Genomes and Genes
Experts and Doctors on environmental pollutants in New York, United States
Locale: New York, United States
Topic: environmental pollutants
- Le Moal J, Sharpe R, Jϕrgensen N, Levine H, Jurewicz J, Mendiola J, et al. Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure. Eur J Public Health. 2016;26:76-83 pubmed publisher..Our work can serve as a basis to construct, as soon as possible, the first multi-country reproductive monitoring system. ..
- Chen H, Costa M. Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009;22:191-6 pubmed publisher..Future studies on nickel's effects on these iron- and 2-oxoglutarate-dependent dioxygenases would deepen our understanding on nickel toxicity and carcinogenicity. ..
- Farzan S, Chen Y, Trachtman H, Trasande L. Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003-2008. Environ Res. 2016;144:149-157 pubmed publisher..Prospective work is needed to investigate the potential long-term health consequences of these findings. ..
- Berkowitz G, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, et al. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environ Health Perspect. 2003;111:79-84 pubmed..These data underscore the need to assess the potentially adverse effects of pesticide exposure on fetuses and infants and the importance of finding alternative methods for pest management to reduce pesticide exposures. ..
- Wolff M, Engel S, Berkowitz G, Ye X, Silva M, Zhu C, et al. Prenatal phenol and phthalate exposures and birth outcomes. Environ Health Perspect. 2008;116:1092-7 pubmed publisher..In addition, positive associations of urinary metabolites with some outcomes may be attributable partly to unresolved confounding with maternal anthropometric factors. ..
- Sutherland J, Costa M. Epigenetics and the environment. Ann N Y Acad Sci. 2003;983:151-60 pubmed
- Perera F, Rauh V, Whyatt R, Tang D, Tsai W, Bernert J, et al. A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures. Neurotoxicology. 2005;26:573-87 pubmed..05). These results underscore the importance of policies that reduce exposure to ETS, air pollution, and pesticides with potentially adverse effects on fetal growth and child neurodevelopment. ..
- Partridge M, Huang S, Kibriya M, Ahsan H, Davidson M, Hei T. Environmental mutagens induced transversions but not transitions in regulatory region of mitochondrial DNA. J Toxicol Environ Health A. 2009;72:301-4 pubmed publisher..Data suggest that only a change in the number of rare transversions would be indicative of an increase in point mutations in mtDNA after exposure to mutagens. ..
- Gallagher C, Moonga B, Kovach J. Cadmium, follicle-stimulating hormone, and effects on bone in women age 42-60 years, NHANES III. Environ Res. 2010;110:105-11 pubmed publisher..78; 95% CI=1.43, 5.42; p< or =0.01). Long-term cadmium exposure at environmental levels is associated with increased serum FSH, and both FSH and UCd are associated with bone loss, in US women aged 42-60 years. ..
- White A, Chen J, Teitelbaum S, McCullough L, Xu X, Hee Cho Y, et al. Sources of polycyclic aromatic hydrocarbons are associated with gene-specific promoter methylation in women with breast cancer. Environ Res. 2016;145:93-100 pubmed publisher..Methylation may be a potential biologic mechanism for the associations between PAHs and breast cancer incidence. ..
- Donohue K, Miller R, Perzanowski M, Just A, Hoepner L, Arunajadai S, et al. Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children. J Allergy Clin Immunol. 2013;131:736-42 pubmed publisher..5 [95% CI, 1.1-2.0], P = .005; OR, 1.4 [95% CI, 1.0-1.9], P = .03; and OR, 1.5 [95% CI, 1.0-2.1], P = .04, respectively). This is the first report of an association between postnatal urinary BPA concentrations and asthma in children. ..
- Alur S, Wang H, Hoeger K, Swan S, Sathyanarayana S, Redmon B, et al. Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology. Fertil Steril. 2015;104:1227-35 pubmed publisher..Further research is needed to explore whether those pursuing fertility treatments take precautions to avoid exposure to environmental toxins, to improve treatment outcomes. ..
