Experts and Doctors on complementary dna in New York, United States

Summary

Locale: New York, United States
Topic: complementary dna

Top Publications

  1. Ruiz i Altaba A, Placzek M, Baldassare M, Dodd J, Jessell T. Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3 beta. Dev Biol. 1995;170:299-313 pubmed
  2. Yang J, Bhaumik M, Liu Y, Stanley P. Regulation of N-linked glycosylation. Neuronal cell-specific expression of a 5' extended transcript from the gene encoding N-acetylglucosaminyltransferase I. Glycobiology. 1994;4:703-12 pubmed
    ..3 kb Mgat-1 mRNA are induced by retinoic acid treatment of P19 EC cells. ..
  3. Struyk A, Canoll P, Wolfgang M, Rosen C, D EUSTACHIO P, Salzer J. Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules. J Neurosci. 1995;15:2141-56 pubmed
    ..These results suggest that these proteins, together with other members of this family, provide diversity to the surfaces of different neuronal populations that could be important in the specification of neuronal connectivity. ..
  4. Applegate D, Feng W, Green R, Taubman M. Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle. J Biol Chem. 1994;269:10683-90 pubmed
    ..However, unlike basic calponin, the acidic isoform did not interact with Ca2+/calmodulin, indicating a functional distinction between the muscle and non-muscle forms. ..
  5. Carcamo J, Weis F, Ventura F, Wieser R, Wrana J, Attisano L, et al. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol Cell Biol. 1994;14:3810-21 pubmed
    ..Hence, we conclude that the type I receptor subunits are primary specifiers of signals sent by TGF-beta and activin receptor complexes. ..
  6. Kuge O, Hara Kuge S, Orci L, Ravazzola M, Amherdt M, Tanigawa G, et al. zeta-COP, a subunit of coatomer, is required for COP-coated vesicle assembly. J Cell Biol. 1993;123:1727-34 pubmed
    ..Unlike other coatomer subunits (beta-, beta'-, gamma-, and epsilon-COP), zeta-COP exists in both coatomer bound and free pools. ..
  7. Ioffe E, Stanley P. Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Proc Natl Acad Sci U S A. 1994;91:728-32 pubmed
    ..Biochemical and morphological analyses of embryos from 8.5 to 13.5 days of gestation showed that Mgat-1-/-embryos are developmentally retarded, most noticeably in neural tissue, and die between 9.5 and 10.5 days of development. ..
  8. Zara J, Hagen F, Ten Hagen K, Van Wuyckhuyse B, Tabak L. Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3. Biochem Biophys Res Commun. 1996;228:38-44 pubmed
    ..This suggests that more than one isoform of ppGaNTase may be required to complete the O-glycosylation of endogenous substrates. ..
  9. Selvakumar A, Steffens U, Dupont B. NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains. Tissue Antigens. 1996;48:285-94 pubmed
    ..The putative transmembrane and cytoplasmic domains are distinctly different from all previously reported KIR cDNAs. ..

More Information

Publications267 found, 100 shown here

  1. Chen Y, Scanlan M, Sahin U, Tureci O, Gure A, Tsang S, et al. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci U S A. 1997;94:1914-8 pubmed
    ..These antigens, initially detected by either cytotoxic T cells (MAGE, BAGE, GAGE-1) or antibodies [HOM-MEL-40(SSX2), NY-ESO-1], represent a pool of antigenic targets for cancer vaccination. ..
  2. Weinstein D, Marden J, Carnevali F, Hemmati Brivanlou A. FGF-mediated mesoderm induction involves the Src-family kinase Laloo. Nature. 1998;394:904-8 pubmed
    ..This work provides the first evidence that a Src-related kinase is involved in vertebrate mesoderm induction. ..
  3. Esaki T, Roy K, Yao R, Galivan J, Sirotnak F. Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences. Gene. 1998;219:37-44 pubmed
    ..Abundance of GH mRNA among tumors varied from low to high, with no discernible correlation with their tissue of origin. ..
  4. Neff S, Mason P, Baxt B. High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit. J Virol. 2000;74:7298-306 pubmed
  5. Krebs C, Jarvis E, Chan J, Lydon J, Ogawa S, Pfaff D. A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors. Proc Natl Acad Sci U S A. 2000;97:12816-21 pubmed
    ..These findings suggest a mechanism in which the activation of nuclear P receptor represses expression of a membrane P receptor, 25-Dx, during lordosis facilitation. ..
