Genomes and Genes
Experts and Doctors on endoplasmic reticulum in New York, United States
Locale: New York, United States
Topic: endoplasmic reticulum
Publications198 found, 100 shown here
- Ota T, Gayet C, Ginsberg H. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest. 2008;118:316-32 pubmed..These results suggest that excessive ER stress in response to increased hepatic lipids may decrease the ability of the liver to secrete triglycerides by limiting apoB secretion, potentially worsening steatosis. ..
- Prasad A, Bloom M, Carpenter D. Role of calcium and ROS in cell death induced by polyunsaturated fatty acids in murine thymocytes. J Cell Physiol. 2010;225:829-36 pubmed publisher..These results suggest that the six PUFAs we studied kill thymocytes by causing release of calcium from endoplasmic reticulum, which causes release of ROS from mitochondria which leads to cell death. ..
- Paek I, Orci L, Ravazzola M, Erdjument Bromage H, Amherdt M, Tempst P, et al. ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi. J Cell Biol. 1997;137:1017-28 pubmed..ERS-24 is localized to the ER and to the Golgi, and it is enriched in transport vesicles associated with these organelles. ..
- He X, Merz G, Yang Y, Mehta P, Schulz H, Yang S. Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenase. Eur J Biochem. 2001;268:4899-907 pubmed..This feature distinguishes it from all known 17beta-hydroxysteroid dehydrogenases, and endows mitochondria with the capability of modulating intracellular levels of the active forms of sex steroids. ..
- Mendes C, Levet C, Chatelain G, Dourlen P, Fouillet A, Dichtel Danjoy M, et al. ER stress protects from retinal degeneration. EMBO J. 2009;28:1296-307 pubmed publisher..We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses. ..
- Timmins J, Ozcan L, Seimon T, Li G, Malagelada C, Backs J, et al. Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest. 2009;119:2925-41 pubmed publisher..These findings raise the possibility that CaMKII inhibitors could be useful in preventing apoptosis in pathological settings involving ER stress-induced apoptosis. ..
- Fu J, Kreibich G. Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum. J Biol Chem. 2000;275:3984-90 pubmed..In the case of the Tac chimera containing only the luminal domain of RII, which by itself exits from the ER and is rapidly degraded, it is retained in the ER and becomes stabilized when coexpressed with OST48. ..
- Chan K, CSANADY L, Seto Young D, Nairn A, Gadsby D. Severed molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain. J Gen Physiol. 2000;116:163-80 pubmed..Our definitions of the boundaries of the NBD1 domain in CFTR are supported by comparison with the solved NBD structures of HisP and RbsA. ..
- Chavan M, Yan A, Lennarz W. Subunits of the translocon interact with components of the oligosaccharyl transferase complex. J Biol Chem. 2005;280:22917-24 pubmed..Based on extrapolation of the structural parameters of the crystal structure of the prokaryotic Sec complex to the eukaryotic complex, we propose a working model to understand the organization of the translocon-OT supercomplex. ..
- Wölk B, Büchele B, Moradpour D, Rice C. A dynamic view of hepatitis C virus replication complexes. J Virol. 2008;82:10519-31 pubmed publisher..We suggest that this MT-dependent transport sustains two distinct RC populations, which are both required during the HCV life cycle. ..
- Georgiev A, Johansen J, Ramanathan V, Sere Y, Beh C, Menon A. Arv1 regulates PM and ER membrane structure and homeostasis but is dispensable for intracellular sterol transport. Traffic. 2013;14:912-21 pubmed publisher..In arv1? cells, specific defects affecting single C-terminal transmembrane domain proteins suggest that Arv1 might regulate membrane insertion of tail-anchored proteins involved in membrane homoeostasis. ..
- Jing D, Baik A, Lu X, Zhou B, Lai X, Wang L, et al. In situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading. FASEB J. 2014;28:1582-92 pubmed publisher..This study develops a novel approach in skeletal mechanobiology and also advances our fundamental knowledge of bone mechanotransduction. ..
- Burmakina S, Geng Y, Chen Y, Fan Q. Heterodimeric coiled-coil interactions of human GABAB receptor. Proc Natl Acad Sci U S A. 2014;111:6958-63 pubmed publisher..The ER retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation. ..
