Experts and Doctors on caenorhabditis elegans in New York, United States

Summary

Locale: New York, United States
Topic: caenorhabditis elegans

Top Publications

  1. Grant B, Greenwald I. Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans. Development. 1997;124:637-44 pubmed
    ..We incorporate these observations, and new information about a related yeast gene, into a proposal for a possible mechanism for SEL-1 function in LIN-12 turnover. ..
  2. Wen C, Levitan D, Li X, Greenwald I. spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. Proc Natl Acad Sci U S A. 2000;97:14524-9 pubmed
  3. Jarriault S, Greenwald I. Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Genes Dev. 2002;16:2713-28 pubmed
  4. Macosko E, Pokala N, Feinberg E, Chalasani S, Butcher R, Clardy J, et al. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. Nature. 2009;458:1171-5 pubmed publisher
    ..The coordination of social behaviours by RMG suggests an anatomical hub-and-spoke model for sensory integration in aggregation, and points to functions for related circuit motifs in the C. elegans wiring diagram. ..
  5. Bargmann C, Marder E. From the connectome to brain function. Nat Methods. 2013;10:483-90 pubmed
    ..Comparisons across these systems suggest approaches to study the functional organization of large circuits based on existing knowledge of small circuits. ..
  6. Roy D, Michaelson D, Hochman T, Santella A, Bao Z, Goldberg J, et al. Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially. Dev Biol. 2016;409:261-271 pubmed publisher
    ..Taken together, our results suggest that cell cycle dynamics are under multiple influences including distance from the niche, age and/or maturation of the germ line, nutrition and, possibly, latitude for physical expansion. ..
  7. McNew J, Sogaard M, Lampen N, Machida S, Ye R, Lacomis L, et al. Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem. 1997;272:17776-83 pubmed
    ..This is the first example of a human SNARE protein functionally replacing a yeast SNARE. This observation implies that the specific details of the vesicle targeting code, like the genetic code, are conserved in evolution. ..
  8. Aurelio O, Hall D, Hobert O. Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization. Science. 2002;295:686-90 pubmed
    ..Dedicated axon maintenance mechanisms may be widely used to ensure the preservation of functional neuronal circuitries. ..
  9. Broday L, Kolotuev I, Didier C, Bhoumik A, Gupta B, Sternberg P, et al. The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans. Genes Dev. 2004;18:2380-91 pubmed

More Information

Publications330 found, 100 shown here

  1. Mika S, Rost B. Protein-protein interactions more conserved within species than across species. PLoS Comput Biol. 2006;2:e79 pubmed
    ..More comprehensive images of protein-protein networks will require the combination of many high-throughput methods, including in silico inferences and predictions. http://www.rostlab.org/results/2006/ppi_homology/ ..
  2. Johnston R, Copeland J, Fasnacht M, Etchberger J, Liu J, Honig B, et al. An unusual Zn-finger/FH2 domain protein controls a left/right asymmetric neuronal fate decision in C. elegans. Development. 2006;133:3317-28 pubmed
    ..These network motifs endow the system with properties that provide insights into how cells adopt their stable terminally differentiated states. ..
  3. Fry A, Laboy J, Huang H, Hart A, Norman K. A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans. Genetics. 2016;202:1153-66 pubmed publisher
    ..Importantly, the role of VAV-1 in promoting cellular stress-induced behavioral quiescence is vital for organism health because VAV-1 is required for normal survival after cellular stress. ..
  4. Gutch M, Flint A, Keller J, Tonks N, Hengartner M. The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Genes Dev. 1998;12:571-85 pubmed
  5. Melendez A, Greenwald I. Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif. Genetics. 2000;155:1127-37 pubmed
    ..We also show that LIN-13 is a nuclear protein that contains multiple zinc fingers and a motif, LXCXE, that has been implicated in Rb binding. These results together suggest a role for LIN-13 in Rb-mediated repression of vulval fates. ..
