Experts and Doctors on g protein coupled receptors in Pennsylvania, United States


Locale: Pennsylvania, United States
Topic: g protein coupled receptors

Top Publications

  1. Ferrer M, Kolodin G, Zuck P, Peltier R, Berry K, Mandala S, et al. A fully automated [35S]GTPgammaS scintillation proximity assay for the high-throughput screening of Gi-linked G protein-coupled receptors. Assay Drug Dev Technol. 2003;1:261-73 pubmed
    ..Here we compare [(35)S]GTPgammaS scintillation proximity binding assays for two different G(i)-coupled GPCRs, and describe their implementation with automated high-throughput systems. ..
  2. Lawson E, Luci D, Ghosh S, Kinney W, Reynolds C, Qi J, et al. Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem. 2009;52:7432-45 pubmed publisher
    ..A discussion of U-II receptor antagonist pharmacophores is presented, and a specifically defined model is suggested from tricycle 13, which has a high degree of conformational constraint. ..
  3. Cox C, Breslin M, Whitman D, Schreier J, McGaughey G, Bogusky M, et al. Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia. J Med Chem. 2010;53:5320-32 pubmed publisher
  4. Kennerdell J, Carthew R. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell. 1998;95:1017-26 pubmed
    ..Our results demonstrate that dsRNA interference can be used to analyze many aspects of gene function. ..
  5. Clements M, McDonald T, Wang R, Xie G, O Dowd B, George S, et al. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun. 2001;284:1189-93 pubmed
    ..Northern analysis of human GPR54 detected expression in several peripheral tissues and many regions of the central nervous system. ..
  6. Athanasiadis A, Rich A, Maas S. Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol. 2004;2:e391 pubmed
    ..The analysis suggests that modification of repetitive elements is a predominant activity for RNA editing with significant implications for cellular gene expression. ..
  7. Xin H, Wang Y, Todd M, Qi J, Minor L. Evaluation of no-wash calcium assay kits: enabling tools for calcium mobilization. J Biomol Screen. 2007;12:705-14 pubmed
  8. Rominger C, Bee W, Copeland R, Davenport E, Gilmartin A, Gontarek R, et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther. 2009;329:995-1005 pubmed publisher
    ..Our mechanism of action characterization of radioligand binding to Smo combined with functional data provides a better understanding of small-molecule interactions with Smo and their influence on the Hh pathway...
  9. Zhang G, Chen T, Connolly B, Lin S, Hargreaves R, Vanko A, et al. In vivo optical imaging of LacZ expression using lacZ transgenic mice. Assay Drug Dev Technol. 2009;7:391-9 pubmed publisher
    ..Thus, this technology can potentially be used to noninvasively image changes of certain endogenous molecules and/or molecular pathways in transgenic animals. ..

More Information


  1. Dunbar R, Gelfand J. Seeing red: flushing out instigators of niacin-associated skin toxicity. J Clin Invest. 2010;120:2651-5 pubmed publisher
    ..These efforts bring us one step closer to solving a key limitation of an important cardioprotective drug and reveal that the skin response to niacin is much more complicated than previously thought...