Genomes and Genes
Experts and Doctors on drug dose response relationship in California, United States
Locale: California, United States
Topic: drug dose response relationship
Publications142 found, 100 shown here
- Singh G, Lanes S, Triadafilopoulos G. Risk of serious upper gastrointestinal and cardiovascular thromboembolic complications with meloxicam. Am J Med. 2004;117:100-6 pubmed..However, only a small number of patients were followed for more than 60 days, and meaningful comparisons were not possible in this subgroup. ..
- Macpherson L, Geierstanger B, Viswanath V, Bandell M, Eid S, Hwang S, et al. The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol. 2005;15:929-34 pubmed..We further show that allicin, an unstable component of fresh garlic, is the chemical responsible for TRPA1 and TRPV1 activation and is therefore likely to cause garlic's pungency. ..
- Zhao L, Yang B, Wang R, Lipton S, Zhang D. Type C botulinum toxin causes degeneration of motoneurons in vivo. Neuroreport. 2010;21:14-18 pubmed publisher..Here, we provide experimental evidence that BoNT/C causes a slow degeneration of motoneurons both in vitro and in vivo. This novel form of BoNT/C-induced cell death may require new treatment strategies. ..
- Poree L, Guo T, Kingery W, Maze M. The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors. Anesth Analg. 1998;87:941-8 pubmed..The analgesic potency of dexmedetomidine was enhanced after nerve injury with a site of action outside the central nervous system. Peripherally restricted alpha2 agonists may be useful in the management of neuropathic pain. ..
- Liao W, Moore R, Shimasaki S. Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9. J Biol Chem. 2004;279:17391-6 pubmed
- Knowles L, Axelrod F, Browne C, Smith J. A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. J Biol Chem. 2004;279:30540-5 pubmed..Altogether, the findings of the study reveal unappreciated links between fatty acid synthase and ubiquitin-dependent proteolysis of cell-cycle regulatory proteins. ..
- Mazerbourg S, Sangkuhl K, Luo C, Sudo S, Klein C, Hsueh A. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem. 2005;280:32122-32 pubmed..Thus, the present approach provides a genomic paradigm for matching paralogous polypeptide ligands with a limited number of evolutionarily related receptors capable of activating specific downstream Smad proteins. ..
- Zimmerman J, Werner D, Ghosh U, Millward R, Bridges T, Luthy R. Effects of dose and particle size on activated carbon treatment to sequester polychlorinated biphenyls and polycyclic aromatic hydrocarbons in marine sediments. Environ Toxicol Chem. 2005;24:1594-601 pubmed..This model was useful in explaining the trends for the effect of activated carbon dose and particle size on PCB aqueous concentrations in well-mixed systems. ..
- Voloboueva L, Suh S, Swanson R, Giffard R. Inhibition of mitochondrial function in astrocytes: implications for neuroprotection. J Neurochem. 2007;102:1383-94 pubmed
- Moran A, Simon J, Shiboski S, Pickering T, Waters D, Rotter J, et al. Differential effects of ramipril on ambulatory blood pressure in African Americans and Caucasians. Am J Hypertens. 2007;20:884-91 pubmed..Despite the small difference in mean response between groups, the majority of African Americans and Caucasians had a similar blood-pressure response to a fixed dose of ramipril. ..
- Arastu Kapur S, Ponder E, Fonović U, Yeoh S, Yuan F, Fonovic M, et al. Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum. Nat Chem Biol. 2008;4:203-13 pubmed publisher..These results suggest that two mechanistically distinct proteases function to regulate processing of downstream substrates required for efficient release of parasites from host red blood cells. ..
- Dutch R, Lehman I. Renaturation of complementary DNA strands by herpes simplex virus type 1 ICP8. J Virol. 1993;67:6945-9 pubmed..The ability of ICP8 to promote the renaturation of complementary single strands suggests a role for ICP8 in the high level of recombination seen in cells infected with herpes simplex virus type 1. ..
- Kehlenbach R, Assheuer R, Kehlenbach A, Becker J, Gerace L. Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1. J Biol Chem. 2001;276:14524-31 pubmed..These results provide physiological evidence that release of Ran-GTP from importin beta by RanBP1 and importin alpha is critical for the recycling of importin beta to a transport-competent state. ..
- Brandt S, Mariani R, Holland A, Hope T, Landau N. Association of chemokine-mediated block to HIV entry with coreceptor internalization. J Biol Chem. 2002;277:17291-9 pubmed..Last, M7-CCR5 is a useful tool for discriminating coreceptor internalization from binding site masking in the evaluation of small molecule inhibitors of HIV-1 entry. ..