  6. Seimiya H, Smith S. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). J Biol Chem. 2002;277:14116-26 pubmed
    ..We discuss potential roles for tankyrase 1-mediated higher order complexes at telomeres and at other subcellular sites. ..
  7. Azmi S, Sun H, Ozog A, Taneja R. mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. J Biol Chem. 2003;278:20098-109 pubmed
    ..Our results suggest that mSharp-1 functions as a transcriptional repressor by DNA binding dependent and independent mechanisms. ..
  8. Kim U, Siegel R, Ren X, Gunther C, Gaasterland T, Roeder R. Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses. Proc Natl Acad Sci U S A. 2003;100:8868-73 pubmed
    ..Further studies on the roles played by these genes in B cells will contribute to an understanding of B cell differentiation. ..
  9. Ebert O, Shinozaki K, Kournioti C, Park M, Garcia Sastre A, Woo S. Syncytia induction enhances the oncolytic potential of vesicular stomatitis virus in virotherapy for cancer. Cancer Res. 2004;64:3265-70 pubmed
    ..0078, log-rank test). The results suggest that fusogenic VSV can be developed into an effective and safe therapeutic agent for cancer treatment in patients, including those with multifocal HCC in the liver. ..
  10. Wardemann H, Hammersen J, Nussenzweig M. Human autoantibody silencing by immunoglobulin light chains. J Exp Med. 2004;200:191-9 pubmed
    ..The greater efficacy of Iglambda chains as silencer of autoreactivity provides a possible explanation for the expansion and altered configuration of the Iglambda locus in evolution. ..
  11. Ahn S, Joyner A. Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell. 2004;118:505-16 pubmed
    ..Finally, by fate mapping Shh-responding cells in Gli2 and Gli3 mutant limbs, we demonstrate that a specific level of positive Hh signaling is not required to specify digit identities. ..
  12. Xu Z, Kukekov N, Greene L. Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop. Mol Cell Biol. 2005;25:9949-59 pubmed
    ..Our findings suggest a self-amplifying, feed-forward loop mechanism by which apoptotic stimuli promote the stabilization of JNK pathway components, thereby contributing to cell death. ..
  13. Suárez Fariñas M, Magnasco M. Comparing microarray studies. Methods Mol Biol. 2007;377:139-52 pubmed
    ..We discuss methods to carry out or refine such comparisons, and detail several common pitfalls to avoid. Finally, we illustrate these ideas with an example case. ..
  14. Rybicki A, Schwartz R, Qiu J, Gilman J. Molecular cloning of mouse erythrocyte protein 4.2: a membrane protein with strong homology with the transglutaminase supergene family. Mamm Genome. 1994;5:438-45 pubmed
    ..2-deficient animal models (for example, ribozyme or homologous recombinant "knockout" models) that should accelerate the understanding of P4.2 function in both erythroid and non-erythroid cells. ..
  15. Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature. 1996;379:458-60 pubmed
    ..To our knowledge, this is the first iodide-transporting molecule to have its cDNA cloned, providing a missing link in the thyroid hormone biosynthetic pathway. ..
  16. Lee J, Platt K, Censullo P, Ruiz i Altaba A. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development. 1997;124:2537-52 pubmed
    ..Thus, our results identify Gli1 as a midline target of Shh and suggest that it mediates the induction of floor plate cells and ventral neurons by Shh acting as a transcriptional regulator. ..
  17. Pan Y, Xu J, Wan B, Zuckerman A, Pasternak G. Identification and differential regional expression of KOR-3/ORL-1 gene splice variants in mouse brain. FEBS Lett. 1998;435:65-8 pubmed
    ..The brainstem had similar levels of KOR-3, KOR-3a, and KOR-3d. In contrast, KOR-3d was most prominent in the cerebellum. KOR-3b levels were very low throughout. ..
  18. Wang B, Shi G, Yao P, Li Z, Chapman H, Bromme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. 1998;273:32000-8 pubmed
  19. De Gasperi R, Gama Sosa M, Sartorato E, Battistini S, Raghavan S, Kolodny E. Molecular basis of late-life globoid cell leukodystrophy. Hum Mutat. 1999;14:256-62 pubmed
    ..This mutation has been found in several other patients with late-onset GLD...
