Experts and Doctors on analysis of variance in California, United States

Summary

Locale: California, United States
Topic: analysis of variance

Top Publications

  1. Keshet G, Tolwani R, Trejo A, Kraft P, Doyonnas R, Clayberger C, et al. Increased host neuronal survival and motor function in BMT Parkinsonian mice: involvement of immunosuppression. J Comp Neurol. 2007;504:690-701 pubmed
    ..Further, they suggest that the immune system plays a role in the development of characteristics typical of PD. ..
  2. Zhang W, Buckmaster P. Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy. J Neurosci. 2009;29:7846-56 pubmed publisher
    ..These findings suggest dysfunction of the dentate basket cell circuit could contribute to hyperexcitability and seizures. ..
  3. Sultzer D, Gray K, Gunay I, Wheatley M, Mahler M. Does behavioral improvement with haloperidol or trazodone treatment depend on psychosis or mood symptoms in patients with dementia?. J Am Geriatr Soc. 2001;49:1294-300 pubmed
    ..In contrast, the presence of delusions in concert with behavioral disturbance does not necessarily predict greater behavioral improvement with haloperidol treatment than in subjects without signs of psychosis. ..
  4. Forde S, Thompson J, Bohannan B. Adaptation varies through space and time in a coevolving host-parasitoid interaction. Nature. 2004;431:841-4 pubmed
    ..We show that gene flow across a spatially structured landscape alters coevolution of parasitoids and their hosts and that the resulting patterns of adaptation can fluctuate in both space and time. ..
  5. Weber M, Chang W, Breier M, Ko D, Swerdlow N. Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation. Behav Pharmacol. 2008;19:786-95 pubmed publisher
    ..We conclude that the heritable pattern of greater PPI 'disruptability' by DA agonists in SD versus LE rats reflects differences in D2 but not D3 receptor-associated mechanisms. ..
  6. Gilpin N, Misra K, Herman M, Cruz M, Koob G, Roberto M. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biol Psychiatry. 2011;69:1091-9 pubmed publisher
    ..Gamma-aminobutyric acid neurons in the CeA likely constitute a major point of convergence for neuromodulator systems recruited during the transition to alcohol dependence. ..
  7. Santhanam G, Yu B, Gilja V, Ryu S, Afshar A, Sahani M, et al. Factor-analysis methods for higher-performance neural prostheses. J Neurophysiol. 2009;102:1315-30 pubmed publisher
    ..We propose that FA-based methods are effective in modeling correlated trial-to-trial neural variability and can be used to substantially increase overall prosthetic system performance. ..
  8. Whitfield T, Schlosburg J, Wee S, Gould A, George O, Grant Y, et al. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci. 2015;35:4296-305 pubmed publisher
  9. Lyons D, Parker K, Zeitzer J, Buckmaster C, Schatzberg A. Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormone. Biol Psychiatry. 2007;62:1171-4 pubmed
    ..68, p = .010). These findings support clinical reports that small hippocampi may be a risk factor for impaired regulation of the hypothalamic-pituitary-adrenal axis in humans with stress-related psychiatric disorders. ..

More Information

Publications91

  1. Gaudry Q, Kristan W. Behavioral choice by presynaptic inhibition of tactile sensory terminals. Nat Neurosci. 2009;12:1450-7 pubmed publisher
    ..These results indicate that feeding predominates behaviors by using serotonin at an early stage of sensory processing, namely on presynaptic terminals of mechanosensory neurons. ..
  2. Assisi C, Stopfer M, Laurent G, Bazhenov M. Adaptive regulation of sparseness by feedforward inhibition. Nat Neurosci. 2007;10:1176-84 pubmed
    ..This simple adaptive mechanism could maintain the sparseness of sensory representations across wide ranges of stimulus conditions. ..
  3. Codeluppi S, Svensson C, Hefferan M, Valencia F, Silldorff M, Oshiro M, et al. The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. J Neurosci. 2009;29:1093-104 pubmed publisher
  4. Belichenko N, Belichenko P, Li H, Mobley W, Francke U. Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. J Comp Neurol. 2008;508:184-95 pubmed publisher
    ..These observations provide the underpinning for studies to further define microarchitectural and physiological consequences of MECP2 deficiency. ..