- Anderson S, Shen T, Lou J, Xing L, Blachere N, Srivastava P, et al. The endoplasmic reticular heat shock protein gp96 is transcriptionally upregulated in interferon-treated cells. J Exp Med. 1994;180:1565-9 pubmed..Further, our studies represent the first demonstration of modulation of expression of a heat shock protein by a cytokine and identify a new enzymatic activity upregulated in IFN-treated cells. ..
- Dai Q, Choy E, Chiu V, Romano J, Slivka S, Steitz S, et al. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998;273:15030-4 pubmed..Thus, the final enzyme in the sequence that modifies CAAX motifs is located in membranes topologically removed from the CAAX protein target membrane. ..
- Goodchild R, Dauer W. The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein. J Cell Biol. 2005;168:855-62 pubmed
- Muchir A, Massart C, van Engelen B, Lammens M, Bonne G, Worman H. Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins. Biochem Biophys Res Commun. 2006;351:1011-7 pubmed
- Seimon T, Obstfeld A, Moore K, Golenbock D, Tabas I. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A. 2006;103:19794-9 pubmed..PRR-induced macrophage death may play important roles in advanced atherosclerosis and in other innate immunity-related processes in which the balance between macrophage survival and death is critical. ..
- Oresic K, Mueller B, Tortorella D. Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Biosci Rep. 2009;29:173-81 pubmed publisher..The results implicate ER quality control in the instability of the Cln variants that probably contributes to the development of NCL. ..
- Kang M, Ryoo H. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Proc Natl Acad Sci U S A. 2009;106:17043-8 pubmed publisher..These results suggest that manipulation of ERAD may serve as a powerful therapeutic strategy against a number of diseases associated with ER stress. ..
- Li G, Scull C, Ozcan L, Tabas I. NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol. 2010;191:1113-25 pubmed publisher..These data provide new insight into how ER stress, oxidative stress, and PKR activation can be integrated to induce apoptosis in a pathophysiologically relevant manner. ..
- George I, Sabbah H, Xu K, Wang N, Wang J. ?-adrenergic receptor blockade reduces endoplasmic reticulum stress and normalizes calcium handling in a coronary embolization model of heart failure in canines. Cardiovasc Res. 2011;91:447-55 pubmed publisher..Whether this mechanism occurs in other animal CHF models or human CHF warrants further study. ..
- Redmann V, Oresic K, Tortorella L, Cook J, Lord M, Tortorella D. Dislocation of ricin toxin A chains in human cells utilizes selective cellular factors. J Biol Chem. 2011;286:21231-8 pubmed publisher..The data support a model in which ricin A chain dislocation occurs via a novel strategy of utilizing the hydrophobic nature of the ER membrane and selective ER components to gain access to the cytosol. ..
- Pon L. Mitochondrial fission: rings around the organelle. Curr Biol. 2013;23:R279-81 pubmed publisher..New work shows that mitochondria do not divide in isolation from other cellular structures. Rather, they carry out this process in partnership with the endoplasmic reticulum and actin filaments. ..
- Biempica L, Rauch H, Quintana N, Sternlieb I. Morphologic and chemical studies on a murine mutation (toxic milk mice) resulting in hepatic copper toxicosis. Lab Invest. 1988;59:500-8 pubmed..By contrast, the hepatocytes of regenerative nodules appeared well preserved. Comparisons with other inherited mammalian disorders associated with hepatic copper toxicosis indicate that copper causes species specific organelle injury. ..
- Wang X, Harding H, Zhang Y, Jolicoeur E, Kuroda M, Ron D. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 1998;17:5708-17 pubmed..These results indicate that a single upstream component, Ire1, plays a role in multiple facets of the ER stress-response in mammalian cells. ..
- Walter M, Davies J, Ioannou Y. Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes. J Lipid Res. 2003;44:243-53 pubmed..These results suggest the existence of alternative endogenous therapeutic targets that can be modulated to reverse the NPC1 disease phenotype. ..
