Genomes and Genes
Experts and Doctors on cell cycle proteins in New York, United States
Locale: New York, United States
Topic: cell cycle proteins
Publications436 found, 100 shown here
- Tapia Alveal C, O Connell M. Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes. Mol Biol Cell. 2011;22:4669-82 pubmed publisher..Thus the HR defect in Smc5/6 mutants appears to be due to the presence of dysfunctional complexes at lesions rather than to reflect an absolute requirement for Smc5/6 to complete HR. ..
- D Angiolella V, Donato V, Forrester F, Jeong Y, Pellacani C, Kudo Y, et al. Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell. 2012;149:1023-34 pubmed publisher..In summary, we have identified a biochemical pathway that controls the abundance of dNTPs and ensures efficient DNA repair in response to genotoxic stress. ..
- Busino L, Millman S, Pagano M. SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma. Sci Signal. 2012;5:pt14 pubmed publisher..Thus, the FBXW7α-dependent degradation of p100 functions as a prosurvival mechanism through control of NF-κB activity. ..
- Cullmann G, Fien K, Kobayashi R, Stillman B. Characterization of the five replication factor C genes of Saccharomyces cerevisiae. Mol Cell Biol. 1995;15:4661-71 pubmed..CDC44/RFC1 is known to interact genetically with the gene encoding proliferating cell nuclear antigen, confirming previous biochemical evidence of their functional interaction in DNA replication. ..
- Collins R, Treisman J. Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes. Genes Dev. 2000;14:3140-52 pubmed..These results suggest that altering the conformation of chromatin is an important mechanism by which Wingless signaling activates gene expression. ..
- Bafico A, Liu G, Goldin L, Harris V, Aaronson S. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell. 2004;6:497-506 pubmed..Together, these findings establish the involvement of autocrine Wnt signaling in human cancer cells. ..
- Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, Jasin M. Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A. 2005;102:737-42 pubmed..The absence of ATM caused defects in folliculogenesis that were similar to those in Dmc1 mutants and that could be suppressed by Spo11 mutation, implying that oocyte death in Atm-deficient animals is a response to defective DSB repair...
- Ishikawa M, Kiba T, Chua N. The Arabidopsis SPA1 gene is required for circadian clock function and photoperiodic flowering. Plant J. 2006;46:736-46 pubmed..Our results indicate that SPA1 not only negatively controls phyA-mediated signaling in seedlings, but also regulates circadian rhythms and flowering time in plants. ..
- Amador V, Ge S, Santamaria P, Guardavaccaro D, Pagano M. APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell. 2007;27:462-73 pubmed..We propose that the APC/C(Cdc20)-mediated degradation of p21 contributes to the full activation of Cdk1 necessary for mitotic events and prevents mitotic slippage during spindle checkpoint activation. ..
- Vasileva A, Tiedau D, Firooznia A, MULLER REICHERT T, Jessberger R. Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression. Curr Biol. 2009;19:630-9 pubmed publisher..However, more than 50 miRNAs are more abundant in Tdrd6(-/-) testes, as are exemplary pre- and pri-miRNAs. We conclude that Tdrd6 is essential for spermiogenesis, for CB structure, and for proper mature and precursor miRNA expression. ..
- Outwin E, Irmisch A, Murray J, O Connell M. Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes. Mol Cell Biol. 2009;29:4363-75 pubmed publisher..In both cases, Separase overexpression bypasses the defect and restores cell viability, showing that defective cohesin removal is a major determinant of the mitotic lethality of Smc5-Smc6 mutants. ..
- Zhao H, Albino A, Jorgensen E, Traganos F, Darzynkiewicz Z. DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry. Cytometry A. 2009;75:840-7 pubmed publisher..The cytometric assessment of CS-induced DDR provides a means to estimate the genotoxicity of CS and to explore the mechanisms of the response as a function of cell cycle phase and cell type. ..
- Revenkova E, Herrmann K, Adelfalk C, Jessberger R. Oocyte cohesin expression restricted to predictyate stages provides full fertility and prevents aneuploidy. Curr Biol. 2010;20:1529-33 pubmed publisher..Frequency and size of litters prove full fertility even in aged females. Thus, SMC1? cohesin needs only be expressed during prophase I prior to the primordial follicle stage to ensure SCC up to advanced age of mice. ..