  20. Tatsis Kotsidis I, Erlanger B. A1 adenosine receptor of human and mouse adipose tissues: cloning, expression, and characterization. Biochem Pharmacol. 1999;58:1269-77 pubmed
    ..In both studies, cellular environment had no affect on binding characteristics. This conclusive evidence resolves earlier conflicting reports in the literature. ..
  21. Hong S, Li C, Rhee H, Park J, He X, Levy B, et al. Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein. Genomics. 1999;62:232-41 pubmed
  22. Shi X, Potvin B, Huang T, Hilgard P, Spray D, Suadicani S, et al. A novel casein kinase 2 alpha-subunit regulates membrane protein traffic in the human hepatoma cell line HuH-7. J Biol Chem. 2001;276:2075-82 pubmed
    ..This study suggests that HuH-7 cells express at least three CK2alpha isoforms and that the pleiotropic TRF1 phenotype is a consequence of a reduction in total CK2 expression. ..
  23. Mochida K, Rivkin E, Gil M, Kierszenbaum A. Keratin 9 is a component of the perinuclear ring of the manchette of rat spermatids. Dev Biol. 2000;227:510-9 pubmed
    ..Results of this study show that rat testis expresses K9 and that this protein is a component the perinuclear ring of the manchette of rat spermatids. ..
  24. Nitabach M, Llamas D, Araneda R, Intile J, Thompson I, Zhou Y, et al. A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors. Proc Natl Acad Sci U S A. 2001;98:705-10 pubmed publisher
    ..This is a mechanism for information transfer between subunits in heteromultimeric ion channels that is likely to underlie the generation of combinatorial signaling diversity in the control of cellular electrical excitability...
  25. Darken R, Scola A, Rakeman A, Das G, Mlodzik M, Wilson P. The planar polarity gene strabismus regulates convergent extension movements in Xenopus. EMBO J. 2002;21:976-85 pubmed
    ..Thus our results strongly support the emerging hypothesis that a vertebrate analog of the planar polarity pathway governs convergent extension movements. ..
  26. Sánchez L, Horner D, Moore D, Henze K, Embley T, MULLER M. Fructose-1,6-bisphosphate aldolases in amitochondriate protists constitute a single protein subfamily with eubacterial relationships. Gene. 2002;295:51-9 pubmed
  27. Liu G, Bafico A, Harris V, Aaronson S. A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol Cell Biol. 2003;23:5825-35 pubmed
    ..Thus, Wnt canonical signaling through LRP6 establishes a novel mechanism for receptor activation which is opposite to the general paradigm of ligand-induced receptor oligomerization. ..
  28. Chen J, Carcamo J, Borquez Ojeda O, Erdjument Bromage H, Tempst P, Golde D. The laminin receptor modulates granulocyte-macrophage colony-stimulating factor receptor complex formation and modulates its signaling. Proc Natl Acad Sci U S A. 2003;100:14000-5 pubmed
    ..These findings provide a mechanistic basis for enhancing host defense cell responsiveness to GM-CSF at transendothelial migration sites while suppressing it in circulation. ..
  29. Hedvat C, Yao J, Sokolic R, Nimer S. Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells. J Biol Chem. 2004;279:6395-400 pubmed
    ..These data demonstrates that MEF is an important regulator of IL-8 expression. ..
  30. Loayza D, Parsons H, Donigian J, Hoke K, de Lange T. DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J Biol Chem. 2004;279:13241-8 pubmed
    ..These data indicate that POT1 has a strong sequence preference for the human telomeric repeat tract and predict that POT1 can bind both the 3' telomeric overhang and the displaced TTAGGG repeats at the base of the t-loop. ..
  31. Azmi S, Ozog A, Taneja R. Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors. J Biol Chem. 2004;279:52643-52 pubmed
    ..Our data suggest that protein-protein interactions between Sharp-1, MyoD, and E47 resulting in interference with MyoD function underlies Sharp-1-mediated repression of myogenic differentiation. ..
  32. Chen W, Tang J, Stanley P. Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant. Glycobiology. 2005;15:259-69 pubmed publisher
  33. Dhar Chowdhury P, Harrell M, Han S, Jankowska D, Parachuru L, Morrissey A, et al. The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function. J Biol Chem. 2005;280:38464-70 pubmed
    ..Our data are consistent with the concept that the activity of these enzymes (possibly by ATP formation in the immediate intracellular microenvironment of this macromolecular K(ATP) channel complex) causes channel closure. ..