  6. Jefferson J, Leung C, Liem R. Plakins: goliaths that link cell junctions and the cytoskeleton. Nat Rev Mol Cell Biol. 2004;5:542-53 pubmed
  7. Laaberki M, Dworkin J. Role of spore coat proteins in the resistance of Bacillus subtilis spores to Caenorhabditis elegans predation. J Bacteriol. 2008;190:6197-203 pubmed publisher
    ..Surprisingly, we found that the spores that were resistant to lysozyme in vitro can be sensitive to C. elegans digestion depending on the extent of the spore coat structure modifications. ..
  8. Hall D, Treinin M. How does morphology relate to function in sensory arbors?. Trends Neurosci. 2011;34:443-51 pubmed publisher
    ..Similar associations between form and function might explain the plethora of dendrite morphologies seen among all sensory neurons. ..
  9. Chan E, Nance J. Mechanisms of CDC-42 activation during contact-induced cell polarization. J Cell Sci. 2013;126:1692-702 pubmed publisher
    ..We propose that radial polarization results from a competition between RhoGEFs, which activate CDC-42 throughout the cortex, and the RhoGAP PAC-1, which inactivates CDC-42 at cell contacts...
  10. Stanley E, Berg K, Einstein D, Lee P, Pixley F, Wang Y, et al. Biology and action of colony--stimulating factor-1. Mol Reprod Dev. 1997;46:4-10 pubmed
    ..Studies on several of these proteins, including protein tyrosine phosphates 1C, the c-cbl proto-oncogene product, and protein tyrosine phosphatase-phi are discussed. ..
  11. Calfon M, Zeng H, Urano F, Till J, Hubbard S, Harding H, et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 2002;415:92-6 pubmed
    ..Our findings suggest that physiological ER load regulates a developmental decision in higher eukaryotes. ..
  12. Lipton J. Mating worms and the cystic kidney: Caenorhabditis elegans as a model for renal disease. Pediatr Nephrol. 2005;20:1531-6 pubmed
    ..C. elegans has also been used to identify a gene family which may have significance for understanding the formation and maintenance of renal tubules. ..
  13. O Meara M, Bigelow H, Flibotte S, Etchberger J, Moerman D, Hobert O. Cis-regulatory mutations in the Caenorhabditis elegans homeobox gene locus cog-1 affect neuronal development. Genetics. 2009;181:1679-86 pubmed publisher
    ..The multiplicity of cis-regulatory elements may ensure the robustness of gene expression. ..
  14. McGovern M, Voutev R, Maciejowski J, Corsi A, Hubbard E. A "latent niche" mechanism for tumor initiation. Proc Natl Acad Sci U S A. 2009;106:11617-22 pubmed publisher
    ..We propose that a latent niche mechanism may underlie tumorigenesis and metastasis in humans. ..
  15. Boateng R, Nguyen K, Hall D, Golden A, Allen A. Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses. Dev Biol. 2017;429:306-320 pubmed publisher
    ..Combined, this data identifies a novel role for ETR-1 in hermaphrodite gametogenesis and in the process of engulfment of germline apoptotic cell corpses. ..
  16. Rongo C, Broihier H, Moore L, Van Doren M, Forbes A, Lehmann R. Germ plasm assembly and germ cell migration in Drosophila. Cold Spring Harb Symp Quant Biol. 1997;62:1-11 pubmed
    ..Further genetic studies will reveal the extent to which molecular aspects of germ cell migration and gonad formation are conserved. ..
  17. Doyle T, Wen C, Greenwald I. SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2000;97:7877-81 pubmed
    ..We postulate that SEL-8 serves as a transcriptional coactivator or as an assembly factor for transcription complexes that contain the LIN-12 or GLP-1 intracellular domains. ..
  18. Zhang L, Wu S, Rubin C. Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery. J Biol Chem. 2001;276:10476-84 pubmed
    ..Activities of DAG-stimulated PKCs and opposing protein Ser/Thr phosphatases can dynamically regulate the distribution of adapter protein between the cell periphery and cytoplasm. ..
