Experts and Doctors on drosophila in California, United States

Summary

Locale: California, United States
Topic: drosophila

Top Publications

  1. Zhu A, Zheng L, Suyama K, Scott M. Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev. 2003;17:1240-52 pubmed
    ..Conversely, trapping of activated Smo mutants in the ER prevents Hh target gene activation. Control of Smo localization appears to be a crucial step in Hh signaling in Drosophila. ..
  2. Kim S, Rulifson E. Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature. 2004;431:316-20 pubmed
    ..Thus, Drosophila CC cells are crucial regulators of glucose homeostasis and they use glucose-sensing and response mechanisms similar to islet cells...
  3. Smith J, Wilson J, Macdonald P. Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos. Cell. 1992;70:849-59 pubmed
    ..Strikingly, formation of these ectopic pole cells is enhanced in nanos mutants. This observation may reflect competition between nanos and the germ cell determinant for a shared and limiting precursor. ..
  4. Lee T, Luo L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron. 1999;22:451-61 pubmed
    ..As an example, we show that the short stop gene is required in mushroom body neurons for the extension and guidance of their axons. ..
  5. Andolfatto P. Adaptive evolution of non-coding DNA in Drosophila. Nature. 2005;437:1149-52 pubmed
    ..These results imply that, although positive selection is clearly an important facet of protein evolution, adaptive changes to non-coding DNA might have been considerably more common in the evolution of D. melanogaster. ..
  6. Baker B, Gorman M, Mar n I. Dosage compensation in Drosophila. Annu Rev Genet. 1994;28:491-521 pubmed publisher
  7. Yao T, Forman B, Jiang Z, Cherbas L, Chen J, McKeown M, et al. Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. Nature. 1993;366:476-9 pubmed
    ..These results redefine the ecdysone receptor as a dynamic complex whose activity may be altered by combinatorial interactions among subunits and ligand. ..
  8. Zisch A, Stallcup W, Chong L, Dahlin Huppe K, Voshol J, Schachner M, et al. Tyrosine phosphorylation of L1 family adhesion molecules: implication of the Eph kinase Cek5. J Neurosci Res. 1997;47:655-65 pubmed
    ..Furthermore, direct phosphorylation of the L1 cytoplasmic domain by Cek5 was demonstrated in an in vitro kinase assay. Tyrosine phosphorylation may represent a novel mechanism of signal cascade initiation through L1. ..
  9. Le N, Simon M. Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase. Mol Cell Biol. 1998;18:4844-54 pubmed
    ..Taken together, these results indicate that DAB is a novel component of the SEV signaling pathway. ..

More Information

Publications194 found, 100 shown here

  1. Rousset R, Wharton K, Zimmermann G, Scott M. Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle. J Biol Chem. 2002;277:49019-26 pubmed
    ..The results further clarify how Nkd may antagonize Wnt signaling via interaction with Dsh, and identify a novel zinc-binding domain in Drosophila Nkd that collaborates with the conserved EFX domain to bind Dsh. ..
  2. Matis M, Axelrod J. Regulation of PCP by the Fat signaling pathway. Genes Dev. 2013;27:2207-20 pubmed publisher
    ..We discuss models for the function of this signaling module as well as several unanswered questions that may guide future investigations. ..
  3. Stoiber M, Celniker S, Cherbas L, Brown B, Cherbas P. Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines. G3 (Bethesda). 2016;6:683-94 pubmed publisher
  4. Zhang J, Schulze K, Hiesinger P, Suyama K, Wang S, Fish M, et al. Thirty-one flavors of Drosophila rab proteins. Genetics. 2007;176:1307-22 pubmed
    ..The high evolutionary conservation and low redundancy of Drosophila Rab proteins make these transgenic lines a useful tool kit for investigating Rab functions in vivo. ..
