Genomes and Genes
Experts and Doctors on amino acid sequence in New York, United States
Locale: New York, United States
Topic: amino acid sequence
Publications730 found, 100 shown here
- Gu W, Roeder R. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell. 1997;90:595-606 pubmed..These results have significant implications regarding the molecular mechanisms of various acetyltransferase-containing transcriptional coactivators whose primary targets have been presumed to be histones. ..
- Tatsis Kotsidis I, Erlanger B. A1 adenosine receptor of human and mouse adipose tissues: cloning, expression, and characterization. Biochem Pharmacol. 1999;58:1269-77 pubmed..In both studies, cellular environment had no affect on binding characteristics. This conclusive evidence resolves earlier conflicting reports in the literature. ..
- Habelhah H, Shah K, Huang L, Burlingame A, Shokat K, Ronai Z. Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue. J Biol Chem. 2001;276:18090-5 pubmed..The newly identified substrate can be phosphorylated by JNK on amino acids 216 and 353, which contribute to heterogeneous nuclear ribonucleoprotein K mediated transcriptional activities. ..
- Mujtaba S, He Y, Zeng L, Farooq A, Carlson J, Ott M, et al. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell. 2002;9:575-86 pubmed
- Nikolaev A, Li M, Puskas N, Qin J, Gu W. Parc: a cytoplasmic anchor for p53. Cell. 2003;112:29-40 pubmed..These results reveal that Parc is a critical regulator in controlling p53 subcellular localization and subsequent function. ..
- Forouhar F, Lee I, Benach J, Kulkarni K, Xiao R, Acton T, et al. A novel NAD-binding protein revealed by the crystal structure of 2,3-diketo-L-gulonate reductase (YiaK). J Biol Chem. 2004;279:13148-55 pubmed..The free enzyme conformation is incompatible with NAD binding. His(44) is likely the catalytic residue of the enzyme. ..
- Mancia F, Shapiro L. ADAM and Eph: how Ephrin-signaling cells become detached. Cell. 2005;123:185-7 pubmed..In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease. ..
- Pan H, Che F, Peng B, Steiner D, Pintar J, Fricker L. The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study. J Neurochem. 2006;98:1763-77 pubmed
- Townley R, Shapiro L. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science. 2007;315:1726-9 pubmed..Unexpectedly, ATP binds without counterions, amplifying its electrostatic effects on a critical regulatory region where all three subunits converge. ..
- Glavy J, Krutchinsky A, Cristea I, Berke I, Boehmer T, Blobel G, et al. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Proc Natl Acad Sci U S A. 2007;104:3811-6 pubmed
- Chmielecki J, Peifer M, Viale A, Hutchinson K, Giltnane J, Socci N, et al. Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm. Genes Chromosomes Cancer. 2012;51:54-65 pubmed publisher..These data validate the ability of this targeted capture-sequencing approach to detect TK fusion events in small amounts of DNA extracted directly from patient samples. ..
- Yang X, Hubbard E, Carlson M. A protein kinase substrate identified by the two-hybrid system. Science. 1992;257:680-2 pubmed..Thus, the two-hybrid system, which is applicable to any cloned gene, can be used to detect physical interactions between protein kinases and functionally related substrate proteins. ..
- Hoffmann A, Chiang C, Oelgeschlager T, Xie X, Burley S, Nakatani Y, et al. A histone octamer-like structure within TFIID. Nature. 1996;380:356-9 pubmed..Together with analyses of native TFIID complexes and accompanying crystallographic studies, the results suggest that there is a histone octamer-like TAF complex within TFIID. ..
- Sanchez J, Murakami Y, Huberman J, Hurwitz J. Isolation, characterization, and molecular cloning of a protein (Abp2) that binds to a Schizosaccharomyces pombe origin of replication (ars3002). Mol Cell Biol. 1998;18:1670-81 pubmed..The null mutant was also sensitive to UV radiation, suggesting that Abp2 may play a role in regulating the cell cycle response to stress signals. ..
- Besset V, Rhee K, Wolgemuth D. The identification and characterization of expression of Pftaire-1, a novel Cdk family member, suggest its function in the mouse testis and nervous system. Mol Reprod Dev. 1998;50:18-29 pubmed
- Tortosa P, Logsdon L, Kraigher B, Itoh Y, Mandic Mulec I, Dubnau D. Specificity and genetic polymorphism of the Bacillus competence quorum-sensing system. J Bacteriol. 2001;183:451-60 pubmed..Some of the implications of these findings for the evolution and the mechanism of the quorum-sensing system are discussed. ..
