Experts and Doctors on drosophila in New York, United States


Locale: New York, United States
Topic: drosophila

Top Publications

  1. Chan S, Mann R. The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences. Genes Dev. 1993;7:796-811 pubmed
    ..Therefore, it is likely that this assay measures the coordinate regulation of many downstream target genes. This expectation is confirmed for at least one Ubx target gene, Distal-less. ..
  2. Wu X, Vakani R, Small S. Two distinct mechanisms for differential positioning of gene expression borders involving the Drosophila gap protein giant. Development. 1998;125:3765-74 pubmed
    ..The differential responses of these target genes to gt repression are critical for the correct positioning and maintenance of segmentation stripes, and normal anterior development. ..
  3. Nance J, Zallen J. Elaborating polarity: PAR proteins and the cytoskeleton. Development. 2011;138:799-809 pubmed publisher
    ..elegans and Drosophila, and emphasize the links that exist between PAR networks and cytoskeletal proteins that both regulate PAR protein localization and act as downstream effectors to elaborate polarity within the cell. ..
  4. Dollar G, Gombos R, Barnett A, Sanchez Hernandez D, Maung S, Mihály J, et al. Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila. Genetics. 2016;202:1135-51 pubmed publisher
    ..It furthermore highlights the importance and complexity of formin-dependent cytoskeletal regulation in multiple organs and developmental contexts. ..
  5. Zuo P, Stanojevic D, Colgan J, Han K, Levine M, Manley J. Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells. Genes Dev. 1991;5:254-64 pubmed
    ..We discuss the possible molecular mechanisms underlying these activities, as well as the potential significance of these results with respect to segmentation in Drosophila. ..
  6. Yan R, Small S, Desplan C, Dearolf C, Darnell J. Identification of a Stat gene that functions in Drosophila development. Cell. 1996;84:421-30 pubmed
    ..Mutations in either of the STAT-binding sites greatly decreased the stripe 3 expression in transgenic flies. Clearly, the JAK-STAT pathway is connected to Drosophila early development. ..
  7. Lo P, Frasch M. Sequence and expression of myoglianin, a novel Drosophila gene of the TGF-beta superfamily. Mech Dev. 1999;86:171-5 pubmed
    ..We also show that the zygotic expression of a recently described Drosophila activin, which maps to the same interval 102 on chromosome 4 as myoglianin, is restricted to the developing central and peripheral nervous system. ..
  8. Forbes A, Lehmann R. Cell migration in Drosophila. Curr Opin Genet Dev. 1999;9:473-8 pubmed
    ..In the female germline, the migratory path of border cells is directed by the homophilic adhesion molecule E cadherin. ..
  9. Baek M, Mann R. Lineage and birth date specify motor neuron targeting and dendritic architecture in adult Drosophila. J Neurosci. 2009;29:6904-16 pubmed publisher
    ..Thus, although Drosophila uses a lineage-based method to generate leg motor neurons, individual lineages are not dedicated to generate neurons that target a single leg segment or muscle type. ..

More Information

Publications381 found, 100 shown here

  1. Colgan J, Manley J. TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters. Genes Dev. 1992;6:304-15 pubmed
  2. Small S, Kraut R, Hoey T, Warrior R, Levine M. Transcriptional regulation of a pair-rule stripe in Drosophila. Genes Dev. 1991;5:827-39 pubmed
    ..Such short-range repression could reflect a general property of promoters composed of multiple, but autonomous regulatory elements. ..
  3. Howard K, Ingham P, Rushlow C. Region-specific alleles of the Drosophila segmentation gene hairy. Genes Dev. 1988;2:1037-46 pubmed
    ..We have located the mutations on the DNA map of the hairy gene. They identify a 5' region of approximately less than 20 kb necessary for this decoding function. ..
  4. Mann R. The specificity of homeotic gene function. Bioessays. 1995;17:855-63 pubmed
    ..Although exd provides part of the answer as to how specificity is achieved, there may be additional cofactors and mechanisms that have yet to be identified. ..
