Experts and Doctors on amino acid sequence homology in Scotland, United Kingdom


Locale: Scotland, United Kingdom
Topic: amino acid sequence homology

Top Publications

  1. Buchman V, Hunter H, Pinon L, Thompson J, Privalova E, Ninkina N, et al. Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system. J Neurosci. 1998;18:9335-41 pubmed
    ..Persyn also becomes detectable in evolutionary recent regions of the brain by adulthood. ..
  2. Ottersbach K, McLean J, Isaacs N, Graham G. A310 helical turn is essential for the proliferation-inhibiting properties of macrophage inflammatory protein-1 alpha (CCL3). Blood. 2006;107:1284-91 pubmed
    ..In addition, this study further attests to the alternative mechanisms of action used by MIP-1alpha in inhibition of hematopoietic progenitor-cell proliferation and regulation of leukocyte migration. ..
  3. Zhang Y, Lucocq J, Yamamoto M, Hayes J. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochem J. 2007;408:161-72 pubmed
    ..Wild-type Nrf1 is glycosylated through its Asn/Ser/Thr-rich domain, between amino acids 296 and 403, and this modification was not observed in an Nrf1(Delta299-400) mutant. Glycosylation of Nrf1 was not necessary to retain it in the ER. ..
  4. Monroig O, Zheng X, Morais S, Leaver M, Taggart J, Tocher D. Multiple genes for functional 6 fatty acyl desaturases (Fad) in Atlantic salmon (Salmo salar L.): gene and cDNA characterization, functional expression, tissue distribution and nutritional regulation. Biochim Biophys Acta. 2010;1801:1072-81 pubmed publisher
    ..The observed differences in tissue expression and nutritional regulation of the fad genes are discussed in relation to gene structures and fish physiology. ..
  5. Fyfe P, Dawson A, Hutchison M, Cameron S, Hunter W. Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery. Acta Crystallogr D Biol Crystallogr. 2010;66:881-8 pubmed publisher
    ..The distinct subunit-subunit interfaces may provide a potential area to target by exploiting the observation that creation of the enzyme active site is dependent on oligomerization. ..
  6. Tan K, Beattie P, Leach D, Rich P, Coulson A, Ward F. Expression and analysis of the gene for the catalytic beta subunit of the sodium-translocating NADH-ubiquinone oxidoreductase of Vibrio alginolyticus. Biochem Soc Trans. 1996;24:12S pubmed
  7. Stark L, Hay R. Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription. J Virol. 1998;72:3037-44 pubmed
    ..Since tRNA(Lys) is the primer for reverse transcription of the HIV-1 genome, this suggests that the interaction between Vpr and LysRS may influence the initiation of HIV-1 reverse transcription. ..
  8. Walden H, Taylor G, Lorentzen E, Pohl E, Lilie H, Schramm A, et al. Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature. J Mol Biol. 2004;342:861-75 pubmed
    ..The comparison confirms the increase in charged surface-exposed residues at the expense of polar residues...
  9. Jaleel M, Villa F, Deak M, Toth R, Prescott A, van Aalten D, et al. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. Biochem J. 2006;394:545-55 pubmed
    ..Taken together, these findings suggest that the UBA domains of AMPK-related kinases play an important role in regulating the conformation, activation and localization of these enzymes. ..

