Genomes and Genes
Experts and Doctors on amino acid sequence in Massachusetts, United States
Locale: Massachusetts, United States
Topic: amino acid sequence
Publications129 found, 100 shown here
- Xu X, Meiler S, Zhong T, Mohideen M, Crossley D, Burggren W, et al. Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nat Genet. 2002;30:205-9 pubmed..Absence of Titin function thus results in blockage of sarcomere assembly and causes a functional disorder resembling human dilated cardiomyopathies, one form of which is described in another paper in this issue. ..
- Chen N, Jiang S, Klein D, Paulus H. Organization and nucleotide sequence of the Bacillus subtilis diaminopimelate operon, a cluster of genes encoding the first three enzymes of diaminopimelate synthesis and dipicolinate synthase. J Biol Chem. 1993;268:9448-65 pubmed
- Arceci R, King A, Simon M, Orkin S, Wilson D. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993;13:2235-46 pubmed..On the basis of its tissue distribution, we speculate that GATA-4 plays a role in gene expression in the heart, intestinal epithelium, primitive endoderm, and gonads. ..
- Maheswaran S, Englert C, Zheng G, Lee S, Wong J, Harkin D, et al. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev. 1998;12:1108-20 pubmed..These observations indicate that Hsp70 is an important cofactor for the function of WT1, and suggest a potential role for this chaperone during kidney differentiation. ..
- Kao R, Morreale E, Wang L, Ivey F, Hoffman C. Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase. Genetics. 2006;173:49-61 pubmed..In addition, Git1 and adenylate cyclase physically interact and partially colocalize in the cell. Thus, Git1 is a critical component of the S. pombe glucose/cAMP pathway. ..
- Arystarkhova E, Wetzel R, Sweadner K. Distribution and oligomeric association of splice forms of Na(+)-K(+)-ATPase regulatory gamma-subunit in rat kidney. Am J Physiol Renal Physiol. 2002;282:F393-407 pubmed
- Song K, Krause C, Shi S, Patterson M, Suto R, Grgurevic L, et al. Identification of a key residue mediating bone morphogenetic protein (BMP)-6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity. J Biol Chem. 2010;285:12169-80 pubmed publisher..Introduction of a lysine residue at the corresponding positions of BMP-2 and BMP-7 allowed for molecular engineering of recombinant BMPs with increased resistance to noggin antagonism. ..
- Sims R, van der Lee S, Naj A, Bellenguez C, Badarinarayan N, Jakobsdottir J, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017;49:1373-1384 pubmed publisher..These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. ..
- Papastoitsis G, Siman R, Scott R, Abraham C. Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. Biochemistry. 1994;33:192-9 pubmed..Sequence analysis reveals high homology to the rat metallopeptidase EC 22.214.171.124, a protease involved in neuropeptide processing. ..
- Frand A, Kaiser C. Two pairs of conserved cysteines are required for the oxidative activity of Ero1p in protein disulfide bond formation in the endoplasmic reticulum. Mol Biol Cell. 2000;11:2833-43 pubmed..The Cys352-Cys355 disulfide could then serve to reoxidize the Cys100-Cys105 cysteine pair, possibly through an intramolecular thiol-disulfide exchange reaction. ..
- Meighan Mantha R, Tolan D. Noncoordinate changes in the steady-state mRNA expressed from aldolase A and aldolase C genes during differentiation of chicken myoblasts. J Cell Biochem. 1995;57:423-31 pubmed..This discordant expression indicates that the aldolase A and C genes may employ different regulatory mechanisms during myoblast differentiation. ..
- Bullitt E, Makowski L. Bacterial adhesion pili are heterologous assemblies of similar subunits. Biophys J. 1998;74:623-32 pubmed..A wide variety of data are considered in light of the possibility that all pilins are similar in molecular architecture, with specific differences designed to optimize their specialized functions in the pilus assembly...
- Evans D, Tillman K, Desrosiers R. Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor. J Virol. 2002;76:327-37 pubmed..Thus, PRA1 associates with envelope glycoproteins from widely divergent lentiviruses. ..
- Sengel C, Gavarini S, Sharma N, Ozelius L, Bragg D. Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain. J Neurochem. 2011;118:1087-100 pubmed publisher..These observations offer additional insight into the role of the coiled-coil domain in THAP1, which may facilitate future analyses of DYT6 mutations in this region. ..