  5. Bahmanyar S, Nelson W, Barth A. Role of APC and its binding partners in regulating microtubules in mitosis. Adv Exp Med Biol. 2009;656:65-74 pubmed
    ..APC localizes to three key locations in mitosis: kinetochores, the cortex and centrosomes. Here, we discuss possible mechanisms for APC function at these sites and suggest new pathways by which APC mutations promote tumorigenesis. ..
  6. van Meyel D, O Keefe D, Jurata L, Thor S, Gill G, Thomas J. Chip and apterous physically interact to form a functional complex during Drosophila development. Mol Cell. 1999;4:259-65 pubmed
    ..This model is confirmed by the activity of a chimeric fusion between Chip and Ap that reconstitutes the complex and rescues the ap mutant phenotype. ..
  7. Nusse R, Fuerer C, Ching W, Harnish K, Logan C, Zeng A, et al. Wnt signaling and stem cell control. Cold Spring Harb Symp Quant Biol. 2008;73:59-66 pubmed publisher
    ..We propose that these modifications control the range of Wnt signaling and have critical roles in establishing niches for stem cells in various tissues. ..
  8. McElwain M, Ko D, Gordon M, Fyrst H, Saba J, Nusse R. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. PLoS ONE. 2011;6:e26993 pubmed publisher
    ..Our data are consistent with a model in which the activity of lipid phosphate phosphatases shapes a concentration gradient of ceramide-1-phosphate (C1P), the product of Dcerk, allowing proper PGC migration. ..
  9. Zinn K, McAllister L, Goodman C. Sequence analysis and neuronal expression of fasciclin I in grasshopper and Drosophila. Cell. 1988;53:577-87 pubmed
    ..This pattern of expression is similar to that in grasshopper. ..
  10. Manak J, Mathies L, Scott M. Regulation of a decapentaplegic midgut enhancer by homeotic proteins. Development. 1994;120:3605-19 pubmed
    ..A 45 bp fragment of DNA from within the enhancer correctly responds to both UBX and ABD-A in a largely tissue-specific manner, thus representing the smallest in vivo homeotic response element (HOMRE) identified to date...
  11. Noordermeer J, Klingensmith J, Perrimon N, Nusse R. dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature. 1994;367:80-3 pubmed
    ..We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation. ..
  12. Drain P, Dubin A, Aldrich R. Regulation of Shaker K+ channel inactivation gating by the cAMP-dependent protein kinase. Neuron. 1994;12:1097-109 pubmed
    ..Since a cell's integrative characteristics can be determined by the rate of inactivation of its voltage-dependent channels, modulation of these rates by phosphorylation is likely to have functional consequences. ..
  13. Nusse R, Samos C, Brink M, Willert K, Cadigan K, Wodarz A, et al. Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila. Cold Spring Harb Symp Quant Biol. 1997;62:185-90 pubmed
  14. Stowers R, Garza D, Rascle A, Hogness D. The L63 gene is necessary for the ecdysone-induced 63E late puff and encodes CDK proteins required for Drosophila development. Dev Biol. 2000;221:23-40 pubmed
    ..L63 proteins are widely distributed among late larval and prepupal tissues and are unlikely to be involved in cell cycle functions. ..
  15. Rousset R, Mack J, Wharton K, Axelrod J, Cadigan K, Fish M, et al. Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev. 2001;15:658-71 pubmed
    ..Our results suggest that Nkd acts directly through Dsh to limit Wg activity and thus determines how efficiently Wnt signals stabilize Armadillo (Arm)/beta-catenin and activate downstream genes. ..
  16. Wu C, Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem. 2002;277:41762-9 pubmed
    ..We have therefore examined whether a soluble form of the Arrow molecule can bind to Wingless and Frizzled, but no interactions were detected. ..
  17. Zhu H, Hummel T, Clemens J, Berdnik D, Zipursky S, Luo L. Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe. Nat Neurosci. 2006;9:349-55 pubmed
    ..This observation provides evidence for a pre- and postsynaptic matching mechanism independent of precise glomerular positioning. ..