  5. Crowley T, Hazelrigg T. A male-specific 3'-UTR regulates the steady-state level of the exuperantia mRNA during spermatogenesis in Drosophila. Mol Gen Genet. 1995;248:370-4 pubmed
    ..Males carrying multiple copies of this transgene are fertile, suggesting that the male-specific 3'-UTR functions to maintain a proper level of exu product in the germline. ..
  6. Han K, Manley J. Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain. Genes Dev. 1993;7:491-503 pubmed
    ..An intriguing feature of the strong repressors was that their DNA-binding activities, measured by gel retention assays with nuclear extracts, were significantly less than those of derivatives inactive in repression. ..
  7. Tomlinson A, Strapps W, Heemskerk J. Linking Frizzled and Wnt signaling in Drosophila development. Development. 1997;124:4515-21 pubmed
    ..Taken together our results significantly strengthen the case for Fz acting in a Wnt signaling pathway in Drosophila. ..
  8. Hobert O, Westphal H. Functions of LIM-homeobox genes. Trends Genet. 2000;16:75-83 pubmed
    ..Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements. ..
  9. Struhl G, Greenwald I. Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci U S A. 2001;98:229-34 pubmed
  10. Wu J, Duggan A, Chalfie M. Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans. Genes Dev. 2001;15:789-802 pubmed
    ..The sequences of these genes and their nuclear location as seen with GFP fusions indicate that they repress transcription of touch cell characteristics in the FLP cells. ..
  11. Bhat M, Rios J, Lu Y, Garcia Fresco G, Ching W, St Martin M, et al. Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron. 2001;30:369-83 pubmed
    ..These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction. ..
  12. Cong F, Schweizer L, Varmus H. Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development. 2004;131:5103-15 pubmed
    ..In addition, the beta-catenin signaling mediated by ectopic expression of LRP is not dependent on Disheveled or Wnt, but can also be augmented by oligomerization of LRP receptors. ..
  13. Oishi K, Gaengel K, Krishnamoorthy S, Kamiya K, Kim I, Ying H, et al. Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Hum Mol Genet. 2006;15:543-53 pubmed
    ..In addition, these fly models can be used for sensitized screens to identify novel interacting genes as well as for high-throughput screening of therapeutic compounds for NS and PTPN11-related cancers...
  14. Stanley P. Regulation of Notch signaling by glycosylation. Curr Opin Struct Biol. 2007;17:530-5 pubmed
    ..Ligand binding and ligand-induced Notch signaling assays have provided insights into how changes in the O-fucose glycans of Notch receptors alter Notch signaling. ..
  15. Ekas L, Cardozo T, Flaherty M, McMillan E, Gonsalves F, Bach E. Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila. Dev Biol. 2010;344:621-36 pubmed publisher
  16. Das T, Cagan R. Drosophila as a novel therapeutic discovery tool for thyroid cancer. Thyroid. 2010;20:689-95 pubmed publisher
    ..In the future, rapid pairing of new genomic information with increasingly complex fly models will aid us in efforts to further tailor drug treatments toward personalized medicine. ..
  17. Gasque G, Conway S, Huang J, Rao Y, Vosshall L. Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target. Sci Rep. 2013;3:srep02120 pubmed publisher
    ..These results highlight the conservation of molecular mechanisms controlling appetite and provide a method for unbiased whole-organism drug screens to identify novel drugs and molecular pathways modulating food intake. ..
  18. Beshel J, Zhong Y. Graded encoding of food odor value in the Drosophila brain. J Neurosci. 2013;33:15693-704 pubmed publisher
    ..We thus demonstrate a possible motivationally scaled neural "value signal" accessible from uniquely identifiable cells. ..
  19. Mohler J. Spatial regulation of segment polarity gene expression in the anterior terminal region of the Drosophila blastoderm embryo. Mech Dev. 1995;50:151-61 pubmed
    ..None of these five known gap genes are required for the activation of the labral segment domains of hh and wg, which are presumably either activated directly by maternal pathways or by an unidentified gap gene...