- Rodrigues E, Bellinger D, Valeri L, Hasan M, Quamruzzaman Q, Golam M, et al. Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health. 2016;15:44 pubmed publisher..In the setting of lower lead levels, the adverse effects of arsenic and manganese on neurodevelopment are observed. ..
- Myers J, Antoniou M, Blumberg B, Carroll L, Colborn T, Everett L, et al. Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement. Environ Health. 2016;15:19 pubmed publisher..S. National Toxicology Program, as well as for biomonitoring as conducted by the U.S. Centers for Disease Control and Prevention. ..
- Goncharov A, Pavuk M, Foushee H, Carpenter D. Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticides. Environ Health Perspect. 2011;119:319-25 pubmed publisher..In this cross-sectional study, serum concentrations of PCBs, especially those congeners with multiple ortho chlorines, were strongly associated with both systolic and diastolic blood pressure. ..
- Valeri L, Mazumdar M, Bobb J, Claus Henn B, Rodrigues E, Sharif O, et al. The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh. Environ Health Perspect. 2017;125:067015 pubmed publisher..Exposure to chemical mixtures is recognized as the real-life scenario in all populations, needing new statistical methods that can assess their complex effects...
- Wolff M, Britton J, Teitelbaum S, Eng S, Deych E, Ireland K, et al. Improving organochlorine biomarker models for cancer research. Cancer Epidemiol Biomarkers Prev. 2005;14:2224-36 pubmed..e., PCB) or long discontinued (i.e., DDE). ..
- Siu E, Mruk D, Porto C, Cheng C. Cadmium-induced testicular injury. Toxicol Appl Pharmacol. 2009;238:240-9 pubmed publisher..Furthermore, some of the recent studies have shed lights on potential therapeutic or preventive approaches that can be developed in future studies by blocking or minimizing the destructive effects of Cd to testicular function in men...
- Bettez N, Groffman P. Nitrogen deposition in and near an urban ecosystem. Environ Sci Technol. 2013;47:6047-51 pubmed publisher..Moreover, this deposition is not being measured by the current deposition monitoring networks that were designed to measure broader regional patterns causing an underestimation of N inputs in urban areas...
- Zheng L, Sanders A, Saland J, Wright R, Arora M. Environmental exposures and pediatric kidney function and disease: A systematic review. Environ Res. 2017;158:625-648 pubmed publisher..There is a need for well-designed epidemiologic studies of environmental chemical exposures and kidney disease outcomes. ..
- Perera F, Hemminki K, Jedrychowski W, Whyatt R, Campbell U, Hsu Y, et al. In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. Cancer Epidemiol Biomarkers Prev. 2002;11:1134-7 pubmed..These results provide the first demonstration of a molecular link between somatic mutation in the newborn and transplacental exposure to common air pollutants, a finding that is relevant to cancer risk assessment. ..
- Wu S, Hivert M, Cardenas A, Zhong J, Rifas Shiman S, Agha G, et al. Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study. Environ Health Perspect. 2017;125:087019 pubmed publisher..DNA methylation may be one of the underlying mechanisms for the adverse effects of prenatal lead on the offspring, but epigenome-wide methylation data for low levels of prenatal lead exposure are lacking...
- Kezios K, Liu X, Cirillio P, Kalantzi O, Wang Y, Petreas M, et al. Prenatal polychlorinated biphenyl exposure is associated with decreased gestational length but not birth weight: archived samples from the Child Health and Development Studies pregnancy cohort. Environ Health. 2012;11:49 pubmed publisher..Previous studies are inconsistent regarding prenatal exposure to PCBs and pregnancy outcomes. We investigated associations between prenatal exposure to PCBs and gestational length and birth weight...
- Howard P, Muir D. Identifying new persistent and bioaccumulative organics among chemicals in commerce II: pharmaceuticals. Environ Sci Technol. 2011;45:6938-46 pubmed publisher..Of the non-HPV compounds, 364 pharmaceuticals were identified that were P&B. This study has yielded some interesting and probable P&B pharmaceuticals that should be considered for further study. ..