- Zhao H, Li J, Traganos F, Halicka H, Zarebski M, Dobrucki J, et al. Cell fixation in zinc salt solution is compatible with DNA damage response detection by phospho-specific antibodies. Cytometry A. 2011;79:470-6 pubmed publisher..Analysis of cells by flow cytometry revealed that ZBF fixation of lymphoblastoid TK6 cells led to about 60 and 33% higher intensity of the side and forward light scatter, respectively, compared to formaldehyde fixed cells. ..
- Huynh J, Garg P, Thin T, Yoo S, Dutta R, Trapp B, et al. Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nat Neurosci. 2014;17:121-30 pubmed publisher..Thus, epigenomic changes in genes affecting oligodendrocyte susceptibility to damage are detected in pathology-free areas of multiple sclerosis-affected brains. ..
- Fu M, Wang C, Reutens A, Wang J, Angeletti R, Siconolfi Baez L, et al. p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. J Biol Chem. 2000;275:20853-60 pubmed..The identification of the AR as a direct target of histone acetyltransferase co-activators has important implications for targeting inhibitors of AR function. ..
- Hao M, Mukherjee S, Sun Y, Maxfield F. Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes. J Biol Chem. 2004;279:14171-8 pubmed
- Sakakibara K, Kubota K, Worku B, Ryer E, Miller J, Koff A, et al. PDGF-BB regulates p27 expression through ERK-dependent RNA turn-over in vascular smooth muscle cells. J Biol Chem. 2005;280:25470-7 pubmed..In summary, our data suggest that p27 is down-regulated by PDGF-BB in vascular smooth muscle cells through an ERK-dependent posttranscriptional mechanism. ..
- Cohen P, Pollack S, Pollard J. Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals. Endocr Rev. 2006;27:398-426 pubmed..This review provides a comprehensive analysis of the use of genetic manipulation, particularly in mice, but also of the analysis of mutations in humans, to elucidate the mechanisms that are required for traverse through prophase I. ..
- Caplan A, Mandal A, Theodoraki M. Molecular chaperones and protein kinase quality control. Trends Cell Biol. 2007;17:87-92 pubmed..This requirement might relate to conformational changes that take place during the protein kinase activity cycle. ..
- Lee K, Nizza S, Hayes T, Bass K, Irmisch A, Murray J, et al. Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function. Genetics. 2007;175:1585-95 pubmed..The requirement for excision factors for the viability of smc6 mutants is consistent with an inability to respond to spontaneous lesions by Smc5/6-dependent recombination. ..
- Hewitt S, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, et al. RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol. 2009;10:655-64 pubmed publisher..ATM activated by the cleaved allele acts in trans on the uncleaved allele to prevent biallelic recombination and chromosome breaks or translocations. ..
- Kuntz K, O Connell M. The G(2) DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer?. Cancer Biol Ther. 2009;8:1433-9 pubmed..It will also discuss the present status and future of potential cancer therapies aimed at inactivating this signaling pathway in tumor cells. ..
- Tsou M, Wang W, George K, Uryu K, Stearns T, Jallepalli P. Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells. Dev Cell. 2009;17:344-54 pubmed publisher..Our results indicate that Plk1 and separase act at different times during M phase to license centrosome duplication, reminiscent of their roles in removing cohesin from chromosomes. ..
- Ugras S, Brill E, Jacobsen A, Hafner M, Socci N, DeCarolis P, et al. Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma. Cancer Res. 2011;71:5659-69 pubmed publisher..Taken together, our findings suggest that miR-143 re-expression vectors or selective agents directed at miR-143 or its targets may have therapeutic value in dedifferentiated liposarcoma. ..
- Iavarone A, Massague J. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Nature. 1997;387:417-22 pubmed..Repression of Cdc25A and induction of p15 are independent effects mediating the inhibition of Cdk4/6 by TFG-beta. ..
- Tong W, Pollard J. Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice. Mol Cell Biol. 1999;19:2251-64 pubmed..This study showing a novel mechanism of cell cycle inhibition by P4 may provide the basis for the development of new antiestrogens. ..
- Maftahi M, Han C, Langston L, Hope J, Zigouras N, Freyer G. The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity. Nucleic Acids Res. 1999;27:4715-24 pubmed..The low viability of rad12 (-) top3 (-)mutants compared with rad12 single mutants suggests that Top3 also functions independently of Rad12. ..
- Lin X, Gelman I. Calmodulin and cyclin D anchoring sites on the Src-suppressed C kinase substrate, SSeCKS. Biochem Biophys Res Commun. 2002;290:1368-75 pubmed..These data suggest that the scaffolding activities of SSeCKS are modulated by mitogenically stimulated kinases such as PKC. ..
