Genomes and Genes
Experts and Doctors on drosophila proteins in New York, United States
Locale: New York, United States
Topic: drosophila proteins
Publications648 found, 100 shown here
- Chen C, Struhl G. Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila. Development. 1999;126:5441-52 pubmed..These results extend prior evidence of a ligand-receptor relationship between Wnt and Frizzled proteins and suggest that Fz and Fz2 are the primary receptors for Wg in Drosophila. ..
- Moloney D, Panin V, Johnston S, Chen J, Shao L, Wilson R, et al. Fringe is a glycosyltransferase that modifies Notch. Nature. 2000;406:369-75 pubmed
- Martinek S, Young M. Specific genetic interference with behavioral rhythms in Drosophila by expression of inverted repeats. Genetics. 2000;156:1717-25 pubmed..As an example, we show that inverted-repeat-mediated interference with the period gene produces a hypomorphic period phenotype. A selective decrease of period RNA appears to be a component of the cellular response. ..
- Betz A, Lampen N, Martinek S, Young M, Darnell J. A Drosophila PIAS homologue negatively regulates stat92E. Proc Natl Acad Sci U S A. 2001;98:9563-8 pubmed..To this end we use a LOF allele and conditionally overexpressed dpias in JAK-STAT pathway mutant backgrounds. We conclude that the correct dpias/stat92E ratio is crucial for blood cell and eye development. ..
- Mckay D, Estella C, Mann R. The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene. Development. 2009;136:61-71 pubmed publisher..Together, these findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll. ..
- Flynt A, Liu N, Martin R, Lai E. Dicing of viral replication intermediates during silencing of latent Drosophila viruses. Proc Natl Acad Sci U S A. 2009;106:5270-5 pubmed publisher..In addition, the denial of bulk viral siRNAs from effector complexes suggests that criteria beyond the structural competency of RNA duplexes influence the assembly of functional silencing complexes. ..
- Schlame M. Formation of molecular species of mitochondrial cardiolipin 2. A mathematical model of pattern formation by phospholipid transacylation. Biochim Biophys Acta. 2009;1791:321-5 pubmed publisher..It is concluded that acyl-specific cardiolipin patterns could arise from phospholipid transacylations in the tafazzin domain, even if tafazzin itself does not have substrate specificity. ..
- Keene A, Mazzoni E, Zhen J, Younger M, Yamaguchi S, Blau J, et al. Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment. J Neurosci. 2011;31:6527-34 pubmed publisher..Our findings provide insights into the coding of sensory information for distinct behavioral functions and the underlying molecular and neuronal circuitry. ..
- Dus M, Min S, Keene A, Lee G, Suh G. Taste-independent detection of the caloric content of sugar in Drosophila. Proc Natl Acad Sci U S A. 2011;108:11644-9 pubmed publisher..Thus, the need to replenish depleted energy stores during periods of starvation may be met through the activity of a taste-independent metabolic sensing pathway...
- Rogulja D, Young M. Control of sleep by cyclin A and its regulator. Science. 2012;335:1617-21 pubmed publisher..CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior. ..
- Jiang J, Rushlow C, Zhou Q, Small S, Levine M. Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo. EMBO J. 1992;11:3147-54 pubmed..Evidence is also presented that the affinities of dl binding sites are important for the efficiency of repression, but are not the sole determinants of the threshold response to the dl gradient. ..
- Young M. The molecular control of circadian behavioral rhythms and their entrainment in Drosophila. Annu Rev Biochem. 1998;67:135-52 pubmed..The recent discovery of PER homologues in mice and humans suggests that a related mechanism controls mammalian circadian behavioral rhythms. ..
- Maurel Zaffran C, Treisman J. pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila. Development. 2000;127:1007-16 pubmed..Pannier is thus the most upstream element yet described in dorsoventral patterning of the eye disc. ..
- Matova N, Anderson K. Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense. Proc Natl Acad Sci U S A. 2006;103:16424-9 pubmed
- Lin M, Park J, Kirov N, Rushlow C. Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. Development. 2006;133:4805-13 pubmed..Thus, the combinatorial action of Smad and Zen activators bound to a number of adjacent sites, and competing negative cues allows for proper gene response to lower than peak levels of the Dpp morphogen. ..
- Tyler D, Okamura K, Chung W, Hagen J, Berezikov E, Hannon G, et al. Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev. 2008;22:26-36 pubmed publisher..These findings demonstrate that antisense transcription and processing contributes to the functional diversification of miRNA genes. ..