- MacCallum D, Losada A, Kobayashi R, Hirano T. ISWI remodeling complexes in Xenopus egg extracts: identification as major chromosomal components that are regulated by INCENP-aurora B. Mol Biol Cell. 2002;13:25-39 pubmed..Apparently contradictory to the generally accepted model, we find that neither chromosome condensation nor chromosomal targeting of condensin is compromised when H3 phosphorylation is drastically reduced by depletion of INCENP-aurora B. ..
- Pajvani U, Du X, Combs T, Berg A, Rajala M, Schulthess T, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem. 2003;278:9073-85 pubmed..Combined, these results shed new light on the regulation of this complex protein and suggest a new model for in vivo activation of the protein, implicating a serum reductase activity. ..
- Wang W, Tereshko V, Boccuni P, MacGrogan D, Nimer S, Patel D. Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets. Structure. 2003;11:775-89 pubmed..Strikingly, phenotypic alterations resulting from point mutations or deletions in the mbt repeats of the related Drosophila SCM protein are clustered in and around the ligand binding pocket. ..
- Wang B, Zhao A, Novick R, Muir T. Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions. Mol Cell. 2014;53:929-40 pubmed publisher..Binding of agonist or inverse-agonist peptides results in twisting of the linker in different directions. These two observations provide a view of the molecular motions triggered by ligand binding in an intact membrane-bound RHK. ..
- Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell. 1991;64:1111-22 pubmed..The data suggest that mik1 and wee1 act cooperatively on cdc2, either directly as the inhibitory tyrosine kinase or as essential activators of that kinase. ..
- Gregor P, Sawadogo M, Roeder R. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev. 1990;4:1730-40 pubmed..The structure of different cDNA clones indicates that USF RNA is differentially spliced, and alternative exon usage may regulate the levels of functional USF protein. ..
- Hsu S, Lothstein L, Horwitz S. Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes. J Biol Chem. 1989;264:12053-62 pubmed..These findings suggest that differential overexpression of distinct mdr genes which encode unique P-glycoprotein isoforms is a possible mechanism for generating diversity in the multidrug-resistant phenotype. ..
- Thery C, Sharpe M, Batley S, Stern C, Gherardi E. Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development. Dev Genet. 1995;17:90-101 pubmed..Interestingly, c-met is often more closely associated with HGF1/MSP than with its known ligand, HGF/SF, raising the possibility that c-met expression may be induced by HGF1/MSP. ..
- Agarwal A, Mune T, Monder C, White P. NAD(+)-dependent isoform of 11 beta-hydroxysteroid dehydrogenase. Cloning and characterization of cDNA from sheep kidney. J Biol Chem. 1994;269:25959-62 pubmed..In humans, this gene is a candidate locus for the syndrome of apparent mineralocorticoid excess, a form of hypertension postulated to result from 11-HSD deficiency in mineralocorticoid target tissues. ..
- Fu Y, Cao Y, Hertzberg K, Grieninger G. Fibrinogen alpha genes: conservation of bipartite transcripts and carboxy-terminal-extended alpha subunits in vertebrates. Genomics. 1995;30:71-6 pubmed
- Martin M, Czajkowski C, Karlin A. The contributions of aspartyl residues in the acetylcholine receptor gamma and delta subunits to the binding of agonists and competitive antagonists. J Biol Chem. 1996;271:13497-503 pubmed..In these transitions, one possibility is that gammaAsp-174 and deltaAsp-180 move closer to bound agonist. ..
- Colgan J, Yuan H, Franke E, Luban J. Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization. J Virol. 1996;70:4299-310 pubmed..These results define the minimal CyPA-binding domain within Gag and provide insight into the mechanism by which CyPA is incorporated into HIV-1 virions. ..
- Georgescu M, Kirsch K, Akagi T, Shishido T, Hanafusa H. The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci U S A. 1999;96:10182-7 pubmed..We also propose that the molecular conformational changes induced by these mutations constitute the mechanism for PTEN inactivation. ..
- Imredy J, MacKinnon R. Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel. J Mol Biol. 2000;296:1283-94 pubmed..These results constrain the possible orientation of dendrotoxin with respect to the K(+) channel structure. We propose that dendrotoxin binds near the pore entryway but does not act as a physical plug. ..