  20. Vandendries E, Johnson D, Reinke R. orthodenticle is required for photoreceptor cell development in the Drosophila eye. Dev Biol. 1996;173:243-55 pubmed
    ..The third intron enhancer is the primary regulatory element controlling otd in the R cells and is not under the control of the glass gene. ..
  21. Baker N, Yu S, Han D. Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr Biol. 1996;6:1290-301 pubmed
    ..Distinct neural tissues might differ in their proneural prepatterns, but use Notch in a similar mechanism. ..
  22. Kirov N, Lieberman P, Rushlow C. The transcriptional corepressor DSP1 inhibits activated transcription by disrupting TFIIA-TBP complex formation. EMBO J. 1996;15:7079-87 pubmed
    ..Our results support the model that DSP1 represses activated transcription by interfering with the binding of TFIIA, a general transcription factor implicated in activated transcription pathways. ..
  23. Iourgenko V, Kliot B, Cann M, Levin L. Cloning and characterization of a Drosophila adenylyl cyclase homologous to mammalian type IX. FEBS Lett. 1997;413:104-8 pubmed
  24. Treisman J, Heberlein U. Eye development in Drosophila: formation of the eye field and control of differentiation. Curr Top Dev Biol. 1998;39:119-58 pubmed
  25. Wu L, Anderson K. Related signaling networks in Drosophila that control dorsoventral patterning in the embryo and the immune response. Cold Spring Harb Symp Quant Biol. 1997;62:97-103 pubmed
  26. Xiao S, Manley J. Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. EMBO J. 1998;17:6359-67 pubmed
    ..We discuss these results with respect to the differential protein-protein interactions that must occur during constitutive and activated splicing. ..
  27. Young M. Circadian rhythms. Marking time for a kingdom. Science. 2000;288:451-3 pubmed
  28. Frasch M, Leptin M. Mergers and acquisitions: unequal partnerships in Drosophila myoblast fusion. Cell. 2000;102:127-9 pubmed
  29. Young M, Kay S. Time zones: a comparative genetics of circadian clocks. Nat Rev Genet. 2001;2:702-15 pubmed
    ..Although autoregulatory genetic networks are a consistent feature in the design of all clocks, the weight of evidence favours their independent evolutionary origins in different kingdoms. ..
  30. Shi H, Xu R. Crystal structure of the Drosophila Mago nashi-Y14 complex. Genes Dev. 2003;17:971-6 pubmed
    ..This unexpected finding provides important insights for understanding the molecular mechanisms of EJC assembly and RRM-mediated protein-protein interactions. ..
  31. Lee A, Treisman J. Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium. Mol Biol Cell. 2004;15:3285-95 pubmed
    ..We suggest that excessive myosin activity in photoreceptor neurons may pull the cell bodies toward the growth cones in a process resembling normal cell migration. ..
  32. Moon W, Hazelrigg T. The Drosophila microtubule-associated protein mini spindles is required for cytoplasmic microtubules in oogenesis. Curr Biol. 2004;14:1957-61 pubmed
    ..Our findings reveal a new role for msps in cell patterning and raise the possibility that other family members may perform similar functions. ..
  33. Levitan M, Etges W. Climate change and recent genetic flux in populations of Drosophila robusta. BMC Evol Biol. 2005;5:4 pubmed
    ..robusta are evolutionary responses to environmental change. Since these chromosomes are known to be sensitive to ambient temperature, regional climatic shifts associated with global warming are likely to be responsible. ..
  34. Pimentel A, Venkatesh T. rap gene encodes Fizzy-related protein (Fzr) and regulates cell proliferation and pattern formation in the developing Drosophila eye-antennal disc. Dev Biol. 2005;285:436-46 pubmed
    ..These results suggest that Rap/Fzr plays an essential role in the timely exit of precursor cells from mitotic cycles and indicate that mechanisms that regulate cell cycle exit are critical during pattern formation and morphogenesis. ..
