Experts and Doctors on collagen in New York, United States


Locale: New York, United States
Topic: collagen

Top Publications

  1. Hazan R, Phillips G, Qiao R, Norton L, Aaronson S. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 2000;148:779-90 pubmed
  2. Cheng J, Sauthoff H, Huang Y, Kutler D, Bajwa S, Rom W, et al. Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus. Mol Ther. 2007;15:1982-90 pubmed
    ..These results demonstrate that intra-tumoral expression of MMP-8 is a possible strategy for improving viral spread and improving the oncolytic activity of replicating adenovirus. ..
  3. Torzilli P, Bhargava M, Park S, Chen C. Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage. Osteoarthritis Cartilage. 2010;18:97-105 pubmed publisher
    ..The molecular mechanisms involved in this process are not clear but probably involve altered mechanochemical signal transduction between the ECM and chondrocyte. ..
  4. Ng K, O Conor C, Kugler L, Cook J, Ateshian G, Hung C. Transient supplementation of anabolic growth factors rapidly stimulates matrix synthesis in engineered cartilage. Ann Biomed Eng. 2011;39:2491-500 pubmed publisher
    ..These findings shed light on possible techniques to rapidly develop engineered cartilage tissue for the future treatment of osteoarthritis. ..
  5. D Ambrosio D, Walewski J, Clugston R, Berk P, Rippe R, Blaner W. Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage. PLoS ONE. 2011;6:e24993 pubmed publisher
    ..One subset of the total HSC population, which expresses early markers of HSC activation, may be "primed" and ready for rapid response to acute liver injury. ..
  6. Boskey A, Christensen B, Taleb H, Sørensen E. Post-translational modification of osteopontin: effects on in vitro hydroxyapatite formation and growth. Biochem Biophys Res Commun. 2012;419:333-8 pubmed publisher
    ..The diverse effects can be explained in terms of the intrinsically disordered nature of OPN and its fragments which enable them to interact with their multiple partners. ..
  7. Perez Aso M, Mediero A, Low Y, Levine J, Cronstein B. Adenosine A2A receptor plays an important role in radiation-induced dermal injury. FASEB J. 2016;30:457-65 pubmed publisher
    ..Our findings suggest that topical application of an A2AR antagonist prevents radiation dermatitis and may be useful in the prevention or amelioration of radiation changes in the skin. ..
  8. Nierman D, Mechanick J. Bone hyperresorption is prevalent in chronically critically ill patients. Chest. 1998;114:1122-8 pubmed
    ..Further studies will determine the efficacy and cost-effectiveness of routine NTx and PTH screening in these patients and the role of vitamin D and antiresorptive therapies. ..
  9. Blank R, Baldini T, Kaufman M, Bailey S, Gupta R, Yershov Y, et al. Spectroscopically determined collagen Pyr/deH-DHLNL cross-link ratio and crystallinity indices differ markedly in recombinant congenic mice with divergent calculated bone tissue strength. Connect Tissue Res. 2003;44:134-42 pubmed
    ..The data illustrate the importance of material properties in addition to mineral quantity to bone tissue strength...

More Information

Publications162 found, 100 shown here

  1. Blue R, Murcia M, Karan C, Jirouskova M, Coller B. Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen. Blood. 2008;111:1248-56 pubmed
    ..Compound 1 provides a prototype for small molecule selective inhibition of alphaIIbbeta3, without receptor priming, via targeting alphaIIb. ..
  2. Fernandez P, Trzaska S, Wilder T, Chiriboga L, Blackburn M, Cronstein B, et al. Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine. Am J Pathol. 2008;172:1675-82 pubmed publisher
    ..These data confirm a fibrogenic role for adenosine in the skin and reveal A(2A) receptor antagonists as novel therapeutic agents for the modulation of dermal fibrotic disorders. ..
  3. Berlin A, Hussain M, Phelps R, Goldberg D. A prospective study of fractional scanned nonsequential carbon dioxide laser resurfacing: a clinical and histopathologic evaluation. Dermatol Surg. 2009;35:222-8 pubmed publisher
    ..Nonsequential scanned fractional CO2 laser resurfacing can lead to improvement in photo-damaged skin, accompanied by histologic and ultrastructural evidence of wound repair and subsequent new collagen formation. ..
