Genomes and Genes
Experts and Doctors on axons in New York, United States
Locale: New York, United States
Publications238 found, 100 shown here
- Marcus R, Blazeski R, Godement P, Mason C. Retinal axon divergence in the optic chiasm: uncrossed axons diverge from crossed axons within a midline glial specialization. J Neurosci. 1995;15:3716-29 pubmed..These results demonstrate that retinal axons diverge within a cellular specialization centered around the midline of the developing optic chiasm, consistent with the hypothesis that cues for divergence are located in this zone. ..
- Matise M, Lustig M, Sakurai T, Grumet M, Joyner A. Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord. Development. 1999;126:3649-59 pubmed
- Lu W, Bhasin M, Tsirka S. Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitis. J Neurosci. 2002;22:10781-9 pubmed..A temporally restricted attenuation of tPA activity could have therapeutic potential in the management of MS. ..
- Guerra C, Wada Y, Leick V, Bell A, Satir P. Cloning, localization, and axonemal function of Tetrahymena centrin. Mol Biol Cell. 2003;14:251-61 pubmed..This is the first demonstration of a specific centrin function associated with axonemal dynein. It suggests that centrin is a key regulatory protein for Tetrahymena axonemal Ca(2+) responses, including ciliary reversal or chemotaxis...
- Labrakakis C, Tong C, Weissman T, Torsney C, Macdermott A. Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat. J Physiol. 2003;549:131-42 pubmed..These fibres project to the superficial lamina of the dorsal horn where the receptors may function to modulate transmitter release near their central terminals. ..
- Kania A, Jessell T. Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions. Neuron. 2003;38:581-96 pubmed..These topographic projections are established, in part, through LIM homeodomain protein control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells. ..
- Cutforth T, Moring L, Mendelsohn M, Nemes A, Shah N, Kim M, et al. Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map. Cell. 2003;114:311-22 pubmed
- Witkovsky P, Stell W, Ishida A. Circuits and properties of signal transmission in the retina. J Neurophysiol. 2006;96:509-11 pubmed..J. Neurophysiol 36: 619-633, 1973. Naka K-I, Marmarelis PZ, and Chan RY. Morphological and functional identifications of catfish retinal neurons. III. Functional identification. J. Neurophysiol 38: 92-131, 1975...
- Baek M, Mann R. Lineage and birth date specify motor neuron targeting and dendritic architecture in adult Drosophila. J Neurosci. 2009;29:6904-16 pubmed publisher..Thus, although Drosophila uses a lineage-based method to generate leg motor neurons, individual lineages are not dedicated to generate neurons that target a single leg segment or muscle type. ..
- Veeranna -, Yang D, Lee J, Vinod K, Stavrides P, Amin N, et al. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol Aging. 2011;32:2016-29 pubmed publisher..Declining PP2A activity, therefore, can account for rising neurofilament phosphorylation in maturing brain, potentially compounding similar changes associated with adult-onset neurodegenerative diseases. ..
- Walker B, Hengst U, Kim H, Jeon N, Schmidt E, Heintz N, et al. Reprogramming axonal behavior by axon-specific viral transduction. Gene Ther. 2012;19:947-55 pubmed publisher..Together, these data identify a novel strategy to manipulate protein expression in axons, and provides a novel approach for using gene therapies for disorders of axonal function. ..
- Yang G, Parkhurst C, Hayes S, Gan W. Peripheral elevation of TNF-? leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2013;110:10306-11 pubmed publisher..These findings indicate that peripheral production of TNF-? is a key mediator of synaptic instability in the primary somatosensory cortex and may contribute to sensory and cognitive deficits seen in autoimmune diseases. ..
- Strotmann J, Conzelmann S, Beck A, Feinstein P, Breer H, Mombaerts P. Local permutations in the glomerular array of the mouse olfactory bulb. J Neurosci. 2000;20:6927-38 pubmed..These local permutations may reflect the developmental history of the glomeruli and are relevant for the construction of spatial odor maps. ..