- Bousché O, Spudich E, Spudich J, Rothschild K. Conformational changes in sensory rhodopsin I: similarities and differences with bacteriorhodopsin, halorhodopsin, and rhodopsin. Biochemistry. 1991;30:5395-400 pubmed..Bands are also detected in the C-H stretch region, possibly due to alterations in the membrane lipids. Similar spectral features are also observed in the lipids of rhodopsin-containing photoreceptor membrane upon light activation. ..
- Garcia Zepeda E, Rothenberg M, Ownbey R, Celestin J, Leder P, Luster A. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med. 1996;2:449-56 pubmed
- Zhu B, Ramachandran B, Gulick T. Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain. J Biol Chem. 2005;280:28749-60 pubmed..Thus, a conserved pattern of alternative splicing in vertebrate MEF2 genes generates an acidic activation domain in MEF2 proteins selectively in tissues where MEF2 target genes are highly expressed. ..
- Tori K, Cheriyan M, Pedamallu C, Contreras M, Perler F. The Thermococcus kodakaraensis Tko CDC21-1 intein activates its N-terminal splice junction in the absence of a conserved histidine by a compensatory mechanism. Biochemistry. 2012;51:2496-505 pubmed publisher..Consequently, inteins have more flexibility to sample catalytic mechanisms, providing insight into various strategies that enzymes use to accomplish catalysis...
- Ozkaynak E, Schnegelsberg P, Jin D, Clifford G, Warren F, Drier E, et al. Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem. 1992;267:25220-7 pubmed..OP-1 is expressed in kidney; however, OP-2 and BMP-2 mRNAs were not detected in any organs studied, suggesting an early developmental role. ..
- Shaw Lee R, Lissemore J, Sullivan D, Tolan D. Alternative splicing of fructose 1,6-bisphosphate aldolase transcripts in Drosophila melanogaster predicts three isozymes. J Biol Chem. 1992;267:3959-67 pubmed..Sequence comparisons of the alternative fourth exons indicate that the duplication leading to the multiple exons is quite old and preceded the origin of the genus Drosophila. ..
- Murthy S, Trimble J, Desrosiers R. Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation. J Virol. 1989;63:3307-14 pubmed..5 kilobases). Although some analogies can be drawn between STP and LMP (lymphocyte membrane protein) of Epstein-Barr virus, STP is not related in sequence to LMP...
- Swairjo M, Concha N, Kaetzel M, Dedman J, Seaton B. Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V. Nat Struct Biol. 1995;2:968-74 pubmed..Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo. ..
- Fusco C, Reymond A, Zervos A. Molecular cloning and characterization of a novel retinoblastoma-binding protein. Genomics. 1998;51:351-8 pubmed..Rim mRNA is expressed ubiquitously at low levels in all human adult tissues tested and at much higher levels in several tumor cell lines. The Rim gene (HGMW-approved symbol RBBP8) is localized on human chromosome 18q11.2. ..
- Stec B, Troxler R, Teeter M. Crystal structure of C-phycocyanin from Cyanidium caldarium provides a new perspective on phycobilisome assembly. Biophys J. 1999;76:2912-21 pubmed..This new role assigned to chromophore beta-155 in phycocyanin sheds light on the numerical relationships among and function of external chromophores found in phycoerythrins and phycoerythrocyanins. ..
- Champliaud M, Baden H, Koch M, Jin W, Burgeson R, Viel A. Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. Genomics. 2000;70:264-8 pubmed..Mouse sciellin was also identified in simple epithelia with barrier properties, lending further support to its importance in epithelial function. ..
- Sano T, Pandori M, Chen X, Smith C, Cantor C. Recombinant core streptavidins. A minimum-sized core streptavidin has enhanced structural stability and higher accessibility to biotinylated macromolecules. J Biol Chem. 1995;270:28204-9 pubmed..Apparently, the terminal regions, present on the surface of natural core streptavidin, spatially hinder biotinylated macromolecules from approaching the biotin binding sites. ..
- Gibbs J, Regier D, Desrosiers R. Construction and in vitro properties of SIVmac mutants with deletions in "nonessential" genes. AIDS Res Hum Retroviruses. 1994;10:333-42 pubmed
- Li S, Wang Q, Chakladar A, Bronson R, Bernards A. Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. Mol Cell Biol. 2000;20:697-701 pubmed..Thus, IQGAP1 does not serve any essential nonredundant functions during murine development but may serve to maintain the integrity of the gastric mucosa in older animals. ..