- Lin F, Kolluri S, Chen G, Zhang X. Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor. J Biol Chem. 2002;277:21414-22 pubmed..Thus, COUP-TF, through its physical interaction with AP-1, promotes anticancer effects of retinoids by potentiating their anti-AP-1 activity. ..
- Vogel J, Keating G, Buchholz B. Protein binding of isofluorophate in vivo after coexposure to multiple chemicals. Environ Health Perspect. 2002;110 Suppl 6:1031-6 pubmed..The sensitivity of AMS for isotope-labeled tracer compounds can be used to probe the physiologic responses of specific biochemical pathways to multiple compound exposures. ..
- Pop C, Timmer J, Sperandio S, Salvesen G. The apoptosome activates caspase-9 by dimerization. Mol Cell. 2006;22:269-75 pubmed
- Weber M, Chang W, Breier M, Ko D, Swerdlow N. Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation. Behav Pharmacol. 2008;19:786-95 pubmed publisher..We conclude that the heritable pattern of greater PPI 'disruptability' by DA agonists in SD versus LE rats reflects differences in D2 but not D3 receptor-associated mechanisms. ..
- Calcutt N, Lopez V, Bautista A, Mizisin L, Torres B, Shroads A, et al. Peripheral neuropathy in rats exposed to dichloroacetate. J Neuropathol Exp Neurol. 2009;68:985-93 pubmed publisher..The DCA-treated rat may provide insight into the pathogenesis of this peripheral neuropathy and facilitate development of adjuvant therapeutics to prevent this disorder that currently restricts the clinical use of DCA. ..
- Gross E, Hsu A, Gross G. Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion. Anesth Analg. 2009;109:1395-402 pubmed publisher..These findings demonstrate that methadone and morphine produce similar myocardial IS-sparing effects that are delta-opioid receptor mediated and that are dependent on the duration of myocardial ischemia. ..
- Feng L, Xia Y, Yoshimura T, Wilson C. Modulation of neutrophil influx in glomerulonephritis in the rat with anti-macrophage inflammatory protein-2 (MIP-2) antibody. J Clin Invest. 1995;95:1009-17 pubmed..05). These results suggest that MIP-2 is a major neutrophil chemoattractant contributing to influx of neutrophils in Ab-induced glomerular inflammation in the rat. ..
- Nozawa K, Casiano C, Hamel J, Molinaro C, Fritzler M, Chan E. Fragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis. Arthritis Res. 2002;4:R3 pubmed..Further studies are needed to determine whether the differences observed in the Golgi complex during apoptosis or necrosis may account for the production of anti-Golgi complex autoantibodies. ..
- Contractor A, Sailer A, Darstein M, Maron C, Xu J, Swanson G, et al. Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice. J Neurosci. 2003;23:422-9 pubmed..These results identify the KA2 subunit as a determinant of kainate receptor function at presynaptic and postsynaptic mossy-fiber kainate receptors. ..
- Markou A, Paterson N, Semenova S. Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation. Ann N Y Acad Sci. 2004;1025:491-503 pubmed..Thus, compounds that increase GABAergic neurotransmission and antagonists at mGluR5 have potential as anti-smoking medications for humans. ..
- Nanda N, Bao M, Lin H, Clauser K, Komuves L, Quertermous T, et al. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem. 2005;280:24680-9 pubmed..These data suggest that PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts. ..
- Zajonc D, Cantu C, Mattner J, Zhou D, Savage P, Bendelac A, et al. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005;6:810-8 pubmed
- Peehl D, Seto E, Hsu J, Feldman D. Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells. J Urol. 2002;168:1583-8 pubmed
- Murphy G, Kremer C, Rodrigues H, Schatzberg A. The apolipoprotein E epsilon4 allele and antidepressant efficacy in cognitively intact elderly depressed patients. Biol Psychiatry. 2003;54:665-73 pubmed..The APOE epsilon4 allele may affect antidepressant treatment outcome, but the effect depends on the medication. Further studies should determine if this result applies to other samples and medications. ..
- Dubin A, Herr D, Chun J. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010;30:7300-9 pubmed publisher..Compared with other known factors, lysophospholipids represent the major activator of calcium signaling identified within NPCs at this early stage in corticogenesis. ..