- Chistoserdov A. Genetic analysis and complete nucleotide sequence of a 2-kb cryptic plasmid from the marine methylotroph Methylophaga thalassica S1. Plasmid. 2000;44:105-9 pubmed..Two smaller open reading frames (orf-1 and orf-2) encode transcriptionally coupled polypeptides of 123 and 101 amino acids (14,486 and 11,241 Da, respectively) with unknown biological function. ..
- Gilles F, Glenn M, Goy A, Remache Y, Zelenetz A. A novel gene STORP (STOmatin-Related Protein) is localized 2 kb upstream of the promyelocytic gene on chromosome 15q22. Eur J Haematol. 2000;64:104-13 pubmed..The function of STORP is unknown. Further study will focus on studying its potential role in red cell function and disorders. ..
- Min J, Yang H, Ivan M, Gertler F, Kaelin W, Pavletich N. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science. 2002;296:1886-9 pubmed..Although the beta sheet-like interactions contribute to the stability of the complex, the hydroxyproline contacts are central to the strict specificity characteristic of signaling. ..
- Lopez Molina L, Mongrand S, Kinoshita N, Chua N. AFP is a novel negative regulator of ABA signaling that promotes ABI5 protein degradation. Genes Dev. 2003;17:410-8 pubmed..Our results suggest that AFP attenuates ABA signals by targeting ABI5 for ubiquitin-mediated degradation in nuclear bodies. ..
- Fiser A, Sali A. Modeller: generation and refinement of homology-based protein structure models. Methods Enzymol. 2003;374:461-91 pubmed
- Choi Y, Konopka J. Accessibility of cysteine residues substituted into the cytoplasmic regions of the alpha-factor receptor identifies the intracellular residues that are available for G protein interaction. Biochemistry. 2006;45:15310-7 pubmed..Altogether, these results define the residues that are accessible to the G protein and provide an important structural framework for the interpretation of the role of Ste2 residues that function in G protein activation. ..
- Bozzacco L, Trumpfheller C, Siegal F, Mehandru S, Markowitz M, Carrington M, et al. DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes. Proc Natl Acad Sci U S A. 2007;104:1289-94 pubmed..Because of the consistency in eliciting CD8+ T cell responses, these data support the testing of alphaDEC-205 fusion mAb as a protein-based vaccine. ..
- Buxbaum J, Cai G, Chaste P, Nygren G, Goldsmith J, Reichert J, et al. Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:484-91 pubmed..Screening of PTEN mutations is warranted in patients with autism and pronounced macrocephaly, even in the absence of other features of PTEN-related tumor syndromes. ..
- Unson C. Expression of glucagon receptors in tetracycline-inducible HEK293S GnT1- stable cell lines: an approach toward purification of receptor protein for structural studies. Biopolymers. 2008;90:287-96 pubmed publisher..This report describes a feasible approach for the preparation of human GR and other family B GPCRs in the quantities required for structural studies. ..
- Xi Q, Wang Z, Zaromytidou A, Zhang X, Chow Tsang L, Liu J, et al. A poised chromatin platform for TGF-? access to master regulators. Cell. 2011;147:1511-24 pubmed publisher..In turn, Smad4 increases K18 acetylation to augment TRIM33-Smad2/3 binding. Thus, nodal effectors use the H3K9me3 mark as a platform to switch master regulators of stem cell differentiation from the poised to the active state. ..
- PERRON J, Dodd J. Structural distinctions in BMPs underlie divergent signaling in spinal neurons. Neural Dev. 2012;7:16 pubmed publisher..Moreover, since residue 48 in BMP7 and the corresponding residue in BMP2 are important for type II BMPR binding, our results provide a basis for a mechanistic understanding of the diverse activities of BMPs in spinal cord development. ..
- Suk H, Zhou C, Yang T, Zhu H, Yu R, Olabisi O, et al. Ablation of calcineurin A? reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. J Biol Chem. 2013;288:3477-88 pubmed publisher..These data also indicate that potentiated cAMP signaling pathway may provide an alternative molecular pathogenesis for the metabolic complications elicited by CsA in transplant patients. ..
- Setton E, March L, Nolan E, Jones T, Cho H, Wheeler W, et al. Expression and function of spineless orthologs correlate with distal deutocerebral appendage morphology across Arthropoda. Dev Biol. 2017;430:224-236 pubmed publisher..These data suggest that ss may be a flagellar (distal antennal) determinant more broadly, and that this function was acquired at the base of Mandibulata. ..
- Griff I, Schekman R, Rothman J, Kaiser C. The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein. J Biol Chem. 1992;267:12106-15 pubmed..The interaction between Sec17p and Sec18p requires an activity provided by yeast membranes, and this putative membrane receptor activity is not extracted by high salt treatment of membranes. ..