- Chen S, Gil O, Ren Y, Zanazzi G, Salzer J, Hillman D. Neurotrimin expression during cerebellar development suggests roles in axon fasciculation and synaptogenesis. J Neurocytol. 2001;30:927-37 pubmed
- Liu K, Gray M, Otto S, Fetcho J, Beattie C. Mutations in deadly seven/notch1a reveal developmental plasticity in the escape response circuit. J Neurosci. 2003;23:8159-66 pubmed..Such plasticity may be key to the evolution of the startle responses in mammals, which use larger populations of neurons in circuits similar to those in the fish escape response. ..
- Tomoda T, Kim J, Zhan C, Hatten M. Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev. 2004;18:541-58 pubmed..Thus, our results demonstrate that the Unc51.1-containing protein complex governs axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. ..
- Watabe Uchida M, John K, Janas J, Newey S, Van Aelst L. The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron. 2006;51:727-39 pubmed..Our findings unveil a pathway linking the Rac activator DOCK7 to a microtubule regulatory protein and highlight the contribution of microtubule network regulation to axon development. ..
- Chang S, Zagha E, Kwon E, Ozaita A, Bobik M, Martone M, et al. Distribution of Kv3.3 potassium channel subunits in distinct neuronal populations of mouse brain. J Comp Neurol. 2007;502:953-72 pubmed..In this study, we identified additional populations and subcellular compartments that are likely to sustain high-frequency firing because of the expression of Kv3.3 and other Kv3 subunits. ..
- Mintz C, Carcea I, McNickle D, Dickson T, Ge Y, Salton S, et al. ERM proteins regulate growth cone responses to Sema3A. J Comp Neurol. 2008;510:351-66 pubmed publisher..Our data support a model in which ERMs can coordinate membrane and actin dynamics in response to Sema3A. ..
- Wang H, Tewari A, Einheber S, Salzer J, Melendez Vasquez C. Myosin II has distinct functions in PNS and CNS myelin sheath formation. J Cell Biol. 2008;182:1171-84 pubmed publisher..Our data indicate that the mechanisms regulating myelination in the peripheral and central nervous systems are distinct. ..
- Hoffman E, Mintz C, Wang S, McNickle D, Salton S, Benson D. Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons. Neuroscience. 2008;157:556-65 pubmed publisher..We find that ethanol does not alter axonal polarization, L1CAM-dependent axon outgrowth or branching, or L1CAM recycling in axonal growth cones. Thus, ethanol inhibition of L1CAM is highly dependent on neuronal context. ..
- Erickson Davis C, Faust P, Vonsattel J, Gupta S, Honig L, Louis E. "Hairy baskets" associated with degenerative Purkinje cell changes in essential tremor. J Neuropathol Exp Neurol. 2010;69:262-71 pubmed publisher..These data indicate that structural changes are not restricted to PCs in ET, and that other neurons within their functional network may be involved in its pathogenesis. ..
- Canetta S, Luca E, Pertot E, Role L, Talmage D. Type III Nrg1 back signaling enhances functional TRPV1 along sensory axons contributing to basal and inflammatory thermal pain sensation. PLoS ONE. 2011;6:e25108 pubmed publisher..Cumulatively, these results implicate Type III Nrg1 as a novel regulator of TRPV1 and a molecular mediator of nociceptive function. ..
- Wu X, Fu Y, Knott G, Lu J, Di Cristo G, Huang Z. GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons. J Neurosci. 2012;32:331-43 pubmed publisher..Therefore, GABA may regulate activity-dependent inhibitory synapse formation by coordinately eliminating certain nascent contacts while promoting the maturation of other nascent synapses. ..
- Ji S, Jaffrey S. Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification. Neuron. 2012;74:95-107 pubmed publisher..Thus, local translation functions as a mechanism by which coincident signals are converted into a retrograde signal that elicits a specific transcriptional response. ..