- Silkworth J, Carlson E, McCulloch C, Illouz K, Goodwin S, Sutter T. Toxicogenomic analysis of gender, chemical, and dose effects in livers of TCDD- or aroclor 1254-exposed rats using a multifactor linear model. Toxicol Sci. 2008;102:291-309 pubmed publisher..This study extends the findings of previous rodent bioassays by identifying groups of genes, other than the well-characterized AHR response genes, whose disruption may be important in the tumorigenic mechanism in this rat strain. ..
- Wassenaar P, Trasande L, Legler J. Systematic Review and Meta-Analysis of Early-Life Exposure to Bisphenol A and Obesity-Related Outcomes in Rodents. Environ Health Perspect. 2017;125:106001 pubmed publisher..Early-life exposure to bisphenol A (BPA) has been implicated to play a role in the development of obesity...
- Xiao X, Cheng C, Mruk D. Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat. J Endocrinol. 2013;216:73-86 pubmed publisher..Taken collectively, these results illustrate that ICAM2 plays an important role in apical ES dynamics during spermatogenesis. ..
- Bashash M, Thomas D, Hu H, Angeles Martinez Mier E, Sanchez B, Basu N, et al. Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico. Environ Health Perspect. 2017;125:097017 pubmed publisher..Few of the epidemiologic studies have been longitudinal, had individual measures of fluoride exposure, addressed the impact of prenatal exposures or involved more than 100 participants...
- Cardenas A, Rifas Shiman S, Godderis L, Duca R, Navas Acien A, Litonjua A, et al. Prenatal Exposure to Mercury: Associations with Global DNA Methylation and Hydroxymethylation in Cord Blood and in Childhood. Environ Health Perspect. 2017;125:087022 pubmed publisher..To date, no studies have evaluated the association between prenatal mercury exposure and DNA hydroxymethylation, an epigenetic modification important for tissue differentiation and embryonic development...
- Gore A, Wu T, Oung T, Lee J, Woller M. A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone neurones. J Neuroendocrinol. 2002;14:814-23 pubmed..These results demonstrate a novel mechanism for effects of the two PCBs directly on GnRH gene expression, and indicate a hypothalamic level for endocrine disruption by these environmental toxicants. ..
- Wolff M, Engel S, Berkowitz G, Teitelbaum S, Siskind J, Barr D, et al. Prenatal pesticide and PCB exposures and birth outcomes. Pediatr Res. 2007;61:243-50 pubmed..In summary, we found suggestive relationships between prenatal environmental biomarkers and birth outcomes in this population. Maternal susceptibility factors including PON1 and maternal weight contributed to the observed effects. ..
- Lederman S, Jones R, Caldwell K, Rauh V, Sheets S, Tang D, et al. Relation between cord blood mercury levels and early child development in a World Trade Center cohort. Environ Health Perspect. 2008;116:1085-91 pubmed publisher..Higher cord blood mercury was associated with reductions in developmental scores at 36 and 48 months, after adjusting for the positive effects of fish/seafood consumption during pregnancy. ..
- Smith S. Chiral toxicology: it's the same thing...only different. Toxicol Sci. 2009;110:4-30 pubmed publisher..quot; ..
- Goncharov A, Bloom M, Pavuk M, Birman I, Carpenter D. Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama. J Hypertens. 2010;28:2053-60 pubmed publisher..The strength of the relationships between PCB exposure and both hypertension and blood pressure suggests that PCB exposure may be an important contributing factor in regulation of blood pressure. ..
- Stein C, Wolff M, Calafat A, Kato K, Engel S. Comparison of polyfluoroalkyl compound concentrations in maternal serum and amniotic fluid: a pilot study. Reprod Toxicol. 2012;34:312-6 pubmed publisher..5 ng/mL whereas PFOS was rarely detected in amniotic fluid until the serum concentration was about 5.5 ng/mL. No PFCs were detected in urine...
- Arora M, Austin C. Teeth as a biomarker of past chemical exposure. Curr Opin Pediatr. 2013;25:261-7 pubmed publisher..Such a retrospective biomarker that precisely measures exposure intensity and timing during prenatal development would substantially aid epidemiologic investigations, particularly case-control studies of rare health outcomes. ..
