Experts and Doctors on caenorhabditis elegans in California, United States


Locale: California, United States
Topic: caenorhabditis elegans

Top Publications

  1. Lee P, Kuhl W, Gelbart T, Kamimura T, West C, Beutler E. Homology between a human protein and a protein of the green garden pea. Genomics. 1994;21:371-8 pubmed
    ..Attempts to induce the mRNA by heat-shock, dehydration, ionizing irradiation, or treatment with iron, t-butylhydroperoxide, or glucocorticoids were unsuccessful. The function of the protein remains unknown. ..
  2. Thomas E, Danielson P, Sutcliffe J. RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum. J Neurosci Res. 1998;52:118-24 pubmed
    ..Relatively strong signals were also detected in some hypothalamic nuclei. Its selective expression suggests that RGS9 may play an important role in modulation of the complex signalling pathways of the basal ganglia. ..
  3. Ghosh Roy A, Wu Z, Goncharov A, Jin Y, Chisholm A. Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase. J Neurosci. 2010;30:3175-83 pubmed publisher
    ..These findings reveal the relationship between Ca(2+)/cAMP signaling and the DLK-1 MAPK (mitogen-activated protein kinase) cascade in regeneration. ..
  4. Moresco J, Carvalho P, Yates J. Identifying components of protein complexes in C. elegans using co-immunoprecipitation and mass spectrometry. J Proteomics. 2010;73:2198-204 pubmed publisher
    ..This should provide a useful guide for biologists planning proteomic experiments. ..
  5. Massirer K, Perez S, Mondol V, Pasquinelli A. The miR-35-41 family of microRNAs regulates RNAi sensitivity in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002536 pubmed publisher
    ..Our results reveal that miRNAs can broadly regulate other small RNA pathways and, thus, have far reaching effects on gene expression beyond directly targeting specific mRNAs. ..
  6. Lackner M, Kornfeld K, Miller L, Horvitz H, Kim S. A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes Dev. 1994;8:160-73 pubmed
    ..We used a new type of mosaic analysis to show that mpk-1 acts cell autonomously in the Pn.p cells. Our results show that mpk-1 plays an important functional role as an activator in ras-mediated cell signaling in vivo. ..
  7. Nabeshima K, Villeneuve A, Hillers K. Chromosome-wide regulation of meiotic crossover formation in Caenorhabditis elegans requires properly assembled chromosome axes. Genetics. 2004;168:1275-92 pubmed
    ..These results indicate that limiting the amount of a major axis component results in a reduced capacity to communicate the presence of a (nascent) crossover and/or to discourage others in response. ..
  8. Shao X, Kang H, Loveless T, Lee G, Seok C, Weis W, et al. Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the ?-catenin·?-catenin-binding interface. J Biol Chem. 2017;292:16477-16490 pubmed publisher
    ..elegans Our data provide novel insights into how cadherin-dependent cell-cell adhesion is modulated in metazoans by conserved elements as well as features unique to specific organisms. ..
  9. Liu Y, Liu X, Wei L, Altman R, Batzoglou S. Eukaryotic regulatory element conservation analysis and identification using comparative genomics. Genome Res. 2004;14:451-8 pubmed
    ..CompareProspector outperformed many other computational motif-finding programs, demonstrating the power of comparative genomics-based biased sampling in eukaryotic regulatory element identification. ..

More Information

Publications114 found, 100 shown here

  1. Kim H, Rogers M, Richmond J, McIntire S. SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans. Nature. 2004;430:891-6 pubmed
    ..Improper clearing of acetylcholine and prolonged excitation of muscles might contribute to the pathogenesis of muscular dystrophies. ..
  2. Silady R, Kato T, Lukowitz W, Sieber P, Tasaka M, Somerville C. The gravitropism defective 2 mutants of Arabidopsis are deficient in a protein implicated in endocytosis in Caenorhabditis elegans. Plant Physiol. 2004;136:3095-103; discussion 3002 pubmed
    ..We hypothesize that a defect in endocytosis may affect both the initial gravity sensing via amyloplasts sedimentation and the subsequent more general tropic growth response. ..