  18. Gu S, Jin L, Zhang F, Sarnow P, Kay M. Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nat Struct Mol Biol. 2009;16:144-50 pubmed publisher
  19. Liu S, Sawada T, Lee S, Yu W, Silverio G, Alapatt P, et al. Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet. 2012;8:e1002537 pubmed publisher
    ..Moreover, the different effects of loss of PINK1 function on Miro protein level in Drosophila and mouse cells may offer one explanation of the distinct phenotypic manifestations of PINK1 mutants in these two species. ..
  20. Krasnow M. Genes that control organ form: lessons from bone and branching morphogenesis. Cold Spring Harb Symp Quant Biol. 1997;62:235-40 pubmed
  21. Vidwans S, Su T. Cycling through development in Drosophila and other metazoa. Nat Cell Biol. 2001;3:E35-9 pubmed
    ..Here we present the various modes of cell-cycle regulation in metazoa and discuss their possible generation by a combination of universally conserved molecules and new regulatory circuits. ..
  22. Benosman S, Ravanan P, Correa R, Hou Y, Yu M, Gulen M, et al. Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling. PLoS ONE. 2013;8:e64256 pubmed publisher
    ..These findings demonstrate an unexpected linkage of the innate immunity machinery to UPR signaling, revealing IRAK2 as a novel amplifier of the IRE1 pathway. ..
  23. Johnson R, Rothman A, Xie J, Goodrich L, Bare J, Bonifas J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996;272:1668-71 pubmed
    ..The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression...
  24. Zagotta W, Aldrich R. Alterations in activation gating of single Shaker A-type potassium channels by the Sh5 mutation. J Neurosci. 1990;10:1799-810 pubmed
    ..By using a kinetic model developed for wild-type A1 channels, we show that an alteration in the amplitude and voltage dependence of the deactivation rate for each subunit (beta) can account for all of the alterations observed. ..
  25. Mattox W, Baker B. Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila. Genes Dev. 1991;5:786-96 pubmed
    ..The finding that transformer-2 controls multiple splicing decisions suggests that a variety of different alternative splicing choices could be regulated by a relatively limited number of trans-acting factors. ..
  26. O Dowd D, Aldrich R. Voltage-clamp analysis of sodium channels in wild-type and mutant Drosophila neurons. J Neurosci. 1988;8:3633-43 pubmed
    ..These results indicate that both the tip-E and sei loci are important in regulation of sodium current density in embryonic neurons. ..
  27. Murphy T, Karpen G. Interactions between the nod+ kinesin-like gene and extracentromeric sequences are required for transmission of a Drosophila minichromosome. Cell. 1995;81:139-48 pubmed
    ..We propose that normal chromosome transmission requires forces generated outside the kinetochore, perhaps to maintain tension on kinetochore microtubules and stabilize the attachment of achiasmate chromosomes to the metaphase spindle. ..
  28. Pfrieger F, Barres B. What the fly's glia tell the fly's brain. Cell. 1995;83:671-4 pubmed
  29. Herbst R, Carroll P, Allard J, Schilling J, Raabe T, Simon M. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell. 1996;85:899-909 pubmed
    ..Analysis of dos mutations indicates that DOS is a positive component of the SEV signaling pathway and suggests that DOS dephosphorylation by CSW may be a key event during signaling by SEV. ..
  30. Macdonald P, Smibert C. Translational regulation of maternal mRNAs. Curr Opin Genet Dev. 1996;6:403-7 pubmed
    ..Substantial progress has also been reported in the identification and characterization of the cis-acting elements and trans-acting factors that mediate translational regulation and their interactions with one another. ..
  31. Metzstein M, Krasnow M. Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. PLoS Genet. 2006;2:e180 pubmed
  32. Dean S, Spudich J. Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS ONE. 2006;1:e131 pubmed
    ..We conclude that the Rho1 pathway leading to myosin localization to the future cytokinetic furrow is relatively straightforward, where only Rok is needed, and it is only needed to maintain phosphorylation of the myosin RLC. ..