- Shin C, Manley J. The SR protein SRp38 represses splicing in M phase cells. Cell. 2002;111:407-17 pubmed..Strikingly, SRp38 was found to be dephosphorylated specifically in mitotic cells, and we show that dephosphorylated SRp38 is required for the observed splicing repression. ..
- Dias D, Dolios G, Wang R, Pan Z. CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc Natl Acad Sci U S A. 2002;99:16601-6 pubmed..Strikingly, CUL7 selectively interacts with Skp1.Fbx29 but not with Skp1.betaTRCP2 or Skp1.Skp2. Thus, CUL7 may define a previously uncharacterized, Fbx29-mediated, and ubiquitin-dependent proteolysis pathway. ..
- Tamma S, Kalyanaraman V, Pahwa S, Dominguez P, Modesto R. The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells. J Leukoc Biol. 2003;73:682-8 pubmed..Jacalin may be used as a possible tool for the study of CD4-mediated signal transduction and HIV-impaired CD4(+) T cell activation. ..
- Karatsoreos I, Yan L, LeSauter J, Silver R. Phenotype matters: identification of light-responsive cells in the mouse suprachiasmatic nucleus. J Neurosci. 2004;24:68-75 pubmed..Furthermore, the findings suggest that gastrin-releasing peptide is a potential mediator of intercellular communication between light-induced and oscillator cells within the SCN. ..
- Smilenov L, Lieberman H, Mitchell S, Baker R, Hopkins K, Hall E. Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics. Cancer Res. 2005;65:933-8 pubmed
- Chen L, Al Awqati Q. Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol. 2005;288:F939-52 pubmed..These studies provide the basis for the future development of strategies to examine the role of individual effector molecules in the determination of the differentiation pattern of the nephron. ..
- Wong L, Recht J, Laurent B. Chromatin remodeling and repair of DNA double-strand breaks. J Mol Histol. 2006;37:261-9 pubmed..Here, we review the current understanding and new hypotheses on how different chromatin-modifying activities function in DNA repair in yeast and metazoan cells. ..
- Liang B, Qiu J, Ratnakumar K, Laurent B. RSC functions as an early double-strand-break sensor in the cell's response to DNA damage. Curr Biol. 2007;17:1432-7 pubmed..Together, these new findings functionally link RSC to DSB sensing, highlighting the importance of ATP-dependent chromatin-remodeling factors in the cell's early response to DNA damage. ..
- Morozov A, Lee S, Zhang Z, Cimica V, Zagzag D, Kalpana G. INI1 induces interferon signaling and spindle checkpoint in rhabdoid tumors. Clin Cancer Res. 2007;13:4721-30 pubmed..IFN treatment and down-modulation of PLK1 constitute potential novel therapeutic strategies for rhabdoid tumors. ..
- Phan R, Saito M, Kitagawa Y, Means A, Dalla Favera R. Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. Nat Immunol. 2007;8:1132-9 pubmed..Because Bcl-6 is required for the maintenance of germinal centers, our findings suggest that the extent of genotoxic stress controls the fate of germinal center B cells by means of Bcl-6. ..
- Kaplow M, Korayem A, Venkatesh T. Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein. Genetics. 2008;178:2003-16 pubmed publisher..We propose that Rap/Fzr targets Loco for ubiquitination, thereby regulating glial differentiation in the developing nervous system. ..
- Barchi M, Roig I, Di Giacomo M, de Rooij D, Keeney S, Jasin M. ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet. 2008;4:e1000076 pubmed publisher..Together, these findings indicate that ATM plays a role in both crossover control and chromosome axis integrity and further suggests that ATM is important for coordinating these features of meiotic chromosome dynamics. ..
- Zhao H, Traganos F, Dobrucki J, Wlodkowic D, Darzynkiewicz Z. Induction of DNA damage response by the supravital probes of nucleic acids. Cytometry A. 2009;75:510-9 pubmed publisher..The data indicate that supravital use of Ho 42, DRAQ5, and DCV induces various degrees of DDR, including activation of ATM, Chk2 and p53, which may have significant consequences on regulatory cell cycle pathways and apoptosis. ..
- Schalch T, Job G, Shanker S, Partridge J, Joshua Tor L. The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nat Struct Mol Biol. 2011;18:1351-7 pubmed publisher..We suggest that the Chp1-Tas3 complex provides a solid and versatile platform to recruit both RNAi-dependent and RNAi-independent gene-silencing pathways for locus-specific regulation of heterochromatin...