- Tran Cao H, Bouvet M, Kaushal S, Keleman A, Romney E, Kim G, et al. Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2010;9:2068-78 pubmed publisher..Our results suggest the potential of this therapeutic paradigm against pancreatic cancer in the adjuvant and maintenance settings. ..
- Evans A, Euteneuer S, Chavez E, MULLEN L, Hui E, Bhatia S, et al. Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. Dev Neurobiol. 2007;67:1721-30 pubmed..This could allow growth cone filopodia increased time to sample their cellular targets, or direct the fibers upward toward the hair cells. ..
- Abramson T, Kedem H, Relman D. Proinflammatory and proapoptotic activities associated with Bordetella pertussis filamentous hemagglutinin. Infect Immun. 2001;69:2650-8 pubmed..pertussis-host interaction. ..
- Boddy M, Shanahan P, McDonald W, Lopez Girona A, Noguchi E, Yates III J, et al. Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol. 2003;23:5939-46 pubmed..These studies indicate that regulation of Rad60 is an important part of the replication checkpoint response controlled by Cds1. We propose that control of Rad60 regulates recombination events at stalled forks. ..
- Yan B, Calderwood D, Yaspan B, Ginsberg M. Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. J Biol Chem. 2001;276:28164-70 pubmed..Furthermore, they suggest that talin cleavage by calpain may contribute to the effects of the protease on the clustering and activation of integrins. ..
- Yasuda H, Barth A, Stellwagen D, Malenka R. A developmental switch in the signaling cascades for LTP induction. Nat Neurosci. 2003;6:15-6 pubmed
- Comoletti D, Flynn R, Jennings L, Chubykin A, Matsumura T, Hasegawa H, et al. Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J Biol Chem. 2003;278:50497-505 pubmed..We show here that glycosylation processing of neuroligin, in addition to mRNA splicing and gene selection, contributes to the specificity of the neurexin-beta/neuroligin-1 association. ..
- Maher P, Hanneken A. Flavonoids protect retinal ganglion cells from oxidative stress-induced death. Invest Ophthalmol Vis Sci. 2005;46:4796-803 pubmed..These results suggest that certain flavonoids can function as potent and effective neuroprotective agents for retinal ganglion cells. ..
- Roberto M, Cruz M, Bajo M, Siggins G, Parsons L, Schweitzer P. The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala. Neuropsychopharmacology. 2010;35:1962-72 pubmed publisher..Our study points to an important role of CB1 in CeA in which the eCBs tonically regulate neuronal activity, and suggests a potent mechanism for modulating CeA tone during challenge with ethanol. ..
- Dialynas D, Shao L, Billman G, Yu J. Engraftment of human T-cell acute lymphoblastic leukemia in immunodeficient NOD/SCID mice which have been preconditioned by injection of human cord blood. Stem Cells. 2001;19:443-52 pubmed
- Bode L, Murch S, Freeze H. Heparan sulfate plays a central role in a dynamic in vitro model of protein-losing enteropathy. J Biol Chem. 2006;281:7809-15 pubmed..Soluble heparin fully compensated for HS loss, providing a reasonable explanation for patient favorable response to heparin therapy. ..
- Richardson H, Zhao Y, Fekete E, Funk C, Wirsching P, Janda K, et al. MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacol Biochem Behav. 2008;88:497-510 pubmed
- Koolpe M, Burgess R, Dail M, Pasquale E. EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. J Biol Chem. 2005;280:17301-11 pubmed..These peptides should be useful as selective inhibitors of the pathological activities of EphB receptors and as targeting agents for imaging probes and therapeutic drugs. ..
- Chen B, Wen Y, Yu X, Polan M. Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas. Fertil Steril. 2009;91:1351-4 pubmed publisher..Relaxin increases elastase activity and protease inhibitor expressions in myometrial smooth muscle cells, but no effect was observed in leiomyoma cells. ..
- Widmaier E, Plotsky P, Sutton S, Vale W. Regulation of corticotropin-releasing factor secretion in vitro by glucose. Am J Physiol. 1988;255:E287-92 pubmed..The rise in glucocorticoids observed in vivo during hypoglycemia may result at least in part from the ability of the hypothalamus to directly sense glucose levels and promote secretion of CRF. ..
- Valdez G, Sabino V, Koob G. Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation. Alcohol Clin Exp Res. 2004;28:865-72 pubmed..These data suggest that activation of the CRF2 receptor may provide a novel target in the attenuation of the stress response characteristic of the early stages of ethanol withdrawal. ..