- Emelyanov A, Konev A, Vershilova E, Fyodorov D. Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo. J Biol Chem. 2010;285:15027-37 pubmed publisher..These results provide evidence for essential biological functions of Drosophila ATRX in vivo and establish ATRX as a major determinant of pericentric beta-heterochromatin identity. ..
- Collins B, Kane E, Reeves D, Akabas M, Blau J. Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron. 2012;74:706-18 pubmed publisher..Thus, the changing balance in activity between clock neurons with opposing behavioral effects generates robust circadian behavior and probably helps organisms transition between discrete behavioral states, such as sleep and wakefulness. ..
- Yang J, Smibert P, Westholm J, Jee D, Maurin T, Lai E. Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila. Nucleic Acids Res. 2014;42:1987-2002 pubmed publisher..Altogether, we document unexpected aspects of miRNA biogenesis and Ago sorting, and provide insights into maturation of Argonaute-cleaved miRNA substrates...
- Alami N, Smith R, Carrasco M, Williams L, Winborn C, Han S, et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 2014;81:536-543 pubmed publisher..Thus, TDP-43 mutations that cause ALS lead to partial loss of a novel cytoplasmic function of TDP-43. ..
- Sanchez C, Teixeira F, Czech B, Preall J, Zamparini A, Seifert J, et al. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Cell Stem Cell. 2016;18:276-90 pubmed publisher..Collectively, these results detail the extensive genetic networks that control stem cell homeostasis and highlight the intricate regulation of protein synthesis during differentiation. ..
- Smith C, Giordano H, DeLotto R. Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain. Genetics. 1994;136:1355-65 pubmed..We propose a model in which the proenzyme determinants of both the snake and easter enzymes mediate interaction between the serine proteases and other components of the dorsal-ventral patterning system. ..
- Liu F, Hata A, Baker J, Doody J, Carcamo J, Harland R, et al. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature. 1996;381:620-3 pubmed..Additionally, we show that DPC4 contains a transcriptional activation domain. The results suggests that the Smad proteins are a new class of transcription factors that mediate responses to the TGF-beta family. ..
- Shen B, Manley J. Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube. Development. 1998;125:4719-28 pubmed..These and other results allow us to propose a model by which multiple phosphorylation-regulated interactions between these three proteins lead to activation of the Dorsal signaling pathway. ..
- Brennan C, Li T, Bender M, Hsiung F, Moses K. Broad-complex, but not ecdysone receptor, is required for progression of the morphogenetic furrow in the Drosophila eye. Development. 2001;128:1-11 pubmed..These results suggest that a novel hormone transduction hierarchy involving an uncharacterized receptor operates in the eye disc. ..
- Lee J, Kraus P, Gaiano N, Nery S, Kohtz J, Fishell G, et al. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development. Dev Biol. 2001;233:122-36 pubmed..Furthermore, overexpression of the mutant form has dominant negative effects on Hedgehog signaling. These data suggest that the importance of the N-terminal cysteine of mature Hedgehog in patterning appendages differs between species. ..
- Hoek M, Zanders T, Cross G. Trypanosoma brucei expression-site-associated-gene-8 protein interacts with a Pumilio family protein. Mol Biochem Parasitol. 2002;120:269-83 pubmed..T. brucei is the most evolutionary divergent organism in which a Puf family protein has been identified, and our initial experiments suggest that this protein may also regulate RNA stability in trypanosomes...
- Henriksen M, Betz A, Fuccillo M, Darnell J. Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. Genes Dev. 2002;16:2379-89 pubmed..We therefore conclude that the short form of STAT92E is a naturally occurring dominant-negative product that can be added to the growing list of negative regulators of STAT activity. ..
- Weber U, Eroglu C, Mlodzik M. Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev Cell. 2003;5:559-70 pubmed..A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic. ..
- Xu M, Kirov N, Rushlow C. Peak levels of BMP in the Drosophila embryo control target genes by a feed-forward mechanism. Development. 2005;132:1637-47 pubmed..In addition, we demonstrate that ectopically expressed Zen can activate targets like Race in the presence of low level Smads, indicating that the role of the highest activity of the BMP gradient is to activate zen. ..