  35. Hazelrigg T, Mansfield J. Green fluorescent protein applications in Drosophila. Methods Biochem Anal. 2006;47:227-57 pubmed
  36. Arama E, Bader M, Srivastava M, Bergmann A, Steller H. The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 2006;25:232-43 pubmed
    ..These observations establish a role for the mitochondria in caspase activation during spermatogenesis. ..
  37. Wu J, Jenny A, Mirkovic I, Mlodzik M. Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila. Mech Dev. 2008;125:30-42 pubmed
    ..Our data suggest that Dgo sequesters Dsh to a functionally distinct Fz/PCP signaling compartment within the cell. ..
  38. Pfleger C, Reiter L. Recent efforts to model human diseases in vivo in Drosophila. Fly (Austin). 2008;2:129-32 pubmed
    ..Here we can only briefly review some of these developments, and we apologize that we do not have the time or space to review all of the findings presented which use Drosophila to understand human disease etiology. ..
  39. King H, Hoelz A, Crane B, Young M. Structure of an enclosed dimer formed by the Drosophila period protein. J Mol Biol. 2011;413:561-72 pubmed publisher
    ..Conservation of PER interaction residues among a family of PAS-AB-containing transcription factors suggests that contacts mediating closed PAS-AB dimers serve a general function. ..
  40. Backes S, Shapiro J, Sabin L, Pham A, Reyes I, Moss B, et al. Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism. Cell Host Microbe. 2012;12:200-10 pubmed publisher
    ..These findings suggest that poxviruses may degrade host miRNAs to promote replication and that virus-mediated small RNA degradation likely contributed to 2'OMe evolution. ..
  41. Thanawala S, Rister J, Goldberg G, Zuskov A, Olesnicky E, Flowers J, et al. Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina. Dev Cell. 2013;25:93-105 pubmed publisher
    ..Our findings show how stochastic and regional inputs are integrated to control photoreceptor subtype specification in the Drosophila retina...
  42. Ayala Camargo A, Anderson A, Amoyel M, Rodrigues A, Flaherty M, Bach E. JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc. Dev Biol. 2013;382:413-26 pubmed publisher
    ..We conclude that JAK/STAT signaling is critical for hinge fate specification and growth of the gap domain and that its restriction to the hinge is required for proper wing development. ..
  43. Dowdle J, Mehta M, Kass E, Vuong B, Inagaki A, Egli D, et al. Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis. PLoS Genet. 2013;9:e1003945 pubmed publisher
  44. Aguilar J, Dunn M, Mingote S, Karam C, Farino Z, Sonders M, et al. Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT. Neuron. 2017;95:1074-1088.e7 pubmed publisher
    ..Together, these data suggest that in response to depolarization, dopamine vesicles utilize a cascade of vesicular transporters to dynamically increase the vesicular pH gradient, thereby increasing dopamine vesicle content. ..
  45. Mohler J, Mahaffey J, Deutsch E, Vani K. Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Development. 1995;121:237-47 pubmed
    ..This role of homeotic selector genes for the segment-specific maintenance of segment polarity gene expression is a unique feature of segmentation in the preoral head region of Drosophila. ..
  46. Brewster R, Lee J, Ruiz i Altaba A. Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. Nature. 1998;393:579-83 pubmed
    ..We propose that the combined function of Gli/Zic genes responds to inductive signals and induces patterned neural cell differentiation. ..
  47. Green J, Gardner C, Wharton R, Aggarwal A. RNA recognition via the SAM domain of Smaug. Mol Cell. 2003;11:1537-48 pubmed
    ..Therefore, in addition to their previously characterized roles in protein-protein interactions, some SAM domains play crucial roles in RNA binding. ..
  48. Das G, Jenny A, Klein T, Eaton S, Mlodzik M. Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development. 2004;131:4467-76 pubmed
    ..These interactions suggest a positive feedback loop initiated by Fz that results in the apical maintenance of other PCP factors through Fmi. ..
  49. Lee H, Frasch M. Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction. Development. 2005;132:1429-42 pubmed
    ..Our data illustrate how the same signal combinations can have opposite effects on different targets in the same cells during tissue induction. ..
