Genomes and Genes
Experts and Doctors on enteric nervous system in New York, United States
Locale: New York, United States
Topic: enteric nervous system
- Poole D, Pelayo J, Scherrer G, Evans C, Kieffer B, Bunnett N. Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice. Gastroenterology. 2011;141:982-991.e18 pubmed publisher..Sustained down-regulation of DOReGFP at the plasma membrane of activated neurons could induce long-lasting tolerance to DOR agonists. ..
- Gershon A, Chen J, Gershon M. A model of lytic, latent, and reactivating varicella-zoster virus infections in isolated enteric neurons. J Infect Dis. 2008;197 Suppl 2:S61-5 pubmed publisher..This in vitro model should facilitate further understanding of latency and reactivation of VZV. ..
- Gershon M, Liu M. Serotonin and neuroprotection in functional bowel disorders. Neurogastroenterol Motil. 2007;19 Suppl 2:19-24 pubmed
- Stallings C, Duigou G, Gershon A, Gershon M, Silverstein S. The cellular localization pattern of Varicella-Zoster virus ORF29p is influenced by proteasome-mediated degradation. J Virol. 2006;80:1497-512 pubmed publisher..Although proteasome inhibition induces ORF29p nuclear accumulation, this is not sufficient to reactivate latent VZV or target the immediate-early protein ORF62p to the nucleus in cultured guinea pig enteric neurons...
- Liu M, Kuan Y, Wang J, Hen R, Gershon M. 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci. 2009;29:9683-99 pubmed publisher..This is the first demonstration of adult enteric neurogenesis; our results suggest that 5-HT(4) receptors are required postnatally for ENS growth and maintenance. ..
- Rao M, Rastelli D, Dong L, Chiu S, Setlik W, Gershon M, et al. Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice. Gastroenterology. 2017;153:1068-1081.e7 pubmed publisher..Contrary to widespread notions, enteric glia are therefore not required for epithelial homeostasis. However, they regulate intestinal motility in a sex-dependent manner. ..
- D Autréaux F, Morikawa Y, Cserjesi P, Gershon M. Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia. Development. 2007;134:2237-49 pubmed..We suggest that enteric neuronal development occurs in stages and that Hand2 expression is required for terminal differentiation but not for precursors to enter the neuronal lineage. ..
- Jiang Y, Liu M, Gershon M. Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. Dev Biol. 2003;258:364-84 pubmed..Netrins also promoted the survival/development of enteric crest-derived cells. The formation of submucosal and pancreatic ganglia thus involves the attraction of DCC-expressing crest-derived cells by netrins. ..
- Fex Svenningsen A, Shan W, Colman D, Pedraza L. Rapid method for culturing embryonic neuron-glial cell cocultures. J Neurosci Res. 2003;72:565-73 pubmed..No overgrowth of fibroblasts or other nonneuronal cells was noted in any cultures, and myelination of the peripheral nervous system and central nervous system cultures was very robust. ..
- Tennyson V, Gershon M, Wade P, Crotty D, Wolgemuth D. Fetal development of the enteric nervous system of transgenic mice that overexpress the Hoxa-4 gene. Dev Dyn. 1998;211:269-91 pubmed
- Wu J, Chen J, Rothman T, Gershon M. Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. Development. 1999;126:1161-73 pubmed
- CHALAZONITIS A, Kessler J. Pleiotropic effects of the bone morphogenetic proteins on development of the enteric nervous system. Dev Neurobiol. 2012;72:843-56 pubmed publisher..Disruption of BMP signaling leads to defects in the gut and in ENS function commensurate with these complex developmental roles. ..
- Gershon M. Developmental determinants of the independence and complexity of the enteric nervous system. Trends Neurosci. 2010;33:446-56 pubmed publisher..It is probable that highly prevalent disorders of gastrointestinal sensation and motility result from subtle defects in ENS development. ..
- CHALAZONITIS A, D Autréaux F, Pham T, Kessler J, Gershon M. Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling. Dev Biol. 2011;350:64-79 pubmed publisher..These observations support the hypotheses that BMPs are required for enteric gliogenesis and act by promoting responsiveness of ENCDC to ErbB3 ligands such as GGF2. ..
- Li Z, Caron M, Blakely R, Margolis K, Gershon M. Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. J Neurosci. 2010;30:16730-40 pubmed publisher..NET expression is essential for development and/or survival of some (5-HT- and calretinin-expressing), but not all (nNOS-expressing), of these neurons. ..
- Margolis K, Stevanovic K, Karamooz N, Li Z, Ahuja A, D Autréaux F, et al. Enteric neuronal density contributes to the severity of intestinal inflammation. Gastroenterology. 2011;141:588-98, 598.e1-2 pubmed publisher..Abnormalities in development of the enteric nervous system might therefore contribute to the pathogenesis of inflammatory bowel disease. ..
- Chen J, Li Z, Pan H, Murphy D, Tamir H, Koepsell H, et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci. 2001;21:6348-61 pubmed..The watery diarrhea is probably attributable to the potentiation of serotonergic signaling in SERT -/- mice, whereas the transient constipation may be caused by episodes of enhanced 5-HT release leading to 5-HT receptor desensitization. ..
- Gershon M. Neural crest development. Do developing enteric neurons need endothelins?. Curr Biol. 1995;5:601-4 pubmed..Recent experiments have led to the unexpected finding that endothelin-3 and the endothelin B receptor are absolutely necessary for the development of the enteric nervous system in the colon, but it is not yet clear why. ..
- Blaugrund E, Pham T, Tennyson V, Lo L, Sommer L, Anderson D, et al. Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence. Development. 1996;122:309-20 pubmed..The other is Mash-1-independent, does not express sympathoadrenal markers, and generates late-born enteric neurons, some of which contain calcitonin gene related peptide. ..
- Chalazonitis A, Pham T, Rothman T, DiStefano P, Bothwell M, Blair Flynn J, et al. Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons. J Neurosci. 2001;21:5620-36 pubmed..A neuropoietic cytokine (CNTF) interacted with NT-3 in vitro, and if applied sequentially, compensated for NT-3 withdrawal. These observations indicate that NT-3 is required for the normal development of the ENS. ..
- CHALAZONITIS A, Pham T, Li Z, Roman D, Guha U, Gomes W, et al. Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit. J Comp Neurol. 2008;509:474-92 pubmed publisher..Although the function of the gut thus displays a remarkable tolerance for ENS defects, subtle functional abnormalities in motility or secretion may arise when ENS defects short of aganglionosis occur during development. ..
- CHALAZONITIS A, D Autréaux F, Guha U, Pham T, Faure C, Chen J, et al. Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset. J Neurosci. 2004;24:4266-82 pubmed..BMP-2 and/or BMP-4 thus limit the size of the ENS but promote the development of specific subsets of enteric neurons, including those that express TrkC. ..
- Tennyson V, Gershon M, Sherman D, Behringer R, Raz R, Crotty D, et al. Structural abnormalities associated with congenital megacolon in transgenic mice that overexpress the Hoxa-4 gene. Dev Dyn. 1993;198:28-53 pubmed..In both animals, the data are consistent with the hypothesis that the defects arise as a result of a defective interaction between the precursors of enteric neurons and smooth muscle. ..
- Liu M, Geddis M, Wen Y, Setlik W, Gershon M. Expression and function of 5-HT4 receptors in the mouse enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2005;289:G1148-63 pubmed..Enteric neuronal 5-HT(4) receptors thus are presynaptic and probably exert their prokinetic effects by strengthening excitatory neurotransmission. ..