- Firth L, Baker N. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell. 2005;8:541-51 pubmed..These studies identify the specific extracellular signals that pattern the retinal cell cycles and show how differentiation can be uncoupled from cell cycle exit. ..
- Yucel G, Small S. Morphogens: precise outputs from a variable gradient. Curr Biol. 2006;16:R29-31 pubmed..Several recent papers examine the patterning activities of Drosophila Bicoid, the first known molecular morphogen and reach different conclusions about the patterning power of a single morphogen gradient. ..
- Ai M, Blais S, Park J, Min S, Neubert T, Suh G. Ionotropic glutamate receptors IR64a and IR8a form a functional odorant receptor complex in vivo in Drosophila. J Neurosci. 2013;33:10741-9 pubmed publisher..These findings provide direct evidence that IR8a is a subunit that forms a functional olfactory receptor with IR64a in vivo to mediate odor detection. ..
- Johnston R, Otake Y, Sood P, Vogt N, Behnia R, Vasiliauskas D, et al. Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye. Cell. 2011;145:956-68 pubmed publisher..Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific repression or activation outcomes. This interlocked FFL motif may be a general mechanism to control terminal cell-fate specification. ..
- Bejarano F, Bortolamiol Becet D, Dai Q, Sun K, Saj A, Chou Y, et al. A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. Development. 2012;139:2821-31 pubmed publisher..By extension, these data suggest that the deregulation of individual miRNAs in other animals may frequently yield relatively specific phenotypes during disease conditions. ..
- Carmena A, Buff E, Halfon M, Gisselbrecht S, Jimenez F, Baylies M, et al. Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev Biol. 2002;244:226-42 pubmed..These reciprocal interactions combine to generate the signal thresholds that are essential for proper specification of progenitors and nonprogenitors from groups of initially equivalent cells. ..
- Staeva Vieira E, Yoo S, Lehmann R. An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control. EMBO J. 2003;22:5863-74 pubmed..We therefore propose that under normal conditions a second, Rad51-independent, repair pathway prevents the lethal effects of DNA damage. ..
- Tomlinson A. Patterning the peripheral retina of the fly: decoding a gradient. Dev Cell. 2003;5:799-809 pubmed..Higher Wg levels induce PR, intermediate levels induce DR, and lower levels induce baldness. The predisposition of dorsal cells to generate DR ommatidia appears to be endowed by the exclusive dorsal expression of Iroquois genes. ..
- Bauer Huang S, Saheki Y, VanHoven M, Torayama I, Ishihara T, Katsura I, et al. Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans. Neural Dev. 2007;2:24 pubmed..The interpretation of these signals by the kinase cascade initiates the sustained difference between the two cells. ..
- Datta R, Small S. Gene regulation: piecing together the puzzle of enhancer evolution. Curr Biol. 2011;21:R542-3 pubmed publisher..A detailed analysis of the fast-evolving sparkling enhancer in Drosophila now identifies key compensatory mechanisms and 'grammar' elements that are critical for maintaining functional integrity. ..
- Mizrak D, Ruben M, Myers G, Rhrissorrakrai K, Gunsalus K, Blau J. Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons. Curr Biol. 2012;22:1871-80 pubmed publisher..The electrical state of a clock neuron can impose time of day to its transcriptional program. We propose that this acts as an internal zeitgeber to add robustness and precision to circadian behavioral rhythms. ..
- Hardy R, Resh M. Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase. J Biol Chem. 2012;287:42881-9 pubmed publisher..Finally, we report the results of a bioinformatics screen to identify other potential Hhat substrates encoded in the human genome. ..
- Liu W, Acin Perez R, Geghman K, Manfredi G, Lu B, Li C. Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc Natl Acad Sci U S A. 2011;108:12920-4 pubmed publisher..Taken together, these results suggest a unique pathogenic mechanism of PINK1 PD: The loss of PINK1 impairs mitochondrial fission, which causes defective assembly of the ETC complexes, leading to abnormal bioenergetics. ..
- Chen Y, Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell. 1996;87:553-63 pubmed..Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement. ..
- Li C, Manley J. Allosteric regulation of even-skipped repression activity by phosphorylation. Mol Cell. 1999;3:77-86 pubmed..Our results suggest a novel mechanism of transcriptional control involving phosphorylation-induced allosteric interference with a repressive protein-protein interaction. ..
- Casares F, Mann R. A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila. Development. 2000;127:1499-508 pubmed..Our results suggest that tsh and hth block wing blade development by repressing some of the activities of the Notch pathway at the D/V compartment boundary. ..