- Novoa I, Zhang Y, Zeng H, Jungreis R, Harding H, Ron D. Stress-induced gene expression requires programmed recovery from translational repression. EMBO J. 2003;22:1180-7 pubmed
- Harding H, Zhang Y, Zeng H, Novoa I, Lu P, Calfon M, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003;11:619-33 pubmed..A signaling pathway initiated by eIF2alpha phosphorylation protects cells against metabolic consequences of ER oxidation by promoting the linked processes of amino acid sufficiency and resistance to oxidative stress. ..
- Pattingre S, Tassa A, Qu X, Garuti R, Liang X, Mizushima N, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005;122:927-39 pubmed..This antiautophagy function of Bcl-2 may help maintain autophagy at levels that are compatible with cell survival, rather than cell death. ..
- Sauane M, Su Z, Gupta P, Lebedeva I, Dent P, Sarkar D, et al. Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis. Proc Natl Acad Sci U S A. 2008;105:9763-8 pubmed publisher..Thus, our results clarify the molecular mechanism by which secreted MDA-7/IL-24 protein (generated from Ad.mda-7-infected cells) exerts cancer-specific killing. ..
- Seimon T, Nadolski M, Liao X, Magallon J, Nguyen M, Feric N, et al. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 2010;12:467-82 pubmed publisher..These findings provide insight into how atherogenic lipoproteins trigger macrophage apoptosis in the setting of ER stress and how TLR activation might promote macrophage apoptosis and plaque necrosis in advanced atherosclerosis. ..
- Sroubek J, McDonald T. Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG). J Biol Chem. 2011;286:21927-36 pubmed publisher..Furthermore, reagents generated for this study provide novel experimental tools to probe compartmentalized cAMP/PKA signaling within cells. ..
- Lai C, Otero J, Hendershot L, Snapp E. ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery. J Biol Chem. 2012;287:7969-78 pubmed publisher..Our findings now directly link ERdj4 to the ERAD machinery and suggest a model in which ERjd4 could help recruit clients from throughout the ER to ERAD sites. ..
- Sturley S, Hussain M. Lipid droplet formation on opposing sides of the endoplasmic reticulum. J Lipid Res. 2012;53:1800-10 pubmed publisher..This default pathway directs droplets into the cytoplasm where they accumulate in many lipid disorders...
- Schwartz T, Blobel G. Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor. Cell. 2003;112:793-803 pubmed..The results suggest that the GTP/GDP switch cycle of SR beta functions as a regulatory switch for the receptor dimerization. We discuss the implications for the translocation pathway. ..
- Wright L, Court H, Mor A, Ahearn I, Casey P, Philips M. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. Mol Cell Biol. 2009;29:1826-33 pubmed publisher..Icmt is a target for anticancer drug discovery, and these data may facilitate efforts to develop small-molecule inhibitors. ..
- Ferro E, Tullai J, Glucksman M, Roberts J. Secretion of metalloendopeptidase 24.15 (EC 188.8.131.52). DNA Cell Biol. 1999;18:781-9 pubmed..15. In summary, EP24.15 appears to be secreted from AtT20 pituitary cells into the extracellular milieu, where the enzyme can participate in the physiologic metabolism of neuropeptides. ..
- Russo D, Lee S, Redman C. Intracellular assembly of Kell and XK blood group proteins. Biochim Biophys Acta. 1999;1461:10-8 pubmed..XK expressed in the absence of Kell was also transported to the cell surface indicating that linkage of Kell and XK is not obligatory for cell surface expression. ..
- Brennwald P. Reversal of fortune. Do Rab GTPases act on the target membrane?. J Cell Biol. 2000;149:1-4 pubmed
- Chavan S, Tian W, Hsueh K, Jawaheer D, Gregersen P, Chu C. Characterization of the human homolog of the IL-4 induced gene-1 (Fig1). Biochim Biophys Acta. 2002;1576:70-80 pubmed..Finally, hFig1 maps to the predicted mFig1 syntenic region on human chromosome 19q13.3-19q13.4, a hot spot for susceptibility to several autoimmune diseases, including SLE. ..
- Bruce J, Yule D, Shuttleworth T. Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells. J Biol Chem. 2002;277:48172-81 pubmed..Tight regulation of both Ca(2+) release and Ca(2+) efflux may represent a general feature of the mechanism whereby cAMP improves the fidelity and specificity of Ca(2+) signaling. ..