  5. Cabrales P, Han G, Nacharaju P, Friedman A, Friedman J. Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide. Am J Physiol Heart Circ Physiol. 2011;300:H49-56 pubmed publisher
    ..Based on the observed physiological properties, NO-np has clear potential as a therapeutic agent to replenish NO in situations where NO production is impaired, insufficient, or consumed, thereby preventing vascular complications. ..
  6. Hao Y, Martin Fardon R, Weiss F. Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence. Biol Psychiatry. 2010;68:240-8 pubmed publisher
    ..The differential behavioral effects of LY379268 and MTEP in rats with a history of long access to cocaine have implications for the treatment target potential of mGluR2/3 and mGluR5. ..
  7. Lyons D, Martel F, Levine S, Risch N, Schatzberg A. Postnatal experiences and genetic effects on squirrel monkey social affinities and emotional distress. Horm Behav. 1999;36:266-75 pubmed
    ..These findings concur with human twin studies that suggest genetic and experiential factors contribute to individual differences in vulnerability to emotional distress. ..
  8. Munhoz C, Sorrells S, Caso J, Scavone C, Sapolsky R. Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner. J Neurosci. 2010;30:13690-8 pubmed publisher
    ..These findings suggest that GCs do not uniformly suppress neuroinflammation and can even enhance it at multiple levels in the pathway linking LPS exposure to inflammation. ..
  9. Bansal V, Costantini T, Ryu S, Peterson C, Loomis W, Putnam J, et al. Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma. 2010;68:1059-64 pubmed publisher
    ..Furthermore, vagal stimulation increased enteric glial activity and may represent the pathway for central nervous system regulation of intestinal permeability. ..
  10. Mosher K, Andres R, Fukuhara T, Bieri G, Hasegawa Moriyama M, He Y, et al. Neural progenitor cells regulate microglia functions and activity. Nat Neurosci. 2012;15:1485-7 pubmed publisher
    ..Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity. ..
  11. Broadbent N, Gaskin S, Squire L, Clark R. Object recognition memory and the rodent hippocampus. Learn Mem. 2010;17:5-11 pubmed publisher
    ..Hippocampal lesions produced moderate and reliable memory impairment. The results suggest that the hippocampus is important for object recognition memory. ..
  12. Keller J, Flores B, Gomez R, Solvason H, Kenna H, Williams G, et al. Cortisol circadian rhythm alterations in psychotic major depression. Biol Psychiatry. 2006;60:275-81 pubmed
  13. Sidhpura N, Weiss F, Martin Fardon R. Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence. Biol Psychiatry. 2010;67:804-11 pubmed publisher
  14. Schiltz J, Sawchenko P. Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults. J Comp Neurol. 2007;502:455-67 pubmed
    ..Residual Fos induction seen in lesioned animals in response to higher doses of LPS provides a basis for probing additional circuits that may be recruited in a hierarchical manner in response to more strenuous or complex immune insults. ..
  15. Goyal R, Longo L. Gene expression in sheep carotid arteries: major changes with maturational development. Pediatr Res. 2012;72:137-46 pubmed
    ..In this study, we tested the hypothesis that the profound developmental and age-related differences in cerebral blood flow are associated with significant underlying changes in gene expression...
  16. Sullivan E, Rohlfing T, Pfefferbaum A. Longitudinal study of callosal microstructure in the normal adult aging brain using quantitative DTI fiber tracking. Dev Neuropsychol. 2010;35:233-56 pubmed publisher
  17. Paneda C, Huitron Resendiz S, Frago L, Chowen J, Picetti R, de Lecea L, et al. Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. J Neurosci. 2009;29:4155-61 pubmed publisher
    ..Our results suggest that NPS receptors may be an important target for drug abuse research and treatment and that CRF(1) mediates the cocaine-seeking and locomotor stimulant effects of NPS, but not its effects on anxiety-like behavior...