  3. Carvalho A, Olson S, Gutierrez E, Zhang K, Noble L, Zanin E, et al. Acute drug treatment in the early C. elegans embryo. PLoS ONE. 2011;6:e24656 pubmed publisher
    ..This method should also open new avenues of investigation by allowing profiling and specificity-testing of inhibitors through comparison with genome-wide phenotypic datasets. ..
  4. Gassmann R, Rechtsteiner A, Yuen K, Muroyama A, Egelhofer T, Gaydos L, et al. An inverse relationship to germline transcription defines centromeric chromatin in C. elegans. Nature. 2012;484:534-7 pubmed publisher
    ..These findings link centromere identity to transcription and shed light on the evolutionary plasticity of centromeres...
  5. Webb A, Brunet A. FOXO flips the longevity SWItch. Nat Cell Biol. 2013;15:444-6 pubmed publisher
    ..In the nematode Caenorhabditis elegans, FOXO is now shown to recruit the nucleosome remodelling complex SWI/SNF to its target genes, which is essential for FOXO to elicit stress resistance and longevity. ..
  6. Cho U, Zimmerman S, Chen L, Owen E, Kim J, Kim S, et al. Rapid and tunable control of protein stability in Caenorhabditis elegans using a small molecule. PLoS ONE. 2013;8:e72393 pubmed publisher
    ..We further show that these new destabilizing domains can be used to regulate protein concentrations in C. elegans. These data reinforce that DD can function in virtually any organism and temperature. ..
  7. Schwieterman A, Steves A, Yee V, Donelson C, Bentley M, Santorella E, et al. The Caenorhabditis elegans Ephrin EFN-4 Functions Non-cell Autonomously with Heparan Sulfate Proteoglycans to Promote Axon Outgrowth and Branching. Genetics. 2016;202:639-60 pubmed publisher
    ..This is the first report of an epidermal ephrin providing a developmental cue to the nervous system. ..
  8. Long T, Rojo Arreola L, Shi D, El Sakkary N, Jarnagin K, Rock F, et al. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017;11:e0005680 pubmed publisher
    ..Transgenic C. elegans is highlighted as a potential screening tool to optimize small molecule chemistries to flatworm molecular drug targets. ..
  9. Cueva J, Mulholland A, Goodman M. Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons. J Neurosci. 2007;27:14089-98 pubmed
    ..We speculate that the microtubule bundle converts external point loads into membrane stretch which, in turn, facilitates MeT channel activation. ..
  10. Colaiácovo M, Stanfield G, Reddy K, Reinke V, Kim S, Villeneuve A. A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline. Genetics. 2002;162:113-28 pubmed
    ..In addition to genes involved in key meiotic prophase events, we identified genes involved in meiotic progression, germline proliferation, and chromosome organization and/or segregation during mitotic growth. ..
  11. Blanchard D, Hutter H, Fleenor J, Fire A. A differential cytolocalization assay for analysis of macromolecular assemblies in the eukaryotic cytoplasm. Mol Cell Proteomics. 2006;5:2175-84 pubmed
  12. Loer C, Rivard L. Evolution of neuronal patterning in free-living rhabditid nematodes I: Sex-specific serotonin-containing neurons. J Comp Neurol. 2007;502:736-67 pubmed
    ..The varying positions of the HSN somas in other species are reminiscent of phenotypes seen in various C. elegans mutants with altered HSN migration, suggesting possible mechanisms for the evolutionary differences we observed. ..
  13. Cheeseman I, Niessen S, Anderson S, Hyndman F, Yates J, Oegema K, et al. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 2004;18:2255-68 pubmed
    ..Thus, this protein network is a conserved constituent of the outer kinetochore, and the functions defined by our analysis in C. elegans are likely to be widely relevant. ..