  34. Del Vecchio R, Tonks N. Characterization of two structurally related Xenopus laevis protein tyrosine phosphatases with homology to lipid-binding proteins. J Biol Chem. 1994;269:19639-45 pubmed
    ..PTPX1 can be recovered in both soluble and membrane fractions from Xenopus oocytes with the membrane form exhibiting approximately 4-fold higher activity than the soluble form. ..
  35. Wax S, Rosenfield C, Taubman M. Identification of a novel growth factor-responsive gene in vascular smooth muscle cells. J Biol Chem. 1994;269:13041-7 pubmed
    ..SM-20 encodes a new member of the immediate early gene family and is unusual in that it is expressed in vascular smooth muscle, but not in fibroblasts. ..
  36. Ho C, Chin S, Carnevale K, Liem R. Translation initiation and assembly of peripherin in cultured cells. Eur J Cell Biol. 1995;68:103-12 pubmed
    ..Taken together, these results strongly suggest that the second ATG is the preferred translation initiation codon for the peripherin gene. ..
  37. Leal Pinto E, Tao W, Rappaport J, Richardson M, Knorr B, Abramson R. Molecular cloning and functional reconstitution of a urate transporter/channel. J Biol Chem. 1997;272:617-25 pubmed
  38. Purdue P, Zhang J, Skoneczny M, Lazarow P. Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor. Nat Genet. 1997;15:381-4 pubmed
    ..These results imply that several peroxisomal proteins are targeted by PTS2 signals and that the various biochemical and clinical defects in RCDP result from a defect in the receptor for this class of PTS...
  39. Gallardo H, Tan C, Ory D, Sadelain M. Recombinant retroviruses pseudotyped with the vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytes. Blood. 1997;90:952-7 pubmed
    ..Nonetheless, the physical stability of VSV-G-coated particles enables the concentration of viral stocks to 10(9) infectious particles per milliliter or more...
  40. Han J, Baker N, Rubin C. Molecular characterization of a novel A kinase anchor protein from Drosophila melanogaster. J Biol Chem. 1997;272:26611-9 pubmed
    ..The DAKAP550 gene was mapped to the 4F1.2 region of the X chromosome; flies that carry a deletion for this portion of the X chromosome lack DAKAP550 protein. ..
  41. Ho A, Blum M. Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice. Exp Neurol. 1997;148:348-59 pubmed
    ..These results suggest that the regulation of bFGF and possibly its receptor signaling efficacy may vary as the brain ages. ..
  42. Kimmelman A, Tolkacheva T, Lorenzi M, Osada M, Chan A. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. Oncogene. 1997;15:2675-85 pubmed
  43. Horowitz D, Kobayashi R, Krainer A. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. RNA. 1997;3:1374-87 pubmed
    ..The third protein in the complex is a new cyclophilin. Cyclophilins have been proposed to act as chaperones in a variety of cellular processes, and we discuss some possible roles of this U4/U6 snRNP-associated cyclophilin. ..
  44. Jurukovski V, Markova N, Karaman Jurukovska N, Randolph R, Su J, Napoli J, et al. Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes. Mol Genet Metab. 1999;67:62-73 pubmed
    ..It encodes a protein that, using NAD+ as a preferred cofactor, utilizes free and CRBP-bound all-trans-retinol and steroids as substrates. ..
  45. Laub F, Aldabe R, Ou J, Ramirez F. Overexpression of a novel zinc-finger protein induces apoptosis in NIH3T3 fibroblasts. Genomics. 2000;70:375-80 pubmed
    ..Finally, overexpression of the Zfp319 protein in stably transfected fibroblasts results in significant reduction of viable cells due to induction of programmed cell death. ..
  46. Funke B, Pandita R, Morrow B. Isolation and characterization of a novel gene containing WD40 repeats from the region deleted in velo-cardio-facial/DiGeorge syndrome on chromosome 22q11. Genomics. 2001;73:264-71 pubmed
    ..We termed this gene WDR14 (WD40 repeat-containing gene deleted in VCFS). It is expressed in a variety of human and mouse adult and fetal tissues with substantial expression levels in the adult thymus, an organ hypoplastic in VCFS/DGS. ..
  47. Hwang K, Eissenberg J, Worman H. Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Proc Natl Acad Sci U S A. 2001;98:11423-7 pubmed
    ..These data provide genetic evidence that an HP1-family protein represses the expression of euchromatic genes in a metazoan, and that histone modifiers cooperate with HP1 in euchromatic gene repression. ..
