Experts and Doctors on animals in Vermont, United States

Summary

Locale: Vermont, United States
Topic: animals

Top Publications

  1. D amico D, Druart M, Donnelly C. Behavior of Escherichia coli O157:H7 during the manufacture and aging of Gouda and stirred-curd Cheddar cheeses manufactured from raw milk. J Food Prot. 2010;73:2217-24 pubmed
    ..coli O157:H7 in Gouda or stirred-curd Cheddar cheese manufactured from raw milk contaminated with low levels of this pathogen. ..
  2. Sinclair P, Gorman N, Walton H, Bement W, Szakacs J, Gonzalez F, et al. Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone. Arch Biochem Biophys. 2000;384:383-90 pubmed
    ..Acetone was not an inducer of hepatic CYP1A2 in the wild-type mice. Although acetone is an inducer of CYP2E1, CYP1A2 appears to have the essential role in acetone-enhancement of uroporphyria. ..
  3. Qiao H, Prasada Rao H, Yang Y, Fong J, Cloutier J, Deacon D, et al. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nat Genet. 2014;46:194-9 pubmed publisher
    ..We suggest that SUMO and ubiquitin have antagonistic roles during meiotic recombination that are balanced to effect differential stabilization of recombination factors at crossover and non-crossover sites. ..
  4. Jacobs J, Sinclair P, Lambrecht R, Sinclair J, Jacobs N. Role of inducer binding in cytochrome P-450 IA2-mediated uroporphyrinogen oxidation. J Biochem Toxicol. 1990;5:193-9 pubmed
    ..We conclude that uroporphyrinogen oxidation is catalyzed by cytochrome P-450 that is free of inducer. ..
  5. Lambrecht R, Sinclair P, Gorman N, Sinclair J. Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2. Arch Biochem Biophys. 1992;294:504-10 pubmed
  6. Sinclair P, Walton H, Gorman N, Jacobs J, Sinclair J. Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes. Toxicol Appl Pharmacol. 1997;147:171-9 pubmed
    ..We conclude that URO accumulation in chick hepatocyte cultures is limited not only by the induction of CYP1A, but also by the stimulation of intracellular UROGEN oxidation. ..
  7. Jacobs J, Nichols C, Andrew A, Marek D, Wood S, Sinclair P, et al. Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol. 1999;157:51-9 pubmed
    ..These results suggest that, in rat hepatocytes, elevated levels of HO alone are not responsible for arsenite-mediated decreases in CYP. ..
  8. White S, Jefferson E, Levy J. Impact of publicly sponsored neutering programs on animal population dynamics at animal shelters: the New Hampshire and Austin experiences. J Appl Anim Welf Sci. 2010;13:191-212 pubmed publisher
    ..Prospective studies should determine the effectiveness and affordability of different models for funding and delivering neutering services. ..
  9. Woloshin S, Schwartz L, Casella S, Kennedy A, Larson R. Press releases by academic medical centers: not so academic?. Ann Intern Med. 2009;150:613-8 pubmed
    ..Press releases from academic medical centers often promote research that has uncertain relevance to human health and do not provide key facts or acknowledge important limitations. National Cancer Institute. ..

More Information

Publications17

  1. Combelles C, Holick E, Paolella L, Walker D, Wu Q. Profiling of superoxide dismutase isoenzymes in compartments of the developing bovine antral follicles. Reproduction. 2010;139:871-81 pubmed publisher
    ..These results lay the ground for future investigations into the potential regulation and roles of antioxidants during folliculogenesis and oogenesis. ..
  2. John Lin C, Yu K, Hatcher A, Huang T, Lee H, Carlson J, et al. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017;20:396-405 pubmed publisher
    ..These populations selectively contribute to synaptogenesis and tumor pathophysiology, providing a blueprint for understanding diverse astrocyte contributions to neurological disease...
  3. Hildick Smith G, Downey M, Gretebeck L, Gersten R, Sandwick R. Ribose 5-phosphate glycation reduces cytochrome c respiratory activity and membrane affinity. Biochemistry. 2011;50:11047-57 pubmed publisher
    ..Collectively, these results demonstrate the negative impact that R5P glycation can have on critical electron transfer and membrane association functions of cyt c. ..
  4. Skinner S, Deleault K, Fecteau R, Brooks S. Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element. J Biol Chem. 2008;283:3191-9 pubmed
    ..It is unclear at this time if ARE-binding protein(s) directly interact with the TAP-NxT1 complex, if each complex is independently targeted by ERK1, or if only one complex is targeted...
  5. Ward J, Reinholdt L, Motley W, Niswander L, Deacon D, Griffin L, et al. Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. PLoS Genet. 2007;3:e139 pubmed
    ..The cloning and characterization of the mei4 allele of Hei10 demonstrates a novel link between cell cycle regulation and mismatch repair during prophase I. ..
  6. Shukla A, Barrett T, Nakayama K, Nakayama K, Mossman B, Lounsbury K. Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. FASEB J. 2006;20:997-9 pubmed
    ..These data reveal a potentially important link between asbestos signaling and integrity of the extracellular matrix (ECM) that likely contributes to asbestos-induced lung remodeling and diseases. ..
  7. Allen G, Bates J. Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury. J Appl Physiol (1985). 2004;96:293-300 pubmed
    ..001). We conclude that the effects of DIs in acute lung injury depend on the degree of lung injury but only to the extent that this injury reflects a disruption of the air-liquid interface...
  8. Spatafora G, Rohrer K, Barnard D, Michalek S. A Streptococcus mutans mutant that synthesizes elevated levels of intracellular polysaccharide is hypercariogenic in vivo. Infect Immun. 1995;63:2556-63 pubmed
    ..The coordinate expression of GlgC and GlgA along with the results of ongoing nucleotide sequence analysis and Northern hybridization experiments support an operon-like arrangement for the glg genes of this oral pathogen...