Experts and Doctors on drosophila proteins in England, United Kingdom


Locale: England, United Kingdom
Topic: drosophila proteins

Top Publications

  1. Buttrick G, Beaumont L, Leitch J, Yau C, Hughes J, Wakefield J. Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo. J Cell Biol. 2008;180:537-48 pubmed publisher
  2. Paroush Z, Finley R, Kidd T, Wainwright S, Ingham P, Brent R, et al. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell. 1994;79:805-15 pubmed
  3. Uv A, Thompson C, Bray S. The Drosophila tissue-specific factor Grainyhead contains novel DNA-binding and dimerization domains which are conserved in the human protein CP2. Mol Cell Biol. 1994;14:4020-31 pubmed
    ..The major dimerization domain is located in a separate region of the protein and is required to stabilize the interactions with DNA. Our data also suggest that Grainyhead activity can be modulated by an N-terminal inhibitory domain. ..
  4. Parton R, Hamilton R, Ball G, Yang L, Cullen C, Lu W, et al. A PAR-1-dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte. J Cell Biol. 2011;194:121-35 pubmed publisher
    ..Our findings explain the biased random posterior cargo movements in the oocyte that establish the germline and posterior. ..
  5. Rohn J, Sims D, Liu T, Fedorova M, Schock F, Dopie J, et al. Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J Cell Biol. 2011;194:789-805 pubmed publisher
  6. Bassi Z, Verbrugghe K, Capalbo L, Gregory S, Montembault E, Glover D, et al. Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. J Cell Biol. 2011;195:595-603 pubmed publisher
    ..We propose that Sti/CIT-K maintains correct RhoA localization at the cleavage site, which is necessary for proper RhoA activity and contractile ring dynamics. ..
  7. Ribeiro P, Kuranaga E, Tenev T, Leulier F, Miura M, Meier P. DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J Cell Biol. 2007;179:1467-80 pubmed publisher
    ..Because DIAP2 efficiently interacts with drICE, our data suggest that DIAP2 controls drICE in its apoptotic and nonapoptotic roles. ..
  8. Lucas E, Raff J. Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosomin. J Cell Biol. 2007;178:725-32 pubmed
    ..We conclude that Cnn maintains the proper connection between the centrioles and the PCM; this connection is required for accurate centriole segregation in somatic cells but is not essential for the asymmetric division of neuroblasts...
  9. Stevens N, Dobbelaere J, Wainman A, Gergely F, Raff J. Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies. J Cell Biol. 2009;187:355-63 pubmed publisher
    ..Thus, Ana3 defines a conserved family of centriolar proteins and plays an important part in ensuring the structural integrity of centrioles and basal bodies. ..