  48. Park C, Takahara K, Umemoto E, Yashima Y, Matsubara K, Matsuda Y, et al. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int Immunol. 2001;13:1283-90 pubmed
    ..This family of mouse C-type lectins is therefore complex, but only one of the new genes, DC-SIGN, is juxtaposed to CD23 and is expressed at high levels in DC. ..
  49. Mirshahi T, Mittal V, Zhang H, Linder M, Logothetis D. Distinct sites on G protein beta gamma subunits regulate different effector functions. J Biol Chem. 2002;277:36345-50 pubmed
    ..These data show that distinct domains within Gbetagamma subserve specific functional roles. ..
  50. Hansis C, Grifo J, Tang Y, Krey L. Assessment of beta-HCG, beta-LH mRNA and ploidy in individual human blastomeres. Reprod Biomed Online. 2002;5:156-61 pubmed
  51. Han Z, Truong Q, Park S, Breslow J. Two Hsp70 family members expressed in atherosclerotic lesions. Proc Natl Acad Sci U S A. 2003;100:1256-61 pubmed
    ..In summary, we describe two genes that code for a subfamily of Hsp70 proteins that may be involved in atherosclerosis susceptibility. ..
  52. Goriounov D, Leung C, Liem R. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. J Cell Sci. 2003;116:1045-58 pubmed
    ..This finding suggests that the physiological functions of these proteins may involve integration of these two components of the cytoskeleton. ..
  53. Komuro A, Nagai M, Navin N, Sudol M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem. 2003;278:33334-41 pubmed
    ..Our data indicate that YAP is a potential signaling partner of the full-length ErbB4 receptor at the membrane and of the COOH-terminal fragment of ErbB-4 that translocates to the nucleus to regulate transcription. ..
  54. Chen Y, Guo X, Deng F, Liang F, Sun W, Ren M, et al. Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proc Natl Acad Sci U S A. 2003;100:14012-7 pubmed
    ..The association of Rab27b with fusiform vesicles and its differentiation-dependent expression suggest that this Rab protein plays a role in regulating the delivery of fusiform vesicles to the apical plasma membrane of umbrella cells. ..
  55. Si K, Giustetto M, Etkin A, Hsu R, Janisiewicz A, Miniaci M, et al. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Cell. 2003;115:893-904 pubmed
    ..We suggest that Aplysia CPEB is one of the stabilizing components of the synaptic mark. ..
  56. Amano H, Hackett N, Kaner R, Whitlock P, Rosengart T, Crystal R. Alteration of splicing signals in a genomic/cDNA hybrid VEGF gene to modify the ratio of expressed VEGF isoforms enhances safety of angiogenic gene therapy. Mol Ther. 2005;12:716-24 pubmed
    ..We conclude that AdVEGF-All and AdVEGF-All6A+ are similar in potency but that AdVEGF-All6A+ is safer. This suggests that AdVEGF-All6A+ may be the preferred candidate for clinical development. ..
  57. Amaravadi R, Glerum D, Tzagoloff A. Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment. Hum Genet. 1997;99:329-33 pubmed
    ..Its presence in humans provides a possible target for genetically inherited deficiencies in cytochrome oxidase. ..
  58. Kaufman L, Hayashi K, Ross M, Ross M, Klotman P. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. J Am Soc Nephrol. 2004;15:1721-30 pubmed
    ..In a human HIVAN kidney biopsy, sidekick expression was increased in glomeruli in a pattern consistent with the mouse model. It is proposed that the dysregulation of sdk-1 protein may play an important role in HIVAN pathogenesis. ..
  59. Weskamp G, Krätzschmar J, Reid M, Blobel C. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. J Cell Biol. 1996;132:717-26 pubmed
    ..We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein. ..
  60. Martinat C, Shendelman S, Jonason A, Leete T, Beal M, Yang L, et al. Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism. PLoS Biol. 2004;2:e327 pubmed
    ..These data are consistent with a protective role for DJ-1, and demonstrate the utility of genetically modified embryonic stem cell-derived neurons as cellular models of neuronal disorders. ..
  61. Ryan X, Alldritt J, Svenningsson P, Allen P, Wu G, Nairn A, et al. The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron. 2005;47:85-100 pubmed
    ..Thus, interaction between Lfc and neurabin/spinophilin selectively regulates Rho-dependent organization of F-actin in spines and is a link between the microtubule and F-actin cytoskeletons in dendrites. ..