- Corty M, Tam J, Grueber W. Dendritic diversification through transcription factor-mediated suppression of alternative morphologies. Development. 2016;143:1351-62 pubmed publisher..This transcriptional hierarchy therefore acts to suppress alternative morphologies to diversify three distinct types of somatosensory neurons. ..
- Domènech Estévez E, Baloui H, MENG X, Zhang Y, Deinhardt K, Dupree J, et al. Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS. J Neurosci. 2016;36:4506-21 pubmed publisher..Together, these data demonstrate the role of Akt in regulatory mechanisms underlying axonal wrapping and myelination in the PNS. ..
- Mombaerts P, Wang F, Dulac C, Chao S, Nemes A, Mendelsohn M, et al. Visualizing an olfactory sensory map. Cell. 1996;87:675-86 pubmed..This genetic approach may be more broadly applied to visualize the development and plasticity of projections in the mammalian nervous system. ..
- Elder G, Friedrich V, Kang C, Bosco P, Gourov A, Tu P, et al. Requirement of heavy neurofilament subunit in the development of axons with large calibers. J Cell Biol. 1998;143:195-205 pubmed..These results demonstrate directly that unlike losing the NF-L or NF-M subunits, loss of NF-H has only a slight effect on NF number in axons. Yet NF-H plays a major role in the development of large diameter axons. ..
- Gibson M, Ingraham L, Dobrjansky A. Soluble factors guide gonadotropin-releasing hormone axonal targeting to the median eminence. Endocrinology. 2000;141:3065-71 pubmed..However, as with so many other redundancies in the reproductive system, it is unlikely that it is the only targeting factor, as bFGF knockout mice are reported to be reproductively competent...
- Cai D, Qiu J, Cao Z, McAtee M, Bregman B, Filbin M. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci. 2001;21:4731-9 pubmed..Thus, the switch from promotion to inhibition by myelin-MAG, which marks the developmental loss of regenerative capacity, is mediated by a developmentally regulated decrease in endogenous neuronal cAMP levels. ..
- Mintz C, Dickson T, Gripp M, Salton S, Benson D. ERMs colocalize transiently with L1 during neocortical axon outgrowth. J Comp Neurol. 2003;464:438-48 pubmed..Furthermore, these data suggest that there is a developmentally regulated switch in MCL function in the developing brain. ..
- Chang C, Adler C, Krause M, Clark S, Gertler F, Tessier Lavigne M, et al. MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol. 2006;16:854-62 pubmed..mig-10 and age-1 lipid signaling promote axon outgrowth; unc-34 and to a lesser extent mig-10 promote filopodia formation. Surprisingly, filopodia are largely dispensable for accurate axon guidance. ..
- Taveggia C, Thaker P, Petrylak A, Caporaso G, Toews A, Falls D, et al. Type III neuregulin-1 promotes oligodendrocyte myelination. Glia. 2008;56:284-93 pubmed..They also indicate that oligodendrocyte myelination, but not differentiation, is promoted by axonal NRG1, underscoring important differences in the control of myelination in the CNS and peripheral nervous system (PNS). ..
- Lee R, Petros T, Mason C. Zic2 regulates retinal ganglion cell axon avoidance of ephrinB2 through inducing expression of the guidance receptor EphB1. J Neurosci. 2008;28:5910-9 pubmed publisher..Our results demonstrate that Zic2 upregulates EphB1 expression and define a link between a transcription factor and expression of a guidance receptor protein essential for axon guidance at the vertebrate midline. ..
- Pocock R, Hobert O. Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans. Nat Neurosci. 2008;11:894-900 pubmed publisher..Similar genetic pathways may cause aberrant human brain development under hypoxic conditions. ..
- de Bivort B, Guo H, Zhong Y. Notch signaling is required for activity-dependent synaptic plasticity at the Drosophila neuromuscular junction. J Neurogenet. 2009;23:395-404 pubmed publisher..Last, we show that endogenous Notch is primarily expressed in the presynaptic cell bodies where its expression level is positively correlated with motor neuron activity. ..