  14. Gu S, Pak J, Guang S, Maniar J, Kennedy S, Fire A. Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint. Nat Genet. 2012;44:157-64 pubmed publisher
    ..These results implicate dsRNA-triggered chromatin modification in C. elegans as a programmable and locus-specific response defining a metastable state that can persist through generational boundaries. ..
  15. Cadigan K, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev. 1997;11:3286-305 pubmed
  16. Simske J, Kaech S, Harp S, Kim S. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell. 1996;85:195-204 pubmed
    ..These results suggest that proper localization of LET-23 receptor to the Pn.p cell junctions is required for signaling activity. ..
  17. Gary J, Wurmser A, Bonangelino C, Weisman L, Emr S. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J Cell Biol. 1998;143:65-79 pubmed
    ..We propose that Fab1p and Vac7p are components of a signal transduction pathway which functions to regulate the efflux or turnover of vacuolar membranes through the regulated production of PtdIns(3,5)P2. ..
  18. Kelly K, Dernburg A, Stanfield G, Villeneuve A. Caenorhabditis elegans msh-5 is required for both normal and radiation-induced meiotic crossing over but not for completion of meiosis. Genetics. 2000;156:617-30 pubmed
  19. Chin G, Villeneuve A. C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpoint. Genes Dev. 2001;15:522-34 pubmed
    ..This progressive loss of fecundity and viability indicates that MRE-11 performs a function essential for maintaining reproductive capacity in the species. ..
  20. Greer E, Maures T, Hauswirth A, Green E, Leeman D, Maro G, et al. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature. 2010;466:383-7 pubmed publisher
    ..These results indicate that the longevity of the soma is regulated by an H3K4 methyltransferase/demethylase complex acting in the C. elegans germline. ..
  21. Spilker K, Wang G, Tugizova M, Shen K. Caenorhabditis elegans Muscleblind homolog mbl-1 functions in neurons to regulate synapse formation. Neural Dev. 2012;7:7 pubmed publisher
    ..Consistent with this result, mbl-1 is also expressed in neurons. Based on these results, we conclude that in addition to its functions in muscle, the Muscleblind splice regulators also function in neurons to regulate synapse formation. ..
  22. Parrish A, She X, Xiang Z, Coin I, Shen Z, Briggs S, et al. Expanding the genetic code of Caenorhabditis elegans using bacterial aminoacyl-tRNA synthetase/tRNA pairs. ACS Chem Biol. 2012;7:1292-302 pubmed publisher
    ..We anticipate our strategies will be generally extendable to other multicellular organisms. ..
  23. Dascher C, Balch W. Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport. J Biol Chem. 1996;271:15866-9 pubmed
    ..These results suggest that rSly1 functions to positively regulate syntaxin 5 function. ..
  24. Tan P, Lackner M, Kim S. MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. Cell. 1998;93:569-80 pubmed
    ..The partnership of tissue-specific and general effectors may confer specificity onto commonly used signaling pathways, creating distinct tissue-specific outcomes. ..
  25. Zapata J, Matsuzawa S, Godzik A, Leo E, Wasserman S, Reed J. The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity. J Biol Chem. 2000;275:12102-7 pubmed
    ..Interactions of DTRAF1 with human TRAF-, TNF receptor-, and IAP-family proteins imply strong evolutionary conservation of TRAF protein structure and function throughout Metazoan evolution. ..
  26. Roy P, Stuart J, Lund J, Kim S. Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans. Nature. 2002;418:975-9 pubmed
    ..These observations reveal a higher-order organization of the structure of the genome, in which the order of the genes along the chromosome id correlated with their expression in specific tissues. ..