More Information

Publications136 found, 100 shown here

  1. Winter A, Keskiaho K, Kukkola L, McCormack G, Felix M, Myllyharju J, et al. Differences in collagen prolyl 4-hydroxylase assembly between two Caenorhabditis nematode species despite high amino acid sequence identity of the enzyme subunits. Matrix Biol. 2007;26:382-95 pubmed
    ..Genetic complementation of the C. briggsae and C. elegans phy-1 mutants was achieved by injection of a wild type phy-1 gene from either species. ..
  2. Winter A, Myllyharju J, Page A. A hypodermally expressed prolyl 4-hydroxylase from the filarial nematode Brugia malayi is soluble and active in the absence of protein disulfide isomerase. J Biol Chem. 2003;278:2554-62 pubmed
    ..elegans. Although active by itself, the B. malayi PHY-1 was not able to replace enzyme function in a C. elegans P4H mutant...
  3. Hudson P, Rizzoli A, Rosa R, Chemini C, Jones L, Gould E. Tick-borne encephalitis virus in northern Italy: molecular analysis, relationships with density and seasonal dynamics of Ixodes ricinus. Med Vet Entomol. 2001;15:304-13 pubmed
    ..ricinus was observed. This study provides evidence to suggest that roe deer may have an important role to play in the maintenance of tick density and in the persistence of TBE virus. ..
  4. Nasir L, Gault E, Campbell S, Veeramalai M, Gilbert D, McFarlane R, et al. Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT). Gene. 2004;336:105-13 pubmed
    ..This data will allow for further investigation of telomerase in canine malignancies as well as the development of the dog as a model system for human telomerase investigations. ..
  5. Woods Y, Rena G, Morrice N, Barthel A, Becker W, Guo S, et al. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. Biochem J. 2001;355:597-607 pubmed
    ..We find that FKHR and DYRK1A co-localize in discrete regions of the nucleus and can be co-immunoprecipitated from cell extracts. These experiments suggest that DYRK1A may phosphorylate FKHR at Ser(329) in vivo. ..
  6. Shimizu H, Burch L, Smith A, Dornan D, Wallace M, Ball K, et al. The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J Biol Chem. 2002;277:28446-58 pubmed
    ..Together, these data identify a novel MDM2 binding interface within the S9-S10 beta-sheet region of p53 that plays a regulatory role in modulating the rate of MDM2-dependent ubiquitination of p53 in cells. ..
  7. Tyndall J, Sinchaikul S, Fothergill Gilmore L, Taylor P, Walkinshaw M. Crystal structure of a thermostable lipase from Bacillus stearothermophilus P1. J Mol Biol. 2002;323:859-69 pubmed
  8. Nettleton P, Gilray J, Caldow G, Gidlow J, Durkovic B, Vilcek S. Recent isolates of bovine respiratory syncytial virus from Britain are more closely related to isolates from USA than to earlier British and current mainland European isolates. J Vet Med B Infect Dis Vet Public Health. 2003;50:196-9 pubmed
    ..When compared with the available sequences of BRSVs from other countries, the recent British isolates were more closely related to US isolates than to earlier British and current mainland European isolates. ..
  9. Wilkinson C, Ferrell K, Penney M, Wallace M, Dubiel W, Gordon C. Analysis of a gene encoding Rpn10 of the fission yeast proteasome reveals that the polyubiquitin-binding site of this subunit is essential when Rpn12/Mts3 activity is compromised. J Biol Chem. 2000;275:15182-92 pubmed
    ..The Mts3 protein was unable to bind to polyubiquitin in vitro, but the Pus1 and Mts3 proteins were found to bind to one another in vitro, which taken together with the genetic data suggests that they are also closely associated in vivo. ..
  10. Bates S, MacCallum D, Bertram G, Munro C, Hughes H, Buurman E, et al. Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence. J Biol Chem. 2005;280:23408-15 pubmed publisher
    ..In a murine model of systemic infection, the null mutant was severely attenuated in virulence. These results demonstrate the importance of glycosylation for cell wall structure and virulence of C. albicans...
  11. Huston E, Lumb S, Russell A, Catterall C, Ross A, Steele M, et al. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. Biochem J. 1997;328 ( Pt 2):549-58 pubmed
    ..It is suggested that these alternatively spliced regions determine changes in the maximal catalytic activity of the isoforms, their susceptibility to inhibition by rolipram and mode of interaction with particulate fractions. ..
  12. Tangney M, Winters G, Mitchell W. Characterization of a maltose transport system in Clostridium acetobutylicum ATCC 824. J Ind Microbiol Biotechnol. 2001;27:298-306 pubmed
    ..A putative gene system for the maltose PTS was identified (from the C. acetobutylicum ATCC 824 genome sequence), encoding an enzyme II(Mal) and a maltose 6-phosphate hydrolase. ..
  13. Rickman C, Medine C, Bergmann A, Duncan R. Functionally and spatially distinct modes of munc18-syntaxin 1 interaction. J Biol Chem. 2007;282:12097-103 pubmed
    ..Furthermore, these functionally divergent interactions occur at distinct cellular locations. These findings provide a molecular explanation for the multiple, spatially distinct roles of munc18-1. ..
  14. Davies R, Campbell S, Whittam T. Mosaic structure and molecular evolution of the leukotoxin operon (lktCABD) in Mannheimia (Pasteurella) haemolytica, Mannheimia glucosida, and Pasteurella trehalosi. J Bacteriol. 2002;184:266-77 pubmed
    ..The recombinational exchanges within the leukotoxin operon have had greatest effect on LktA and probably provide an adaptive advantage against the host antibody response by generating novel antigenic variation at surface-exposed sites...