  19. Hashmi S, Zhang J, Oksov Y, Lustigman S. The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development. J Biol Chem. 2004;279:6035-45 pubmed
    ..The CPZ-1 native protein in these affected regions may have a role in the cuticular and the basement membrane extracellular matrix assembly process. The present findings have defined a critical role for cathepsin Z in nematode biology. ..
  20. Yoneda T, Benedetti C, Urano F, Clark S, Harding H, Ron D. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci. 2004;117:4055-66 pubmed
    ..These observations support the existence of a mitochondrial unfolded protein response that couples mitochondrial chaperone gene expression to changes in the protein handling environment in the organelle. ..
  21. Middendorf M, Ziv E, Adams C, Hom J, Koytcheff R, Levovitz C, et al. Discriminative topological features reveal biological network mechanisms. BMC Bioinformatics. 2004;5:181 pubmed
    ..Our method is a first step towards systematizing network models and assessing their predictability, and we anticipate its usefulness for a number of communities. ..
  22. Prasad B, Clark S. Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans. Development. 2006;133:1757-66 pubmed
    ..We show that retromer protein VPS-35 is required in Wnt-expressing cells and propose that retromer activity is needed to generate a fully active Wnt signal. ..
  23. Chang C, Adler C, Krause M, Clark S, Gertler F, Tessier Lavigne M, et al. MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol. 2006;16:854-62 pubmed
    ..mig-10 and age-1 lipid signaling promote axon outgrowth; unc-34 and to a lesser extent mig-10 promote filopodia formation. Surprisingly, filopodia are largely dispensable for accurate axon guidance. ..
  24. Haynes C, Oldfield C, Ji F, Klitgord N, Cusick M, Radivojac P, et al. Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol. 2006;2:e100 pubmed
    ..The results of this study demonstrate that intrinsic structural disorder is a distinctive and common characteristic of eukaryotic hub proteins, and that disorder may serve as a determinant of protein interactivity. ..
  25. Stanhill A, Haynes C, Zhang Y, Min G, Steele M, Kalinina J, et al. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Mol Cell. 2006;23:875-85 pubmed
    ..These features include enhanced cleavage of peptide substrates and suggest that AIRAP adapts the cell's core protein degradation machinery to counteract proteotoxicity induced by an environmental toxin. ..
  26. Poole R, Hobert O. Early embryonic programming of neuronal left/right asymmetry in C. elegans. Curr Biol. 2006;16:2279-92 pubmed
  27. Zhang J, Yang C, Brey C, Rodriguez M, Oksov Y, Gaugler R, et al. Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition. Exp Cell Res. 2009;315:2568-80 pubmed publisher
    ..We present the first clear in vivo evidence supporting essential regulatory roles of KLF-3 in fat storage in C. elegans and shed light on the human equivalent in disease-gene association. ..
  28. Altun Z, Chen B, Wang Z, Hall D. High resolution map of Caenorhabditis elegans gap junction proteins. Dev Dyn. 2009;238:1936-50 pubmed publisher
    ..Therefore, innexins likely play roles in almost all body functions, including embryonic development, cell fate determination, oogenesis, egg laying, pharyngeal pumping, excretion, and locomotion. ..
  29. Kullyev A, Dempsey C, Miller S, Kuan C, Hapiak V, Komuniecki R, et al. A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans. Genetics. 2010;186:929-41 pubmed publisher
    ..Epistatic analyses suggest that SER-7 and SER-5 act upstream of AMPA receptor GLR-1 signaling. Our work provides genetic evidence that fluoxetine may influence neuronal functions and behavior by directly targeting serotonin receptors. ..
  30. Zhang X, Greenwald I. Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans. Genetics. 2011;188:847-58 pubmed publisher
    ..Relief of repression of lag-2 in P6.p offers a plausible mechanistic basis for spatial restriction of lag-2 in generating the precise spatial pattern of VPC fates. ..