  18. Buckmaster P, Lew F. Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J Neurosci. 2011;31:2337-47 pubmed publisher
    ..These findings are consistent with the hypotheses that hilar neuron loss and ectopic granule cells might contribute to temporal lobe epileptogenesis. ..
  19. Tyagi N, Lewis J, Yashar C, Vo D, Jiang S, Mundt A, et al. Daily online cone beam computed tomography to assess interfractional motion in patients with intact cervical cancer. Int J Radiat Oncol Biol Phys. 2011;80:273-80 pubmed publisher
    ..0001). Interfraction motion results in a high probability of missing the CTV using conventional planning margins, but the volume of CTV missed is small. Adaptive radiotherapy approaches are needed to improve treatment accuracy. ..
  20. Yoshioka H, Niizuma K, Katsu M, Sakata H, Okami N, Chan P. Consistent injury to medium spiny neurons and white matter in the mouse striatum after prolonged transient global cerebral ischemia. J Neurotrauma. 2011;28:649-60 pubmed publisher
    ..This model can be highly applicable for elucidating molecular mechanisms in the brain after global ischemia. ..
  21. Land B, Narayanan N, Liu R, Gianessi C, Brayton C, Grimaldi D, et al. Medial prefrontal D1 dopamine neurons control food intake. Nat Neurosci. 2014;17:248-53 pubmed publisher
    ..Finally, photostimulating these axons in the mBLA is sufficient to increase feeding, recapitulating the effects of mPFC D1 stimulation. These data describe a new circuit for top-down control of food intake. ..
  22. Zahr N, Mayer D, Rohlfing T, Hasak M, Hsu O, Vinco S, et al. Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy. Biol Psychiatry. 2010;67:846-54 pubmed publisher
    ..Rapid recovery of ventricular volume and metabolite levels with removal of the causative agent argues for transient rather than permanent effects of a single EtOH binge episode in rats. ..
  23. Pangratz Fuehrer S, Hestrin S. Synaptogenesis of electrical and GABAergic synapses of fast-spiking inhibitory neurons in the neocortex. J Neurosci. 2011;31:10767-75 pubmed publisher
    ..Together, our results suggest that chemical and electrical connections among FS cells can contribute to patterned neocortical activity only by the end of the first postnatal week. ..
  24. McGranahan T, Patzlaff N, Grady S, Heinemann S, Booker T. ?4?2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. J Neurosci. 2011;31:10891-902 pubmed publisher
    ..This is the first work to develop a dopaminergic specific deletion of a nAChR subunit and examine resulting changes in nicotine-related behaviors. ..
  25. Mysore S, Asadollahi A, Knudsen E. Signaling of the strongest stimulus in the owl optic tectum. J Neurosci. 2011;31:5186-96 pubmed publisher
  26. Marchetti F, Bishop J, Lowe X, Wyrobek A. Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide. Toxicol Sci. 2009;107:194-205 pubmed publisher
  27. Roth W, Wilhelm F, Trabert W. Voluntary breath holding in panic and generalized anxiety disorders. Psychosom Med. 1998;60:671-9 pubmed
    ..Our physiological results provide no direct support for an overly sensitive suffocation alarm system in PD. Lower pCO2 may be due to anxiety causing hyperventilation in patients prone to panic. ..
  28. Sorrells S, Caso J, Munhoz C, Hu C, Tran K, Miguel Z, et al. Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation. J Neurosci. 2013;33:7877-89 pubmed publisher
    ..Finally, GCs compromised neuron survival, an effect mediated by GR in myeloid and endothelial cells to a greater extent than by neuronal GR. ..
  29. Foltenyi K, Greenspan R, NEWPORT J. Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nat Neurosci. 2007;10:1160-7 pubmed
    ..These results suggest that sleep and its regulation by EGFR signaling may be ancestral to insects and mammals. ..
  30. Prestwood T, Morar M, Zellweger R, Miller R, May M, Yauch L, et al. Gamma interferon (IFN-?) receptor restricts systemic dengue virus replication and prevents paralysis in IFN-?/? receptor-deficient mice. J Virol. 2012;86:12561-70 pubmed publisher
    ..These results demonstrate the roles of IFN-?R signaling in protection from initial systemic and subsequent CNS disease following DENV infection and demonstrate the importance of CD8(+) T cells in preventing DENV-induced CNS disease...