- Cai L, Harris W, Marshak D, Gross J, Crabb J. Structural analysis of bovine pancreatic thread protein. J Protein Chem. 1990;9:623-32 pubmed..The present results provide a firm protein base for ongoing molecular, physical-chemical, and structure-function studies of this unusual protein. ..
- Speiser P, White P. Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex. DNA. 1989;8:745-51 pubmed
- Bardin C, Gunsalus G, Musto N, Cheng C, Reventos J, Smith C, et al. Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors. J Steroid Biochem. 1988;30:131-9 pubmed..We conclude that the "extracellular steroid binding proteins" and steroid receptors do not appear to have descended from a common ancestor. ..
- Yen S, Kenessey A, Lee S, Dickson D. The distribution and biochemical properties of a Cdc2-related kinase, KKIALRE, in normal and Alzheimer brains. J Neurochem. 1995;65:2577-84 pubmed..The results indicate that in CNS, the KKIALRE protein is mainly a glial protein that is up-regulated in gliosis and that it probably plays no role in the hyperphosphorylation of tau in AD brains. ..
- Gangloff S, McDonald J, Bendixen C, Arthur L, Rothstein R. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol Cell Biol. 1994;14:8391-8 pubmed
- Zhong Z, Wen Z, Darnell J. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994;264:95-8 pubmed..Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface. ..
- Lam H, Dragan L, Tsou H, Merk H, Peacocke M, Goerz G, et al. Molecular basis of variegate porphyria: a de novo insertion mutation in the protoporphyrinogen oxidase gene. Hum Genet. 1997;99:126-9 pubmed..These data establish that a frameshift mutation in PPO is the underlying mutation in this patient with VP and explain the sporadic occurrence of the phenotype in this family. ..
- Binley J, Arshad H, Fouts T, Moore J. An investigation of the high-avidity antibody response to glycoprotein 120 of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 1997;13:1007-15 pubmed..As most broadly neutralizing anti-gp120 antibodies recognize discontinuous epitopes, this skewing effect must be taken into account when interpreting studies using polyclonal sera. ..
- Routhier E, Bruenn J. Functions of conserved motifs in the RNA-dependent RNA polymerase of a yeast double-stranded RNA virus. J Virol. 1998;72:4427-9 pubmed..The results help define the conserved regions of the RDRP involved in polymerase function and those essential for other reasons...
- Cutforth T, Gaul U. A methionine aminopeptidase and putative regulator of translation initiation is required for cell growth and patterning in Drosophila. Mech Dev. 1999;82:23-8 pubmed..These results provide genetic evidence for post-transcriptional control in the development of multicellular organisms. ..
- Dhalluin C, Carlson J, Zeng L, He C, Aggarwal A, Zhou M. Structure and ligand of a histone acetyltransferase bromodomain. Nature. 1999;399:491-6 pubmed..Thus, the bromodomain is functionally linked to the HAT activity of co-activators in the regulation of gene transcription...
- Martin Serrano J, Li K, Bieniasz P. Cyclin T1 expression is mediated by a complex and constitutively active promoter and does not limit human immunodeficiency virus type 1 Tat function in unstimulated primary lymphocytes. J Virol. 2002;76:208-19 pubmed..These results strongly suggest that CycT1 expression levels in unstimulated primary lymphocytes do not profoundly limit HIV-1 gene expression or provide an adequate mechanistic explanation for proviral latency in vivo. ..
- Kidd S, Lieber T. Furin cleavage is not a requirement for Drosophila Notch function. Mech Dev. 2002;115:41-51 pubmed..We further show that the behaviour of fly and mouse N can be interchanged simply by swapping the regions in which the mammalian furin-like cleavage site is located. ..
- Stein J, Broihier H, Moore L, Lehmann R. Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila. Development. 2002;129:3925-34 pubmed
- Marenda D, Zraly C, Feng Y, Egan S, Dingwall A. The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex. Mol Cell Biol. 2003;23:289-305 pubmed
- Zhang H, Yang Z, Shen Y, Tong L. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science. 2003;299:2064-7 pubmed..Mutagenesis and kinetic studies reveal the functional roles of conserved residues here. The herbicides target the active site of CT, providing a lead for inhibitor development against human ACCs. ..
- Huang L, Hung L, Odell M, Yokota H, Kim R, Kim S. Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii. J Struct Funct Genomics. 2002;2:121-7 pubmed..Preliminary biochemical experiments show that MJ0882 specifically binds to AdoMet, which is the essential co-factor for methyltransferases...