  31. Jafari G, Xie Y, Kullyev A, Liang B, Sze J. Regulation of extrasynaptic 5-HT by serotonin reuptake transporter function in 5-HT-absorbing neurons underscores adaptation behavior in Caenorhabditis elegans. J Neurosci. 2011;31:8948-57 pubmed publisher
  32. Pohl C, Tiongson M, Moore J, Santella A, Bao Z. Actomyosin-based self-organization of cell internalization during C. elegans gastrulation. BMC Biol. 2012;10:94 pubmed publisher
    ..Our results suggest that the mode of C. elegans gastrulation can be unified with the general notions of monolayer remodeling and with distinct cellular mechanisms of actomyosin-based morphogenesis. ..
  33. Rapti G, Li C, Shan A, Lu Y, Shaham S. Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans. Nat Neurosci. 2017;20:1350-1360 pubmed publisher
    ..Taken together, our studies reveal previously undescribed glial roles in pioneer-axon guidance, suggesting conserved principles of brain assembly. ..
  34. Kierszenbaum A. Intramanchette transport (IMT): managing the making of the spermatid head, centrosome, and tail. Mol Reprod Dev. 2002;63:1-4 pubmed
    ..Details of specific role of Ran GTPase in nucleocytoplasmic transport and its relocation from the manchette to the centrosome to the sperm tail await elucidation...
  35. Chuang C, Bargmann C. A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling. Genes Dev. 2005;19:270-81 pubmed
    ..TIR-1 and other TIR proteins are implicated in vertebrate and invertebrate innate immunity, as are NSY-1/ASK1 kinases, so this pathway may also have a conserved function in immune signaling. ..
  36. Pocock R, Hobert O. Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans. Nat Neurosci. 2008;11:894-900 pubmed publisher
    ..Similar genetic pathways may cause aberrant human brain development under hypoxic conditions. ..
  37. Saheki Y, Bargmann C. Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha(2)delta subunit UNC-36. Nat Neurosci. 2009;12:1257-65 pubmed publisher
    ..Genetic and cell biological interactions suggest that CALF-1 couples intracellular traffic to functional maturation of CaV2 presynaptic calcium channels. ..
  38. Westholm J, Ladewig E, Okamura K, Robine N, Lai E. Common and distinct patterns of terminal modifications to mirtrons and canonical microRNAs. RNA. 2012;18:177-92 pubmed publisher
    ..Finally, we found that 3' resection occurs broadly across AGO1-loaded canonical miRNA and star species. Altogether, these findings substantially broaden the complexity of terminal modification pathways acting upon small regulatory RNAs. ..
  39. Flavell S, Pokala N, Macosko E, Albrecht D, Larsch J, Bargmann C. Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans. Cell. 2013;154:1023-1035 pubmed publisher
    ..The slow temporal dynamics of this neuromodulatory circuit supplement fast motor circuits to organize long-lasting behavioral states. ..
  40. Du H, Chalfie M. Genes regulating touch cell development in Caenorhabditis elegans. Genetics. 2001;158:197-207 pubmed
    ..In addition to the touch cell abnormalities, vab-15 animals variably exhibit embryonic or larval lethality, cell degenerations, malformation of the posterior body, uncoordinated movement, and defective egg laying. ..
  41. Raich W, Moorman C, Lacefield C, Lehrer J, Bartsch D, Plasterk R, et al. Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Genetics. 2003;163:571-80 pubmed
    ..Our results suggest that increased gene dosage of human DYRK1A in trisomy 21 may disrupt the function of fully differentiated neurons and that this disruption is reversible. ..
  42. Denli A, Tops B, Plasterk R, Ketting R, Hannon G. Processing of primary microRNAs by the Microprocessor complex. Nature. 2004;432:231-5 pubmed
    ..Considered together, these results indicate a role for Pasha in miRNA maturation and miRNA-mediated gene regulation. ..
  43. Perens E, Shaham S. C. elegans daf-6 encodes a patched-related protein required for lumen formation. Dev Cell. 2005;8:893-906 pubmed
    ..We propose that amphid lumen morphogenesis is coordinated by neuron-derived cues and a DAF-6/CHE-14 system that regulates vesicle dynamics during tubulogenesis...