  27. Johnson S, Tan F, McCullough H, Riordan D, Fire A. Flexibility and constraint in the nucleosome core landscape of Caenorhabditis elegans chromatin. Genome Res. 2006;16:1505-16 pubmed
    ..elegans, this analysis provides a reference from which to begin an investigation of relationships between the nucleosomal pattern, chromosomal architecture, and lineage-based gene activity on a genome-wide scale. ..
  28. Bessler J, Reddy K, Hayashi M, Hodgkin J, Villeneuve A. A role for Caenorhabditis elegans chromatin-associated protein HIM-17 in the proliferation vs. meiotic entry decision. Genetics. 2007;175:2029-37 pubmed
  29. Ou C, Poon V, Maeder C, Watanabe S, Lehrman E, Fu A, et al. Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Cell. 2010;141:846-58 pubmed publisher
    ..Thus, PCT-1 and CDK-5 pathways direct polarized trafficking of presynaptic components by inhibiting dynein-mediated retrograde transport and setting the balance between anterograde and retrograde motors. ..
  30. Whitfield C, Benard C, Barnes T, Hekimi S, Kim S. Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol Biol Cell. 1999;10:2087-100 pubmed
    ..LIN-10 may function in secretion of LET-23 to the basolateral membrane domain, or it may be involved in tethering LET-23 at the basolateral plasma membrane once it is secreted. ..
  31. Evans E, Kawli T, Tan M. Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans. PLoS Pathog. 2008;4:e1000175 pubmed publisher
    ..Our results reveal a new mechanism by which P. aeruginosa suppresses host immune defense. ..
  32. Gent J, Schvarzstein M, Villeneuve A, Gu S, Jantsch V, Fire A, et al. A Caenorhabditis elegans RNA-directed RNA polymerase in sperm development and endogenous RNA interference. Genetics. 2009;183:1297-314 pubmed publisher
    ..These and other data suggest a working model in which a major role of the RRF-3/ERI pathway is to generate siRNAs that set patterns of gene expression through feedback repression of a set of critical targets during spermatogenesis. ..
  33. Schvarzstein M, Wignall S, Villeneuve A. Coordinating cohesion, co-orientation, and congression during meiosis: lessons from holocentric chromosomes. Genes Dev. 2010;24:219-28 pubmed publisher
    ..Finally, we illustrate how analysis of holocentric meiosis can inform our thinking about mechanisms that operate on monocentric chromosomes. ..
  34. Petzold B, Park S, Ponce P, Roozeboom C, Powell C, Goodman M, et al. Caenorhabditis elegans body mechanics are regulated by body wall muscle tone. Biophys J. 2011;100:1977-85 pubmed publisher
    ..elegans body mechanics. Modulation of body stiffness would enable nematodes to tune locomotion or swimming gaits and may have implications in touch sensation. ..
  35. Kaech S, Whitfield C, Kim S. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell. 1998;94:761-71 pubmed
    ..Each of the binding interactions within this complex is conserved, suggesting that this complex may also mediate basolateral localization in mammals. ..
  36. Darby C, Falkow S. Mimicry of a G protein mutation by pertussis toxin expression in transgenic Caenorhabditis elegans. Infect Immun. 2001;69:6271-5 pubmed
    ..These results indicate that PTX is functional in nematodes and acts specifically on the C. elegans homologue of the mammalian target. ..
  37. Ryder S, Frater L, Abramovitz D, Goodwin E, Williamson J. RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1. Nat Struct Mol Biol. 2004;11:20-8 pubmed
    ..Similarities between the SBE and the branch-site signal indicate a possible competition mechanism for STAR/GSG regulation of splicing variants. ..
  38. Zhang F, Wang L, Brauner M, Liewald J, Kay K, Watzke N, et al. Multimodal fast optical interrogation of neural circuitry. Nature. 2007;446:633-9 pubmed
    ..NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits. ..
  39. Sann S, Crane M, Lu H, Jin Y. Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans. PLoS ONE. 2012;7:e37930 pubmed publisher
    ..These results suggest that rabx-5 regulation of RAB-5 compartments is important for maintaining proper synaptic function throughout the lifetime...