- Shneider N, Brown M, Smith C, Pickel J, Alvarez F. Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival. Neural Dev. 2009;4:42 pubmed publisher..This provides a mouse model with which to explore the specific role of gamma-fusimotor activity in motor behaviors. ..
- Hall A, Lalli G. Rho and Ras GTPases in axon growth, guidance, and branching. Cold Spring Harb Perspect Biol. 2010;2:a001818 pubmed publisher..This article highlights the contribution of Rho and Ras GTPases to axonogenesis. ..
- Petros T, Bryson J, Mason C. Ephrin-B2 elicits differential growth cone collapse and axon retraction in retinal ganglion cells from distinct retinal regions. Dev Neurobiol. 2010;70:781-94 pubmed publisher..The detailed characterization of growth cone behavior in this study comprises an assay for the study of Eph signaling in RGCs, and provides insight into the phenomena of growth cone collapse and axon retraction in general. ..
- Rao M, Mohan P, Kumar A, Yuan A, Montagna L, Campbell J, et al. The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons. PLoS ONE. 2011;6:e17087 pubmed publisher..Based on observations that the Myo Va motor domain binds to intermediate filament (IF) proteins of several classes, Myo Va interactions with IFs may serve similar roles in organizing organelle topography in different cell types. ..
- Carmel J, Kimura H, Berrol L, Martin J. Motor cortex electrical stimulation promotes axon outgrowth to brain stem and spinal targets that control the forelimb impaired by unilateral corticospinal injury. Eur J Neurosci. 2013;37:1090-102 pubmed publisher..Thus, M1 electrical stimulation promotes increases in corticofugal axon length to multiple M1 targets. We propose the axon length change was driven by competition into an adaptive pattern resembling lost connections...
- Einheber S, Hannocks M, Metz C, Rifkin D, Salzer J. Transforming growth factor-beta 1 regulates axon/Schwann cell interactions. J Cell Biol. 1995;129:443-58 pubmed
- Yang X, Kuo Y, Devay P, Yu C, Role L. A cysteine-rich isoform of neuregulin controls the level of expression of neuronal nicotinic receptor channels during synaptogenesis. Neuron. 1998;20:255-70 pubmed..Thus, CRD-NRG appears to be both a necessary and a sufficient signal for the control of neuronal nAChR expression during synaptogenesis. ..
- Elder G, Friedrich V, Margita A, Lazzarini R. Age-related atrophy of motor axons in mice deficient in the mid-sized neurofilament subunit. J Cell Biol. 1999;146:181-92 pubmed..These studies argue that neurofilaments are necessary for the structural maintenance of some populations of axons during aging and that the NF-M subunit is especially critical. ..
- Akassoglou K, Kombrinck K, Degen J, Strickland S. Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury. J Cell Biol. 2000;149:1157-66 pubmed..tPA/plasmin-mediated fibrinolysis may be a widespread protective mechanism in neuroinflammatory pathologies. ..
- Yang X, Arber S, William C, Li L, Tanabe Y, Jessell T, et al. Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron. 2001;30:399-410 pubmed..Our results demonstrate that AChR expression is patterned in the absence of innervation, raising the possibility that similarly prepatterned muscle-derived cues restrict axon growth and initiate synapse formation. ..
- Ibanez Tallon I, Gorokhova S, Heintz N. Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus. Hum Mol Genet. 2002;11:715-21 pubmed..Comparison of the mouse model and the human data suggests that the degree of ciliary dysfunction is causally related to the severity of human PCD, particularly the presence of hydrocephalus. ..
- Del Punta K, Puche A, Adams N, Rodriguez I, Mombaerts P. A divergent pattern of sensory axonal projections is rendered convergent by second-order neurons in the accessory olfactory bulb. Neuron. 2002;35:1057-66 pubmed..Convergence of receptor type information in the olfactory bulb may represent a common design in olfactory systems. ..