- Jones B, Abeysekera M, Galinska J, Jolicoeur E. Transcriptional control of glial and blood cell development in Drosophila: cis-regulatory elements of glial cells missing. Dev Biol. 2004;266:374-87 pubmed..Our results indicate that gcm transcription is controlled by a combination of general and lineage-specific elements, positive autoregulation, and neuronal repression. ..
- Flaherty M, Zavadil J, Ekas L, Bach E. Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway. Dev Dyn. 2009;238:2235-53 pubmed publisher..These data suggest that this study will be a useful resource for the identification of additional Stat92E targets. ..
- Treisman J. Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development. 2001;128:603-15 pubmed..These novel and specific phenotypes suggest that TRAP240 and TRAP230 act in concert to mediate an unknown developmental signal or a combination of signals. ..
- Lo P, Frasch M. A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila. Mech Dev. 2001;104:49-60 pubmed..We also describe the tinman cis sequences that mediate tinman repression by seven-up and examine whether Seven-up can bind these sequences to directly inhibit tinman. ..
- Reynolds Kenneally J, Mlodzik M. Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye. Dev Biol. 2005;285:38-48 pubmed..However, cell-autonomous effects of Notch within and posterior to the furrow are independent of Upd. Here, Notch autonomously maintains cells in a proliferative state and blocks photoreceptor differentiation. ..
- Datta S, Vasconcelos M, Ruta V, Luo S, Wong A, Demir E, et al. The Drosophila pheromone cVA activates a sexually dimorphic neural circuit. Nature. 2008;452:473-7 pubmed publisher..The observation that cVA activates a sexually dimorphic circuit in the protocerebrum suggests a mechanism by which a single pheromone can elicit different behaviours in males and in females. ..
- Shapiro P, Hsu H, Jung H, Robbins E, Ryoo H. Regulation of the Drosophila apoptosome through feedback inhibition. Nat Cell Biol. 2008;10:1440-6 pubmed publisher..We speculate that this feedback inhibition allows cells to regulate the degree of caspase activation for apoptotic and non-apoptotic purposes. ..
- Jattani R, Patel U, Kerman B, Myat M. Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo. Dev Dyn. 2009;238:853-63 pubmed publisher..Our studies reveal for the first time that beta2t is expressed in embryogenesis and that beta2t plays an important role in salivary gland and myoblast migration, possibly through proper regulation of integrin adhesion proteins. ..
- Schaeffer V, Janody F, Loss C, Desplan C, Wimmer E. Bicoid functions without its TATA-binding protein-associated factor interaction domains. Proc Natl Acad Sci U S A. 1999;96:4461-6 pubmed..This means that the interactions observed in vitro between Bcd and TAFII60 or TAFII110 aid transcriptional activation but are dispensable for normal development. ..
- Holdridge C, Dorsett D. Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster. Mol Cell Biol. 1991;11:1894-900 pubmed..We propose that su(Hw) protein interferes nonspecifically with protein-protein interactions required for heat shock transcription, perhaps sterically, or by altering the ability of DNA to bend or twist. ..
- Price J, Blau J, Rothenfluh A, Abodeely M, Kloss B, Young M. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell. 1998;94:83-95 pubmed..This would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity. ..
- Morris J, Hong A, Lilly M, Lehmann R. twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis. Development. 2005;132:1165-74 pubmed..We propose that Twin/Ccr4 functions during early oogenesis to coordinate cyst division, oocyte fate specification and egg chamber maturation. ..
- Mikeladze Dvali T, Wernet M, Pistillo D, Mazzoni E, Teleman A, Chen Y, et al. The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell. 2005;122:775-87 pubmed..This represents an unexpected postmitotic role for genes controlling cell proliferation (warts and its partner hippo and salvador) and cell growth (melted). ..
- Gonsalves F, Klein K, Carson B, Katz S, Ekas L, Evans S, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A. 2011;108:5954-63 pubmed publisher..Importantly, these Wnt inhibitors are specifically cytotoxic to human colon tumor biopsy cultures as well as colon cancer cell lines that exhibit deregulated Wnt signaling. ..
- Matthews B, Grueber W. Dscam1-mediated self-avoidance counters netrin-dependent targeting of dendrites in Drosophila. Curr Biol. 2011;21:1480-7 pubmed publisher..Counterbalancing roles for Dscam1 may be deployed in diverse contexts during neural circuit formation. ..