  40. Leinwand S, Chalasani S. Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans. Nat Neurosci. 2013;16:1461-7 pubmed publisher
    ..Our results indicate that sensory context and neuropeptide signaling modify neural networks and suggest general mechanisms for generating flexible behavioral outputs by modulating neural circuit composition. ..
  41. Reed J, Bischoff J. BIRinging chromosomes through cell division--and survivin' the experience. Cell. 2000;102:545-8 pubmed
  42. Greer E, Banko M, Brunet A. AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity. Ann N Y Acad Sci. 2009;1170:688-92 pubmed publisher
  43. Mair W, Morantte I, Rodrigues A, Manning G, Montminy M, Shaw R, et al. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 2011;470:404-8 pubmed publisher
  44. Martinez Perez E, Villeneuve A. HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis. Genes Dev. 2005;19:2727-43 pubmed
    ..We propose a model in which HTP-1 functions to establish or maintain multiple constraints that operate to ensure coordination of events leading to chiasma formation. ..
  45. Hayashi M, Mlynarczyk Evans S, Villeneuve A. The synaptonemal complex shapes the crossover landscape through cooperative assembly, crossover promotion and crossover inhibition during Caenorhabditis elegans meiosis. Genetics. 2010;186:45-58 pubmed publisher
  46. Holtz J, Pasquinelli A. Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans. RNA. 2009;15:400-5 pubmed publisher
    ..The awareness that endogenous miRNA pathways can be sensitive to environment is an important consideration for elucidating the mechanism used by miRNAs to regulate target mRNA and protein expression. ..
  47. Mair W, Panowski S, Shaw R, Dillin A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS ONE. 2009;4:e4535 pubmed publisher
    ..1, highlighting the importance of first optimizing DR to identify universal regulators of DR mediated longevity. ..
  48. Krieg M, Dunn A, Goodman M. Mechanical control of the sense of touch by ?-spectrin. Nat Cell Biol. 2014;16:224-33 pubmed publisher
    ..Genetic manipulations that decrease such spectrin-dependent tension also selectively impair touch sensation, suggesting that such pre-tension is essential for efficient responses to external mechanical stimuli. ..
  49. Raices M, Maruyama H, Dillin A, Karlseder J. Uncoupling of longevity and telomere length in C. elegans. PLoS Genet. 2005;1:e30 pubmed
    ..Collectively, our data indicate that telomere length and life span can be uncoupled in a post-mitotic setting, suggesting separate pathways for replication-dependent and -independent aging. ..
  50. Stanfield G, Villeneuve A. Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans males. Curr Biol. 2006;16:252-63 pubmed
  51. Audhya A, McLeod I, Yates J, Oegema K. MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. PLoS ONE. 2007;2:e956 pubmed
    ..MVB-12 has two human homologs that co-localize and co-immunoprecipitate with the ESCRT-I component TSG101. Thus, MVB-12 is a conserved core component of metazoan ESCRT-I that regulates its activity during MVB biogenesis. ..
  52. Poon V, Klassen M, Shen K. UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites. Nature. 2008;455:669-73 pubmed publisher
  53. Hershberg R, Petrov D. Selection on codon bias. Annu Rev Genet. 2008;42:287-99 pubmed publisher
  54. Carmel A, Wu J, Lehmann Blount K, Williamson J. High-affinity consensus binding of target RNAs by the STAR/GSG proteins GLD-1, STAR-2 and Quaking. BMC Mol Biol. 2010;11:48 pubmed publisher
    ..The general requirements determined for high-affinity RNA binding by STAR proteins will help facilitate the identification of novel regulatory targets in vivo. ..