- Wisco D, Anderson E, Chang M, Norden C, Boiko T, FOLSCH H, et al. Uncovering multiple axonal targeting pathways in hippocampal neurons. J Cell Biol. 2003;162:1317-28 pubmed..Instead, they were found to travel to the axon on a direct route. Therefore, our results suggest that multiple distinct pathways operate in hippocampal neurons to achieve axonal accumulation of membrane proteins. ..
- Qu J, Li X, Novitch B, Zheng Y, Kohn M, Xie J, et al. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003;23:7122-33 pubmed..PAK4-null embryos also had defects in proper folding of the caudal portion of the neural tube, suggesting an important role for PAK4 in neural tube development. ..
- Mehta N, Loria P, Hobert O. A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23. Genetics. 2004;166:1253-67 pubmed..We have thus defined separable activities of LIN-23 in two distinct processes, cell cycle control and axon patterning. We propose that LIN-23 targets distinct substrates for ubiquitination within each process. ..
- Rambukkana A. Mycobacterium leprae-induced demyelination: a model for early nerve degeneration. Curr Opin Immunol. 2004;16:511-8 pubmed..The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration. ..
- Sung Y, Chiu D, Ambron R. Activation and retrograde transport of protein kinase G in rat nociceptive neurons after nerve injury and inflammation. Neuroscience. 2006;141:697-709 pubmed..They also establish the association between protein kinase G, the induction of long-term hyperexcitability, and chronic pain in rodents. ..
- Zhang L, Gavin T, DeCaprio A, LoPachin R. Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons. Toxicol Sci. 2010;117:180-9 pubmed publisher..Given their critical role in cytoskeletal physiology, MAPs could represent a relevant target for the induction of gamma-diketone axonopathy. ..
- Jung H, LaCombe J, Mazzoni E, Liem K, Grinstein J, Mahony S, et al. Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron. 2010;67:781-96 pubmed publisher..Genome-wide analysis of Hoxc9 binding suggests that this mode of repression is mediated by direct interactions with Hox regulatory elements, independent of chromatin marks typically associated with repressed Hox genes. ..
- Louis E, Faust P, Ma K, Yu M, Cortes E, Vonsattel J. Torpedoes in the cerebellar vermis in essential tremor cases vs. controls. Cerebellum. 2011;10:812-9 pubmed publisher..These data further confirm the central role of the cerebellum in the underlying pathophysiology of this common neurological disorder. ..
- He J, Zhou R, Wu Z, Carrasco M, Kurshan P, Farley J, et al. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species. Proc Natl Acad Sci U S A. 2016;113:6029-34 pubmed publisher..Finally, we found that spectrin is capable of adopting a similar periodic organization in neurons of a variety of animal species, including Caenorhabditis elegans, Drosophila, Gallus gallus, Mus musculus, and Homo sapiens. ..
- Rodriguez I, Feinstein P, Mombaerts P. Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Cell. 1999;97:199-208 pubmed..The projection pattern is disrupted by deleting the coding region of VR2, but an unrelated seven-transmembrane protein, the odorant receptor M71, can partially substitute for VR2. ..
- Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, et al. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron. 2005;47:681-94 pubmed..These results indicate that levels of NRG1 type III, independent of axon diameter, provide a key instructive signal that determines the ensheathment fate of axons. ..
- Hara Y, Yakovleva T, Bakalkin G, Pickel V. Dopamine D1 receptors have subcellular distributions conducive to interactions with prodynorphin in the rat nucleus accumbens shell. Synapse. 2006;60:1-19 pubmed..They also indicate that dynorphin peptides have distributions that would enable their participation in modulation of DA release or D1R-mediated postsynaptic responses in Acb shell neurons. ..
- Bhat M, Rios J, Lu Y, Garcia Fresco G, Ching W, St Martin M, et al. Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron. 2001;30:369-83 pubmed..These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction. ..