- Gault W, Olguin P, Weber U, Mlodzik M. Drosophila CK1-?, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. J Cell Biol. 2012;196:605-21 pubmed publisher..Our findings suggest that polarized Rab11-mediated vesicle trafficking regulated by CK1-? is required for PCP-directed processes. ..
- Dai Q, Ren A, Westholm J, Serganov A, Patel D, Lai E. The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. Genes Dev. 2013;27:602-14 pubmed publisher..Altogether, we define novel DNA-binding activity in a conserved family of transcriptional repressors, opening a molecular window on this extensive gene family. ..
- Campbell G, Goring H, Lin T, Spana E, Andersson S, Doe C, et al. RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. Development. 1994;120:2957-66 pubmed..This suggests that RK2 is not required for early glial determination, but rather for aspects of glial differentiation or function that are required for embryonic viability. ..
- Knirr S, Azpiazu N, Frasch M. The role of the NK-homeobox gene slouch (S59) in somatic muscle patterning. Development. 1999;126:4525-35 pubmed..Together, these findings provide new insights into the regulatory interactions that establish the somatic muscle pattern. ..
- Malathi K, Xiao Y, Mitchell A. Catalytic roles of yeast GSK3beta/shaggy homolog Rim11p in meiotic activation. Genetics. 1999;153:1145-52 pubmed..Therefore, Ime1p and Rim11p have two genetically separable functions in the sporulation program. However, catalytic activity of Rim11p is required for sporulation in the presence or absence of Ume6p. ..
- Lee E, Yu S, Baker N. The scabrous protein can act as an extracellular antagonist of notch signaling in the Drosophila wing. Curr Biol. 2000;10:931-4 pubmed..Our results indicate that Sca can act on N to reduce its availability for paracrine and autocrine interactions with DI and Ser, and can act as an antagonist of N signaling. ..
- Kloss B, Rothenfluh A, Young M, Saez L. Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron. 2001;30:699-706 pubmed..The varying associations of PER, DBT and TIM appear to determine the onset and duration of nuclear PER function within the Drosophila clock. ..
- Jaeger J, Surkova S, Blagov M, Janssens H, Kosman D, Kozlov K, et al. Dynamic control of positional information in the early Drosophila embryo. Nature. 2004;430:368-71 pubmed
- Oberstein A, Pare A, Kaplan L, Small S. Site-specific transgenesis by Cre-mediated recombination in Drosophila. Nat Methods. 2005;2:583-5 pubmed..The system is simple and efficient, and will permit precise comparisons between multiple transgenic constructs. ..
- True J, Yeh S, Hovemann B, Kemme T, Meinertzhagen I, Edwards T, et al. Drosophila tan encodes a novel hydrolase required in pigmentation and vision. PLoS Genet. 2005;1:e63 pubmed publisher..This is, to our knowledge, the first molecular genetic characterization of NBAD hydrolase and carcinine hydrolase activity in any organism and is central to the understanding of pigmentation and photoreceptor function...
- Miura G, Buglino J, Alvarado D, Lemmon M, Resh M, Treisman J. Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Dev Cell. 2006;10:167-76 pubmed..These data suggest a role for palmitoylation in restricting Spitz diffusion, allowing its local concentration to reach the threshold required for biological function. ..
- Louis M, Huber T, Benton R, Sakmar T, Vosshall L. Bilateral olfactory sensory input enhances chemotaxis behavior. Nat Neurosci. 2008;11:187-99 pubmed..We found additional evidence that the overall accuracy of navigation is enhanced by the increase in the signal-to-noise ratio conferred by bilateral sensory input. ..
- Yukilevich R, True J. African morphology, behavior and phermones underlie incipient sexual isolation between us and Caribbean Drosophila melanogaster. Evolution. 2008;62:2807-28 pubmed publisher..These results imply that Caribbean mating preferences are likely to be based on African traits and that even at such early stages of sexual isolation, individuals may already cue in on several traits simultaneously during mate choice. ..
- Ryoo H, Baehrecke E. Distinct death mechanisms in Drosophila development. Curr Opin Cell Biol. 2010;22:889-95 pubmed publisher..Surprisingly, the cell corpse engulfment receptor Draper also functions in autophagic cell death. These advances facilitate our understanding of the cell death mechanisms in development and disease. ..