  50. Reim I, Mohler J, Frasch M. Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila. Mech Dev. 2005;122:1056-69 pubmed
    ..Through this activity, mid and H15 are required for the normal functional diversification of cardioblasts and the expression of tin-dependent terminal differentiation genes within the dorsal vessel. ..
  51. Navarro C, Bullock S, Lehmann R. Altered dynein-dependent transport in piRNA pathway mutants. Proc Natl Acad Sci U S A. 2009;106:9691-6 pubmed publisher
    ..We propose that aggregate formation is a cellular response to protect germ cells from DNA damage caused by elevated retrotransposon expression. ..
  52. Fernandez Gonzalez R, Zallen J. Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells. Phys Biol. 2011;8:045005 pubmed publisher
    ..We discuss models to explain how the architecture of cytoskeletal networks regulates their contractile behavior and the mechanisms that give rise to oscillatory cell behaviors in intercalating cells...
  53. Datta R, Small S. Gene regulation: piecing together the puzzle of enhancer evolution. Curr Biol. 2011;21:R542-3 pubmed publisher
    ..A detailed analysis of the fast-evolving sparkling enhancer in Drosophila now identifies key compensatory mechanisms and 'grammar' elements that are critical for maintaining functional integrity. ..
  54. Karuppudurai T, Lin T, Ting C, Pursley R, Melnattur K, Diao F, et al. A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila. Neuron. 2014;81:603-615 pubmed publisher
    ..We conclude that R7s→Dm8→Tm5c form a hard-wired glutamatergic circuit that mediates UV preference by pooling ∼16 R7 signals for transfer to the lobula, a higher visual center. ..
  55. Basler K, Hafen E. Specification of cell fate in the developing eye of Drosophila. Bioessays. 1991;13:621-31 pubmed
    ..Genetic dissection of this pathway should therefore identify components of a signalling cascade activated by a tyrosine kinase. ..
  56. Casanova J. Pattern formation under the control of the terminal system in the Drosophila embryo. Development. 1990;110:621-8 pubmed
    ..Moreover, they suggest that different elements of the terminal pattern can be specified in response to distinct levels of graded tailless activity. ..
  57. Frasch M, Levine M. Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila. Genes Dev. 1987;1:981-95 pubmed
  58. Tracey W, Ning X, Klingler M, Kramer S, Gergen J. Quantitative analysis of gene function in the Drosophila embryo. Genetics. 2000;154:273-84 pubmed
    ..The maternal GAL4 system will have applications both for the measurement of gene activity in reverse genetic experiments as well as for the identification of genetic factors that have quantitative effects on gene function in vivo. ..
  59. Harms E, Chu T, Henrion G, Strickland S. The only function of Grauzone required for Drosophila oocyte meiosis is transcriptional activation of the cortex gene. Genetics. 2000;155:1831-9 pubmed
    ..These experiments further define a new transcriptional pathway that controls the meiotic cell cycle in Drosophila oocytes. ..
  60. Duvernell D, Eanes W. Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba. Genetics. 2000;156:1191-201 pubmed
    ..D. simulans shows substantial linkage phase structuring that suggests historical population subdivision...
  61. Carmena A, Buff E, Halfon M, Gisselbrecht S, Jimenez F, Baylies M, et al. Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev Biol. 2002;244:226-42 pubmed
    ..These reciprocal interactions combine to generate the signal thresholds that are essential for proper specification of progenitors and nonprogenitors from groups of initially equivalent cells. ..
  62. Gilboa L, Forbes A, Tazuke S, Fuller M, Lehmann R. Germ line stem cell differentiation in Drosophila requires gap junctions and proceeds via an intermediate state. Development. 2003;130:6625-34 pubmed
  63. Wang Y, Mamiya A, Chiang A, Zhong Y. Imaging of an early memory trace in the Drosophila mushroom body. J Neurosci. 2008;28:4368-76 pubmed publisher
    ..Our results suggest that increased Ca(2+) activity in response to a conditioned olfactory stimulus may be a neural correlate of early memory in the MB...