- Tori K, Perler F. The Arthrobacter species FB24 Arth_1007 (DnaB) intein is a pseudogene. PLoS ONE. 2011;6:e26361 pubmed publisher..This study restores the unity of the Class 3 intein signature sequence in active inteins by demonstrating that the Arsp-FB24 Arth_1007 intein is an inactive pseudogene...
- Schwaid A, Shannon D, Ma J, Slavoff S, Levin J, Weerapana E, et al. Chemoproteomic discovery of cysteine-containing human short open reading frames. J Am Chem Soc. 2013;135:16750-3 pubmed publisher..The discovery of additional human SEPs and their conservation indicate the potential importance of these molecules in biology. ..
- Brown K, Lawrence R, Sonenshein G. Concerted modulation of alpha 1(XI) and alpha 2(V) collagen mRNAs in bovine vascular smooth muscle cells. J Biol Chem. 1991;266:23268-73 pubmed..These results suggest concerted regulation of alpha 1(XI) and alpha 2(V) collagen gene expression, which is distinct from that for the chains of type I and type III collagen with respect to cell density and serum. ..
- Akiyoshi D, Denaro M, Zhu H, Greenstein J, Banerjee P, Fishman J. Identification of a full-length cDNA for an endogenous retrovirus of miniature swine. J Virol. 1998;72:4503-7 pubmed..The existence of these PERV clones will enable studies of infection by endogenous retroviruses in xenotransplantation. ..
- Martin S, Heinrich G, Sandell J. Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish. J Comp Neurol. 1998;396:253-66 pubmed..The zebrafish GAD65 and GAD67 are present in identified neurons in the forebrain, midbrain, hindbrain, and spinal cord, and they catalyze the production of GABA in the developing embryo. ..
- Champliaud M, Burgeson R, Jin W, Baden H, Olson P. cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope. J Biol Chem. 1998;273:31547-54 pubmed..Simple and columnar epithelia, with the exception of the amnion, showed no reaction. ..
- Libby R, Champliaud M, Claudepierre T, Xu Y, Gibbons E, Koch M, et al. Laminin expression in adult and developing retinae: evidence of two novel CNS laminins. J Neurosci. 2000;20:6517-28 pubmed
- Brown M, Begley G, Czerwiec E, Stenberg L, Jacobs M, Kalume D, et al. Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation. Biochemistry. 2005;44:9150-9 pubmed..It also provides the first formal evidence to prove that gamma-carboxylation occurs as a post-translational rather than a cotranslational process. ..
- Kuo L, Miller A, Lee S, Kozuma C. Site-directed mutagenesis of Escherichia coli ornithine transcarbamoylase: role of arginine-57 in substrate binding and catalysis. Biochemistry. 1988;27:8823-32 pubmed..The entropy of activation is -5.5 eu for the wild-type reaction and -29 eu for the mutant reaction, accounting for a loss of 6-7 kcal/mol in the rate-determining step of the enzymic reaction.(ABSTRACT TRUNCATED AT 400 WORDS) ..
- Thompson C, Koleske A, Chao D, Young R. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell. 1993;73:1361-75 pubmed..In vitro transcription and template commitment assays confirm that SRB2 and SRB5 are components of a functional preinitiation complex and are required for efficient transcription initiation. ..
- Sheridan A, Force T, Yoon H, O LEARY E, Choukroun G, Taheri M, et al. PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. Mol Cell Biol. 2001;21:4470-81 pubmed..Thus PLIP, a splice variant of Tip60, interacts with cPLA(2) and potentiates cPLA(2)-mediated PGE(2) production and apoptosis. ..
- Li Z, Carlow C. Characterization of transcription factors that regulate the type IV secretion system and riboflavin biosynthesis in Wolbachia of Brugia malayi. PLoS ONE. 2012;7:e51597 pubmed publisher..In addition, our results demonstrate a requirement of vitamin B2 for worm health and fertility, and imply a nutritional role of the symbiont for the filarial parasite host...
- Schatz D, Oettinger M, Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell. 1989;59:1035-48 pubmed..RAG-1 may activate V(D)J recombination indirectly, or it may encode the V(D)J recombinase itself. ..
- Lavie A, Allen K, Petsko G, Ringe D. X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis. Biochemistry. 1994;33:5469-80 pubmed..Calculations of the solvent-accessible surface of possible dimers, with and without the alpha-helical C-terminal domain, suggest that the tetramer is the active form of this xylose isomerase. ..
- Yoon D, Lee H, Seol W, DeMaria M, Rosenzweig M, Jung J. Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. Immunity. 1997;6:571-82 pubmed..Thus, Tap is likely to be an important cellular mediator of Tip function in T cell transformation by herpesvirus saimiri. ..