  4. Branski R, Barbieri S, Weksler B, Saltman B, Krishna P, Kraus D, et al. Effects of transforming growth factor-beta1 on human vocal fold fibroblasts. Ann Otol Rhinol Laryngol. 2009;118:218-26 pubmed
    ..We studied the effect of transforming growth factor (TGF)-beta on immortalized human vocal fold fibroblasts...
  5. Fickl S, Schneider D, Zuhr O, Hinze M, Ender A, Jung R, et al. Dimensional changes of the ridge contour after socket preservation and buccal overbuilding: an animal study. J Clin Periodontol. 2009;36:442-8 pubmed publisher
    ..Overbuilding the buccal aspect in combination with socket preservation is not a suitable technique to compensate for the alterations after tooth extraction. ..
  6. Lorenc Z, Nir E, Azachi M. Characterization of physical properties and histologic evaluation of injectable Dermicol-p35 porcine-collagen dermal filler. Plast Reconstr Surg. 2010;125:1805-13 pubmed publisher
    ..Together, these results suggest that Dermicol-P35 27G offers several advantages that may result in improved clinical experiences for both patients and clinicians. ..
  7. Katz B. Efficacy of a new fractional CO2 laser in the treatment of photodamage and acne scarring. Dermatol Ther. 2010;23:403-6 pubmed publisher
    ..The SmartSkin fractional CO(2) system (Cynosure, Inc., Westford, MA, USA) provides significant improvement for the treatment of facial wrinkles, hyperpigmentation, pore size, and skin laxity associated with photodamage. ..
  8. Wu H, Ren C, Yang F, Qin Y, Zhang Y, Liu J. Extraction and identification of collagen-derived peptides with hematopoietic activity from Colla Corii Asini. J Ethnopharmacol. 2016;182:129-36 pubmed publisher
  9. Weiss H, Lages B. Platelet prothrombinase activity and intracellular calcium responses in patients with storage pool deficiency, glycoprotein IIb-IIIa deficiency, or impaired platelet coagulant activity--a comparison with Scott syndrome. Blood. 1997;89:1599-611 pubmed
    ..In addition, the study provides further support for the concept that the development of agents that could induce a Scott syndrome defect in normal platelets may provide a new approach to antithrombotic therapy. ..
  10. Duffy A, Hogle N, LaPerle K, Fowler D. Comparison of two composite meshes using two fixation devices in a porcine laparoscopic ventral hernia repair model. Hernia. 2004;8:358-64 pubmed
    ..Histology showed equal ingrowth. PCO induces fewer adhesions than BC. There is no difference in the ingrowth of the two mesh types. The PLA achieves equivalent mesh incorporation to the PT. ..
  11. Peng Y, Li C, Chen F, Wang Z, Ligr M, Melamed J, et al. Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Am J Pathol. 2008;172:225-35 pubmed
    ..Our findings implicate ARA70 beta as a regulator of tumor cell growth and metastasis by affecting gene expression. ..
  12. Martinez L, Han G, Chacko M, Mihu M, Jacobson M, Gialanella P, et al. Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection. J Invest Dermatol. 2009;129:2463-9 pubmed publisher
    ..Together, these data suggest that these NO-releasing nanoparticles have the potential to serve as a novel class of topically applied antimicrobials for the treatment of cutaneous infections and wounds. ..
  13. Perez Aso M, Chiriboga L, Cronstein B. Pharmacological blockade of adenosine A2A receptors diminishes scarring. FASEB J. 2012;26:4254-63 pubmed publisher
    ..Taken together, our work strongly suggests that pharmacological A2AR blockade can be used to diminish scarring while improving the collagen composition and tensile strength of the healed wound. ..
  14. Nevins A, Cymerman J. Revitalization of open apex teeth with apical periodontitis using a collagen-hydroxyapatite scaffold. J Endod. 2015;41:966-73 pubmed publisher
    ..This may leave teeth more fully developed and less likely to fracture. ..
  15. Skaggs D, Weidenbaum M, Iatridis J, Ratcliffe A, Mow V. Regional variation in tensile properties and biochemical composition of the human lumbar anulus fibrosus. Spine (Phila Pa 1976). 1994;19:1310-9 pubmed
    ..The regional differences in tensile properties may result predominantly from structural rather than compositional variations and may contribute to the clinical frequency of anulus failure in the posterolateral region. ..