  55. Stadler M, Artiles K, Pak J, Fire A. Contributions of mRNA abundance, ribosome loading, and post- or peri-translational effects to temporal repression of C. elegans heterochronic miRNA targets. Genome Res. 2012;22:2418-26 pubmed publisher
  56. Kuang E, Okumura C, Sheffy Levin S, Varsano T, Shu V, Qi J, et al. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet. 2012;8:e1003007 pubmed publisher
    ..Collectively, the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 processing and autophagy. ..
  57. Hubert T, Wu Z, Chisholm A, Jin Y. S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans. J Neurosci. 2014;34:758-63 pubmed publisher
    ..We further show that the antidiabetic drug phenformin, which activates AMP kinase, can promote axon regrowth. Our data reveal a new function for an S6 kinase acting through an AMP kinase in regenerative growth of injured axons. ..
  58. Hosfield D, Guan Y, Haas B, Cunningham R, Tainer J. Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis. Cell. 1999;98:397-408 pubmed
  59. Eisenmann D, Kim S. Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development. Genetics. 2000;156:1097-116 pubmed
    ..In addition, two of these genes, bar-1 and mom-3/mig-14, are known to function in processes regulated by Wnt signaling, suggesting that a Wnt signaling pathway is acting during vulval development. ..
  60. Patel M, Lehrman E, Poon V, Crump J, Zhen M, Bargmann C, et al. Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nat Neurosci. 2006;9:1488-98 pubmed
  61. Hellman A, Shen K. Sensory transduction channel subunits, tax-4 and tax-2, modify presynaptic molecular architecture in C. elegans. PLoS ONE. 2011;6:e24562 pubmed publisher
    ..The change in puncta number can be rescued cell-autonomously in AFD. These results suggest that sensory transduction genes tax-4 and tax-2 are necessary for the proper assembly of presynapses. ..
  62. Xu X, Kim S. The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans. PLoS Genet. 2012;8:e1003108 pubmed publisher
    ..These results identify egl-27 as a novel factor that links stress and aging pathways...
  63. Libuda D, Uzawa S, Meyer B, Villeneuve A. Meiotic chromosome structures constrain and respond to designation of crossover sites. Nature. 2013;502:703-6 pubmed publisher
  64. Bahmanyar S, Biggs R, Schuh A, Desai A, MULLER REICHERT T, Audhya A, et al. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev. 2014;28:121-6 pubmed publisher
  65. Ramot D, MacInnis B, Lee H, Goodman M. Thermotaxis is a robust mechanism for thermoregulation in Caenorhabditis elegans nematodes. J Neurosci. 2008;28:12546-57 pubmed publisher
    ..We suggest that, similar to biochemical networks, animals evolve behavioral strategies that are robust, rather than strategies that rely on fine tuning of specific behavioral parameters. ..
  66. Dammermann A, Pemble H, Mitchell B, McLeod I, Yates J, Kintner C, et al. The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. Genes Dev. 2009;23:2046-59 pubmed publisher
  67. Van Nostrand E, S nchez Blanco A, Wu B, Nguyen A, Kim S. Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003325 pubmed publisher
    ..These results illustrate how unc-62 regulation of intestinal gene expression is responsible for limiting lifespan during the normal aging process...
  68. Bell R, Fu B, Fire A. Cas9 Variants Expand the Target Repertoire in Caenorhabditis elegans. Genetics. 2016;202:381-8 pubmed publisher
  69. Mann F, Van Nostrand E, Friedland A, Liu X, Kim S. Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans. PLoS Genet. 2016;12:e1005956 pubmed publisher
    ..Overexpression of elt-2 extends lifespan and slows the rate of gene expression changes that occur during normal aging. Thus, our results identify the developmental regulator ELT-2 as a major driver of normal aging in C. elegans. ..
  70. Zalevsky J, MacQueen A, Duffy J, Kemphues K, Villeneuve A. Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast. Genetics. 1999;153:1271-83 pubmed
    ..We discuss a model in which HIM-14 promotes crossing over by interfering with Holliday junction branch migration. ..