- Angst M, Ramaswamy B, Davies M, Maze M. Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Anesthesiology. 2004;101:744-52 pubmed..These results provide further evidence suggesting that systemic administration of dexmedetomidine lacks broad analgesic activity in models of acute pain at doses not rendering humans unconscious. ..
- Deng C, Brown J, You D, Brown J. Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae. Genetics. 2005;170:591-600 pubmed..These results suggest that Mre11 (with Sae2) and Slx4 represent two new structure-specific endonucleases that protect cells from trapped topoisomerase by removing topoisomerase-DNA adducts. ..
- Yachi P, Ampudia J, Gascoigne N, Zal T. Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol. 2005;6:785-92 pubmed..Thus, the interaction of CD8 with a nonstimulatory peptide-MHC complex helps mediate T cell recognition of antigen, improving the coreceptor function of CD8. ..
- Gruol D, Quina L, Netzeband J, Nguyen D, Gullette C. Developmental changes in Ca2+-regulated functions of early postnatal Purkinje neurons. J Neurosci Res. 2006;83:1381-92 pubmed..This age dependence may play an important role in the normal developmental program and could contribute to the critical window of sensitivity observed for certain toxic agents during early development. ..
- Kimoto Y, Kessler R, Constantinou C. Relaxation mechanisms of antispasmodics papaverine and thiphenamil on the human corpus cavernosum. J Urol. 1990;144:1497-9 pubmed..These results suggest that papaverine and thiphenamil relax CC tissue by the inhibition of extracellular Ca2+ influx (mainly voltage-dependent Ca2+ influx) and by the inhibition of release and/or storage of intracellular stored Ca2+. ..
- Deryugina E, Ratnikov B, Postnova T, Rozanov D, Strongin A. Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase. J Biol Chem. 2002;277:9749-56 pubmed..Regulation of integrin maturation and functionality may be an important role of MT1-MMP in tumor cells. ..
- Yun T, Baglia F, Myles T, Navaneetham D, Lopez J, Walsh P, et al. Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively. J Biol Chem. 2003;278:48112-9 pubmed..GPIb alpha plays a critical role in the co-localization of thrombin and FXI and the resultant efficient activation of FXI. ..
- Johnson J, Maher P, Hanneken A. The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression. Invest Ophthalmol Vis Sci. 2009;50:2398-406 pubmed publisher..These findings indicate that the greatest benefit from eriodictyol may be its ability to regulate gene expression and enhance multiple cellular defenses to oxidative injury. ..
- Verras M, Sun Z. Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor. Mol Endocrinol. 2005;19:391-8 pubmed..Moreover, using a pulse-chase experiment, we showed that IGF-I enhances the stability of beta-catenin in prostate cancer cells. Our findings delineate a novel pathway for IGF-I in modulating androgen signaling through beta-catenin. ..
- Eraly S, Vallon V, Vaughn D, Gangoiti J, Richter K, Nagle M, et al. Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem. 2006;281:5072-83 pubmed..We have also demonstrated in xenopus oocytes that some of these compounds interact with OAT1 in vitro. Thus, these latter compounds might represent physiological substrates of OAT1. ..
- Sabeti J, Nelson T, Purdy R, Gruol D. Steroid pregnenolone sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses: role for L-type calcium channels and sigma-receptors. Hippocampus. 2007;17:349-69 pubmed
- Osterberg L, Urquhart J, Blaschke T. Understanding forgiveness: minding and mining the gaps between pharmacokinetics and therapeutics. Clin Pharmacol Ther. 2010;88:457-9 pubmed publisher..Interruptions in dosing can interrupt drug action, but the consequences vary according to length of interruption, drug, drug formulation, length of the patient's prior exposure to the drug, and the disease being treated. ..
- Munhoz C, Sorrells S, Caso J, Scavone C, Sapolsky R. Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner. J Neurosci. 2010;30:13690-8 pubmed publisher..These findings suggest that GCs do not uniformly suppress neuroinflammation and can even enhance it at multiple levels in the pathway linking LPS exposure to inflammation. ..
- Malloy P, Eccleshall T, Gross C, Van Maldergem L, Bouillon R, Feldman D. Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness. J Clin Invest. 1997;99:297-304 pubmed..In conclusion, we describe a new ligand binding domain mutation in the VDR that causes HVDRR due to decreased affinity for 1,25(OH)2D3 which can be effectively treated with extremely high doses of hormone. ..
