Experts and Doctors on cohort studies in North Carolina, United States


Locale: North Carolina, United States
Topic: cohort studies

Top Publications

  1. Savitz D, Klebanoff M, Wellenius G, Jensen E, Longnecker M. Persistent organochlorines and hypertensive disorders of pregnancy. Environ Res. 2014;132:1-5 pubmed publisher
  2. Kappelman M, Crandall W, Colletti R, Goudie A, Leibowitz I, Duffy L, et al. Short pediatric Crohn's disease activity index for quality improvement and observational research. Inflamm Bowel Dis. 2011;17:112-7 pubmed publisher
    ..60, P < 0.001 versus 0.61, P < 0.001). The Short PCDAI is a practical and valid tool to measure pediatric CD activity. Its use should facilitate quality improvement and observational research. ..
  3. Rager J, Auerbach S, Chappell G, Martin E, Thompson C, Fry R. Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort. Chem Res Toxicol. 2017;30:1911-1920 pubmed publisher
    ..Together, findings present a variety of BMD measures to estimate doses at which prenatal iAs exposure influences neonatal outcome-relevant transcriptomic, proteomic, and epigenomic profiles. ..
  4. Thomas K, Dosemeci M, Coble J, Hoppin J, Sheldon L, Chapa G, et al. Assessment of a pesticide exposure intensity algorithm in the agricultural health study. J Expo Sci Environ Epidemiol. 2010;20:559-69 pubmed publisher
    ..Refinement of the algorithm may be possible using the results from this and other measurement studies. ..
  5. Moore K, Smith J, Laughlin Tommaso S, Baird D. Cervical neoplasia-related factors and decreased prevalence of uterine fibroids among a cohort of African American women. Fertil Steril. 2014;101:208-14 pubmed publisher
    ..Further investigation is needed on the relationship between fibroids and cervical neoplasia and human papillomavirus-related mechanisms. ..
  6. Winnike J, Li Z, Wright F, Macdonald J, O Connell T, Watkins P. Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humans. Clin Pharmacol Ther. 2010;88:45-51 pubmed publisher
    ..This "early-intervention pharmaco-metabonomics" approach should now be tested in clinical trials of other potentially hepatotoxic drugs. ..
  7. Farraj A, Hazari M, Winsett D, Kulukulualani A, Carll A, Haykal Coates N, et al. Overt and latent cardiac effects of ozone inhalation in rats: evidence for autonomic modulation and increased myocardial vulnerability. Environ Health Perspect. 2012;120:348-54 pubmed publisher
  8. Vannappagari V, Nkhoma E, Atashili J, Laurent S, Zhao H. Prevalence, severity, and duration of thrombocytopenia among HIV patients in the era of highly active antiretroviral therapy. Platelets. 2011;22:611-8 pubmed publisher
    ..In conclusion, while the prevalence of severe thrombocytopenia was low, it occurred at levels associated with bleeding and was persistent among a small proportion of patients despite receipt of HAART. ..
  9. Reding K, Young M, Szpiro A, Han C, DeRoo L, Weinberg C, et al. Breast Cancer Risk in Relation to Ambient Air Pollution Exposure at Residences in the Sister Study Cohort. Cancer Epidemiol Biomarkers Prev. 2015;24:1907-9 pubmed publisher
    ..Though these results suggest there is no substantial increased risk for breast cancer overall in relation to air pollution, NO2, a marker of traffic-related air pollution, may differentially affect ER(+)/PR(+) breast cancer. ..