  16. Exposito J, D Alessio M, Di Liberto M, Ramirez F. Complete primary structure of a sea urchin type IV collagen alpha chain and analysis of the 5' end of its gene. J Biol Chem. 1993;268:5249-54 pubmed
    ..M., Etkin, M., and Benson, S. (1991) Dev. Biol. 148, 261-272) who demonstrated its involvement in the biomineralization process of cultured mesenchyme cells...
  17. Wisniewski D, Strife A, Swendeman S, Erdjument Bromage H, Geromanos S, Kavanaugh W, et al. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Blood. 1999;93:2707-20 pubmed
  18. Nieto N, Friedman S, Cederbaum A. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology. 2002;35:62-73 pubmed
    ..Thus, besides perturbing the homeostasis of hepatocytes, CYP2E1-derived diffusible oxidants may also interact with stellate cells and contribute to hepatic fibrosis. ..
  19. Govindaraj S, Cohen M, Genden E, Costantino P, Urken M. The use of acellular dermis in the prevention of Frey's syndrome. Laryngoscope. 2001;111:1993-8 pubmed
    ..At the conclusion of this presentation, the participant should be able to discuss the indications and advantages of using acellular dermis in the prevention of post-parotidectomy gustatory sweating (Frey's Syndrome)...
  20. Tanaka S, Antoniv T, Liu K, Wang L, Wells D, Ramirez F, et al. Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice. J Biol Chem. 2004;279:56024-31 pubmed
    ..This study thus reiterates the complex and highly combinatorial nature of the regulatory network governing COL1A2 transcription in vivo. ..
  21. Klotz S, Foronjy R, Dickstein M, Gu A, Garrelds I, Danser A, et al. Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness. Circulation. 2005;112:364-74 pubmed
    ..Lack of significant effects on the RV suggest that hemodynamic unloading of the LV (not provided to the RV) might be the primary factor that regulates these extracellular matrix changes. ..
  22. Mulhall J, Muller A, Donohue J, Mullerad M, Kobylarz K, Paduch D, et al. The functional and structural consequences of cavernous nerve injury are ameliorated by sildenafil citrate. J Sex Med. 2008;5:1126-1136 pubmed publisher
    ..Sildenafil use in the CN crush injury model preserves erectile function that appears to be mediated predominantly through preservation of smooth muscle content and endothelial function as well as through reduction in apoptosis. ..
  23. Matsuo N, Tanaka S, Yoshioka H, Koch M, Gordon M, Ramirez F. Collagen XXIV (Col24a1) gene expression is a specific marker of osteoblast differentiation and bone formation. Connect Tissue Res. 2008;49:68-75 pubmed publisher
    ..These findings lend further support to the hypothesis that collagen XXIV may be implicated in the formation of a mineralization-competent bone matrix. ..
  24. Katebi M, Fernandez P, Chan E, Cronstein B. Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis. Inflammation. 2008;31:299-303 pubmed publisher
    ..Moreover, these results provide further evidence that adenosine A(2A) receptors may represent a new target for the treatment of such fibrosing diseases as scleroderma or nephrogenic fibrosing dermopathy. ..
  25. Greenstein A, Aldoroty R. Parastomal hernia repair using cross-linked porcine dermis: report of a case. Surg Today. 2008;38:1048-51 pubmed publisher
    ..This case report describes a novel method of parastomal hernia repair using cross-linked acellular porcine dermal collagen matrix, a new biological material suitable for hernia repair. ..
  26. Neviaser A, Andarawis Puri N, Flatow E. Basic mechanisms of tendon fatigue damage. J Shoulder Elbow Surg. 2012;21:158-63 pubmed publisher
    ..We hope that this more realistic animal model of tendon fatigue damage will allow better assessment of biologic, mechanical, tissue-engineering, and rehabilitation strategies to improve repair success. ..
  27. Draper L, Disa J. Do acellularized dermal matrices change the rationale for immediate versus delayed breast reconstruction?. Clin Plast Surg. 2012;39:113-118 pubmed publisher
    ..The current literature on ADMs is reviewed and the potential advantages and disadvantages of their use are highlighted. Technical considerations on how to effectively use these materials is presented. ..
  28. Xiang G, Seki T, Schuster M, Witkowski P, Boyle A, See F, et al. Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia. J Biol Chem. 2005;280:39394-402 pubmed
    ..Strategies to inhibit VDUP1 expression and/or function during acute ischemic events may be beneficial to cardiac functional recovery and prevention of left ventricular remodeling. ..