More Information


  1. Montembault E, Zhang W, Przewloka M, Archambault V, Sevin E, Laue E, et al. Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes. J Cell Biol. 2010;191:1351-65 pubmed publisher
    ..Our findings indicate that Nesd is a novel carbohydrate-binding protein that functions together with centralspindlin in late cytokinesis, thus highlighting the importance of glycosylation in this process...
  2. McGill S, Chia W, Karp R, Ashburner M. The molecular analyses of an antimorphic mutation of Drosophila melanogaster, Scutoid. Genetics. 1988;119:647-61 pubmed
    ..Thus mutation of either noc or sna, genes which are apparently unrelated in their wild-type functions, can revert the antimorphic phenotype of Sco. ..
  3. Sommer B, Oprins A, Rabouille C, Munro S. The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster. J Cell Biol. 2005;169:953-63 pubmed
    ..Thus, the exocyst may act in both Golgi to plasma membrane traffic and endocytic cycling, and hence in oocytes is recruited to clathrin-coated pits to facilitate the rapid recycling of Yolkless. ..
  4. Martinez Campos M, Basto R, Baker J, Kernan M, Raff J. The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis. J Cell Biol. 2004;165:673-83 pubmed
    ..Moreover, the flagella in mutant sperm are nonmotile. Thus, D-PLP is essential for the formation of functional cilia and flagella in flies. ..
  5. Page L, Sowerby P, Lui W, Robinson M. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. J Cell Biol. 1999;146:993-1004 pubmed
    ..The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins. ..
  6. Martin Bermudo M, Dunin Borkowski O, Brown N. Modulation of integrin activity is vital for morphogenesis. J Cell Biol. 1998;141:1073-81 pubmed
    ..These results suggest that the alphaPS2 subunit cytoplasmic domain is required for inside-out regulation of integrin affinity, as has been seen with the integrin alphaIIbbeta3. ..
  7. Lucas E, Khanal I, Gaspar P, Fletcher G, Polesello C, Tapon N, et al. The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells. J Cell Biol. 2013;201:875-85 pubmed publisher
    ..Instead, Warts phosphorylates and inhibits the actin regulator Ena to activate F-actin Capping protein activity on inner membranes and thereby restricts F-actin polymerization mainly to the outer rim of the migrating cluster. ..
  8. Law A, Vehlow A, Kotini M, Dodgson L, Soong D, Theveneau E, et al. Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J Cell Biol. 2013;203:673-89 pubmed publisher
    ..Pico also controls directed cell protrusions of border cell clusters in a Scar-dependent manner. Taken together, Lpd is an essential, evolutionary conserved regulator of the Scar/WAVE complex during cell migration in vivo...
  9. Taylor M, Beatty K, Hunter H, Baylies M. Drosophila MEF2 is regulated by twist and is expressed in both the primordia and differentiated cells of the embryonic somatic, visceral and heart musculature. Mech Dev. 1995;50:29-41 pubmed
    ..DMEF2 is also expressed in both the segregating primordia and the differentiated cells of the somatic, visceral and heart musculature. It is the only known gene expressed in these three main types of muscle throughout differentiation. ..
  10. Franz A, Roque H, Saurya S, Dobbelaere J, Raff J. CP110 exhibits novel regulatory activities during centriole assembly in Drosophila. J Cell Biol. 2013;203:785-99 pubmed publisher
    ..Finally, and unexpectedly, CP110 suppresses centriole overduplication induced by the overexpression of centriole duplication proteins. These studies identify novel and surprising functions for CP110 in vivo in flies. ..
  11. Roberts D, Jowett T, Hughes J, Smith D, Glover D. The major serum protein of Drosophila larvae, larval serum protein 1, is dispensable. Eur J Biochem. 1991;195:195-201 pubmed
    ..The three null alleles have been combined to give a strain without the gene for larval serum protein 1 which survives. ..
  12. Drummond D, Hennessey E, Sparrow J. The binding of mutant actins to profilin, ATP and DNase I. Eur J Biochem. 1992;209:171-9 pubmed
    ..Also amino acid changes can exert significant effects on the binding of ligands to distant parts of the actin structure. ..
  13. Wainwright S, Ish Horowicz D. Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains. Mol Cell Biol. 1992;12:2475-83 pubmed
    ..We show that the h protein in Drosophila virilis closely resembles that in D. melanogaster and includes completely conserved bHLH and WRPW domains...
  14. Bulgakova N, Grigoriev I, Yap A, Akhmanova A, Brown N. Dynamic microtubules produce an asymmetric E-cadherin-Bazooka complex to maintain segment boundaries. J Cell Biol. 2013;201:887-901 pubmed publisher
