. Su Z, Sarkar D, Emdad L, Barral P, Fisher P. Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression. J Cell Physiol. 2007;213:502-10 pubmed
    ..IRF-1 is a tumor suppressor and the expression profile of RIG-I together with its regulation by IRF-1 and the presence of a caspase-recruitment domain in RIG-I suggest that RIG-I might also possess tumor suppressor properties. ..
  78. Nwachukwu J, Li W, Pineda Torra I, Huang H, Ruoff R, Shapiro E, et al. Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27. Mol Endocrinol. 2007;21:2864-76 pubmed
  79. Voutev R, Hubbard E. A "FLP-Out" system for controlled gene expression in Caenorhabditis elegans. Genetics. 2008;180:103-19 pubmed publisher
    ..Finally, we introduce a set of traditional and Gateway-compatible vectors to facilitate construction of plasmids for this technology using any promoter, reporter, and gene/hairpin of interest. ..
  80. Ho H, Antoniv T, Ji J, Ivashkiv L. Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1. J Immunol. 2008;181:5089-97 pubmed
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