  62. Murthy K, Manley J. The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. Genes Dev. 1995;9:2672-83 pubmed
    ..We discuss the significance of these multiple functions and also a possible evolutionary link between yeast and mammalian polyadenylation suggested by the properties and sequence of 160K. ..
  63. Dong L, Chapline C, Mousseau B, Fowler L, Ramsay K, Stevens J, et al. 35H, a sequence isolated as a protein kinase C binding protein, is a novel member of the adducin family. J Biol Chem. 1995;270:25534-40 pubmed
    ..Taken together, these results indicate that 35H is a new, widely expressed form of adducin capable of forming heterodimers with alpha-adducin. We propose naming this adducin homologue gamma-adducin. ..
  64. Wang Z, Roeder R. Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains. Proc Natl Acad Sci U S A. 1995;92:7026-30 pubmed
    ..TFIIIB90 is also required for transcription of human 7SK and U6 RNA genes by RNA polymerase III, but apparently within a complex distinct from the TBP/TFIIIB90 complex. ..
  65. Petrukhin K, Lutsenko S, Chernov I, Ross B, Kaplan J, Gilliam T. Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions. Hum Mol Genet. 1994;3:1647-56 pubmed
    ..It appears that the mechanism of alternative splicing serves to regulate the amount of functional WD protein produced in brain, kidney, placenta, and possibly in liver. ..
  66. Chen M, Achkar C, Gudas L. Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenases. Mol Pharmacol. 1994;46:88-96 pubmed
    ..AHD-2 is more active than AHD-M1 in this conversion, but AHD-2 is not the enzyme responsible for this conversion in F9 embryonic stem cells. ..
  67. Yu J, Lin J, Wu X, Sun T. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. J Cell Biol. 1994;125:171-82 pubmed
  68. Lee A, Hsu E. Isolation and characterization of the Xenopus terminal deoxynucleotidyl transferase. J Immunol. 1994;152:4500-7 pubmed
  69. Krätzschmar J, Lum L, Blobel C. Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. J Biol Chem. 1996;271:4593-6 pubmed
    ..These features are consistent with a model in which metargidin is an integrin ligand which, as a transmembrane protein, might function in cell-cell adhesion and/or signaling. ..
  70. Ye G, Breslow E, Meister A, Guo jie G. The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning. J Biol Chem. 1996;271:32293-300 pubmed
    ..The results suggest unexpected evolutionary relationships among the hydantoinases and rat kidney 5-oxoprolinase which share the common property of hydrolyzing the imide bond of 5-membered rings but which do not all require ATP. ..
  71. Roy K, Mitsugi K, Sirotnak F. Additional organizational features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoter. J Biol Chem. 1997;272:5587-93 pubmed
    ..An unusual splice variant identified infrequently in a mouse liver cDNA library was 2.67 kilobases in size and incorporated exons A1a and A1b and a segment of the downstream promoter region along with exons B1c and B1b and exons 2-15. ..
  72. Wu S, Staudinger J, Olson E, Rubin C. Structure, expression, and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. PKC3 is required for the normal progression of embryogenesis and viability of the organism. J Biol Chem. 1998;273:1130-43 pubmed
    ..A candidate anchoring/targeting protein, which binds PKC3 in vitro, has been identified. ..
  73. Xue H, O NEILL D, Morrow J, Bank A. A novel mouse gene, HemT, encoding an hematopoietic cell-specific transcript. Gene. 1999;231:49-58 pubmed
    ..A third type of HemT transcript is expressed only in testis. The erythroid transcript is expressed preferentially in uninduced MELC as compared to induced MELC, and is likely to be expressed in early erythroid cell populations. ..
  74. Fu J, Pirozzi G, Sanjay A, Levy R, Chen Y, De Lemos Chiarandini C, et al. Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains. Eur J Cell Biol. 2000;79:219-28 pubmed
    ..We also show that the retention function of the transmembrane domain is strengthened by the presence of a flanking luminal region consisting of 15 amino acids. ..
  75. Yao Y, Doki Y, Jiang W, Imoto M, Venkatraj V, Warburton D, et al. Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins. Exp Cell Res. 2000;257:22-32 pubmed
    ..2-12, a locus that is amplified in several types of human cancer. These results suggest that DIP1 may be involved in the control of gene expression and differentiation, but its precise function remains to be determined. ..
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