  31. Brill J, Lee M, Zhao S, Fernald R, Huguenard J. Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami. J Neurosci. 2006;26:6813-22 pubmed
    ..Chronic VPA treatment significantly potentiated the effect of BIBP3226 on oscillation duration but not on oscillation period. These results demonstrate a novel mechanism for the antiepileptic actions of chronic VPA therapy. ..
  32. Kim H, Raphael A, LADOW E, McGurk L, Weber R, Trojanowski J, et al. Therapeutic modulation of eIF2? phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nat Genet. 2014;46:152-60 pubmed publisher
    ..These findings indicate that the dysfunction induced by prolonged stress granule formation might contribute directly to ALS and that compounds that mitigate this process may represent a novel therapeutic approach. ..
  33. Boyer M, Compas B, Stanger C, Colletti R, Konik B, Morrow S, et al. Attentional biases to pain and social threat in children with recurrent abdominal pain. J Pediatr Psychol. 2006;31:209-20 pubmed
    ..Their attentional biases relate to individual differences in symptom severity. Implications for models of pediatric pain and future studies are discussed. ..
  34. Blechert J, Feige B, Joos A, Zeeck A, Tuschen Caffier B. Electrocortical processing of food and emotional pictures in anorexia nervosa and bulimia nervosa. Psychosom Med. 2011;73:415-21 pubmed publisher
    ..Conclusions Patients with eating disorders show a generalized attentional bias for food images, regardless of caloric value. This might explain the persistent preoccupation with food in these individuals. ..
  35. Li S, Zeng L, Feng L, Chen D. Rac1-dependent intracellular superoxide formation mediates vascular endothelial growth factor-induced placental angiogenesis in vitro. Endocrinology. 2010;151:5315-25 pubmed publisher
    ..This NADPH oxidase system appears to generate the second messenger superoxide that plays a critical role in the signaling control of the VEGF-induced placental angiogenesis. ..
  36. Chen C, Fernald R. Visual information alone changes behavior and physiology during social interactions in a cichlid fish (Astatotilapia burtoni). PLoS ONE. 2011;6:e20313 pubmed publisher
    ..Perhaps, while experiencing visual social stressors, the smaller male uses an opportunistic strategy, acting like a subordinate male while maintaining the physiology of a dominant male...
  37. Miyamoto T, Petrus M, Dubin A, Patapoutian A. TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. Nat Commun. 2011;2:369 pubmed publisher
    ..Our study demonstrates that activation of an ion channel can induce NOS-independent NO production in keratinocytes. ..
  38. Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger P, et al. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat Neurosci. 2005;8:279-87 pubmed
    ..1(L) that is important for modulating inward rectification. Taken together, these results suggest the cytoplasmic domains of Kir channels undergo structural changes to modulate gating and inward rectification. ..
  39. Amador Arjona A, Elliott J, Miller A, Ginbey A, Pazour G, Enikolopov G, et al. Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory. J Neurosci. 2011;31:9933-44 pubmed publisher
    ..This novel mouse model provides evidences that cognitive deficits associated with ciliary defects (ciliopathies) might be, in part, mediated by the deficiency of primary cilia in adult hippocampal stem/progenitor cells. ..
  40. Howlett R, Hogan M. Intracellular PO(2) decreases with increasing stimulation frequency in contracting single Xenopus muscle fibers. J Appl Physiol (1985). 2001;91:632-6 pubmed
    ..The linear decrease in intracellular PO(2) with stimulation frequency, and thus energy demand, suggests that a fall in intracellular PO(2) correlates with increased oxygen uptake in these single contracting cells...
  41. Hope T, Markl M, Wigström L, Alley M, Miller D, Herfkens R. Comparison of flow patterns in ascending aortic aneurysms and volunteers using four-dimensional magnetic resonance velocity mapping. J Magn Reson Imaging. 2007;26:1471-9 pubmed
    ..023), while in aneurysm patients the velocity increased (145 mm/second increase, P < 0.001). Dilation of the ascending aorta skews normal flow in the ascending aorta, changing retrograde and helical flow patterns. ..
