Experts and Doctors on cyclooxygenase 1 in New York, United States


Locale: New York, United States
Topic: cyclooxygenase 1

Top Publications

  1. Upmacis R, Deeb R, Hajjar D. Regulation of prostaglandin H2 synthase activity by nitrogen oxides. Biochemistry. 1999;38:12505-13 pubmed
    ..However, other forms of NO(x)() inhibit PGHS-1. These results may have implications in the regulation of vascular function and tone in normal and atherosclerotic arteries. ..
  2. Wang X, Li G, Wang A, Zhang Z, Merchan J, Halmos B. Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells. Mol Carcinog. 2013;52:218-28 pubmed publisher
    ..Overall, our results suggest that combined HDACI and COX inhibition should be explored clinically to achieve more meaningful benefits from HDACI therapy in lung cancer. ..
  3. Lowenstein J, Amato G, Kolokotronis S. The real maccoyii: identifying tuna sushi with DNA barcodes--contrasting characteristic attributes and genetic distances. PLoS ONE. 2009;4:e7866 pubmed publisher
    ..This research fulfills this requirement for tuna, and supports the nomination of northern bluefin tuna for CITES listing in 2010. ..
  4. Nomura T, Chang H, Lu R, Hankin J, Murphy R, Schuster V. Prostaglandin signaling in the renal collecting duct: release, reuptake, and oxidation in the same cell. J Biol Chem. 2005;280:28424-9 pubmed
    ..Our data are consistent with a new model that offers significant new mechanisms for the fine control of eicosanoid signaling. ..
  5. Kelley K, Ho L, Winger D, Freire Moar J, Borelli C, Aisen P, et al. Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol. 1999;155:995-1004 pubmed
    ..This model system will allow the systematic examination of the role of COX-2 in mechanisms of neurodegeneration that involve excitatory amino acid pathways. ..
  6. Ye X, Liu S. Lipopolysaccharide down-regulates Sp1 binding activity by promoting Sp1 protein dephosphorylation and degradation. J Biol Chem. 2002;277:31863-70 pubmed
    ..Our results demonstrate that challenge of mice with LPS in vivo down-regulates Sp1 DNA binding activity through promoting Sp1 protein dephosphorylation and degradation. ..
  7. Anrather J, Gallo E, Kawano T, Orio M, Abe T, Gooden C, et al. Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. PLoS ONE. 2011;6:e25916 pubmed publisher
  8. Chan E, Zhang H, Fernandez P, Edelman S, Pillinger M, Ragolia L, et al. Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk. Arthritis Res Ther. 2007;9:R4 pubmed
    ..NS398-treated THP-1 macrophages show greater vulnerability to form foam cells. Increased cardiovascular risk with COX inhibition may be ascribed at least in part to altered cholesterol metabolism...
  9. Wang G, Sarkar P, Peterson J, Anrather J, Pierce J, Moore J, et al. COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ. Am J Physiol Heart Circ Physiol. 2013;305:H1451-61 pubmed publisher
    ..Our findings provide the first evidence of a spatial and functional framework that underlies ANG-II signaling in the SFO and reveal novel targets for antihypertensive therapies. ..

More Information


  1. Qin W, Peng Y, Ksiezak Reding H, Ho L, Stetka B, Lovati E, et al. Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease. Mol Psychiatry. 2006;11:172-81 pubmed
    ..The study provides support for the potential pharmacogenomic identification of N141I PS2 FAD cases that might preferentially benefit from inhibition of COX-2 during the progression of clinical dementia. ..
  2. Walch L, Morris P. Cyclooxygenase 2 pathway mediates IL-1beta regulation of IL-1alpha, -1beta, and IL-6 mRNA levels in Leydig cell progenitors. Endocrinology. 2002;143:3276-83 pubmed
    ..Taken together, our data demonstrate that this COX2 cascade is a regulator of cytokines in Leydig progenitors. ..
  3. Qin W, Ho L, Pompl P, Peng Y, Zhao Z, Xiang Z, et al. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. J Biol Chem. 2003;278:50970-7 pubmed
  4. Cao X, Peterson J, Wang G, Anrather J, Young C, Guruju M, et al. Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain. Hypertension. 2012;59:869-76 pubmed publisher
    ..Thus, COX 1-derived PGE(2) signaling through EP(1)R in the SFO is required for the ROS-mediated HTN induced by systemic infusion of Ang II and suggests that EP(1)R in the SFO may provide a novel target for antihypertensive therapy. ..
  5. Yermakova A, Rollins J, Callahan L, Rogers J, O Banion M. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J Neuropathol Exp Neurol. 1999;58:1135-46 pubmed
    ..Currently used NSAIDs inhibit both isoforms of cyclooxygenase. The present study shows that COX-1 is widely expressed in human brain, and raises the possibility that COX-1 may contribute to CNS pathology. ..
  6. Capone C, Faraco G, Anrather J, Zhou P, Iadecola C. Cyclooxygenase 1-derived prostaglandin E2 and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II. Hypertension. 2010;55:911-7 pubmed publisher
    ..The findings provide the first evidence that EP1Rs are involved in the deleterious cerebrovascular effects of Ang II and suggest new therapeutic approaches to counteract them. ..
  7. Kirschenbaum A, Liotta D, Yao S, Liu X, Klausner A, Unger P, et al. Immunohistochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the human fetal and adult male reproductive tracts. J Clin Endocrinol Metab. 2000;85:3436-41 pubmed
    ..The distinct cell type-specific expression patterns of Cox-2 in the prostate (smooth muscle) vs. the seminal vesicles and ejaculatory ducts (epithelium) may reflect the different roles of PGs in these tissues. ..
  8. Flores D, Liu Y, Liu W, Satlin L, Rohatgi R. Flow-induced prostaglandin E2 release regulates Na and K transport in the collecting duct. Am J Physiol Renal Physiol. 2012;303:F632-8 pubmed publisher
    ..We speculate that dietary sodium intake modulates tubular flow rate to regulate paracrine PGE(2) release and cation transport in the CD. ..