- Zhang Y, Chellappan S. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene. 1995;10:2085-93 pubmed..We believe that DP2 also plays a major role in modulating the function of E2F in cell cycle regulation and oncogenesis. ..
- Sgambato A, Han E, Zhou P, Schieren I, Weinstein I. Overexpression of cyclin E in the HC11 mouse mammary epithelial cell line is associated with growth inhibition and increased expression of p27(Kip1). Cancer Res. 1996;56:1389-99 pubmed..These findings indicate that increased expression of this cyclin E cDNA in HC11 cells inhibits rather than stimulates growth and that this may be due to increased expression of the inhibitor p27(Kip1). ..
- Casaccia Bonnefil P, Hardy R, Teng K, Levine J, Koff A, Chao M. Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development. 1999;126:4027-37 pubmed
- Chang E, Bartholomeusz G, Pimental R, Chen J, Lai H, Wang L, et al. Direct binding and In vivo regulation of the fission yeast p21-activated kinase shk1 by the SH3 domain protein scd2. Mol Cell Biol. 1999;19:8066-74 pubmed..We propose that Scd2 functions as an organizing center, or scaffold, for the Cdc42 complex in fission yeast and that it acts in concert with Cdc42 to positively regulate Shk1 function. ..
- Euskirchen G. Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell. 2002;1:229-40 pubmed..Based on the colocalization of these four proteins, the minichromosome instability and the spindle defects seen in nnf1 mutants, I propose that Nnf1p is part of a new group of proteins necessary for chromosome segregation. ..
- Kohn M, Bronson R, Harlow E, Dyson N, Yamasaki L. Dp1 is required for extra-embryonic development. Development. 2003;130:1295-305 pubmed..Thus, DP1 is absolutely required for extra-embryonic development and consequently embryonic survival, consistent with E2F/DP1 normally acting to promote growth in vivo. ..
- Kohn M, Leung S, Criniti V, Agromayor M, Yamasaki L. Dp1 is largely dispensable for embryonic development. Mol Cell Biol. 2004;24:7197-205 pubmed..5 tissues with the absence of Dp1. Thus, Dp1 is largely dispensable for embryonic development, despite the absolute extraembryonic requirement for Dp1, which is highly reminiscent of the restricted roles for Rb and cyclins E1/E2 in vivo. ..
- Snyder M, He W, Zhang J. The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. Proc Natl Acad Sci U S A. 2005;102:14539-44 pubmed..Together, these results demonstrate that, in addition to their roles in DNA replication, the MCM proteins are also necessary for transcription activation. ..
- Shi Y, Manley J. A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock. Mol Cell. 2007;28:79-90 pubmed..Together, our study delineates a complex mechanism involving multiple factors by which a stress signaling pathway regulates protein phosphorylation and, in turn, pre-mRNA splicing. ..
- Burkard M, Maciejowski J, Rodriguez Bravo V, Repka M, Lowery D, Clauser K, et al. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 2009;7:e1000111 pubmed publisher..Our findings illuminate two key mechanisms governing the initiation of cytokinesis in human cells and illustrate the power of chemical genetics to probe such regulation both in time and space. ..
- Benson E, Zhao B, Sassoon D, Lee S, Aaronson S. Effects of p21 deletion in mouse models of premature aging. Cell Cycle. 2009;8:2002-4 pubmed..EMBO Rep 2009). Here, we provide an overview of the effects of p21 deletion in different models of premature aging. ..
- García Rodríguez L, Crider D, Gay A, Salanueva I, Boldogh I, Pon L. Mitochondrial inheritance is required for MEN-regulated cytokinesis in budding yeast. Curr Biol. 2009;19:1730-5 pubmed publisher..Our studies identify a novel MEN-linked regulatory system that inhibits cytokinesis in response to defects in mitochondrial inheritance in budding yeast. ..
- Peart M, Poyurovsky M, Kass E, Urist M, Verschuren E, Summers M, et al. APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle. 2010;9:3956-64 pubmed..These data suggest that APC/C(Cdc20) specifically targets E2F1 for degradation in early mitosis and reveal a novel mechanism for limiting free E2F1 levels in cells, failure of which may compromise cell survival and/or homeostasis. ..
- Katsel P, Tan W, Abazyan B, Davis K, Ross C, Pletnikov M, et al. Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes. Schizophr Res. 2011;130:238-49 pubmed publisher..Thus, OLG function may be perturbed by mutant hDISC1 in a model system that provides new avenues for studying aspects of the pathogenesis of SZ. ..