- Li G, Yan Q, Oen H, Lennarz W. A specific segment of the transmembrane domain of Wbp1p is essential for its incorporation into the oligosaccharyl transferase complex. Biochemistry. 2003;42:11032-9 pubmed
- Leventhal A, Leslie C, Tabas I. Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking. J Biol Chem. 2004;279:8084-92 pubmed
- Pan M, Cederbaum A, Zhang Y, Ginsberg H, Williams K, Fisher E. Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J Clin Invest. 2004;113:1277-87 pubmed
- Dey A, Kessova I, Cederbaum A. Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1. Arch Biochem Biophys. 2006;447:155-66 pubmed..These results suggest that CYP2E1 mediated oxidative stress downregulates the expression of GRP proteins in HepG2 cells and oxidative stress is an important mechanism in causing ER dysfunction in these cells. ..
- Woo C, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald K, et al. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol. 2009;11:1473-80 pubmed publisher..We speculate that this mechanism evolved to promote survival of TLR-expressing cells that experience prolonged levels of physiological ER stress in the course of the host response to invading pathogens. ..
- Seimon T, Kim M, Blumenthal A, Koo J, Ehrt S, Wainwright H, et al. Induction of ER stress in macrophages of tuberculosis granulomas. PLoS ONE. 2010;5:e12772 pubmed publisher..Therefore future work is needed to determine if ER-stress is causative for apoptosis and plays a role in the host response to infection. ..
- Lim M, Devi L, Rozenfeld R. Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis. Cell Death Dis. 2011;2:e170 pubmed publisher..We propose that CBD, by selectively inducing death of activated HSCs, represents a potential therapeutic agent for the treatment of liver fibrosis. ..
- Rehman A, Hemmert K, Ochi A, Jamal M, Henning J, Barilla R, et al. Role of fatty-acid synthesis in dendritic cell generation and function. J Immunol. 2013;190:4640-9 pubmed publisher..Our findings elucidate the role of fatty-acid synthesis in DC development and function and have implications to the design of DC vaccines for immunotherapy. ..
- Tiganis T, Bennett A, Ravichandran K, Tonks N. Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. Mol Cell Biol. 1998;18:1622-34 pubmed..These results indicate that TC45 recognizes not only selected substrates in a cellular context but also specific sites within substrates and thus may regulate discrete signaling events. ..
- Harding H, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell. 2000;5:897-904 pubmed..PERK thus plays a major role in the ability of cells to adapt to ER stress. ..
- Einbond L, Mighty J, Redenti S, Wu H. Actein induces calcium release in human breast cancer cells. Fitoterapia. 2013;91:28-38 pubmed publisher..Actein alters the activity of the ER IP3 receptor and Na,K-ATPase, induces calcium release and modulates the NF-?B and MEK pathways and may be worthwhile to explore to prevent and treat breast cancer. ..
- Böhme U, Cross G. Mutational analysis of the variant surface glycoprotein GPI-anchor signal sequence in Trypanosoma brucei. J Cell Sci. 2002;115:805-16 pubmed..However, because the VSG is a major virulence factor, it is possible that small changes in the efficiency of GPI anchoring, undetectable in our experiments, might have influenced the evolution of VSG GPI signal sequences. ..
- deSouza N, Reiken S, Ondrias K, Yang Y, Matkovich S, Marks A. Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. J Biol Chem. 2002;277:39397-400 pubmed..PKA phosphorylation of IP3R1 increases channel activity in planar lipid bilayers. These studies indicate that regulation of IP3R1 function via PKA phosphorylation involves components of a macromolecular signaling complex. ..
- Fiedler K, Veit M, Stamnes M, Rothman J. Bimodal interaction of coatomer with the p24 family of putative cargo receptors. Science. 1996;273:1396-9 pubmed..The either-or bimodal binding of coatomer to p24 tails suggests models for how coatomer can potentially package retrograde-directed and anterograde-directed cargo into distinct COPI-coated vesicles...
- Grullich C, Duvoisin R, Wiedmann M, van Leyen K. Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte. FEBS Lett. 2001;489:51-4 pubmed..We find that inhibitor treatment retarded mitochondrial degradation, as shown by persistence of marker proteins and by direct visualization of mitochondria by electron microscopy. ..