  42. Philips G, Sherff C, Menges S, Carew T. The tail-elicited tail withdrawal reflex of Aplysia is mediated centrally at tail sensory-motor synapses and exhibits sensitization across multiple temporal domains. Learn Mem. 2011;18:272-82 pubmed publisher
    ..This preparation now provides an experimentally powerful system in which to directly examine the unique and combined roles of synaptic and nuclear signaling in different temporal domains of memory formation...
  43. Zhu Y, Colak T, Shenoy M, Liu L, Pai R, Li C, et al. Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis. Gastroenterology. 2011;141:370-7 pubmed publisher
    ..These findings emphasize a key role for NGF in pancreatic pain and highlight the role it plays in the modulation of TRPV1 expression and activity in CP. ..
  44. Fein G, Klein L, Finn P. Impairment on a simulated gambling task in long-term abstinent alcoholics. Alcohol Clin Exp Res. 2004;28:1487-91 pubmed
    ..The possibility is raised that alcoholics who cannot achieve long-term abstinence are even more impaired on their decision making and have more abnormal personality profiles than the abstinent alcoholics studied here. ..
  45. Subramaniam S, Hsiao G. Gene-expression measurement: variance-modeling considerations for robust data analysis. Nat Immunol. 2012;13:199-203 pubmed publisher
    ..However, analyses of the measurements have often ignored statistically robust methods that account for variance, resulting in misleading biological interpretations. ..
  46. Calabrese B, Halpain S. Essential role for the PKC target MARCKS in maintaining dendritic spine morphology. Neuron. 2005;48:77-90 pubmed
    ..Thus, MARCKS is a key factor in the maintenance of dendritic spines and contributes to PKC-dependent morphological plasticity. ..
  47. Li X, Masliah E, Reixach N, Buxbaum J. Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?. J Neurosci. 2011;31:12483-90 pubmed publisher
  48. Liu L, Kim J, Koike M, Yoon Y, Tang X, Ma H, et al. FasL shedding is reduced by hypothermia in experimental stroke. J Neurochem. 2008;106:541-50 pubmed publisher
    ..Hypothermia prevented total FasL decreases, and most of it remained membrane-bound. These findings reveal new observations regarding the effect of mild hypothermia on the Fas/FasL and MMP systems. ..
  49. Cummings D, Alaghband Y, Hickey M, Joshi P, Hong S, Zhu C, et al. A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease. J Neurophysiol. 2012;107:677-91 pubmed publisher
  50. Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb S, Lanfranco M, et al. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. J Neurosci. 2012;32:15124-32 pubmed publisher
  51. Char J, Dunn C, Davies Z, Milla C, Moss R, Wine J. The magnitude of ivacaftor effects on fluid secretion via R117H-CFTR channels: Human in vivo measurements. PLoS ONE. 2017;12:e0175486 pubmed publisher
    ..We conclude that in vivo, R117H PO is strongly increased by ivacaftor, but channel number, mainly determined by variable deletion of exon 10, has a marked influence on outcomes. ..
  52. Faustman W, Moses J, Ringo D, Newcomer J. Left-handedness in male schizophrenic patients is associated with increased impairment on the Luria-Nebraska Neuropsychological Battery. Biol Psychiatry. 1991;30:326-34 pubmed
    ..The findings suggest a unique interaction between left-handedness and neuropsychological impairment in schizophrenia and could support a relationship between left-handedness, early cerebral insult, and cognitive deficits. ..
  53. Chen J, Shah J, Harris J, Bui T, Schaberg K, Kong C, et al. Clinical Outcomes in Elderly Patients Treated for Oral Cavity Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2017;98:775-783 pubmed publisher
    ..ECOG and HN-CCI scores may be useful to evaluate the candidacy of elderly patients for adjuvant therapy. However, the benefit of adjuvant therapy in this population remains elusive and should be investigated prospectively. ..