  29. Arvanian V, Horner P, Gage F, Mendell L. Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. J Neurosci. 2003;23:8706-12 pubmed
    ..We conclude that chronic NT-3 enhances the potency of segmental and descending projections via mechanisms different from those underlying acute changes. ..
  30. Nieto N, Cederbaum A. S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. J Biol Chem. 2005;280:30963-74 pubmed
    ..These observations unveil a novel mechanism by which AdoMet could ameliorate liver fibrosis. ..
  31. Patel M, Talmor M, Nolan W. Botox and collagen for glabellar furrows: advantages of combination therapy. Ann Plast Surg. 2004;52:442-7; discussion 447 pubmed
    ..05). Patient satisfaction further highlighted the superiority of the combination approach. By simultaneously addressing the static and dynamic aspects of glabellar furrows, dual therapy provides optimal treatment of this problem. ..
  32. Romanos G, Asnani K, Hingorani D, Deshmukh V. PERIOSTIN: role in formation and maintenance of dental tissues. J Cell Physiol. 2014;229:1-5 pubmed publisher
    ..It has been shown to be an integral regulator of periodontal disease pathogenesis and repair. This review focuses on the various functional aspects of periostin in dental connective tissue development and maintenance. ..
  33. Fleischmajer R, Fisher L, MacDonald E, Jacobs L, Perlish J, Termine J. Decorin interacts with fibrillar collagen of embryonic and adult human skin. J Struct Biol. 1991;106:82-90 pubmed
    ..Also, significant amounts of core protein was identified lacking the dermatan sulfate chain. This study suggests that the core protein of decorin interacts with collagen fibrils although its specific function remains unknown. ..
  34. Tall E, Bernstein A, Oliver N, Gray J, Masur S. TGF-?-stimulated CTGF production enhanced by collagen and associated with biogenesis of a novel 31-kDa CTGF form in human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2010;51:5002-11 pubmed publisher
  35. Kolker A, Brown D, Redstone J, Scarpinato V, Wallack M. Multilayer reconstruction of abdominal wall defects with acellular dermal allograft (AlloDerm) and component separation. Ann Plast Surg. 2005;55:36-41; discussion 41-2 pubmed
    ..By minimizing tension and providing a durable biocompatible matrix for support, component separation with bilaminar acellular dermal allograft should be considered for the repair of complex and recurrent ventral hernias. ..
  36. Golovatch P, Mercer B, Lemaitre V, Wallace A, Foronjy R, D ARMIENTO J. Role for cathepsin K in emphysema in smoke-exposed guinea pigs. Exp Lung Res. 2009;35:631-45 pubmed publisher
    ..Elevation of cathepsin K in guinea pig lungs after smoke exposure likely constitutes a critical event leading to the disruption of lung extracellular matrix in this model. ..
  37. Uddin S, Qin Y. Enhancement of osteogenic differentiation and proliferation in human mesenchymal stem cells by a modified low intensity ultrasound stimulation under simulated microgravity. PLoS ONE. 2013;8:e73914 pubmed publisher
    ..001) in LIPUS treated-SMG cultures relative to SMG-only cultures. The data suggest that LIPUS treatment can restore normal osteogenic differentiation of MSCs from disuse by daily short duration stimulation. ..
  38. Reeves C, Wang X, Charles Horvath P, Vink J, Borisenko V, Young J, et al. Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity. PLoS ONE. 2012;7:e34862 pubmed publisher
    ..We identified an ANTXR2/MT1-MMP complex and demonstrated that MT1-MMP activity is dependent on ANTXR2 expression levels in cells. Thus, we have discovered that ANTXR1 and ANTXR2 function as positive regulators of MT1-MMP activity. ..
  39. Cohen D, Kaufmann J. Hypersensitivity reactions to products and devices in plastic surgery. Facial Plast Surg Clin North Am. 2003;11:253-65 pubmed
  40. Hasan S, Weinberg M, Khatib O, Jazrawi L, Strauss E. The Effect of Platelet-rich Fibrin Matrix on Rotator Cuff Healing in a Rat Model. Int J Sports Med. 2016;37:36-42 pubmed publisher
    ..PRFM does not recapitulate the native enthesis, but rather induces an exuberant and disordered healing response that is characterized by fibrovascular scar tissue. ..