  44. Ji Q, Hashmi S, Liu Z, Zhang J, Chen Y, Huang C. CeRh1 (rhr-1) is a dominant Rhesus gene essential for embryonic development and hypodermal function in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2006;103:5881-6 pubmed publisher
    ..Taken together, our data provide direct evidence for the essentiality of the CeRh1 gene in C. elegans, establishing a useful animal model for investigating CO(2) channel function by cross-species complementation...
  45. Govorunova E, Moussaif M, Kullyev A, Nguyen K, McDonald T, Hall D, et al. A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans. PLoS ONE. 2010;5:e10368 pubmed publisher
    ..The role of eat-6 in modulation of excitatory neurotransmission by 5-HT may provide a genetic explanation for the therapeutic effects of the drugs targeting 5-HT receptors in the treatment of migraine patients. ..
  46. Albrecht D, Bargmann C. High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments. Nat Methods. 2011;8:599-605 pubmed publisher
    ..The devices are inexpensive, easy to fabricate, reusable and suitable for delivering any liquid-borne stimulus. ..
  47. Chihara D, Nance J. An E-cadherin-mediated hitchhiking mechanism for C. elegans germ cell internalization during gastrulation. Development. 2012;139:2547-56 pubmed publisher
    ..Our findings reveal that quiescent PGCs employ a post-transcriptionally regulated hitchhiking mechanism to internalize during gastrulation, and demonstrate a morphogenetic role for the conserved association of PGCs with the endoderm. ..
  48. Cecere G, Hoersch S, Jensen M, Dixit S, Grishok A. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Mol Cell. 2013;50:894-907 pubmed publisher
    ..We propose a model wherein the recruitment of ZFP-1/DOT-1.1 and deposition of H3K79 methylation at highly expressed genes initiates a negative feedback mechanism for the modulation of their expression. ..
  49. Zhuravlev Y, Hirsch S, Jordan S, Dumont J, Shirasu Hiza M, Canman J. CYK-4 regulates Rac, but not Rho, during cytokinesis. Mol Biol Cell. 2017;28:1258-1270 pubmed publisher
    ..Instead, we found that the rescue of cytokinesis in CYK-4 mutants by Rac inactivation was Cdc42 dependent. Together our data suggest that CYK-4 GAP activity opposes Rac (and perhaps Cdc42) during cytokinesis. ..
  50. Flamand M, Gan H, Mayya V, Gunsalus K, Duchaine T. A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing. Nucleic Acids Res. 2017;45:7212-7225 pubmed publisher
    ..Our results delineate multiple cooperative mechanisms in miRNA-mediated silencing and further support the consideration of target site cooperation as a fundamental characteristic of miRNA function. ..
  51. Lin F, Worman H. Structural organization of the human gene (LMNB1) encoding nuclear lamin B1. Genomics. 1995;27:230-6 pubmed
  52. Johnston R, Hobert O. A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature. 2003;426:845-9 pubmed
    ..lsy-6 is the first microRNA to our knowledge with a role in neuronal patterning, providing new insights into left/right axis formation. ..
  53. Chen N, Stein L. Conservation and functional significance of gene topology in the genome of Caenorhabditis elegans. Genome Res. 2006;16:606-17 pubmed
  54. Chelur D, Chalfie M. Targeted cell killing by reconstituted caspases. Proc Natl Acad Sci U S A. 2007;104:2283-8 pubmed
    ..The high degree of target specificity and tight regulation of induction of recCaspase would be advantageous in creating animal models that are ablated for specific cells and in other targeted cell killings. ..
  55. Bounoutas A, Kratz J, Emtage L, Ma C, Nguyen K, Chalfie M. Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway. Proc Natl Acad Sci U S A. 2011;108:3982-7 pubmed publisher
    ..This reduction requires a p38 MAPK pathway (DLK-1, MKK-4, and PMK-3) and the transcription factor CEBP-1. Cells may use this feedback pathway that couples microtubule state and MAPK activation to regulate cellular functions. ..