- Wolgemuth D. Function of the A-type cyclins during gametogenesis and early embryogenesis. Results Probl Cell Differ. 2011;53:391-413 pubmed publisher..In contrast, cyclin A2-deficiency is marked by early embryonic lethality; thus, understanding the function of cyclin A2 in the adult germ line awaits conditional mutagenesis or other approaches to knock down its expression. ..
- Goetz S, Liem K, Anderson K. The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell. 2012;151:847-858 pubmed publisher..We propose that cell-cycle regulators target TTBK2 to the basal body, where it modifies specific targets to initiate ciliogenesis. ..
- Tapia Alveal C, Lin S, Yeoh A, Jabado O, O Connell M. H2A.Z-dependent regulation of cohesin dynamics on chromosome arms. Mol Cell Biol. 2014;34:2092-104 pubmed publisher..Z suppress the mitotic defects conferred by Smc5/6 dysfunction. Together, H2A.Z and the SMC complexes ensure genome integrity through accurate chromosome segregation. ..
- Reynisdottir I, Massague J. The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 1997;11:492-503 pubmed..These properties allow p15 and p27 to coordinately inhibit cdk4 and cdk2. ..
- Wang S, Ghosh R, Chellappan S. Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Mol Cell Biol. 1998;18:7487-98 pubmed
- Li S, Aufiero B, Schiltz R, Walsh M. Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP. Proc Natl Acad Sci U S A. 2000;97:7166-71 pubmed..These observations are consistent with the ability of CDP/cut to regulate genes as a transcriptional repressor, suggesting acetylation as a mechanism that regulates CDP/cut function. ..
- Suzuki A, Hemmati Brivanlou A. Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis. Mol Cell. 2000;5:217-29 pubmed
- Li Q, Zhang M, Kumar S, Zhu L, Chen D, Bagchi M, et al. Identification and implantation stage-specific expression of an interferon-alpha-regulated gene in human and rat endometrium. Endocrinology. 2001;142:2390-400 pubmed..More importantly, our studies reveal that a complex interplay between the steroid hormone and IFN pathways regulates the expression of these genes in the endometrium at the time of implantation. ..
- Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar Uniyal M, et al. Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J Biol Chem. 2001;276:36194-9 pubmed..Taken together, our studies strongly suggest that the oxidative stress-induced activation of p53 is at least in part mediated by Plk3. ..
- Silverman J, Takai H, Buonomo S, Eisenhaber F, de Lange T. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev. 2004;18:2108-19 pubmed..These data reveal that human Rif1 contributes to the ATM-mediated protection against DNA damage and point to a remarkable difference in the primary function of this protein in yeast and mammals. ..
- Perez de Castro I, Benet M, Jimenez M, Alzabin S, Malumbres M, Pellicer A. Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation. Cancer Res. 2005;65:3249-56 pubmed
- Theodoraki M, Kunjappu M, Sternberg D, Caplan A. Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context. Exp Cell Res. 2007;313:3851-8 pubmed..This suggests that NPM-ALK protects the mature kinase. Furthermore, Akt failed to bind to the Cdc37 chaperone in cells expressing NPM-ALK, which also correlates with increased Akt stability. ..
- Spektor A, Tsang W, Khoo D, Dynlacht B. Cep97 and CP110 suppress a cilia assembly program. Cell. 2007;130:678-90 pubmed..Identification of Cep97 and other genes involved in regulation of cilia assembly may accelerate our understanding of human ciliary diseases, including renal disease and retinal degeneration. ..
- Wang L, Stone S, Hoatlin M, Gautier J. Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst). 2008;7:1973-81 pubmed publisher..Together, our data suggest that FA proteins play a role in replication restart at collapsed replication forks. ..
- Feng Y, Chen M, Manley J. Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator. Nat Struct Mol Biol. 2008;15:1040-8 pubmed publisher..Together, our data demonstrate that SRp38, in addition to its role as a splicing repressor, can function as an unusual sequence-specific splicing activator. ..
- Tse A, Sheikh T, Alan H, Chou T, Schwartz G. 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. Mol Pharmacol. 2009;75:124-33 pubmed publisher..Taken together, 17AAG specifically inhibits the G(2)/M checkpoint in p53-defective cells by down-regulation of two critical checkpoint kinases, Chk1 and Wee1. ..