- Koch M, Olson P, Albus A, Jin W, Hunter D, Brunken W, et al. Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain. J Cell Biol. 1999;145:605-18 pubmed..It seems likely that these apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. ..
- Nichols K, Crispino J, Poncz M, White J, Orkin S, Maris J, et al. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet. 2000;24:266-70 pubmed..Our findings underscore the importance of FOG-1:Gata-1 associations in both megakaryocyte and erythroid development, and suggest that other X-linked anaemias or thrombocytopenias may be caused by defects in GATA1. ..
- Lue S, Kelley S. An aminoacyl-tRNA synthetase with a defunct editing site. Biochemistry. 2005;44:3010-6 pubmed..This enhanced specificity must compensate for the presence of a defunct editing site and ensures translational accuracy. ..
- Chin H, Patnaik D, Esteve P, Jacobsen S, Pradhan S. Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis. Biochemistry. 2006;45:3272-84 pubmed..Thus, SUV39H1 utilizes both the chromodomain and the SET domain for catalysis. ..
- Hwang S, Boswell S, Seo J, Lee S. Novel oxidative stress-responsive gene ERS25 functions as a regulator of the heat-shock and cell death response. J Biol Chem. 2008;283:13063-9 pubmed publisher..Together, the data presented here demonstrate that ERS25 may play a critical role in regulation of heat-shock response and apoptosis. ..
- Newman R, Hall L, Kirmaier A, Pozzi L, Pery E, Farzan M, et al. Evolution of a TRIM5-CypA splice isoform in old world monkeys. PLoS Pathog. 2008;4:e1000003 pubmed publisher..Whether the formation of novel genes through alternative splicing has played a wider role in the evolution of the TRIM family remains to be investigated...
- Yahata T, de Caestecker M, Lechleider R, Andriole S, Roberts A, Isselbacher K, et al. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000;275:8825-34 pubmed..These results indicate that MSG1 interacts with both the DNA-binding Smad proteins and the p300/CBP coactivators through its N- and C-terminal regions, respectively, and enhances the functional link between Smads and p300/CBP. ..
- Koch M, Murrell J, Hunter D, Olson P, Jin W, Keene D, et al. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization. J Cell Biol. 2000;151:221-34 pubmed..Functional studies were performed and show that beta-netrin promotes neurite elongation from olfactory bulb explants. Together, these data suggest that beta-netrin is important in neural, kidney, and vascular development. ..
- Li X, Sapp E, Valencia A, Kegel K, Qin Z, Alexander J, et al. A function of huntingtin in guanine nucleotide exchange on Rab11. Neuroreport. 2008;19:1643-7 pubmed publisher..These data suggest a role for huntingtin in a complex that activates Rab11. ..
- Brace L, Southworth M, Tori K, Cushing M, Perler F. The Deinococcus radiodurans Snf2 intein caught in the act: detection of the Class 3 intein signature Block F branched intermediate. Protein Sci. 2010;19:1525-33 pubmed publisher..Analysis of the Deinococcus radiodurans Snf2 intein confirms this splicing mechanism. Moreover, the Class 3 specific Block F branched intermediate was isolated, providing the first direct proof of its existence...
- Claffey K, Herrera V, Brecher P, Ruiz Opazo N. Cloning and tissue distribution of rat heart fatty acid binding protein mRNA: identical forms in heart and skeletal muscle. Biochemistry. 1987;26:7900-4 pubmed..The structural differences between heart FABP and other members of this multigene family may be related to the functional requirements of oxidative muscle for fatty acids as a fuel source. ..
- Lekutis C, Letvin N. Biochemical and molecular characterization of rhesus monkey major histocompatibility complex class II DR. Hum Immunol. 1995;43:72-80 pubmed..In this way it has also been possible to determine which subset of the DRB sequences amplified from a B-LCL are actually expressed. ..
- Dunlap P, Callahan S. Characterization of a periplasmic 3':5'-cyclic nucleotide phosphodiesterase gene, cpdP, from the marine symbiotic bacterium Vibrio fischeri. J Bacteriol. 1993;175:4615-24 pubmed..The mutant exhibited no obvious sensitivity to high extracellular concentrations of cAMP (5 and 10 mM), suggesting that the enzyme does not play a role in defense against extracellular cAMP...