  15. Dix C, Soundararajan H, Dzhindzhev N, Begum F, Suter B, Ohkura H, et al. Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs. J Cell Biol. 2013;202:479-94 pubmed publisher
    ..Our data therefore reveal a critical role for Lis1 within the mRNA localization machinery and suggest a model in which Lis1 facilitates motor complex association with cargos by promoting the interaction of dynein with dynactin. ..
  16. Tan S, Lyulcheva E, Dean J, Bennett D. Mars promotes dTACC dephosphorylation on mitotic spindles to ensure spindle stability. J Cell Biol. 2008;182:27-33 pubmed publisher
    ..A nonphosphorylatable form of dTACC is capable of rescuing the lethality of mars mutants. We propose that Mars mediates spatially controlled dephosphorylation of dTACC, which is critical for spindle stabilization. ..
  17. Munro T, Kwon S, Schnapp B, St Johnston D. A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP. J Cell Biol. 2006;172:577-88 pubmed
    ..Our findings establish a parallel requirement for IBEs in the regulation of localized maternal mRNAs in D. melanogaster and X. laevis. ..
  18. Green C, Levashina E, McKimmie C, Dafforn T, Reichhart J, Gubb D. The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2. Genetics. 2000;156:1117-27 pubmed
    ..Absence of Spn43Ac, however, gives a clear phenotype, which will allow a mutational analysis of critical features of the molecular structure of serpins. ..
  19. Jimenez G, Verrijzer C, Ish Horowicz D. A conserved motif in goosecoid mediates groucho-dependent repression in Drosophila embryos. Mol Cell Biol. 1999;19:2080-7 pubmed
    ..Our results indicate that Gro does not form stable associations with other proteins but that it may be able to assemble into homomultimeric complexes. ..
  20. Jimenez G, Paroush Z, Ish Horowicz D. Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev. 1997;11:3072-82 pubmed
    ..These results show that Gro is not generally required for repression, but acts as a specific corepressor for a fraction of negative regulators, including Hairy and En. ..
  21. Couso J, Martinez Arias A. Notch is required for wingless signaling in the epidermis of Drosophila. Cell. 1994;79:259-72 pubmed
    ..In addition, we observe that mutations in N behave as dominant enhancers of wg and that there exist allele-specific interactions between the two loci. Our results suggest that the product of wg is a ligand for N. ..
  22. Gao S, Giansanti M, Buttrick G, Ramasubramanyan S, Auton A, Gatti M, et al. Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis. J Cell Biol. 2008;180:521-35 pubmed publisher
  23. Stramer B, Moreira S, Millard T, Evans I, Huang C, Sabet O, et al. Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo. J Cell Biol. 2010;189:681-9 pubmed publisher
    ..The same is true in orbit/clasp mutants, indicating a pivotal role for this microtubule-binding protein in the assembly and/or functioning of the microtubule arm during polarized migration and contact repulsion. ..
  24. Stofanko M, Kwon S, Badenhorst P. Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity. PLoS ONE. 2010;5:e14051 pubmed publisher
    ..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge. ..
  25. Barros T, Kinoshita K, Hyman A, Raff J. Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. J Cell Biol. 2005;170:1039-46 pubmed
    ..This may explain why centrosomes are such dominant sites of MT assembly during mitosis. ..
  26. Chan H, Brogna S, O Kane C. Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. Mol Biol Cell. 2001;12:1409-19 pubmed
    ..Clonal analyses suggest that dbe(+) is required for survival of dividing cells. In dbe mutants, a novel rRNA-processing defect is found and accumulation of an abnormal rRNA precursor is detected. ..
  27. Bar K, Facer P, Williams N, Tam P, Anand P. Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease. Gastroenterology. 1997;112:1381-5 pubmed
    ..Its staining pattern suggests that it is localized in glia or Schwann cells. There seems to be no difference of GDNF levels between affected and unaffected intestinal segments in Hirschsprung's disease. ..
  28. Sweeney S, Broadie K, Keane J, Niemann H, O Kane C. Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Neuron. 1995;14:341-51 pubmed
    ..Targeted expression of toxin can produce specific behavioral defects; in one case, the olfactory escape response is reduced. ..
  29. Hoogwerf A, Akam M, Roberts D. A genetic analysis of the rose-gespleten region (68C8-69B5) of Drosophila melanogaster. Genetics. 1988;118:665-70 pubmed
    ..None was rescued by the active Lsp-2 gene transformed on to chromosome II and we conclude that, as yet, we have no lethal mutations of Lsp-2. ..