- Wang S, Zheng T, Chanock S, Jedrychowski W, Perera F. Methods for detecting interactions between genetic polymorphisms and prenatal environment exposure with a mother-child design. Genet Epidemiol. 2010;34:125-32 pubmed publisher..The application on a real mother-child pair data from a study conducted in Krakow, Poland, suggested four significant gene-environment interactions after multiple comparisons adjustment. ..
- Wang S, Chanock S, Tang D, Li Z, Edwards S, Jedrychowski W, et al. Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns. Ann Hum Genet. 2010;74:46-56 pubmed publisher..The strongest and most consistent effect observed was between PAH and haplotype ACCGGC of the CYP1B1 gene. ..
- Kekatpure V, Dannenberg A, Subbaramaiah K. HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J Biol Chem. 2009;284:7436-45 pubmed publisher..Given the established link between activation of AhR signaling and xenobiotic metabolism, inhibitors of HDAC6 may alter drug or carcinogen metabolism. ..
- Lujambio A, Villanueva A. The usual SASPects of liver cancer. Aging (Albany NY). 2015;7:348-9 pubmed
- He Y, Zheng Y. Assessment of in vivo bioaccessibility of arsenic in dietary rice by a mass balance approach. Sci Total Environ. 2010;408:1430-6 pubmed publisher..Mass balance established during a controlled dietary experiment over 10 days is shown to be a useful approach to evaluate in vivo bioaccessibility and metabolism of arsenic uptake from diet and is applicable to study with more subjects. ..
- Yang L, Li X, Crusius J, Jans U, Melcer M, Zhang P. Persistent chlordane concentrations in Long Island Sound sediment: implications from chlordane, 210Pb, and 137Cs profiles. Environ Sci Technol. 2007;41:7723-9 pubmed..S. Continued chlordane input and significant sediment mixing may have contributed to the persistent chlordane concentrations in surficial sediment, which poses long-term threats to benthic organisms in LIS. ..
- Chen Q, Garabrant D, Hedgeman E, Little R, Elliott M, Gillespie B, et al. Estimation of background serum 2,3,7,8-TCDD concentrations by using quantile regression in the UMDES and NHANES populations. Epidemiology. 2010;21 Suppl 4:S51-7 pubmed publisher..The methods and results discussed in this article have wide application in studies of the concentrations of chemicals in human serum and in environmental samples. ..
- Arenas I, Navas Acien A, Ergui I, Lamas G. Enhanced vasculotoxic metal excretion in post-myocardial infarction patients following a single edetate disodium-based infusion. Environ Res. 2017;158:443-449 pubmed publisher..Edetate disodium-based infusions markedly enhanced the urinary excretion of lead and cadmium, toxic metals with established epidemiologic evidence and mechanisms linking them to coronary and vascular events. ..
- Stellman J, Stellman S, Christian R, Weber T, Tomasallo C. The extent and patterns of usage of Agent Orange and other herbicides in Vietnam. Nature. 2003;422:681-7 pubmed..Our identification of specific military herbicide targets has led to a more coherent understanding of spraying. Common errors in earlier interpretations of the spray data are also discussed. ..
- Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, et al. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health. 2017;16:81 pubmed publisher..Our findings suggest that certain genetic polymorphisms within/near genes relevant to neurodevelopment might modify the toxic effects of Pb exposure via oxidative stress. ..
- Chiu Y, Claus Henn B, Hsu H, Pendo M, Coull B, Austin C, et al. Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents. Environ Res. 2017;159:458-465 pubmed publisher..The sex-specific associations might be strongest with measures of whole body stability, for which the critical exposure window was during the prenatal period. ..
- Aronson D, Weeks J, Meylan B, Guiney P, Howard P. Environmental release, environmental concentrations, and ecological risk of N,N-Diethyl-m-toluamide (DEET). Integr Environ Assess Manag. 2012;8:135-66 pubmed publisher..The ecological risk of DEET usage is evaluated by examining the relationship of the expected dose/response to observed concentrations...