- Seigel G, Lotery A, Kummer A, Bernard D, Greene N, Turmaine M, et al. Retinal pathology and function in a Cln3 knockout mouse model of juvenile Neuronal Ceroid Lipofuscinosis (batten disease). Mol Cell Neurosci. 2002;19:515-27 pubmed
- Shan W, Yoshida M, Wu X, Huntley G, Colman D. Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure. J Neurosci Res. 2002;69:292-304 pubmed..Our findings show that N-cadherin is likely to be a key factor in responsive synaptogenesis following status epilepticus, where it functions as a mediator of de novo synapse formation. ..
- Evans K, Gomes E, Reisenweber S, Gundersen G, Lauring B. Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing. J Cell Biol. 2005;168:599-606 pubmed..Using purified components, we also show that Spastin interacts directly with microtubules and is sufficient for severing. These studies suggest that defects in microtubule severing are a cause of axonal degeneration in human disease. ..
- Fuss S, Omura M, Mombaerts P. The Grueneberg ganglion of the mouse projects axons to glomeruli in the olfactory bulb. Eur J Neurosci. 2005;22:2649-54 pubmed
- Hofmeyer K, Maurel Zaffran C, Sink H, Treisman J. Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. Proc Natl Acad Sci U S A. 2006;103:11595-600 pubmed..We conclude that Liprin-alpha does not simply act by regulating LAR localization but also has LAR-independent functions. ..
- Ratcliffe E, Setru S, Chen J, Li Z, D Autréaux F, Gershon M. Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut. J Comp Neurol. 2006;498:567-80 pubmed..005); antibodies to DCC again blocked this preferential outgrowth (P < 0.05). These data suggest that netrins, which are expressed in the bowel, attract DCC-expressing vagal sensory axons. ..
- Salzer J, Brophy P, Peles E. Molecular domains of myelinated axons in the peripheral nervous system. Glia. 2008;56:1532-40 pubmed publisher..This domain organization is essential for action potential propagation by saltatory conduction and for the overall function and integrity of the axon. ..
- Wang M, Hood D, Cho J, Ghadiali Q, De Moraes C, De Moraes G, et al. Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography. Arch Ophthalmol. 2009;127:875-81 pubmed publisher..Local measures of RGC layer thickness can be obtained from fdOCT scans using a manual segmentation procedure, and these measures show qualitative agreement with visual field sensitivity. ..
- Marcucci F, Maier Balough E, Zou D, Firestein S. Exuberant growth and synapse formation of olfactory sensory neuron axonal arborizations. J Comp Neurol. 2011;519:3713-26 pubmed publisher..We hypothesize that exuberant branches and synapses are eliminated to achieve the mature pattern in a process likely to be regulated by neural activity. ..
- Rebsam A, Bhansali P, Mason C. Eye-specific projections of retinogeniculate axons are altered in albino mice. J Neurosci. 2012;32:4821-6 pubmed publisher..These results suggest that the defects in afferent targeting and activity-dependent refinement in the albino dLGN arise from RGC misspecification together with potential perturbations of early activity patterns in the albino retina...
- Kuwajima T, Yoshida Y, Takegahara N, Petros T, Kumanogoh A, Jessell T, et al. Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing. Neuron. 2012;74:676-90 pubmed publisher..These findings suggest a mechanism by which a complex of Sema6D, Nr-CAM, and Plexin-A1 at the chiasm midline alters the sign of Sema6D and signals Nr-CAM/Plexin-A1 receptors on RGCs to implement the contralateral RGC projection. ..
- Lee S, Zhang W, Ravi M, Weschenfelder M, Bastmeyer M, Levine J. Atypical protein kinase C and Par3 are required for proteoglycan-induced axon growth inhibition. J Neurosci. 2013;33:2541-54 pubmed publisher..These results suggest a model in which NG2 binding to neurons activates PKC? and modifies Par complex function. They also identify the Par complex as a novel therapeutic target for promoting axon regeneration after CNS injury. ..