  56. Arnadottir J, O HAGAN R, Chen Y, Goodman M, Chalfie M. The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons. J Neurosci. 2011;31:12695-704 pubmed publisher
    ..Finally, electrophysiological examination of heterologously expressed complexes suggests that mutant MEC-10 proteins may affect channel current via MEC-2. ..
  57. Wehman A, Poggioli C, Schweinsberg P, Grant B, Nance J. The P4-ATPase TAT-5 inhibits the budding of extracellular vesicles in C. elegans embryos. Curr Biol. 2011;21:1951-9 pubmed publisher
    ..Our results also suggest that viral budding and ECV budding may share common molecular mechanisms. ..
  58. Topalidou I, Cooper K, Pereira L, Ailion M. Dopamine negatively modulates the NCA ion channels in C. elegans. PLoS Genet. 2017;13:e1007032 pubmed publisher
    ..Finally, we demonstrate that dopamine, through DOP-3, negatively regulates NCA activity. Thus, this study identifies a pathway by which dopamine modulates the activity of the NCA channels. ..
  59. Deng X, Yin X, Allan R, Lu D, Maurer C, Haimovitz Friedman A, et al. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science. 2008;322:110-5 pubmed publisher
  60. Cochella L, Tursun B, Hsieh Y, Galindo S, Johnston R, Chuang C, et al. Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1. Genes Dev. 2014;28:34-43 pubmed publisher
    ..These asymmetries serve to increase the ability of the animal to discriminate distinct chemosensory inputs. ..
  61. Du H, Gu G, William C, Chalfie M. Extracellular proteins needed for C. elegans mechanosensation. Neuron. 1996;16:183-94 pubmed
    ..We propose that these proteins provide an extracellular attachment point for the mechanosensory channels of the touch cells. ..
  62. Mehta N, Loria P, Hobert O. A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23. Genetics. 2004;166:1253-67 pubmed
    ..We have thus defined separable activities of LIN-23 in two distinct processes, cell cycle control and axon patterning. We propose that LIN-23 targets distinct substrates for ubiquitination within each process. ..
  63. Marciniak S, Yun C, Oyadomari S, Novoa I, Zhang Y, Jungreis R, et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004;18:3066-77 pubmed
    ..CHOP deletion thus protects cells from ER stress by decreasing ER client protein load and changing redox conditions within the organelle. ..
  64. Wang Y, Levy D. C. elegans STAT: evolution of a regulatory switch. FASEB J. 2006;20:1641-52 pubmed
    ..Our results shed new light on the evolution and function of the STAT signaling pathway and on the structural requirements for STAT activation. ..
  65. Chuang C, VanHoven M, Fetter R, Verselis V, Bargmann C. An innexin-dependent cell network establishes left-right neuronal asymmetry in C. elegans. Cell. 2007;129:787-99 pubmed
    ..NSY-5 forms hemichannels and intercellular gap-junction channels in Xenopus oocytes, consistent with a combination of cell-intrinsic and network functions. These results provide insight into gap-junction activity in developing circuits. ..
  66. Flowers E, Poole R, Tursun B, Bashllari E, Pe er I, Hobert O. The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans. Development. 2010;137:1799-805 pubmed publisher
    ..We propose that Groucho-mediated gene regulatory events involve heteromeric complexes of distinct Groucho-like proteins. ..
  67. Calixto A, Chelur D, Topalidou I, Chen X, Chalfie M. Enhanced neuronal RNAi in C. elegans using SID-1. Nat Methods. 2010;7:554-9 pubmed publisher
    ..Expression of sid-1(+) from cell-specific promoters in sid-1 mutants results in cell-specific feeding RNAi. We used these strains to identify a role for integrin signaling genes in mechanosensation. ..