- Eto K, Puzon McLaughlin W, Sheppard D, Sehara Fujisawa A, Zhang X, Takada Y. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem. 2000;275:34922-30 pubmed
- Yanagawa N, Shih R, Jo O, Said H. Riboflavin transport by isolated perfused rabbit renal proximal tubules. Am J Physiol Cell Physiol. 2000;279:C1782-6 pubmed..Finally, we found that addition of chlorpromazine, a phenothiazine derivative, inhibited both J(lb) and J(bl), raising the concern about the nutritional status in patients receiving such a type of medication...
- Valdez G, Roberts A, Chan K, Davis H, Brennan M, Zorrilla E, et al. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin Exp Res. 2002;26:1494-501 pubmed..Attenuation of ethanol self-administration via central injection of D-Phe-CRF(12-41) implicates CRF as an underlying mechanism regulating long-term motivational effects associated with alcohol dependence. ..
- Hanneken A, Lin F, Johnson J, Maher P. Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death. Invest Ophthalmol Vis Sci. 2006;47:3164-77 pubmed..This select group of flavonoids and the foods that contain high levels of these compounds may have some clinical benefit for patients with retinal diseases associated with oxidative stress. ..
- Hah S, Sumbad R, de Vere White R, Turteltaub K, Henderson P. Characterization of oxaliplatin-DNA adduct formation in DNA and differentiation of cancer cell drug sensitivity at microdose concentrations. Chem Res Toxicol. 2007;20:1745-51 pubmed..This sensitivity for measuring oxaliplatin-DNA adducts is the highest reported to date. The sensitivity offered by this method may be applicable to other DNA-damaging drugs, metabolisms studies, and diagnostics development. ..
- Smith A, Smith D, Zigmond M, Amalric M, Koob G. Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm. Psychopharmacology (Berl). 2000;148:355-60 pubmed..These results provide further evidence that the execution of the reaction-time task is dependent preferentially upon the activation of D2 receptors, but not D1 or D3 receptors. ..
- Degryse B, Neels J, Czekay R, Aertgeerts K, Kamikubo Y, Loskutoff D. The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1. J Biol Chem. 2004;279:22595-604 pubmed..Activation of this LRP-dependent signaling pathway by PAI-1 may begin to explain how the inhibitor stimulates cell migration in a variety of normal and pathological processes. ..
- Chen A, Perrin M, Brar B, Li C, Jamieson P, Digruccio M, et al. Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids. Mol Endocrinol. 2005;19:441-58 pubmed
- Hao Y, Martin Fardon R, Weiss F. Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence. Biol Psychiatry. 2010;68:240-8 pubmed publisher..The differential behavioral effects of LY379268 and MTEP in rats with a history of long access to cocaine have implications for the treatment target potential of mGluR2/3 and mGluR5. ..
- Wang X, Li X, Meisenhelder J, Hunter T, Yoshida S, Asami T, et al. Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev Cell. 2005;8:855-65 pubmed..Our results support a BRI1-activation model that involves inhibition of kinase activity by its C-terminal domain, which is relieved upon ligand binding to the extracellular domain. ..
- Gass J, Bethune M, Siegel M, Spencer A, Khosla C. Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology. 2007;133:472-80 pubmed
- Xiao B, Dubin A, Bursulaya B, Viswanath V, Jegla T, Patapoutian A. Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci. 2008;28:9640-51 pubmed publisher..These data suggest separable structural requirements for modulation of TRPA1 by covalent and nonreactive molecules. Whether this region is involved in binding or gating of TRPA1 channels is discussed...
- Chavez Noriega L, Crona J, Washburn M, Urrutia A, Elliott K, Johnson E. Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1997;280:346-56 pubmed..The unique selectivity profiles displayed by human nAChRs constitute a valuable tool for the development of selective nicotinic analogs as potential therapeutic drugs. ..
- Hess S, Daggett L, Deal C, Lu C, Johnson E, Velicelebi G. Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. J Neurochem. 1998;70:1269-79 pubmed..The hNMDAR1A/2D combination represents a pharmacologically and functionally distinct receptor subtype and may constitute a potentially important target for therapeutic agents active in the human CNS. ..
- Beutler E, Gelbart T, West C. Synergy between TLR2 and TLR4: a safety mechanism. Blood Cells Mol Dis. 2001;27:728-30 pubmed..The greater sensitivity of MDP-stimulated cells to LPS may explain the data that were once interpreted incorrectly as indicating that Tlr2 is the endotoxin receptor. ..
