Experts and Doctors on endocytosis in Pennsylvania, United States


Locale: Pennsylvania, United States
Topic: endocytosis

Top Publications

  1. Traub L. Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat Rev Mol Cell Biol. 2009;10:583-96 pubmed publisher
    ..Cargo loading also seems to govern whether coats ultimately bud or dismantle abortively at the cell surface. ..
  2. Barth B, I Altino─člu E, Shanmugavelandy S, Kaiser J, Crespo Gonzalez D, DiVittore N, et al. Targeted indocyanine-green-loaded calcium phosphosilicate nanoparticles for in vivo photodynamic therapy of leukemia. ACS Nano. 2011;5:5325-37 pubmed publisher
    ..Altogether, this study demonstrates that leukemia-targeted ICG-loaded CPSNPs offer the promise to effectively treat relapsing and multidrug-resistant leukemia and to improve the life of leukemia patients. ..
  3. Zoladek T, Tobiasz A, Vaduva G, Boguta M, Martin N, Hopper A. MDP1, a Saccharomyces cerevisiae gene involved in mitochondrial/cytoplasmic protein distribution, is identical to the ubiquitin-protein ligase gene RSP5. Genetics. 1997;145:595-603 pubmed
    ..Identification of MDP1 as RSP5, along with our previous identification of MDP2/VRP1 and MDP3/PAN1, implicate interactions of the ubiquitin system, the actin cytoskeleton and protein synthesis in the subcellular distribution of proteins. ..
  4. Zhao W, Santini F, Breese R, Ross D, Zhang X, Stone D, et al. Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. J Biol Chem. 2010;285:7619-32 pubmed publisher
    ..Validation of this model in human disease would identify therapeutic targets for Alzheimer disease. ..
  5. Alibhoy A, Giardina B, Dunton D, Chiang H. Vps34p is required for the decline of extracellular fructose-1,6-bisphosphatase in the vacuole import and degradation pathway. J Biol Chem. 2012;287:33080-93 pubmed
    ..We suggest that VPS34 plays a critical role in the decline of extracellular FBPase in response to glucose. ..
  6. Giardina B, Dunton D, Chiang H. Vid28 protein is required for the association of vacuole import and degradation (Vid) vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction. J Biol Chem. 2013;288:11636-48 pubmed publisher
    ..We suggest that the ARM domain is required for the association of Vid vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction. ..
  7. Vaduva G, Martin N, Hopper A. Actin-binding verprolin is a polarity development protein required for the morphogenesis and function of the yeast actin cytoskeleton. J Cell Biol. 1997;139:1821-33 pubmed
    ..We speculate that the effects of verprolin upon the actin cytoskeleton might influence mitochondrial protein sorting/function via mRNA distribution. ..
  8. Vaduva G, Martinez Quiles N, Anton I, Martin N, Geha R, Hopper A, et al. The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast. J Biol Chem. 1999;274:17103-8 pubmed
    ..A role for WIP in cell polarity provides a framework for unifying, under a common paradigm, distinct molecular defects associated with immunodeficiencies like Wiskott-Aldrich syndrome. ..
  9. Schaefer T, Bell I, Pfeifer M, Ghosh M, Trible R, Fuller C, et al. The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs. Virology. 2002;302:106-22 pubmed

More Information


  1. Lee H, Walker J, Williams J, Goodier R, Payne J, Moss S. Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. J Biol Chem. 2007;282:29777-84 pubmed
    ..Our studies thus suggest that PKC-dependent phosphorylation of KCC2 may play a central role in modulating both the functional expression of this critical transporter in the brain and the strength of synaptic inhibition. ..
  2. Brown C, Wolfe A, Cui D, Chiang H. The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation. J Biol Chem. 2008;283:26116-27 pubmed publisher
    ..Taken together, our results indicate a strong connection between the Vid trafficking pathway and the endocytic pathway. ..
  3. Murakami T, Felinski E, Antonetti D. Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem. 2009;284:21036-46 pubmed publisher
    ..These data demonstrate a novel mechanism of VEGF-induced occludin phosphorylation and ubiquitination that contributes to TJ trafficking and subsequent vascular permeability. ..
  4. Brown C, Dunton D, Chiang H. The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation. J Biol Chem. 2010;285:1516-28 pubmed publisher
    ..Following the fusion of endosomes with the vacuole, cargo proteins are then degraded in the vacuole. ..
  5. Shingler K, Yoder J, Carnegie M, Ashley R, Makhov A, Conway J, et al. The enterovirus 71 A-particle forms a gateway to allow genome release: a cryoEM study of picornavirus uncoating. PLoS Pathog. 2013;9:e1003240 pubmed publisher
    ..These structural characteristics identify the two-fold channel as the site where a gateway forms and regulates the process of genome release...
  6. Winters C, Hong Brown L, Chiang H. The Shape of Vesicle-Containing Organelles Is Critical for Their Functions in Vesicle Endocytosis. DNA Cell Biol. 2017;36:909-921 pubmed publisher
    ..We conclude that the shape of vesicle-containing organelles is critical for their functions in vesicle endocytosis...