  54. Contractor A, Sailer A, Darstein M, Maron C, Xu J, Swanson G, et al. Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice. J Neurosci. 2003;23:422-9 pubmed
    ..These results identify the KA2 subunit as a determinant of kainate receptor function at presynaptic and postsynaptic mossy-fiber kainate receptors. ..
  55. Owens E, Goodacre C, Loh P, Hanke G, Okamura M, Jo K, et al. A multicenter interracial study of facial appearance. Part 1: A comparison of extraoral parameters. Int J Prosthodont. 2002;15:273-82 pubmed
    ..Additional research with larger patient populations would be needed to confirm or refute these trends. ..
  56. Ehlers C, Spence J, Wall T, Gilder D, Carr L. Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California Indians. Alcohol Clin Exp Res. 2004;28:1481-6 pubmed
    ..Results from this study suggest that ALDH1A1*2 may be associated with protection from the development of alcohol and other substance use disorders. ..
  57. McCann R, Remington R, Van Selst M. A dual-task investigation of automaticity in visual word processing. J Exp Psychol Hum Percept Perform. 2000;26:1352-70 pubmed
    ..Either way, word processing is not as automatic as activation models suggest. ..
  58. KNOWLES J, Rajadas J, Nguyen T, Yang T, LeMieux M, Vander Griend L, et al. The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci. 2009;29:10627-37 pubmed publisher
  59. Dayas C, Liu X, Simms J, Weiss F. Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone. Biol Psychiatry. 2007;61:979-89 pubmed
    ..In addition, the data implicate the hippocampus, amygdala, and PVN as potential substrates for the inhibitory effects of NTX on conditioned reinstatement. ..
  60. Haditsch U, Leone D, Farinelli M, Chrostek Grashoff A, Brakebusch C, Mansuy I, et al. A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Mol Cell Neurosci. 2009;41:409-19 pubmed publisher
    ..Furthermore, Rac1 mutants display deficits in working/episodic-like memory in the delayed matching-to-place (DMP) task suggesting that Rac1 is a central regulator of rapid encoding of novel spatial information in vivo. ..
  61. Rissman R, Lee K, Vale W, Sawchenko P. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci. 2007;27:6552-62 pubmed
  62. Calfas K, Sallis J, Nichols J, Sarkin J, Johnson M, Caparosa S, et al. Project GRAD: two-year outcomes of a randomized controlled physical activity intervention among young adults. Graduate Ready for Activity Daily. Am J Prev Med. 2000;18:28-37 pubmed
    ..Additional research is needed to determine optimal interventions for physical activity and to validate or alter current behavior change theory. ..
  63. Donovan M, Paulino G, Raybould H. CCK(1) receptor is essential for normal meal patterning in mice fed high fat diet. Physiol Behav. 2007;92:969-74 pubmed
    ..These results suggest that the CCK(1)R is involved in regulating caloric intake on a meal to meal basis, but that other factors are responsible for regulation of daily food intake. ..
  64. Beraki S, Litrus L, Soriano L, Monbureau M, To L, Braithwaite S, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS ONE. 2013;8:e69233 pubmed publisher
  65. Lepage J, Hong D, MAZAIKA P, Raman M, Sheau K, Marzelli M, et al. Genomic imprinting effects of the X chromosome on brain morphology. J Neurosci. 2013;33:8567-74 pubmed publisher
  66. Khalifeh Soltani A, McKleroy W, Sakuma S, Cheung Y, Tharp K, Qiu Y, et al. Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med. 2014;20:175-83 pubmed publisher
    ..Collectively, our results imply a role for Mfge8 in regulating the absorption and storage of dietary fats, as well as in the development of obesity and its complications. ..
  67. Miller N, Lawson C, Chen X, Lim S, Schlaepfer D. Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins. PLoS ONE. 2012;7:e37830 pubmed publisher
    ..Rgnef-/- MEF phenotypes were rescued by epitope-tagged Rgnef re-expression. Rgnef-/- MEF phenotypes were due to Rgnef loss and support an essential role for Rgnef in RhoA regulation downstream of integrins in control of cell migration. ..
  68. Chen Q, Peto C, Shelton G, Mizisin A, Sawchenko P, Schubert D. Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration. J Neurosci. 2009;29:118-30 pubmed publisher
    ..These findings demonstrate that MOCA is required for maintaining the functional integrity of axons and define a model for the steps leading to axonal degeneration. ..