  33. Kong E, Allouche L, Chapot P, Vranizan K, Moore M, Heberlein U, et al. Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Alcohol Clin Exp Res. 2010;34:302-16 pubmed publisher
    ..Our findings implicate novel roles for these genes in regulating ethanol behavioral responses. ..
  34. Vladar E, Antic D, Axelrod J. Planar cell polarity signaling: the developing cell's compass. Cold Spring Harb Perspect Biol. 2009;1:a002964 pubmed publisher
    ..In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms. ..
  35. Markova Raina P, Petrov D. High sensitivity to aligner and high rate of false positives in the estimates of positive selection in the 12 Drosophila genomes. Genome Res. 2011;21:863-74 pubmed publisher
  36. Berdnik D, Favaloro V, Luo L. The SUMO protease Verloren regulates dendrite and axon targeting in olfactory projection neurons. J Neurosci. 2012;32:8331-40 pubmed publisher
    ..Our study provides the first in vivo evidence for a specific role of a SUMO protease during neuronal target selection that can be dissociated from its functions in neuronal proliferation and survival. ..
  37. Nambu J, Murphy Erdosh C, Andrews P, Feistner G, Scheller R. Isolation and characterization of a Drosophila neuropeptide gene. Neuron. 1988;1:55-61 pubmed
  38. Mar n I, Franke A, Bashaw G, Baker B. The dosage compensation system of Drosophila is co-opted by newly evolved X chromosomes. Nature. 1996;383:160-3 pubmed publisher
    ..In this neo-X chromosome, the pattern of MSL binding correlates with the known pattern of dosage compensation...
  39. Parfitt K, Reist N, Li J, Burgess R, Deitcher D, DiAntonio A, et al. Drosophila genetics and the functions of synaptic proteins. Cold Spring Harb Symp Quant Biol. 1995;60:371-7 pubmed
  40. Cadigan K, Fish M, Rulifson E, Nusse R. Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing. Cell. 1998;93:767-77 pubmed
    ..In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, Dfz2 broadens the range of Wg action by protecting it from degradation. ..
  41. Capdevila J, lzpisúa Belmonte J. Extracellular modulation of the Hedgehog, Wnt and TGF-beta signalling pathways during embryonic development. Curr Opin Genet Dev. 1999;9:427-33 pubmed
  42. Stowers R, Russell S, Garza D. The 82F late puff contains the L82 gene, an essential member of a novel gene family. Dev Biol. 1999;213:116-30 pubmed
    ..L82 mutations were identified by transgene rescue of developmental delay and eclosion lethal phenotypes. ..
  43. Vidwans S, O Farrell P. Cytoskeleton: centrosom-in absentia. Curr Biol. 1999;9:R764-6 pubmed
  44. Panda S, Hogenesch J, Kay S. Circadian rhythms from flies to human. Nature. 2002;417:329-35 pubmed
    ..To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila. ..
  45. Patterson R, Juarez M, Hermann A, Sasik R, Hardiman G, McGinnis W. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. PLoS ONE. 2013;8:e61773 pubmed publisher
    ..These include puncture-induced activation only in epidermal cells in the immediate vicinity of wounds, or in all epidermal cells, or specifically in the fat body, or in multiple tissues...
  46. Sutherland D, Samakovlis C, Krasnow M. branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell. 1996;87:1091-101 pubmed
  47. Kiger A, White Cooper H, Fuller M. Somatic support cells restrict germline stem cell self-renewal and promote differentiation. Nature. 2000;407:750-4 pubmed
  48. Liu Z, Steward R, Luo L. Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. Nat Cell Biol. 2000;2:776-83 pubmed
    ..These results implicate Lis1 as a regulator of the microtubule cytoskeleton and show that it is important for diverse physiological functions in the nervous system. ..
  49. Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, et al. Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. J Biol Chem. 2001;276:11189-98 pubmed
    ..These findings indicate that myomegalin is a novel protein that functions as an anchor to localize components of the cAMP-dependent pathway to the Golgi/centrosomal region of the cell. ..