- Yegneswaran S, Mesters R, Griffin J. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex. J Biol Chem. 2003;278:33312-8 pubmed..These data suggest that residues 404-418 in fXa provide fVa binding sites, whereas residues 557-571 in fII and 415-429 in fXa mediate interactions between fXa and fII in the prothrombinase complex. ..
- Herman D, Jenssen K, Burnett R, Soragni E, Perlman S, Gottesfeld J. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol. 2006;2:551-8 pubmed..This class of HDAC inhibitors may yield therapeutics for Friedreich's ataxia...
- White A, Bigby T, Stevenson D. Intranasal ketorolac challenge for the diagnosis of aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2006;97:190-5 pubmed..Mild bronchospasm occurred in 3 patients, and 2 of these occurred at higher starting doses of ketorolac. Nasal ketorolac administration is a reasonably accurate and safe method for diagnosing aspirin-exacerbated respiratory disease. ..
- Renhowe P, Pecchi S, Shafer C, Machajewski T, Jazan E, Taylor C, et al. Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors. J Med Chem. 2009;52:278-92 pubmed publisher..1 microM. On the basis of its favorable in vitro and in vivo properties, compound 5 was selected for clinical evaluation and is currently in phase I clinical trials. ..
- Imam F, Sutherland D, Huang W, Krasnow M. stumps, a Drosophila gene required for fibroblast growth factor (FGF)-directed migrations of tracheal and mesodermal cells. Genetics. 1999;152:307-18 pubmed..The results suggest that stumps function promotes FGF-directed cell migrations, either by potentiating the FGF signaling process or by coupling the signal to the cellular machinery required for directed cell movement. ..
- Hall S, Gibbs C, Leung L. Identification of critical residues on thrombin mediating its interaction with fibrin. Thromb Haemost. 2001;86:1466-74 pubmed..Mapping of these fibrin-binding residues on thrombin revealed that they are localized within exosite I, and comprise a subset of the residues important in fibrinogen recognition. ..
- Pilch J, Habermann R, Felding Habermann B. Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions. J Biol Chem. 2002;277:21930-8 pubmed..We conclude that the presence of alpha(v)beta3 in a functionally activated state provides a unique advantage for circulating tumor cells by promoting tumor cell arrest in the presence of flow-dependent shear forces. ..
- Kim Y, Suh N, Sporn M, Reed J. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J Biol Chem. 2002;277:22320-9 pubmed
- Spangenburg E. SOCS-3 induces myoblast differentiation. J Biol Chem. 2005;280:10749-58 pubmed..These data suggest that IGF-I induces myoblast differentiation, in part, by increasing SOCS-3 expression. ..
- Takagi Y, Masuda C, Chang W, Komori H, Wang D, Hunter T, et al. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Mol Cell. 2005;18:237-43 pubmed..Rather, it correlates with reduced transcriptional induction of genes involved in DNA repair, suggesting that the E3 Ub ligase activity of TFIIH mediates the transcriptional response to DNA damage. ..
- Sceniak M, MacIver M. Cellular actions of urethane on rat visual cortical neurons in vitro. J Neurophysiol. 2006;95:3865-74 pubmed..These results are consistent with observations seen in vivo during urethane anesthesia where urethane produced minimal disruption of signal transmission in the neocortex...
- Genovese M, Kaine J, Lowenstein M, Del Giudice J, Baldassare A, Schechtman J, et al. Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I/II randomized, blinded, placebo-controlled, dose-ranging study. Arthritis Rheum. 2008;58:2652-61 pubmed publisher..Ocrelizumab therapy in combination with MTX was well tolerated. Doses of 200 mg (2 infusions) and higher showed better clinical responses, better reduction of C-reactive protein levels, and very low immunogenicity. ..
- Choi J, Khansaheb M, Joo N, Krouse M, Robbins R, Weill D, et al. Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process. J Clin Invest. 2009;119:1189-200 pubmed publisher..Thus, in CF, the reduced ability of mucosal irritants to stimulate airway gland secretion via SubP may be another factor that predisposes the airways to infections...
- Kim Y, Girardi M, Duvic M, Kuzel T, Link B, Pinter Brown L, et al. Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma. J Am Acad Dermatol. 2010;63:975-83 pubmed publisher..This trial was not designed to rigorously assess efficacy. Single-agent PF-3512676 was well tolerated and demonstrated antitumor activity in patients with refractory CTCL. ..