  41. Currie R. Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y). J Biol Chem. 1997;272:30880-8 pubmed
    ..This protein-protein interaction site may function to modulate NF-Y activity through stabilization of NF-Y binding to its CCAAT box DNA-binding site. ..
  42. Borczuk A, Niedt G, Sablay L, Kress Y, Mannion C, Factor S, et al. Fibrous long-spacing collagen in bacillary angiomatosis. Ultrastruct Pathol. 1998;22:127-33 pubmed
    ..An association between FLS collagen and endothelial cells in normal tissue (Descemet's membrane) and in certain vascular proliferations appears to exist...
  43. Kennedy M, Keller G. Hematopoietic commitment of ES cells in culture. Methods Enzymol. 2003;365:39-59 pubmed
  44. Wang Z, Lloyd A, Burket J, Gourion Arsiquaud S, Donnelly E. Altered distributions of bone tissue mineral and collagen properties in women with fragility fractures. Bone. 2016;84:237-244 pubmed publisher
    ..Fx-HRT biopsies are consistent with greater tissue age and greater BMD arising from decreased osteoclastic resorption in HRT-treated patients. ..
  45. Leung C, Zheng M, Prater S, Liem R. The BPAG1 locus: Alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles. J Cell Biol. 2001;154:691-7 pubmed
    ..The absence of BPAG1-a is the likely cause of sensory neurodegeneration in mutant mice. BPAG1-b is highly expressed in muscles, and has extra exons encoding a second IFBD between the plakin and SR-containing rod domains of BPAG1-a. ..
  46. Frenkel S, Bradica G, Brekke J, Goldman S, Ieska K, Issack P, et al. Regeneration of articular cartilage--evaluation of osteochondral defect repair in the rabbit using multiphasic implants. Osteoarthritis Cartilage. 2005;13:798-807 pubmed
    ..It also renders these devices excellent vehicles for chondrocyte or stem cell transplantation. ..
  47. Bedi A, Kovacevic D, Hettrich C, Gulotta L, Ehteshami J, Warren R, et al. The effect of matrix metalloproteinase inhibition on tendon-to-bone healing in a rotator cuff repair model. J Shoulder Elbow Surg. 2010;19:384-91 pubmed publisher
    ..Modulation of MMP activity after rotator cuff repair may offer a novel biologic pathway to augment tendon-to-bone healing after rotator cuff repair. ..
  48. Kovacevic D, Fox A, Bedi A, Ying L, Deng X, Warren R, et al. Calcium-phosphate matrix with or without TGF-?3 improves tendon-bone healing after rotator cuff repair. Am J Sports Med. 2011;39:811-9 pubmed publisher
    ..The delivery of TGF-?(3) with an injectable Ca-P matrix at the supraspinatus tendon footprint has promise to improve healing after soft tissue repair. ..
  49. Kelly T, Ng K, Ateshian G, Hung C. Analysis of radial variations in material properties and matrix composition of chondrocyte-seeded agarose hydrogel constructs. Osteoarthritis Cartilage. 2009;17:73-82 pubmed publisher
    ..No differences in GAG distribution may be due to sufficient chemical signals and building blocks for GAG synthesis throughout the constructs. ..
  50. Cho Y, Klein M, Talmage D. Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells. Cell Growth Differ. 1998;9:147-54 pubmed
  51. Fayad J, Baino T, Parisier S. Preliminary results with the use of AlloDerm in chronic otitis media. Laryngoscope. 2003;113:1228-30 pubmed
    ..AlloDerm can provide a suitable grafting material when fascia is not available or when the size of the defect precludes the use of fascia. ..
  52. Sumiyoshi H, Laub F, Yoshioka H, Ramirez F. Embryonic expression of type XIX collagen is transient and confined to muscle cells. Dev Dyn. 2001;220:155-62 pubmed
    ..5 embryos and the cerebral cortex and hippocampus of the new born brain. Unlike all other tissues, expression of Col19a1 in the central nervous system gradually increases after birth. ..
  53. Meshel A, Wei Q, Adelstein R, Sheetz M. Basic mechanism of three-dimensional collagen fibre transport by fibroblasts. Nat Cell Biol. 2005;7:157-64 pubmed
    ..Thus, we suggest that cyclic myosin II-B assembly and contraction in lamellipodia power 3D fibre movements. ..