- Ford H, Landesman Bollag E, Dacwag C, Stukenberg P, Pardee A, Seldin D. Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein. J Biol Chem. 2000;275:22245-54 pubmed
- Yang F, Vought B, Satterlee J, Walker A, Jim Sun Z, Watts J, et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006;442:700-4 pubmed..Taken together, our findings demonstrate that ARC105 is a key effector of SREBP-dependent gene regulation and control of lipid homeostasis in metazoans. ..
- Watkins D, McAdam S, Liu X, Strang C, Milford E, Levine C, et al. New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci. Nature. 1992;357:329-33 pubmed..These studies underline the importance of gathering genetic data on endangered native human populations. ..
- Dick F, Sailhamer E, Dyson N. Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins. Mol Cell Biol. 2000;20:3715-27 pubmed..Mutation of this binding site allows pRB to function as a cell cycle regulator while being resistant to inactivation by viral oncoproteins. ..
- Dick F, Dyson N. Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins. J Virol. 2002;76:6224-34 pubmed..These residues most likely form ionic interactions with conserved acidic amino acids on E7 since a stable pRB/E7 interaction was restored when the lysine residues on pRB and the acidic residues on E7 were interchanged. ..
- Kuhn J, Radoshitzky S, Guth A, Warfield K, Li W, Vincent M, et al. Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor. J Biol Chem. 2006;281:15951-8 pubmed publisher..These studies identify the receptor-binding domains of both viruses, indicate that these viruses utilize a common receptor, and suggest that a single small molecule or vaccine can be developed to inhibit infection of all filoviruses...
- Mauris J, Evans T. Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity. PLoS ONE. 2009;4:e7175 pubmed publisher..Finally, the C-terminal 123 amino acid residues of Aae MutL were sufficient to display Mn(++) induced nicking activity. ..
- Jin M, Fujita M, Culley B, Apolinario E, Yamamoto M, Maundrell K, et al. sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase. Genetics. 1995;140:457-67 pubmed..Therefore, sck1 appears to function in a redundant fashion to pka1, but to varying degrees, in the pathways regulated by pka1. ..
- Lucero H, Chojnicki E, Mandiyan S, Nelson H, Nelson N. Cloning and expression of a yeast gene encoding a protein with ATPase activity and high identity to the subunit 4 of the human 26 S protease. J Biol Chem. 1995;270:9178-84 pubmed..N-Ethylmaleimide inhibits the ATPase activity of both forms of Yhs4p. We propose that Yhs4p ATPase may play an essential role in the regulatory function of the proteolytic activity of the yeast 26 S protease. ..
- Russek S, Farb D. Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform. Genomics. 1994;23:528-33 pubmed..This organization of GABAAR gene clusters may have been preserved as linkage provides a mechanism for facilitating coordinate gene expression. ..
- Marchionni M, Goodearl A, Chen M, Bermingham McDonogh O, Kirk C, Hendricks M, et al. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature. 1993;362:312-8 pubmed..These factors are probably important in the development and regeneration of the nervous system. ..
- Maranto A. Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium. J Biol Chem. 1994;269:1222-30 pubmed..The subcellular distribution and appearance of staining is consistent with localization on the endoplasmic reticulum, with the highest concentration of staining occurring adjacent to the apical brush border of villus cells. ..
- White D, Gilmore T. Temperature-sensitive transforming mutants of the v-rel oncogene. J Virol. 1993;67:6876-81 pubmed..5 degrees C but rapidly senesced at 41.5 degrees C. Both mutant v-Rel proteins were also ts for DNA binding in vitro. These mutants may be valuable for identifying genes directly regulated by v-rel. ..
- Di Cunto F, Calautti E, Hsiao J, Ong L, Topley G, Turco E, et al. Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. J Biol Chem. 1998;273:29706-11 pubmed..In contrast, CRIK exhibits a restricted pattern of expression, suggesting that this kinase may fulfill a more specialized function in specific cell types. ..
- Schaefer L, Beermann M, Miller J. Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien. Genomics. 1999;56:310-6 pubmed..9-kb band in liver. Immunostaining of native and epitope tagged proteins localized the mouse Cops2 protein in both the cytoplasm and the nucleus, with larger amounts in the nucleus in some cells. ..
- Makkinje A, Quinn D, Chen A, Cadilla C, Force T, Bonventre J, et al. Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stres. J Biol Chem. 2000;275:17838-47 pubmed..Expression of Gene 33 at sufficient levels may enable a compensatory reprogramming of cellular function in response to chronic stress, which may have pathophysiological consequences. ..