  71. MacQueen A, Villeneuve A. Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2. Genes Dev. 2001;15:1674-87 pubmed
    ..We propose that chk-2 functions during premeiotic S phase to enable chromosomes to become competent for subsequent meiotic prophase events and/or to coordinate replication with entry into prophase. ..
  72. Gassmann R, Essex A, Hu J, Maddox P, Motegi F, Sugimoto A, et al. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008;22:2385-99 pubmed publisher
  73. Van Nostrand E, Kim S. Integrative analysis of C. elegans modENCODE ChIP-seq data sets to infer gene regulatory interactions. Genome Res. 2013;23:941-53 pubmed publisher
    ..We experimentally showed that two of the new candidate aging regulators can extend lifespan when overexpressed, indicating that this approach can identify novel functional regulators of complex processes. ..
  74. Zhou J, Saba J. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem Biophys Res Commun. 1998;242:502-7 pubmed
    ..Chromosomal localization mapped this SPL gene to Chromosome 10 at 32 cM. Here, we report the identification of the first mammalian sphingosine phosphate lyase gene. ..
  75. Wang J, Tsai M, Poulin G, Adler A, Chen S, Liu H, et al. The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev. 2010;24:327-32 pubmed publisher
    ..Thus, UTX defines an evolutionarily conserved mechanism to enable coordinate transcription of a RB network in cell fate control. ..
  76. Liu O, Shen K. The transmembrane LRR protein DMA-1 promotes dendrite branching and growth in C. elegans. Nat Neurosci. 2011;15:57-63 pubmed publisher
    ..Worms lacking dma-1 were defective in sensing harsh touch. DMA-1 is the first transmembrane LRR protein to be implicated in dendritic branching and expands the breadth of roles of LRR receptors in nervous system development. ..
  77. Chia P, Patel M, Shen K. NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins. Nat Neurosci. 2012;15:234-42 pubmed publisher
    ..Altogether, we identify a role for the actin cytoskeleton during presynaptic development and characterize a molecular pathway whereby NAB-1 links synaptic partner recognition to active zone assembly. ..
  78. Petzold B, Park S, Mazzochette E, Goodman M, PRUITT B. MEMS-based force-clamp analysis of the role of body stiffness in C. elegans touch sensation. Integr Biol (Camb). 2013;5:853-64 pubmed publisher
    ..We investigate the theoretical body deformation predicted under applied force and conclude that local mechanical loads induce inward bending deformation of the skin to drive touch sensation in C. elegans. ..
  79. Rosu S, Zawadzki K, Stamper E, Libuda D, Reese A, Dernburg A, et al. The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance. PLoS Genet. 2013;9:e1003674 pubmed publisher
    ..The proposed negative feedback regulation of DSB formation simultaneously (1) ensures that sufficient DSBs are made to guarantee CO formation and (2) prevents excessive DSB levels that could have deleterious effects. ..
  80. Nandakumar M, Tan M. Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. PLoS Genet. 2008;4:e1000273 pubmed publisher
    ..The conservation of p38 MAP kinase signaling in both stress and immune responses further encourages exploring the function of GLA and SDA in humans. ..
  81. Maro G, Klassen M, Shen K. A beta-catenin-dependent Wnt pathway mediates anteroposterior axon guidance in C. elegans motor neurons. PLoS ONE. 2009;4:e4690 pubmed publisher
    ..Together, our data provide evidence that Wnt-mediated axon guidance can be transduced through a beta-catenin-dependent pathway. ..
  82. Bessler J, Andersen E, Villeneuve A. Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line. PLoS Genet. 2010;6:e1000830 pubmed publisher
    ..Further, these and other data support a model in which these two modifications function independently in adult C. elegans germ cells...
  83. Stadler M, Fire A. Wobble base-pairing slows in vivo translation elongation in metazoans. RNA. 2011;17:2063-73 pubmed publisher
    ..These data support a model in which ribosomal translocation is slowed at wobble codon positions. ..
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