  54. Miller E, Delos D, Baldini T, Wright T, Pleshko Camacho N. Abnormal mineral-matrix interactions are a significant contributor to fragility in oim/oim bone. Calcif Tissue Int. 2007;81:206-14 pubmed
  55. Gulotta L, Kovacevic D, Ehteshami J, Dagher E, Packer J, Rodeo S. Application of bone marrow-derived mesenchymal stem cells in a rotator cuff repair model. Am J Sports Med. 2009;37:2126-33 pubmed publisher
    ..Further studies are needed to determine if cell-based strategies need to be combined with growth and differentiation factors to be effective. ..
  56. Lee J, Zhou Z, Taub P, Ramcharan M, Li Y, Akinbiyi T, et al. BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. PLoS ONE. 2011;6:e17531 pubmed publisher
    ..This strategy of pretreating BM-MSCs with BMP-12 prior to in vivo transplantation may be useful in MSC-based tendon reconstruction or tissue engineering. ..
  57. Mruk D, Cheng C. An in vitro system to study Sertoli cell blood-testis barrier dynamics. Methods Mol Biol. 2011;763:237-52 pubmed publisher
    ..This information is based on the routine use of this system in our laboratory to study the Sertoli cell blood-testis barrier in the past two decades, which should be helpful for investigators in the field...
  58. Greenwald J, Mehrara B, Spector J, Warren S, Fagenholz P, Smith L, et al. In vivo modulation of FGF biological activity alters cranial suture fate. Am J Pathol. 2001;158:441-52 pubmed
    ..Our data may facilitate the development of novel, less invasive treatment options for children with craniosynostosis...
  59. Xu J, Rodriguez D, Petitclerc E, Kim J, Hangai M, Moon Y, et al. Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. J Cell Biol. 2001;154:1069-79 pubmed
    ..Together, these studies suggest a novel mechanism by which proteolysis contributes to angiogenesis by exposing hidden regulatory elements within matrix-immobilized collagen type IV. ..
  60. Li Z, Hou W, Escalante Torres C, Gelb B, Bromme D. Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate. J Biol Chem. 2002;277:28669-76 pubmed
    ..These findings reveal a novel mechanism of bone collagen degradation and suggest that targeting cathepsin K complex formation would be an effective and specific treatment for diseases with excessive bone resorption such as osteoporosis. ..
  61. Boskey A, Moore D, Amling M, Canalis E, Delany A. Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls. J Bone Miner Res. 2003;18:1005-11 pubmed
    ..These spectroscopic data are consistent with a mechanism of decreased bone formation and remodeling. ..
  62. Ky A, Sylla P, Steinhagen R, Steinhagen E, Khaitov S, Ly E. Collagen fistula plug for the treatment of anal fistulas. Dis Colon Rectum. 2008;51:838-43 pubmed publisher
    ..Given the relatively low morbidity associated with the procedure, Anal Fistula Plug should be considered as a first-line treatment for patients with simple fistulas and as an alternative in selected patients with complex fistulas. ..
  63. HUNT R, Mandal R, Walters R, Schaffer J. Pachydermodactyly. Dermatol Online J. 2010;16:5 pubmed
    ..Past medical history included allergic rhinitis and asthma. Similar hand findings were not present in any other members of his family. ..
  64. Purushothaman K, Purushothaman M, Muntner P, Lento P, O Connor W, Sharma S, et al. Inflammation, neovascularization and intra-plaque hemorrhage are associated with increased reparative collagen content: implication for plaque progression in diabetic atherosclerosis. Vasc Med. 2011;16:103-8 pubmed publisher
    ..58; p < 0.001) in DM plaques. In conclusion, our study suggests that enhanced type III collagen deposition was associated with inflammation, neovascularization and IPH, and may be a contributing factor in DM plaque progression. ..
  65. Zhou H, Felsen D, Sandulache V, Amin M, Kraus D, Branski R. Prostaglandin (PG)E2 exhibits antifibrotic activity in vocal fold fibroblasts. Laryngoscope. 2011;121:1261-5 pubmed publisher
    ..In addition, we describe a novel organotypic model, a critical step in the development of therapeutic trials...
  66. Lim H, Danias J. Label-free morphometry of retinal nerve fiber bundles by second-harmonic-generation microscopy. Opt Lett. 2012;37:2316-8 pubmed publisher
    ..The utility of axonal SHG is demonstrated for imaging the neuroanatomy of fresh ex vivo retina, and the three-dimensional structure of the axons of retinal ganglion cells is quantitatively analyzed. ..