- Walker J, Lee K, Desai R, Erickson J. The Drosophila melanogaster sex determination gene sisA is required in yolk nuclei for midgut formation. Genetics. 2000;155:191-202 pubmed..To our knowledge, this is the first report of a requirement for the yolk nuclei in Drosophila development. ..
- Klein T, Jenny A, Djiane A, Mlodzik M. CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. Curr Biol. 2006;16:1337-43 pubmed..Furthermore, we have identified the primary kinase target residue of CKIepsilon on Dsh. Thus, our data suggest that CKIepsilon modulates Wnt/beta-catenin and Fz/PCP signaling pathways via kinase-dependent and -independent mechanisms. ..
- Xiang K, Nagaike T, Xiang S, Kilic T, Beh M, Manley J, et al. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010;467:729-33 pubmed publisher..Because catalytically active Ssu72 overcomes this inhibition, our results show a role for mammalian Ssu72 in transcription-coupled pre-mRNA 3'-end processing. ..
- Ayer S, Benyajati C. The binding site of a steroid hormone receptor-like protein within the Drosophila Adh adult enhancer is required for high levels of tissue-specific alcohol dehydrogenase expression. Mol Cell Biol. 1992;12:661-73 pubmed..Such alternative binding may play a role in the tissue-specific and developmental transcription of Adh. ..
- Immanuel D, Zinszner H, Ron D. Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II. Mol Cell Biol. 1995;15:4562-71 pubmed..We conclude that SARFH and, by homology, EWS and TLS participate in a function common to the expression of most genes transcribed by RNA Pol II. ..
- Lee P, Shabbir A, Cardozo C, Caplan A. Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase. Mol Biol Cell. 2004;15:1785-92 pubmed..These data suggest that Cdc37 and Sti1 have functional overlap in stabilizing Hsp90:client complexes. Finally, we show that Cns1 functions in MAP kinase signaling in association with Cpr7. ..
- Curtiss J, Burnett M, Mlodzik M. distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila. Dev Biol. 2007;306:685-702 pubmed..These data demonstrate a role for Dan and Danr in eye development and provide a link between eye specification and differentiation. ..
- Weber U, Pataki C, Mihaly J, Mlodzik M. Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. Dev Biol. 2008;316:110-23 pubmed publisher..Taken together with previous work establishing a Notch-dependent Su(H) function in R4, we conclude that Fos, Yan, Pnt, and Su(H) integrate Egfr, Fz, and Notch signaling input in R3 or R4 to establish cell fate and ommatidial polarity. ..
- Slattery M, Ma L, Negre N, White K, Mann R. Genome-wide tissue-specific occupancy of the Hox protein Ultrabithorax and Hox cofactor Homothorax in Drosophila. PLoS ONE. 2011;6:e14686 pubmed publisher..Together, these data provide the first whole-genome analysis of the binding sites and target genes regulated by Ubx to specify the morphologies of the adult T3 segment of the fly. ..
- Parisi F, Riccardo S, Zola S, Lora C, Grifoni D, Brown L, et al. dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth. Dev Biol. 2013;379:64-75 pubmed publisher..In addition, the regulation of Desat1 controls the synthesis of triglycerides in FB and this may affect the humoral signal that controls DILP2 release in the brain. ..
- de Bivort B, Guo H, Zhong Y. Notch signaling is required for activity-dependent synaptic plasticity at the Drosophila neuromuscular junction. J Neurogenet. 2009;23:395-404 pubmed publisher..Last, we show that endogenous Notch is primarily expressed in the presynaptic cell bodies where its expression level is positively correlated with motor neuron activity. ..
- Wehrli M, Tomlinson A. Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. Development. 1998;125:1421-32 pubmed..Further, we show that the polarizing information acting in this equatorial/polar axis (Eq/Pl) is established in at least two steps - the activity of one signaling molecule functions to establish the graded activity of a second signal. ..
- Qiu P, Pan P, Govind S. A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. Development. 1998;125:1909-20 pubmed..These findings are discussed in light of similar hematopoietic functions of Rel/I(kappa)B-family proteins in mice. ..
- Xu X, Yin Z, Hudson J, Ferguson E, Frasch M. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 1998;12:2354-70 pubmed..Thus, integration of positive and negative regulators on enhancers of target genes appears to be an important mechanism in tissue-specific induction by TGF-beta molecules. ..