  64. Dahdal D, Reeves D, Ruben M, Akabas M, Blau J. Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms. Neuron. 2010;68:964-77 pubmed publisher
    ..Although no clock neurons produce GABA, hyperexciting GABAergic neurons disrupts behavioral rhythms and s-LN(v) molecular clocks. Therefore, s-LN(v)s require GABAergic inputs for 24 hr rhythms. ..
  65. Mizrak D, Ruben M, Myers G, Rhrissorrakrai K, Gunsalus K, Blau J. Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons. Curr Biol. 2012;22:1871-80 pubmed publisher
    ..The electrical state of a clock neuron can impose time of day to its transcriptional program. We propose that this acts as an internal zeitgeber to add robustness and precision to circadian behavioral rhythms. ..
  66. Rodrigues A, Zoranovic T, Ayala Camargo A, Grewal S, Reyes Robles T, Krasny M, et al. Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development. 2012;139:4051-61 pubmed publisher
    ..As hyper-activated STATs are causal to tumorigenesis and stem cell niche occupancy, our results have therapeutic implications for cancer and regenerative medicine. ..
  67. Li W, Prazak L, Chatterjee N, Grüninger S, Krug L, Theodorou D, et al. Activation of transposable elements during aging and neuronal decline in Drosophila. Nat Neurosci. 2013;16:529-31 pubmed publisher
    ..These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function. ..
  68. Treisman J. Retinal differentiation in Drosophila. Wiley Interdiscip Rev Dev Biol. 2013;2:545-57 pubmed publisher
  69. Frasch M, Chen X, Lufkin T. Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila. Development. 1995;121:957-74 pubmed
    ..These results suggest an evolutionary conservation between HOM-C/Hox family members, which includes a conservation of certain DNA regulatory elements and possible regulatory cascades. ..
  70. Mullen J, DiNardo S. Establishing parasegments in Drosophila embryos: roles of the odd-skipped and naked genes. Dev Biol. 1995;169:295-308 pubmed
    ..We present a model describing how the altered expression patterns of fushi tarazu, engrailed, and wingless generate the mutant phenotype. ..
  71. Norris J, Manley J. Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism. Genes Dev. 1995;9:358-69 pubmed
    ..We also show that the intracytoplasmic domain of Toll, and specifically the region sharing homology with the interleukin-1 receptor, is sufficient to induce dl-tube nuclear translocation. ..
  72. Roote C, Zusman S. Alternatively spliced forms of the Drosophila alphaPS2 subunit of integrin are sufficient for viability and can replace the function of the alphaPS1 subunit of integrin in the retina. Development. 1996;122:1985-94 pubmed
    ..However, ectopic expression of if(m8) or if(C) shows that either splice form Of alphaPS2 can functionally replace alphaPS1 and rescue the mew eye phenotype. ..
  73. Sandigursky M, Yacoub A, Kelley M, Deutsch W, Franklin W. The Drosophila ribosomal protein S3 contains a DNA deoxyribophosphodiesterase (dRpase) activity. J Biol Chem. 1997;272:17480-4 pubmed
  74. Morozov P, Sitnikova T, Churchill G, Ayala F, Rzhetsky A. A new method for characterizing replacement rate variation in molecular sequences. Application of the Fourier and wavelet models to Drosophila and mammalian proteins. Genetics. 2000;154:381-95 pubmed
    ..We illustrate the application of the new method by analyzing human immunoglobulin and Drosophilid alcohol dehydrogenase sequences...
  75. Walters J, Munoz C, Paaby A, Dinardo S. Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation. Dev Biol. 2005;286:415-26 pubmed
    ..This establishes one important role for the Serrate signaling territory, which is to define the extent of denticle field specification. ..
  76. Steinhauer J, Liu H, Miller E, Treisman J. Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues. J Cell Sci. 2013;126:4469-78 pubmed publisher
    ..Taken together, our data support the model that localized trafficking of the pro-protein restricts its ability to activate the receptor in polarized tissues. ..