  69. Crews B, Wikoff W, Patti G, Woo H, Kalisiak E, Heideker J, et al. Variability analysis of human plasma and cerebral spinal fluid reveals statistical significance of changes in mass spectrometry-based metabolomics data. Anal Chem. 2009;81:8538-44 pubmed publisher
    ..These data demonstrate the reproducibility of the global metabolomics platform using LC/MS and reveal the robustness of the approach for biomarker discovery. ..
  70. Sullivan E, Rose J, Pfefferbaum A. Physiological and focal cerebellar substrates of abnormal postural sway and tremor in alcoholic women. Biol Psychiatry. 2010;67:44-51 pubmed publisher
    ..Reduction in sway and tremor with stabilizing factors indicate that adaptive mechanisms involving sensorimotor integration can be invoked to compensate for vermian-related dysfunction. ..
  71. Perry S, de Jong B, Solnick J, de la Luz Sanchez M, Yang S, Lin P, et al. Infection with Helicobacter pylori is associated with protection against tuberculosis. PLoS ONE. 2010;5:e8804 pubmed publisher
    ..That immunity to TB may be enhanced by exposure to other microbial agents may have important implications for vaccine development and disease control. ..
  72. Apostolova L, Beyer M, Green A, Hwang K, Morra J, Chou Y, et al. Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia. Mov Disord. 2010;25:687-95 pubmed publisher
    ..Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. ..
  73. Lee J, Gupta D, Panetta N, Levi B, James A, Wan D, et al. Elucidating mechanisms of osteogenesis in human adipose-derived stromal cells via microarray analysis. J Craniofac Surg. 2010;21:1136-41 pubmed publisher
    ..We plan to further exploit these data via in vitro treatment of hASCs with these soluble cytokines and in vivo translation using a nude mouse calvarial defect model. ..
  74. Akong Moore K, Chow O, von Köckritz Blickwede M, Nizet V. Influences of chloride and hypochlorite on neutrophil extracellular trap formation. PLoS ONE. 2012;7:e42984 pubmed publisher
    ..To better understand the roles of various ROS in NETosis, we explore the role of MPO, its substrates chloride ion (Cl(-)) and hydrogen peroxide (H(2)O(2)), and its product hypochlorite (HOCl) in NETosis...
  75. Dulawa S, Grandy D, Low M, Paulus M, Geyer M. Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci. 1999;19:9550-6 pubmed
    ..Hence, D4R-/- mice exhibit reductions in behavioral responses to novelty, reflecting a decrease in novelty-related exploration. ..
  76. Ohara P, Torabinejad M, Kettering J. Antibacterial effects of various endodontic medicaments on selected anaerobic bacteria. J Endod. 1993;19:498-500 pubmed
    ..A zone of inhibition was recorded for each plate and the results were analyzed statistically. Formocresol produced significantly larger zones of inhibition than any of the other medicaments...
  77. Sangha S, Chadick J, Janak P. Safety encoding in the basal amygdala. J Neurosci. 2013;33:3744-51 pubmed publisher
    ..These data demonstrate the presence of neurons in the basal amygdala that are selectively responsive to Safety Cues. Furthermore, these data suggest that safety and reward learning use overlapping mechanisms in the basal amygdala. ..
  78. Xing W, Pourteymoor S, Mohan S. Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway. Physiol Genomics. 2011;43:749-57 pubmed publisher
  79. Blaine K, Lambert J. Digestive retention times for Allen's swamp monkey and L'Hoest's monkey: data with implications for the evolution of cercopithecine digestive strategy. Integr Zool. 2012;7:183-91 pubmed publisher
    ..These data are consistent with the hypothesis that relatively lengthy retention times are a primitive trait for Cercopithecinae...
  80. McGregor R, Wu M, Barber G, Ramanathan L, Siegel J. Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level. J Neurosci. 2011;31:15455-67 pubmed publisher
    ..The current results also indicate that comparable and complementary specificities must exist in other arousal systems. ..
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