- Fink A, Croce K, Huang Z, Abbott L, Jessell T, Azim E. Presynaptic inhibition of spinal sensory feedback ensures smooth movement. Nature. 2014;509:43-8 pubmed publisher..Our findings define the neural substrate of a genetically hardwired gain control system crucial for the smooth execution of movement. ..
- Kuwajima T, Mason C. Live or Die? Depends on Who You Are. Neuron. 2017;94:1043-1046 pubmed publisher..2017) and Norsworthy et al. (2017) implicate the transcription factor Sox11 as a key player after optic nerve injury-in DLK signaling of RGC cell death, and in RGC regeneration and survival but only in certain RGCs. ..
- Dodd J, Morton S, Karagogeos D, Yamamoto M, Jessell T. Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons. Neuron. 1988;1:105-16 pubmed..These observations provide evidence that axonal guidance and pathway selection in vertebrates may be regulated in part by the transient and selective expression of distinct surface glycoproteins on subsets of developing neurons. ..
- Volgyi B, Bloomfield S. Axonal neurofilament-H immunolabeling in the rabbit retina. J Comp Neurol. 2002;453:269-79 pubmed..These results thus support the idea that certain subtypes of amacrine and horizontal cells maintain true axons in the mammalian retina. ..
- Hempstead B, Salzer J. Neurobiology. A glial spin on neurotrophins. Science. 2002;298:1184-6 pubmed
- MELENDEZ VASQUEZ C, Carey D, Zanazzi G, Reizes O, Maurel P, Salzer J. Differential expression of proteoglycans at central and peripheral nodes of Ranvier. Glia. 2005;52:301-8 pubmed..These results indicate that the molecular composition and extracellular environment of the PNS and CNS nodes of Ranvier are significantly distinct. ..
- CAMPOS L, Chakrabarty S, Haque R, Martin J. Regenerating motor bridge axons refine connections and synapse on lumbar motoneurons to bypass chronic spinal cord injury. J Comp Neurol. 2008;506:838-50 pubmed..Our findings suggests that bridge motoneurons could be used by descending motor pathways as premotor interneurons to transmit neural signals to bypass a chronic spinal injury. ..
- Sillitoe R, Vogel M, Joyner A. Engrailed homeobox genes regulate establishment of the cerebellar afferent circuit map. J Neurosci. 2010;30:10015-24 pubmed publisher..In summary, our data suggest that En1/2 are master regulators of three-dimensional organization of the cerebellum and coordinately regulate morphology, patterned gene expression, and afferent topography. ..
- Yu W. Regulation of nitric oxide synthase expression in motoneurons following nerve injury. Dev Neurosci. 1997;19:247-54 pubmed..Since cell loss was most severe in the hypoglossal nucleus following nerve avulsion, it appears that prolonged expression of NOS at high levels may be neurotoxic. ..
- Elder G, Friedrich V, Pereira D, Tu P, Zhang B, Lee V, et al. Mice with disrupted midsized and heavy neurofilament genes lack axonal neurofilaments but have unaltered numbers of axonal microtubules. J Neurosci Res. 1999;57:23-32 pubmed..Thus in vivo rodent neurofilaments are obligate heteropolymers requiring NF-L plus either NF-M or NF-H to form a filamentous network. ..
- Yang X, Li W, Prescott E, Burden S, Wang J. DNA topoisomerase IIbeta and neural development. Science. 2000;287:131-4 pubmed..The defects in motor axon growth in IIbeta mutant mice resulted in a breathing impairment and death of the pups shortly after birth...
- Kania A, Johnson R, Jessell T. Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. Cell. 2000;102:161-73 pubmed..Thus, LIM homeodomain proteins act within motor neurons and cells that guide motor axons to establish the fidelity of a binary choice in axonal trajectory. ..
- Chen Z, Strickland S. Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve. J Cell Biol. 2003;163:889-99 pubmed..In mutant mice, after sciatic nerve crush, the axons showed impaired regeneration. These experiments demonstrate that laminin is an essential component for axon myelination and regeneration in the PNS. ..