  50. Farkas R, Giansanti M, Gatti M, Fuller M. The Drosophila Cog5 homologue is required for cytokinesis, cell elongation, and assembly of specialized Golgi architecture during spermatogenesis. Mol Biol Cell. 2003;14:190-200 pubmed
    ..Our study suggests that Drosophila spermatogenesis can be an effective sensitized genetic system to uncover in vivo functions for proteins involved in Golgi architecture and/or vesicle transport. ..
  51. Finley K, Edeen P, Cumming R, Mardahl Dumesnil M, Taylor B, Rodriguez M, et al. blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. J Neurosci. 2003;23:1254-64 pubmed
    ..The high degree of conservation between Drosophila and human bchs suggests that study of the functional pathway of BCHS and associated mutant phenotype may provide useful insights into human neurodegenerative disorders. ..
  52. Luong N, Davies C, Wessells R, Graham S, King M, Veech R, et al. Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Cell Metab. 2006;4:133-42 pubmed
    ..Thus, the regulation of dTOR activity may be an ancient "systems biological" means of regulating metabolism and senescence, that has important evolutionary, physiological, and clinical implications. ..
  53. Davies E, Fuller M. Regulation of self-renewal and differentiation in adult stem cell lineages: lessons from the Drosophila male germ line. Cold Spring Harb Symp Quant Biol. 2008;73:137-45 pubmed publisher
  54. Hong W, Zhu H, Potter C, Barsh G, Kurusu M, Zinn K, et al. Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map. Nat Neurosci. 2009;12:1542-50 pubmed publisher
    ..The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation. ..
  55. Solc C, Aldrich R. Gating of single non-Shaker A-type potassium channels in larval Drosophila neurons. J Gen Physiol. 1990;96:135-65 pubmed
    ..The model provided good fits to these data, as well as to the ensemble averages. With the exception of the rates leading to initial opening, the transitions in the model were largely independent of voltage. ..
  56. Crews S, Thomas J, Goodman C. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell. 1988;52:143-51 pubmed
    ..No similarity is observed between sim and any known nuclear protein, but, surprisingly, it is similar to the Drosophila period (per) locus gene product, which controls the periodicity of biological rhythms. ..
  57. Montell D, Goodman C. Drosophila substrate adhesion molecule: sequence of laminin B1 chain reveals domains of homology with mouse. Cell. 1988;53:463-73 pubmed
    ..Moreover, the number, length, and unique amino acid sequences of each of the 13 EGF-like repeats are highly conserved between Drosophila and mouse, suggesting that each may serve a unique function in protein-protein interactions. ..
  58. Chang C, Shen W, Rozenfeld S, Lawrence H, Largman C, Cleary M. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev. 1995;9:663-74 pubmed
  59. Le M, Duricka D, Karpen G. Islands of complex DNA are widespread in Drosophila centric heterochromatin. Genetics. 1995;141:283-303 pubmed
    ..Cloning and sequencing of a small part of one island, Tahiti, demonstrated the presence of a retroposon. The implications of these findings to heterochromatin structure and function are discussed. ..
  60. Winston R, Millar D, Gottesfeld J, Kent S. Characterization of the DNA binding properties of the bHLH domain of Deadpan to single and tandem sites. Biochemistry. 1999;38:5138-46 pubmed
    ..This study constitutes the first detailed biophysical characterization of the DNA binding properties of a bHLH protein. ..
  61. Tarui T, Mazar A, Cines D, Takada Y. Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J Biol Chem. 2001;276:3983-90 pubmed
  62. Harmer S, Panda S, Kay S. Molecular bases of circadian rhythms. Annu Rev Cell Dev Biol. 2001;17:215-53 pubmed
    ..The different uses of common components may reflect the important role that the circadian clock plays in adaptation of species to particular environmental niches. ..