- Chen K, Minwalla L, Ni L, Orlow S. Correction of defective early tyrosinase processing by bafilomycin A1 and monensin in pink-eyed dilution melanocytes. Pigment Cell Res. 2004;17:36-42 pubmed
- Vallee R, Varma D, Dujardin D. ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?. Cell Cycle. 2006;5:2447-51 pubmed..Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here. ..
- Søgaard M, Tani K, Ye R, Geromanos S, Tempst P, Kirchhausen T, et al. A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell. 1994;78:937-48 pubmed
- Miller S, Binder E, Blackman M, Carruthers V, Kim K. A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii. J Biol Chem. 2001;276:45341-8 pubmed..This secondary processing is inhibited by brefeldin A and serine protease inhibitors. TgSUB1 is a candidate processing enzyme for several microneme proteins cleaved within the secretory pathway or during invasion. ..
- Li Y, Zhang Y, Dorweiler B, Cui D, Wang T, Woo C, et al. Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem. 2008;283:34833-43 pubmed publisher..These data suggest a novel action and mechanism of eNampt that could affect the balance of macrophage survival and death in the setting of obesity, which in turn could play important roles in obesity-associated diseases. ..
- Jelk J, Gao N, Serricchio M, Signorell A, Schmidt R, Bangs J, et al. Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1. J Biol Chem. 2013;288:20616-23 pubmed publisher..These results suggest that rather than facilitating M5-DLO flipping, Rft1 facilitates conversion of M5-DLO to mDLO by another mechanism, possibly by acting as an M5-DLO chaperone. ..
- Frindt G, Gravotta D, Palmer L. Regulation of ENaC trafficking in rat kidney. J Gen Physiol. 2016;147:217-27 pubmed publisher..These results imply that stimulation of ENaC surface expression results at least in part from increased rates of formation of fully processed subunits in the Golgi and subsequent trafficking to the apical membrane. ..
- Gow A, Lazzarini R. A cellular mechanism governing the severity of Pelizaeus-Merzbacher disease. Nat Genet. 1996;13:422-8 pubmed..Moreover, we show that transport-competent mutant DM20s facilitate trafficking of cognate PLPs and hence may influence disease severity...
- Wu W, Lin F, Worman H. Intracellular trafficking of MAN1, an integral protein of the nuclear envelope inner membrane. J Cell Sci. 2002;115:1361-71 pubmed..These results are in agreement with the 'diffusion-retention' model for targeting integral proteins to the inner nuclear membrane. ..
- Han S, Liang C, DeVries Seimon T, Ranalletta M, Welch C, Collins Fletcher K, et al. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab. 2006;3:257-66 pubmed..These studies suggest that defective insulin signaling and reduced Akt activity impair the ability of macrophages to deal with ER stress-induced apoptosis within atherosclerotic plaques. ..
- Chen Y, Bharill S, Altun Z, O HAGAN R, Coblitz B, Isacoff E, et al. Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins. Mol Biol Cell. 2016;27:1272-85 pubmed publisher..These results suggest that MEC-6 and POML-1 interact with MEC-4 to facilitate expression and localization of MEC-4 on the cell surface. Thus MEC-6 and POML-1 act more like chaperones for MEC-4 than channel components. ..
- Choy E, Chiu V, Silletti J, Feoktistov M, Morimoto T, Michaelson D, et al. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 1999;98:69-80 pubmed..Thus, prenylated CAAX proteins do not associate directly with the PM but instead associate with the endomembrane and are subsequently transported to the PM, a process that requires a secondary targeting motif. ..
- Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding H, et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 2000;287:664-6 pubmed..Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals. ..
- Zito E, Chin K, Blais J, Harding H, Ron D. ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol. 2010;188:821-32 pubmed publisher..These findings point to an unexpectedly selective function for ERO1-beta in oxidative protein folding in insulin-producing cells that is required for glucose homeostasis in vivo. ..
- Wen C, Greenwald I. p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans. J Cell Biol. 1999;145:1165-75 pubmed
- Gao X, Dean N. Distinct protein domains of the yeast Golgi GDP-mannose transporter mediate oligomer assembly and export from the endoplasmic reticulum. J Biol Chem. 2000;275:17718-27 pubmed..These studies are consistent with a model in which Vrg4p oligomerizes in the ER and is subsequently transported to the Golgi via a mechanism that involves positive sorting rather than passive default. ..