  67. Friedlander D, Milev P, Karthikeyan L, Margolis R, Margolis R, Grumet M. The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J Cell Biol. 1994;125:669-80 pubmed
  68. Leung C, Green K, Liem R. Plakins: a family of versatile cytolinker proteins. Trends Cell Biol. 2002;12:37-45 pubmed
    ..Here, we describe the members of the plakin family and their interaction partners, and give examples of the cellular defects that result from their dysfunction. ..
  69. Wang L, Tanaka S, Ramirez F. GATA-4 binds to an upstream element of the human alpha2(I) collagen gene (COL1A2) and inhibits transcription in fibroblasts. Matrix Biol. 2005;24:333-40 pubmed
    ..Finally, a chromatin immunoprecipitation assay documented GATA-4 ability to bind to the HS2 element in vivo. These results are therefore the first to implicate GATA-4 in regulating constitutive COL1A2 gene expression in fibroblasts. ..
  70. Otsu K, Das S, Houser S, Quadri S, Bhattacharya S, Bhattacharya J. Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells. Blood. 2009;113:4197-205 pubmed publisher
    ..Thus, our findings show for the first time that at high numbers, MSCs are potentially cytotoxic and that when injected locally in tumor tissue they might be effective antiangiogenesis agents suitable for cancer therapy. ..
  71. Dahl B, Spotts E, Truong J. Corneal collagen cross-linking: an introduction and literature review. Optometry. 2012;83:33-42 pubmed publisher
    ..CXL is an effective treatment for limiting the progression of keratectasia, thus reducing the need for penetrating keratoplasty. CXL has a similar side-effect profile and similar risk level as PRK. ..
  72. Florin W, Mandel L. Foreign body reaction to facial dermal fillers: case report. J Oral Maxillofac Surg. 2012;70:2352-5 pubmed publisher
    ..5 cm in height. Posteriorly, palpation of the left parotid gland revealed the gland to be painless, normal in tone, and not swollen. No swelling or discomfort was evident on the right side. No trismus was present...
  73. Weichman K, Wilson S, Weinstein A, Hazen A, Levine J, Choi M, et al. The use of acellular dermal matrix in immediate two-stage tissue expander breast reconstruction. Plast Reconstr Surg. 2012;129:1049-58 pubmed publisher
    ..Therefore, it should only be used in specific patients and in minimal amounts. Indications for its use include single-stage permanent implant reconstruction and inadequate local muscle coverage of the tissue expander. Therapeutic, III. ..
  74. Uyttendaele H, Soriano J, Montesano R, Kitajewski J. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev Biol. 1998;196:204-17 pubmed
    ..These data suggest that Wnt and Notch signaling may play opposite roles in mammary gland development, a finding consistent with the convergence of the wingless and Notch signaling pathways found in Drosophila. ..
  75. Mari M, Wu D, Nieto N, Cederbaum A. CYP2E1-dependent toxicity and up-regulation of antioxidant genes. J Biomed Sci. 2001;8:52-8 pubmed
    ..Such interactions between CYP2E1, mitochondria and altered GSH homeostasis, and elevation of collagen levels, may play a role in alcohol-induced liver injury. ..
  76. Pedroja B, Kang L, Imas A, Carmeliet P, Bernstein A. Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling. J Biol Chem. 2009;284:20708-17 pubmed publisher
    ..6-fold increase in collagen deposition over wild type cells. These data suggest that PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease. ..
  77. Alikhani M, Khoo E, Alyami B, Raptis M, Salgueiro J, Oliveira S, et al. Osteogenic effect of high-frequency acceleration on alveolar bone. J Dent Res. 2012;91:413-9 pubmed publisher
    ..These studies propose a simple mechanical therapy that may play a significant role in alveolar bone formation and maintenance. ..
  78. Ghafar M, Anastasiadis A, Olsson L, Chichester P, Kaplan S, Buttyan R, et al. Hypoxia and an angiogenic response in the partially obstructed rat bladder. Lab Invest. 2002;82:903-9 pubmed
    ..These results further support the concept that hypoxia is involved in the cellular remodeling as well as in the progressive functional impairment exhibited by the urinary bladder after PBOO. ..