- Ye K, Malinina L, Patel D. Recognition of small interfering RNA by a viral suppressor of RNA silencing. Nature. 2003;426:874-8 pubmed..Our structure provides an illustration of siRNA sequestering by a viral protein...
- Zimmerman S, Tran P, Daga R, Niwa O, Chang F. Rsp1p, a J domain protein required for disassembly and assembly of microtubule organizing centers during the fission yeast cell cycle. Dev Cell. 2004;6:497-509 pubmed
- Wu P, Ma D, Pierzchala M, Wu J, Yang L, Mai X, et al. The Drosophila acetylcholine receptor subunit D alpha5 is part of an alpha-bungarotoxin binding acetylcholine receptor. J Biol Chem. 2005;280:20987-94 pubmed..A peptide-specific antibody raised against the D alpha5 subunit provides further evidence that this subunit is a component of an alpha-bungarotoxin binding nicotinic acetylcholine receptor from the central nervous system of Drosophila. ..
- Rakeman A, Anderson K. Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching. Development. 2006;133:3075-83 pubmed..Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo. ..
- Janzen C, Hake S, Lowell J, Cross G. Selective di- or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei. Mol Cell. 2006;23:497-507 pubmed..We propose that DOT1A and DOT1B influence the trypanosome cell cycle by regulating the degree of H3K76 methylation. ..
- Yaddanapudi K, Palacios G, Towner J, Chen I, Sariol C, Nichol S, et al. Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses. FASEB J. 2006;20:2519-30 pubmed publisher..In contrast, only rhesus T cells were sensitive to REBOV peptides. These findings are consistent with the observation that REBOV is not pathogenic in humans and have implications for understanding the pathogenesis of filoviral HF...
- Trotman L, Wang X, Alimonti A, Chen Z, Teruya Feldstein J, Yang H, et al. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell. 2007;128:141-56 pubmed
- Anastassopoulou C, Ketas T, Depetris R, Thomas A, Klasse P, Moore J. Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41. Virology. 2011;413:47-59 pubmed publisher..Modeling the VCV inhibition data from the two cell types suggests that D101.12 discriminates between high- and low-VCV affinity forms of CCR5 less than D1/85.16, a resistant virus with three FP substitutions. ..
- Wu J, Park J, Dooley K, Cropek D, West A, Banta S. Rapid development of new protein biosensors utilizing peptides obtained via phage display. PLoS ONE. 2011;6:e24948 pubmed publisher..1±0.6 nM). These results demonstrate a simple and rapid platform for developing and assessing the performance of sensitive, peptide-based biosensors for new protein targets. ..
- Teplova M, Hafner M, Teplov D, Essig K, Tuschl T, Patel D. Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Genes Dev. 2013;27:928-40 pubmed publisher..Overall, our studies define principles underlying RNA target selection by STAR homodimers and provide insights into the post-transcriptional regulatory function of mammalian QKI proteins. ..
- Hynes M, Gitt M, Barondes S, Jessell T, Buck L. Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons. J Neurosci. 1990;10:1004-13 pubmed..5 on the same neurons, are consistent with the idea that carbohydrate-mediated interactions contribute to the development of this subset of mammalian neurons. ..
- Celenza J, Carlson M. Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein. Mol Cell Biol. 1989;9:5034-44 pubmed..C-terminal deletions of SNF1 also reduced dependence on SNF4. Our findings suggest that SNF4 acts as a positive effector of the kinase but does not serve a regulatory function in signaling glucose availability. ..
- Baxt B, Mason P. Foot-and-mouth disease virus undergoes restricted replication in macrophage cell cultures following Fc receptor-mediated adsorption. Virology. 1995;207:503-9 pubmed..Thus, macrophages can be infected with FMDV via FcR-mediated adsorption, and infection of these cells could contribute to pathology or provide a reservoir of infectious virus in carrier animals. ..
- Hsieh M, Hensley P, Brenowitz M, Fetrow J. A molecular model of the inducer binding domain of the galactose repressor of Escherichia coli. J Biol Chem. 1994;269:13825-35 pubmed
- Broccoli D, Chong L, Oelmann S, Fernald A, Marziliano N, van Steensel B, et al. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. Hum Mol Genet. 1997;6:69-76 pubmed..The TRF1 genes are not syntenic; the hTRF1 gene localized to human chromosome 8 band q13 while the mTRF1 gene localized to mouse chromosome 17 band E3. The data indicate that the genes for mammalian telomeric proteins evolve rapidly. ..