  63. Jefferis G, Marin E, Watts R, Luo L. Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodies. Curr Opin Neurobiol. 2002;12:80-6 pubmed
    ..This same theme of sequential generation has been observed in the generation of the three major types of mushroom body neurons. ..
  64. Ng J, Nardine T, Harms M, Tzu J, Goldstein A, Sun Y, et al. Rac GTPases control axon growth, guidance and branching. Nature. 2002;416:442-7 pubmed
    ..These results demonstrate the central role of Rac GTPases in multiple aspects of axon development in vivo, and suggest that axon growth, guidance and branching could be controlled by differential activation of Rac signalling pathways. ..
  65. Prakash S, Caldwell J, Eberl D, Clandinin T. Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets. Nat Neurosci. 2005;8:443-50 pubmed
    ..We propose that N-cadherin mediates a homophilic, attractive interaction between photoreceptor growth cones and their targets that precedes synaptic partner choice. ..
  66. Foltenyi K, Greenspan R, NEWPORT J. Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nat Neurosci. 2007;10:1160-7 pubmed
    ..These results suggest that sleep and its regulation by EGFR signaling may be ancestral to insects and mammals. ..
  67. Chadha A, Cook B. Dissection of gain control mechanisms in Drosophila mechanotransduction. J Neurosci. 2012;32:13052-61 pubmed
    ..The slow adjustment of gain, manifest as diminished sensitivity, is associated with the accumulation of Ca(2+). ..
  68. Staubach F, Baines J, Künzel S, Bik E, Petrov D. Host species and environmental effects on bacterial communities associated with Drosophila in the laboratory and in the natural environment. PLoS ONE. 2013;8:e70749 pubmed publisher
    ..This makes it a strong candidate for being part of what could be a natural D. melanogaster and D. simulans core microbiome. Furthermore, we were able to identify candidate pathogens in natural fly isolates. ..
  69. Celniker S. Susan Celniker: Foundational Resources To Study a Dynamic Genome. Genetics. 2016;204:845-848 pubmed publisher
  70. Murphy T, Karpen G. Localization of centromere function in a Drosophila minichromosome. Cell. 1995;82:599-609 pubmed
    ..We propose that the essential core is the site of kinetochore formation and that flanking DNA provides two functions: sister chromatid cohesion and indirect assistance in kinetochore formation or function. ..
  71. Gorman M, Kuroda M, Baker B. Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila. Cell. 1993;72:39-49 pubmed
    ..These data support a model whereby the activity of the mle protein is regulated through its association with one or more of the other msl proteins. ..
  72. Chang C, Brocchieri L, Shen W, Largman C, Cleary M. Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus. Mol Cell Biol. 1996;16:1734-45 pubmed
  73. Smibert C, Wilson J, Kerr K, Macdonald P. smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo. Genes Dev. 1996;10:2600-9 pubmed
    ..Translational repression is essential, as embryos expressing a nanos mRNA with mutated SREs develop with anterior body patterning defects and die, despite correct localization of the RNA. ..
  74. Lee T, Winter C, Marticke S, Lee A, Luo L. Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis. Neuron. 2000;25:307-16 pubmed
    ..Thus, RhoA is an important regulator of dendritic morphogenesis, while distinct mechanisms are used for axonal morphogenesis. ..
  75. Wharton K, Zimmermann G, Rousset R, Scott M. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol. 2001;234:93-106 pubmed
    ..Misexpression of mouse nkd1 in Drosophila antagonizes Wg function. The data suggest that the vertebrate Nkd-related proteins, similar to their fly counterpart, may act as inducible antagonists of Wnt signals. ..
  76. Keisman E, Christiansen A, Baker B. The sex determination gene doublesex regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc. Dev Cell. 2001;1:215-25 pubmed
    ..Instead, we show that dsx regulates the A/P organizer to control growth of each genital primordium, and then directs each genital primordium to differentiate defined adult structures in both sexes. ..