- Kibe T, Osawa G, Keegan C, de Lange T. Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2010;30:1059-66 pubmed publisher..No additional telomere dysfunction phenotypes were observed, establishing that the main role of TPP1 is to allow POT1a and POT1b to protect chromosome ends. ..
- Lee Theilen M, Matthews A, Kelly D, Zheng S, Chaudhuri J. CtIP promotes microhomology-mediated alternative end joining during class-switch recombination. Nat Struct Mol Biol. 2011;18:75-9 pubmed publisher..Our results establish CtIP as a bona fide component of microhomology-dependent A-NHEJ and unmask a hitherto unrecognized physiological role of microhomology-mediated end joining in a C-NHEJ-proficient environment. ..
- Squatrito M, Brennan C, Helmy K, Huse J, Petrini J, Holland E. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell. 2010;18:619-29 pubmed publisher..Finally, we observed that the DDR is constitutively activated in a subset of human GBMs, and such activation correlates with regions of hypoxia. ..
- Deriano L, Chaumeil J, Coussens M, Multani A, Chou Y, Alekseyenko A, et al. The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature. 2011;471:119-23 pubmed publisher..These results reveal a novel genome guardian role for RAG2 and suggest that similar 'end release/end persistence' mechanisms underlie genomic instability and lymphomagenesis in Rag2(c/c) p53(-/-) and Atm(-/-) mice. ..
- King B, Trimarchi T, Reavie L, Xu L, Mullenders J, Ntziachristos P, et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 2013;153:1552-66 pubmed publisher..Finally, we demonstrated that small-molecule-mediated suppression of MYC activity leads to T-ALL remission, suggesting an effective therapeutic strategy. ..
- Wu D, Asiedu M, Matsumura F, Wei Q. Phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) at threonine 544 by aurora B kinase promotes the binding of polo-like kinase 1 to MyoGEF. J Biol Chem. 2014;289:7142-50 pubmed publisher..Taken together, our results suggest that aurora B coordinates with Plk1 to regulate MyoGEF activation and localization, thus contributing to the regulation of cytokinesis. ..
- Athuluri Divakar S, Vasquez Del Carpio R, Dutta K, Baker S, Cosenza S, Basu I, et al. A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. Cell. 2016;165:643-55 pubmed publisher..We also find that ribosertib binds to the RBDs of Ral-GDS and PI3Ks. These results suggest that targeting of RBDs across multiple signaling pathways by rigosertib may represent an effective strategy for inactivation of RAS signaling. ..
- Sun H, Charles C, Lau L, Tonks N. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 1993;75:487-93 pubmed..The mutant 3CH134 protein also forms a physical complex with the phosphorylated form of p42MAPK. These findings suggest that 3CH134 is a physiological MAP kinase phosphatase; we propose the name MKP-1 for this phosphatase. ..
- Matsumoto T. A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2. Mol Cell Biol. 1997;17:742-50 pubmed..A possible role of slp1+ is proposed. ..
- Su Z, Shi Y, Fisher P. Subtraction hybridization identifies a transformation progression-associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene. Proc Natl Acad Sci U S A. 1997;94:9125-30 pubmed..Moreover, these studies support the hypothesis that constitutive expression of a DNA damage response may mediate cancer progression. ..
- Kirov N, Shtilbans A, Rushlow C. Isolation and characterization of a new gene encoding a member of the HIRA family of proteins from Drosophila melanogaster. Gene. 1998;212:323-32 pubmed..The conservation of these homologous regions in HIRA-encoded proteins from evolutionary distant organisms suggests that they are important for the activity of the members of the family. ..
- Dhalluin C, Carlson J, Zeng L, He C, Aggarwal A, Zhou M. Structure and ligand of a histone acetyltransferase bromodomain. Nature. 1999;399:491-6 pubmed..Thus, the bromodomain is functionally linked to the HAT activity of co-activators in the regulation of gene transcription...
- Qian Z, Gilbert M, Kandel E. Temporal and spatial regulation of the expression of BAD2, a MAP kinase phosphatase, during seizure, kindling, and long-term potentiation. Learn Mem. 1994;1:180-8 pubmed..In these regions, the induction of a MAP kinase-specific phosphatase may provide a negative feedback control associated with long-term synaptic changes. ..
- Cross F, Jacobson M. Conservation and function of a potential substrate-binding domain in the yeast Clb5 B-type cyclin. Mol Cell Biol. 2000;20:4782-90 pubmed..These results support the idea of a modular, structurally conserved cyclin domain involved in substrate targeting. ..
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