- Hendrickson E, Guevera P, Pe aloza V zquez A, Shao J, Bender C, Ausubel F. Virulence of the phytopathogen Pseudomonas syringae pv. maculicola is rpoN dependent. J Bacteriol. 2000;182:3498-507 pubmed..However, constitutive expression of hrpL in ES4326 rpoN::Km(r) did not restore coronatine production, showing that coronatine biosynthesis requires factors other than hrpL...
- Yahata T, Takedatsu H, Dunwoodie S, Braganca J, Swingler T, Withington S, et al. Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells. Genomics. 2002;80:601-13 pubmed..These results implied possible roles for Cited4 in regulation of gene expression during development and differentiation of blood cells, endothelial cells, and mammary epithelial cells. ..
- Feschenko M, Donnet C, Wetzel R, Asinovski N, Jones L, Sweadner K. Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus. J Neurosci. 2003;23:2161-9 pubmed..At least two other FXYD family members have been detected in the CNS, suggesting that additional complexity of sodium pump regulation will be found. ..
- Gómez del Arco P, Maki K, Georgopoulos K. Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition. Mol Cell Biol. 2004;24:2797-807 pubmed..We thus propose that Ikaros's activity as a regulator of the G(1)-S transition is controlled by phosphorylation in response to signaling events that down-modulate its DNA binding activity. ..
- Boston Howes W, Gibb S, Williams E, Pasinelli P, Brown R, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J Biol Chem. 2006;281:14076-84 pubmed..Taken together, our findings suggest that caspase-3 cleavage of EAAT2 is one mechanism responsible for the impairment of glutamate uptake in mutant SOD1-linked ALS. ..
- Lu Y, Chen N, Paulus H. Identification of aecA mutations in Bacillus subtilis as nucleotide substitutions in the untranslated leader region of the aspartokinase II operon. J Gen Microbiol. 1991;137:1135-43 pubmed..abstract truncated at 250 words) ..
- Hästbacka J, de la Chapelle A, Mahtani M, Clines G, Reeve Daly M, Daly M, et al. The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell. 1994;78:1073-87 pubmed..These results demonstrate the power of linkage disequilibrium mapping in isolated populations for positional cloning. ..
- Hake L, Richter J. CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation. Cell. 1994;79:617-27 pubmed..Partial restoration of polyadenylation in depleted extracts is achieved by the addition of CPEB, thus demonstrating that this protein is required for cytoplasmic polyadenylation. ..
- Lu Y, Settleman J. The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Genes Dev. 1999;13:1168-80 pubmed
- Chen L, Roberts M. Overexpression, purification, and analysis of complementation behavior of E. coli SuhB protein: comparison with bacterial and archaeal inositol monophosphatases. Biochemistry. 2000;39:4145-53 pubmed..These physical differences, rather than the I-1-Pase activity, may be involved in the biological role of wild-type SuhB in E. coli...
- Begley G, Furie B, Czerwiec E, Taylor K, Furie G, Bronstein L, et al. A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phyla. J Biol Chem. 2000;275:36245-9 pubmed..The vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid appears to be a highly conserved function in the animal kingdom. ..
- Landry S, Hoffman C. The git5 Gbeta and git11 Ggamma form an atypical Gbetagamma dimer acting in the fission yeast glucose/cAMP pathway. Genetics. 2001;157:1159-68 pubmed
- Nielsen C, Friedman B, Birren B, Burge C, Galagan J. Patterns of intron gain and loss in fungi. PLoS Biol. 2004;2:e422 pubmed..Contrary to standard models, we find no increased frequency of intron loss toward the 3' ends of genes. Thus, recent intron dynamics do not support a model whereby 5' intron positional bias is generated solely by 3'-biased intron loss. ..
- Zheng Y, Roberts R, Kasif S, Guan C. Characterization of two new aminopeptidases in Escherichia coli. J Bacteriol. 2005;187:3671-7 pubmed..ypdE is the immediate downstream gene of ypdF, and its start codon overlaps with the stop codon of ypdF by 1 base. YpdE is shown to be a metalloaminopeptidase and has a broad exoaminopeptidase activity. ..
- Luo X, Inouye H, Gross A, Hidalgo M, Sharma D, Lee D, et al. Cytoplasmic domain of zebrafish myelin protein zero: adhesive role depends on beta-conformation. Biophys J. 2007;93:3515-28 pubmed..Our findings support the idea that the adhesive role of P0 at the cytoplasmic apposition in compact myelin depends on the cytoplasmic domain of P0 being in the beta-conformation. ..
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