  77. Penton A, Wodarz A, Nusse R. A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin. Genetics. 2002;161:747-62 pubmed
    ..We also recovered second-site-suppressing mutations in axin, mapping at a region that may specifically interact with overexpressed Dsh. ..
  78. Simonsen A, Cumming R, Brech A, Isakson P, SCHUBERT D, Finley K. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy. 2008;4:176-84 pubmed
  79. Jeon M, Nguyen H, Bahri S, Zinn K. Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev. 2008;3:3 pubmed publisher
    ..Strong phenotypes are only observed in triple mutants in which both type III RPTPs are eliminated together with Ptp69D or Ptp52F. Our results allow us to construct a complete genetic interaction matrix for all six of the RPTPs. ..
  80. Lee S, Liu H, Lin W, Guo H, Lu B. LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. J Neurosci. 2010;30:16959-69 pubmed publisher
    ..These results implicate synaptic dysfunction caused by deregulated protein synthesis and aberrant MT dynamics in LRRK2 pathogenesis and offer a new paradigm for understanding and ultimately treating PD. ..
  81. Wang J. Presynaptic modulation of early olfactory processing in Drosophila. Dev Neurobiol. 2012;72:87-99 pubmed publisher
    ..This review will focus on the GABA(B) (gamma-aminobutyric acid) receptor-mediated presynaptic inhibition, and neuropeptide-mediated presynaptic modulation in Drosophila...
  82. Deitcher D, Ueda A, Stewart B, Burgess R, Kidokoro Y, Schwarz T. Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin. J Neurosci. 1998;18:2028-39 pubmed
    ..Thus, at least a portion of the spontaneous "minis" that are seen at the synapse can be generated by a protein complex that is distinct from that required for an evoked synaptic response. ..
  83. DiAntonio A, Parfitt K, Schwarz T. Synaptic transmission persists in synaptotagmin mutants of Drosophila. Cell. 1993;73:1281-90 pubmed
    ..The lethality of synaptotagmin in late first instar larvae is probably due to a perturbation of transmission that leaves the main apparatus for vesicle docking and fusion intact. ..
  84. Tsunoda S, Sun Y, Suzuki E, Zuker C. Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors. J Neurosci. 2001;21:150-8 pubmed
    ..This may be a general mechanism used by cells to target different signaling machinery to the pertinent subcellular location. ..
  85. Cadigan K, Jou A, Nusse R. Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless. Development. 2002;129:3393-402 pubmed
    ..These results are summarized in a model where daughterless is a major, but probably not the only, target of wingless action in the eye. ..
  86. Dehal P, Boore J. Two rounds of whole genome duplication in the ancestral vertebrate. PLoS Biol. 2005;3:e314 pubmed
    ..Our results highlight the potential for these large-scale genomic events to have driven the evolutionary success of the vertebrate lineage...
  87. Gordon M, Ayres J, Schneider D, Nusse R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008;4:e1000111 pubmed publisher
    ..These results are consistent with a model in which the regulation of host factors, including edin, must be tightly controlled to avoid the detrimental consequences of having too much or too little activity...
  88. Mangelsdorf D, Ong E, Dyck J, Evans R. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature. 1990;345:224-9 pubmed
    ..By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology. ..
  89. Mathies L, Kerridge S, Scott M. Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes. Development. 1994;120:2799-809 pubmed
    ..By responding to signals as well as localized transcription regulators, the tsh transcription factor is produced in a spatial pattern distinct from any of the homeotic genes. ..
  90. Bashaw G, Baker B. The regulation of the Drosophila msl-2 gene reveals a function for Sex-lethal in translational control. Cell. 1997;89:789-98 pubmed
    ..We also provide evidence that the repression of MSL-2 is directly regulated by Sex-lethal at the level of translation. ..
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    ..We also show that two of the six (Hsp90 and Hsc70) are required in vivo for ecdysone receptor activity, and that EcR is the primary target of the chaperone complex. ..
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    ..We propose a novel function for Boule in the CNS as a negative regulator of developmental axon pruning. ..