  68. Lumpkin E, Marshall K, Nelson A. The cell biology of touch. J Cell Biol. 2010;191:237-48 pubmed publisher
    ..A comparative evolutionary approach across mechanosensory cell types and genetically tractable species is beginning to uncover the cellular logic of touch reception. ..
  69. Islas Trejo A, Land M, Tcherepanova I, Freedman J, Rubin C. Structure and expression of the Caenorhabditis elegans protein kinase C2 gene. Origins and regulated expression of a family of Ca2+-activated protein kinase C isoforms. J Biol Chem. 1997;272:6629-40 pubmed
    ..Although 77- and 78-kDa PKC2 isoforms are evident throughout post-embryonic development, an 81-kDa isoform appears to be adapted for function in L1 and L2 larvae. ..
  70. Aurelio O, Boulin T, Hobert O. Identification of spatial and temporal cues that regulate postembryonic expression of axon maintenance factors in the C. elegans ventral nerve cord. Development. 2003;130:599-610 pubmed
    ..Our findings illustrate the importance of spatial and temporal control of gene expression in the nervous system and, furthermore, implicate heterochronic genes in postmitotic neural patterning events. ..
  71. Rodriguez Boulan E, Müsch A, Le Bivic A. Epithelial trafficking: new routes to familiar places. Curr Opin Cell Biol. 2004;16:436-42 pubmed
    ..A promising area of research is the study of trafficking functions of novel polarity genes identified in Drosophila and Caenorhabditis elegans. ..
  72. Berry K, Hobert O. Mapping functional domains of chloride intracellular channel (CLIC) proteins in vivo. J Mol Biol. 2006;359:1316-33 pubmed
    ..The PTM region thus provides both targeting information and CLIC functional specificity, possibly adapting GST-type proteins to function as ion channels. ..
  73. Katic I, Greenwald I. EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Genetics. 2006;174:1907-15 pubmed
    ..emb-4 encodes a large nuclearly localized protein containing a predicted ATPase domain and has apparent orthologs in fission yeast, plants, and animals. ..
  74. Barrios A, Nurrish S, Emmons S. Sensory regulation of C. elegans male mate-searching behavior. Curr Biol. 2008;18:1865-71 pubmed publisher
    ..This study identifies key parts of the neural circuit that regulates a sexual appetitive behavior in C. elegans. ..
  75. Du Z, Santella A, He F, Tiongson M, Bao Z. De novo inference of systems-level mechanistic models of development from live-imaging-based phenotype analysis. Cell. 2014;156:359-72 pubmed publisher
    ..Our study provides a powerful approach for automated and quantitative interpretation of complex in vivo information. ..
  76. Shreffler W, Magardino T, Shekdar K, Wolinsky E. The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons. Genetics. 1995;139:1261-72 pubmed
    ..sup-40 may encode an ion channel component or regulator that can correct the osmotic defect caused by abnormal unc-8 channels. ..
  77. Haltiwanger R, Lowe J. Role of glycosylation in development. Annu Rev Biochem. 2004;73:491-537 pubmed
    ..melanogaster, and C. elegans. ..
  78. Kinchen J, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, et al. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature. 2005;434:93-9 pubmed
  79. Teplova M, Hafner M, Teplov D, Essig K, Tuschl T, Patel D. Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Genes Dev. 2013;27:928-40 pubmed publisher
    ..Overall, our studies define principles underlying RNA target selection by STAR homodimers and provide insights into the post-transcriptional regulatory function of mammalian QKI proteins. ..
  80. Wang W, Perens E, Oikonomou G, Wallace S, Lu Y, Shaham S. IGDB-2, an Ig/FNIII protein, binds the ion channel LGC-34 and controls sensory compartment morphogenesis in C. elegans. Dev Biol. 2017;430:105-112 pubmed publisher
    ..Our findings reveal a novel membrane protein complex and suggest possible mechanisms for how sensory compartment size is controlled. ..
  81. Levitan D, Greenwald I. LIN-12 protein expression and localization during vulval development in C. elegans. Development. 1998;125:3101-9 pubmed
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