More Information


  1. Cotten C, Goldstein R, McDonald S, Goldberg R, Salhab W, Carlo W, et al. Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. Pediatr Res. 2014;75:424-30 pubmed publisher
    ..None of the differences were statistically significant. CP prevalence was also similar among genotype groups. Disability was not associated with the APOE genotype in this cohort of HIE survivors. ..
  2. Smith S, Maixner D, Greenspan J, Dubner R, Fillingim R, Ohrbach R, et al. Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study. J Pain. 2011;12:T92-101 pubmed publisher
    ..Over 350 candidate pain genes were assessed using a candidate gene panel, with several genes displaying preliminary evidence for association with TMD status. ..
  3. Martin L, Smith S, Khoutorsky A, Magnussen C, Samoshkin A, Sorge R, et al. Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest. 2017;127:3353-3366 pubmed publisher
    ..Thus, EGFR and EREG may be suitable therapeutic targets for persistent pain conditions. ..
  4. Wouters M, Lambrechts D, Knapp M, Cleynen I, Whorwell P, Agreus L, et al. Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome. Gut. 2014;63:1103-11 pubmed publisher
    ..Further studies are warranted to validate our findings and to determine the mechanisms underlying IBS pathophysiology. ..
  5. Ouellet D, Grossmann K, Limentani G, Nebot N, Lan K, Knowles L, et al. Effects of particle size, food, and capsule shell composition on the oral bioavailability of dabrafenib, a BRAF inhibitor, in patients with BRAF mutation-positive tumors. J Pharm Sci. 2013;102:3100-9 pubmed publisher
    ..Dabrafenib has been administered in pivotal clinical studies on an empty stomach using micronized drug substance in HPMC capsules. ..
  6. Joubert B, Håberg S, Nilsen R, Wang X, Vollset S, Murphy S, et al. 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2012;120:1425-31 pubmed publisher
    ..Our findings implicate epigenetic mechanisms in the pathogenesis of the adverse health outcomes associated with this important in utero exposure. ..
  7. Dickerson M, Johnston J, Delea T, White A, Andrews E. The causal role for genital ulcer disease as a risk factor for transmission of human immunodeficiency virus. An application of the Bradford Hill criteria. Sex Transm Dis. 1996;23:429-40 pubmed
    ..The evidence from the literature is discussed, and the criteria for causal inference proposed by Sir Austin Bradford Hill are applied...
  8. Wade T, Sams E, Brenner K, Haugland R, Chern E, Beach M, et al. Rapidly measured indicators of recreational water quality and swimming-associated illness at marine beaches: a prospective cohort study. Environ Health. 2010;9:66 pubmed publisher
    ..This study provides the first evidence of a relationship between gastrointestinal illness and estimates of fecal indicator organisms determined by qPCR at marine beaches. ..
  9. Farrelly M, Nonnemaker J, Davis K, Hussin A. The Influence of the National truth campaign on smoking initiation. Am J Prev Med. 2009;36:379-84 pubmed publisher
    ..69, p<0.001), and living with both parents at baseline (OR=0.79, p<0.001). The current study strengthens the available evidence for antismoking campaigns as a viable strategy for preventing youth smoking. ..
  10. Longnecker M. Pharmacokinetic variability and the miracle of modern analytical chemistry. Epidemiology. 2006;17:350-1 pubmed
  11. London S, Yuan J, Coetzee G, Gao Y, Ross R, Yu M. CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2000;9:987-91 pubmed
  12. Woodhead J, Howell B, Yang Y, Harrill A, Clewell H, Andersen M, et al. An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury. J Pharmacol Exp Ther. 2012;342:529-40 pubmed publisher
    ..The modeling also suggests that modification of the current treatment nomograms should be considered...
  13. Finkelstein E, Khavjou O, Will J. Cost-effectiveness of WISEWOMAN, a program aimed at reducing heart disease risk among low-income women. J Womens Health (Larchmt). 2006;15:379-89 pubmed
  14. Hudnell H, House D, Schmid J, Koltai D, Stopford W, Wilkins J, et al. Human visual function in the North Carolina clinical study on possible estuary-associated syndrome. J Toxicol Environ Health A. 2001;62:575-94 pubmed
    ..These results suggest that factor(s) associated with the North Carolina estuaries, including the possibility of exposure to TPC toxin(s), may impair visual system function...