- Tiganis T, Flint A, Adam S, Tonks N. Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97. J Biol Chem. 1997;272:21548-57 pubmed
- Kretzschmar M, Doody J, Massague J. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature. 1997;389:618-22 pubmed..Thus, Smadl receives opposing regulatory inputs through RTKs and RS/TKs, and it is this balance that determines the level of Smad1 activity in the nucleus, and so possibly the role of Smad1 in the control of cell fate. ..
- Dai Q, Choy E, Chiu V, Romano J, Slivka S, Steitz S, et al. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998;273:15030-4 pubmed..Thus, the final enzyme in the sequence that modifies CAAX motifs is located in membranes topologically removed from the CAAX protein target membrane. ..
- Tai A, Chuang J, Sung C. Localization of Tctex-1, a cytoplasmic dynein light chain, to the Golgi apparatus and evidence for dynein complex heterogeneity. J Biol Chem. 1998;273:19639-49 pubmed..Distinct populations of dynein complexes are likely to exist, and such diversity may occur in part at the level of their light chain compositions. ..
- Zheng N, Fraenkel E, Pabo C, Pavletich N. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev. 1999;13:666-74 pubmed..E2F4 and DP2 interact through an extensive protein-protein interface, and structural features of this interface suggest it contributes to the preference for heterodimers over homodimers in DNA binding. ..
- Pucci M, Bao Y, Chan B, Itoh S, Lu R, Copeland N, et al. Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. Am J Physiol. 1999;277:R734-41 pubmed..These studies highlight the species-dependence of tissue expression and function of PGT and lay the groundwork for the use of the mouse as a model system for the study of PGT function. ..
- Chu T, Henrion G, Haegeli V, Strickland S. Cortex, a Drosophila gene required to complete oocyte meiosis, is a member of the Cdc20/fizzy protein family. Genesis. 2001;29:141-52 pubmed
- Chen I, Gotschlich E. ComE, a competence protein from Neisseria gonorrhoeae with DNA-binding activity. J Bacteriol. 2001;183:3160-8 pubmed publisher..Thus, we identified a novel gonococcal DNA-binding competence factor which is necessary for DNA uptake and does not affect pilus biogenesis or function...
- Liu H, Heath S, Sobin C, Roos J, Galke B, Blundell M, et al. Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc Natl Acad Sci U S A. 2002;99:3717-22 pubmed..Our results have implications for understanding the genetic basis of the 22q11-associated psychiatric phenotypes and provide further insights into the genomic instability of this region. ..
- Keller J, Smith P, Benach J, Christendat D, DeTitta G, Hunt J. The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase. Structure. 2002;10:1475-87 pubmed..Therefore, MT0146/CbiT probably functions as a precorrin methyltransferase and represents the first enzyme identified with this activity that does not have the canonical precorrin methyltransferase fold...
- Hong Y, Stanley P. Lec3 Chinese hamster ovary mutants lack UDP-N-acetylglucosamine 2-epimerase activity because of mutations in the epimerase domain of the Gne gene. J Biol Chem. 2003;278:53045-54 pubmed publisher..Lec3 mutants with no UDP-GlcNAc 2-epimerase activity represent sensitive hosts for characterizing disease-causing mutations in the human GNE gene that give rise to sialuria, hereditary inclusion body myopathy, and Nonaka myopathy...
- Faraldo Gómez J, Roux B. Electrostatics of ion stabilization in a ClC chloride channel homologue from Escherichia coli. J Mol Biol. 2004;339:981-1000 pubmed..Finally, it is shown that, in contrast to K-channels, and in analogy to the SBP/PBP sulfate/phosphate-binding proteins, the contribution of helix macrodipoles to chloride binding in EcClC is only marginal. ..
- Topper M, Luo Y, Zhadina M, Mohammed K, Smith L, Muesing M. Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication. J Virol. 2007;81:3012-7 pubmed..Although IN belongs to the very small set of nonhistone proteins modified by HAT-mediated activity, an obligate role for acetylation at the reactive CTD lysines in HIV-1 IN cannot be confirmed. ..
- Sawasdikosol S, Pyarajan S, Alzabin S, Matejovic G, Burakoff S. Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway. J Biol Chem. 2007;282:34693-9 pubmed..We speculate that this unique signaling pathway enables PGE(2) signals to engage a proven negative regulator of TCR signal transduction pathway and uses it to inhibit T cell activation. ..