  79. Hanauske Abel H, Popowicz A, Remotti H, Newfield R, Levy J. Tyrosinemia I, a model for human diseases mediated by 2-oxoacid-utilizing dioxygenases: hepatotoxin suppression by NTBC does not normalize hepatic collagen metabolism. J Pediatr Gastroenterol Nutr. 2002;35:73-8 pubmed
    ..13.11.27) and prolyl 4-hydroxylase (P4-H; E.C., essential for tyrosine and collagen metabolism, respectively...
  80. Sumiyoshi H, Mor N, Lee S, Doty S, Henderson S, Tanaka S, et al. Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone. J Cell Biol. 2004;166:591-600 pubmed
    ..Therefore, these findings identify collagen XIX as the first structural determinant of sphincteric muscle function, and as the first extrinsic factor of skeletal myogenesis in the murine esophagus. ..
  81. Loike J, Cao L, Budhu S, Hoffman S, Silverstein S. Blockade of alpha 5 beta 1 integrins reverses the inhibitory effect of tenascin on chemotaxis of human monocytes and polymorphonuclear leukocytes through three-dimensional gels of extracellular matrix proteins. J Immunol. 2001;166:7534-42 pubmed
  82. Klein S, de Fougerolles A, Blaikie P, Khan L, Pepe A, Green C, et al. Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Mol Cell Biol. 2002;22:5912-22 pubmed
    ..These results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation. ..
  83. Urtasun R, Cubero F, Vera M, Nieto N. Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology. 2009;136:1410-22, e1-4 pubmed publisher
    ..ONOO- could induce a protective mechanism in HSC in early stages of liver injury. ..
  84. Khorasani H, Zheng Z, Nguyen C, Zara J, Zhang X, Wang J, et al. A quantitative approach to scar analysis. Am J Pathol. 2011;178:621-8 pubmed publisher
    ..These results demonstrate that fractal dimension and lacunarity are more sensitive than Fourier transform analysis for quantification of scar morphology. ..
  85. Shimizu E, Jong G, Partridge N, Rosenberg P, Lin L. Histologic observation of a human immature permanent tooth with irreversible pulpitis after revascularization/regeneration procedure. J Endod. 2012;38:1293-7 pubmed publisher
    ..This case report describes the histological findings of tissue formed in the canal space of an immature permanent tooth #9 with irreversible pulpitis without apical periodontitis after revascularization...
  86. Jones B, Hung C, Ateshian G. Biphasic Analysis of Cartilage Stresses in the Patellofemoral Joint. J Knee Surg. 2016;29:92-8 pubmed publisher
  87. Ding I, Sun J, Fenton B, Liu W, Kimsely P, Okunieff P, et al. Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas. Cancer Res. 2001;61:526-31 pubmed
    ..12 +/- 0.16 versus 2.44 +/- 0.35]. Our data suggest that intratumoral delivery of the endostatin gene efficiently suppresses murine mammary carcinoma growth and support the potential utility of the endostatin gene for cancer therapy. ..
  88. Dolgilevich S, Siri F, Atlas S, Eng C. Changes in collagenase and collagen gene expression after induction of aortocaval fistula in rats. Am J Physiol Heart Circ Physiol. 2001;281:H207-14 pubmed
  89. Klotz S, Danser A, Foronjy R, Oz M, Wang J, Mancini D, et al. The impact of angiotensin-converting enzyme inhibitor therapy on the extracellular collagen matrix during left ventricular assist device support in patients with end-stage heart failure. J Am Coll Cardiol. 2007;49:1166-74 pubmed
  90. Goldberg D. Correction of tear trough deformity with novel porcine collagen dermal filler (Dermicol-P35). Aesthet Surg J. 2009;29:S9-S11 pubmed publisher
    ..In this article, we present the clinical outcomes of patients who have received treatment with a novel ribose crosslinked porcine collagen dermal filler for the correction of tear trough deformity. ..
  91. Avraham T, Yan A, Zampell J, Daluvoy S, Haimovitz Friedman A, Cordeiro A, et al. Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis. Am J Physiol Cell Physiol. 2010;299:C589-605 pubmed publisher
    ..ASM deficiency confers LEC protection from radiation-induced apoptosis but does not prevent lymphatic dysfunction...
  92. Bhatt R, Tomoda T, Fang Y, Hatten M. Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Genes Dev. 2000;14:2216-28 pubmed
    ..Our results therefore indicate that collagen-DDR1 signaling is essential for granule neuron axon formation and further suggest a unique role of pia in cerebellar cortex histogenesis. ..