Experts and Doctors on caenorhabditis elegans in North Carolina, United States
Locale: North Carolina, United States
Topic: caenorhabditis elegans
Hall J, Haas K, Freedman J. Role of MTL-1, MTL-2, and CDR-1 in mediating cadmium sensitivity in Caenorhabditis elegans. Toxicol Sci. 2012;128:418-26 pubmed publisher
..Following cadmium exposure, PC levels increased. The lack of cadmium hypersensitivity when these genes are deleted may be attributed to the compensatory effects of increases in PCs...
Sullivan Brown J, Tandon P, Bird K, Dickinson D, Tintori S, Heppert J, et al
. Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation. Genetics. 2016;202:123-39 pubmed publisher
..We show that nckap1 contributes to neural tube closure in Xenopus. This work identifies in vivo roles for homologs of mammalian neural tube defect genes in two manipulable genetic model systems. ..
Boyd W, Smith M, Kissling G, Rice J, Snyder D, Portier C, et al
. Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development. PLoS ONE. 2009;4:e7024 pubmed publisher
..This study supports the utility of the C. elegans growth assay and mathematical modeling in determining the effects of potentially toxic substances in an alternative model organism using high-throughput technologies. ..
McElwee M, Freedman J. Comparative toxicology of mercurials in Caenorhabditis elegans. Environ Toxicol Chem. 2011;30:2135-41 pubmed publisher
..In general, MeHgCl was more toxic to C. elegans than HgCl(2), particularly when assaying behaviors that require neuromuscular function. ..
Qiu C, Kershner A, Wang Y, Holley C, Wilinski D, Keles S, et al
. Divergence of Pumilio/fem-3 mRNA binding factor (PUF) protein specificity through variations in an RNA-binding pocket. J Biol Chem. 2012;287:6949-57 pubmed publisher
..Loss of the pocket requires only substitution of one serine, as appears to have occurred during the evolution of certain fungal species. ..
Rice J, Boyd W, Chandra D, Smith M, Den Besten P, Freedman J. Comparison of the toxicity of fluoridation compounds in the nematode Caenorhabditis elegans. Environ Toxicol Chem. 2014;33:82-8 pubmed publisher
..This suggests that silicofluorides have similar toxicity to NaF...
Hall J, McElwee M, Freedman J. Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. PLoS ONE. 2017;12:e0177432 pubmed publisher
..Identification of portions of the insulin signaling pathway as regulators of metallothionein expression supports the hypothesis that longevity is affected by the expression of this efficient ROS scavenger. ..