- Martinelli G, Friedrich V, Holstein G. L-citrulline immunostaining identifies nitric oxide production sites within neurons. Neuroscience. 2002;114:111-22 pubmed..We conclude that nitric oxide is produced and released at focal sites within neurons that are identifiable using L-citrulline as a marker. ..
- Purdue P, Lazarow P. Peroxisome biogenesis. Annu Rev Cell Dev Biol. 2001;17:701-52 pubmed
- Lilliehook C, Chan S, Choi E, Zaidi N, Wasco W, Mattson M, et al. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci. 2002;19:552-9 pubmed..Taken together, these data suggest that calsenilin causes cells to be more susceptible to apoptotic triggers, possibly by altering calcium dynamics. ..
- Kanner E, Klein I, Friedlander M, Simon S. The amino terminus of opsin translocates "posttranslationally" as efficiently as cotranslationally. Biochemistry. 2002;41:7707-15 pubmed..Longer nascent opsin peptides have a lower efficiency of cotranslational translocation but an even lower efficiency of posttranslational translocation. We also show that SRP is required for both co- and posttranslational targeting. ..
- Ryu E, Harding H, Angelastro J, Vitolo O, Ron D, Greene L. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci. 2002;22:10690-8 pubmed..Our findings, coupled with evidence from familial forms of Parkinson's disease, raise the possibility of widespread involvement of endoplasmic reticulum stress and the unfolded protein response in the pathophysiology of this disease. ..
- Sanyal S, Menon A. Specific transbilayer translocation of dolichol-linked oligosaccharides by an endoplasmic reticulum flippase. Proc Natl Acad Sci U S A. 2009;106:767-72 pubmed publisher..Our results suggest a simple structural model for the interaction between the DLO head group and the flippase. ..
- Li J, Hu H, Niu Q, Fang C. Cell surface activation of the erythropoietin receptor by Friend spleen focus-forming virus gp55. J Virol. 1995;69:1714-19 pubmed..Thus, our results support the hypothesis that the mitogenic activation of the EPO-R by gp55 requires the interaction of the two proteins at the cell surface...
- Shen J, Chen X, Hendershot L, Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell. 2002;3:99-111 pubmed..These results suggest that BiP retains ATF6 in the ER by inhibiting its GLSs and that dissociation of BiP during ER stress allows ATF6 to be transported to the Golgi. ..
- Harding H, Novoa I, Bertolotti A, Zeng H, Zhang Y, Urano F, et al. Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum. Cold Spring Harb Symp Quant Biol. 2001;66:499-508 pubmed
- Kikuchi H, Almer G, Yamashita S, Guegan C, Nagai M, Xu Z, et al. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci U S A. 2006;103:6025-30 pubmed..Our results suggest a toxic mechanism for mutant SOD1 by which this ubiquitously expressed pathogenic protein could affect motor neuron survival and contribute to the selective motor neuronal degeneration in ALS. ..
- Mancias J, Goldberg J. The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope. Mol Cell. 2007;26:403-14 pubmed publisher..The concept of a conformational epitope as a transport signal suggests packaging mechanisms in which a coat is sensitive to the folded state of a cargo protein or the assembled state of a multiprotein complex...
- Lee M, Moura P, Miller E, Fidock D. Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif. Mol Microbiol. 2008;68:1535-46 pubmed publisher..Furthermore, the number and position of tER sites with respect to the cis-Golgi suggests a co-ordinated biogenesis of these domains. ..
- Ullman E, Pan J, Zong W. Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury. Mol Cell Biol. 2011;31:2902-19 pubmed publisher..Hence, on one hand, SCCA1 inhibits cell death induced by lysosomal injury while, on the other hand, it sensitizes cells to ER stress by activating caspase-8 independently of the death receptor apoptotic pathway. ..
- Cui D, Thorp E, Li Y, Wang N, Yvan Charvet L, Tall A, et al. Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. J Leukoc Biol. 2007;82:1040-50 pubmed..These findings have implications for macrophage physiology in both AC clearance and atherosclerotic plaque progression. ..