  77. Mohler J, Vani K. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development. 1992;115:957-71 pubmed
    ..Sequence analysis of the hedgehog locus suggests the protein product is a transmembrane protein, which may, therefore, be directly involved in cell-cell communication. ..
  78. Harding K, Hoey T, Warrior R, Levine M. Autoregulatory and gap gene response elements of the even-skipped promoter of Drosophila. EMBO J. 1989;8:1205-12 pubmed
    ..7 and -0.4 kb are needed for stripes 2 and 7. It is possible that these latter regions are directly regulated by the products of gap genes. ..
  79. Lane M, Kalderon D. Localization and functions of protein kinase A during Drosophila oogenesis. Mech Dev. 1995;49:191-200 pubmed
    ..The migration of a subset of follicle cells, the border cells, is also disrupted by germline PKA mutations, implying that nurse cell junctions provide an essential path for border cell migrations. ..
  80. Greenwood S, Struhl G. Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos. Development. 1997;124:4879-86 pubmed
  81. Arkov A, Wang J, Ramos A, Lehmann R. The role of Tudor domains in germline development and polar granule architecture. Development. 2006;133:4053-62 pubmed
    ..Combining genetic analysis with structural modeling of specific Tudor domains, we propose that these domains serve as ;docking platforms' for polar granule assembly. ..
  82. Gelb B, Tartaglia M. Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction. Hum Mol Genet. 2006;15 Spec No 2:R220-6 pubmed
    ..As these genes also encode proteins relevant for RAS-MAPK signal transduction, all of the syndromes discussed in this article now can be understood to constitute a class of disorders caused by dysregulated RAS-MAPK signaling...
  83. DasGupta R, Nybakken K, Booker M, Mathey Prevot B, Gonsalves F, Changkakoty B, et al. A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. Genome Biol. 2007;8:R203 pubmed
    ..Furthermore, we investigate other factors that may influence the outcome of such screens, including cell-type specificity, robustness of reporters, and assay normalization, which determine the efficacy of RNAi-knockdown of target genes. ..
  84. Struhl G, Johnston P, Lawrence P. Control of Drosophila body pattern by the hunchback morphogen gradient. Cell. 1992;69:237-249 pubmed
    ..Thus, hb protein functions as a classical morphogen, triggering several distinct responses as a function of its graded distribution. ..
  85. Yin J, del Vecchio M, Zhou H, Tully T. CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell. 1995;81:107-15 pubmed
    ..Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed. ..
  86. Benedyk M, Mullen J, DiNardo S. odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos. Genes Dev. 1994;8:105-17 pubmed
    ..Thus, opa does not act in a spatially restricted manner to establish the position of en and wg expression. Rather, opa must cooperate with other spatially restricted proteins to achieve proper subdivision of the Drosophila embryo. ..
  87. Ballinger D, Xue N, Harshman K. A Drosophila photoreceptor cell-specific protein, calphotin, binds calcium and contains a leucine zipper. Proc Natl Acad Sci U S A. 1993;90:1536-40 pubmed
    ..The calphotin protein binds calcium and contains a long C-terminal leucine zipper. Potential implications of these properties are discussed. ..
  88. Zhao J, Lazzarini R, Pick L. Functional dissection of the mouse Hox-a5 gene. EMBO J. 1996;15:1313-22 pubmed
    ..Our results suggest that this type of protein-protein interaction may be essential for the biological activities of Hox-a5 and Scr. ..
  89. Jiang J, Struhl G. Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. Cell. 1996;86:401-9 pubmed
  90. Karpilow J, Pimentel A, Shamloula H, Venkatesh T. Neuronal development in the Drosophila compound eye: photoreceptor cells R1, R6, and R7 fail to differentiate in the retina aberrant in pattern (rap) mutant. J Neurobiol. 1996;31:149-65 pubmed
    ..These results suggest that the rap gene encodes an R8-specific function that plays a role in the determination of the photoreceptor cells R1, R6, and R7. ..
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