  15. Cutler C, Cramb G. Branchial expression of an aquaporin 3 (AQP-3) homologue is downregulated in the European eel Anguilla anguilla following seawater acclimation. J Exp Biol. 2002;205:2643-51 pubmed
    ..The potential roles for this aquaporin isoform in water or solute transport in the eel gill are discussed. ..
  16. Tian L, Coghill L, MacDonald S, Armstrong D, Shipston M. Leucine zipper domain targets cAMP-dependent protein kinase to mammalian BK channels. J Biol Chem. 2003;278:8669-77 pubmed
    ..Thus LZ1 is required for the association and regulation of mammalian BK channels by PKA, and other putative leucine zippers in the BK channel protein may provide anchoring for other regulatory enzyme complexes. ..
  17. Westrop G, Goodall G, Mottram J, Coombs G. Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine. J Biol Chem. 2006;281:25062-75 pubmed
    ..Humans lack cysteine synthase; therefore, this parasite enzyme could be an exploitable drug target. ..
  18. Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, et al. A novel mammalian receptor for the evolutionarily conserved type II GnRH. Proc Natl Acad Sci U S A. 2001;98:9636-41 pubmed publisher
    ..Surprisingly, the type II receptor is expressed in the majority of gonadotropes. The presence of two GnRH receptors in gonadotropes, together with the differences in their signaling, suggests different roles in gonadotrope functioning...
  19. Sullivan M, Rena G, Begg F, Gordon L, Olsen A, Houslay M. Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2. Biochem J. 1998;333 ( Pt 3):693-703 pubmed
  20. Cazalla D, Zhu J, Manche L, Huber E, Krainer A, Caceres J. Nuclear export and retention signals in the RS domain of SR proteins. Mol Cell Biol. 2002;22:6871-82 pubmed
    ..However, the SR protein SC35 has two long stretches of RS repeats, yet it is not a shuttling protein. We demonstrate the presence of a dominant nuclear retention signal in the RS domain of SC35. ..
  21. Wilson L, Reyns G, Darras V, Coughtrie M. cDNA cloning, functional expression, and characterization of chicken sulfotransferases belonging to the SULT1B and SULT1C families. Arch Biochem Biophys. 2004;428:64-72 pubmed
    ..This is the first detailed characterization of sulfotransferases from the chicken, and it demonstrates that the avian and mammalian SULT1 enzymes are closely related in both structure and function. ..
  22. Brown R, Chapman K, Kotelevtsev Y, Yau J, Lindsay R, Brett L, et al. Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2. Biochem J. 1996;313 ( Pt 3):1007-17 pubmed
    ..11 beta-HSD2 transcripts are expressed in fetal kidney (but not lung, liver or brain) at 21-26 weeks, suggesting that an 11 beta-HSD2 distribution resembling that in the adult is established by this stage in human development. ..
  23. Dowd S, Sneddon A, Keyse S. Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. J Cell Sci. 1998;111 ( Pt 22):3389-99 pubmed
    ..Pyst2 binds p42 MAP kinase in vivo and both MAP kinase binding and substrate selectivity correlate with the ability of different recombinant MAP and SAP kinases to cause catalytic activation of the Pyst2 phosphatase in vitro. ..
  24. Olorunniji F, Stark W. The catalytic residues of Tn3 resolvase. Nucleic Acids Res. 2009;37:7590-602 pubmed publisher
    ..The involvement of some residues in both synapsis and catalysis suggests that they contribute to a regulatory mechanism, in which engagement of catalytic residues with the substrate is coupled to correct assembly of the synapse. ..
  25. Slack D, Seternes O, Gabrielsen M, Keyse S. Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. J Biol Chem. 2001;276:16491-500 pubmed
  26. Blindauer C, Harrison M, Robinson A, Parkinson J, Bowness P, Sadler P, et al. Multiple bacteria encode metallothioneins and SmtA-like zinc fingers. Mol Microbiol. 2002;45:1421-32 pubmed
    ..We have identified 12 smtA-like genes in sequence databases including four of the gatA type. ..
  27. Feng G, Kellett E, Scorer C, Wilde J, White J, Milligan G. Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation. J Biol Chem. 2003;278:33400-7 pubmed
    ..This represents the first example of an opioid receptor-interacting protein that functions to disrupt agonist-mediated G protein activation. ..
  28. Penha Goncalves M, Onions D, Nicolson L. Cloning and sequencing of equine transforming growth factor-beta 1 (TGF beta-1) cDNA. DNA Seq. 1997;7:375-8 pubmed
    ..We report the cloning and sequencing of the cDNA for TGF-beta type 1 isoform of the horse. The predicted mature equine TGF beta-1 peptide is 112 amino acids in length and exhibits 99% identity to mature human TGF beta-1...
  29. Equinet L, Bapteste E, Thellier M, Ouarzane Amara M, Vivar s C, Desportes Livage I, et al. The genes encoding cAMP-dependent protein kinase catalytic subunit homologues of the microsporidia Encephalitozoon intestinalis and E. cuniculi: molecular characterisation and phylogenetic analysis. Parasitol Int. 2004;53:277-85 pubmed publisher
    ..cuniculi orthologue (EcPKAc) is a single copy gene. RT-PCR data showed that the EiPKAc gene is expressed in at least one of the intracellular stages during infection of the mammalian host cell by E. intestinalis...
  30. Allard S, Giraud M, Whitfield C, Graninger M, Messner P, Naismith J. The crystal structure of dTDP-D-Glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-l-rhamnose pathway. J Mol Biol. 2001;307:283-95 pubmed
    ..The quaternary structure of RmlB and its similarity to a number of other closely related short-chain dehydrogenase/reductase enzymes have enabled us to propose a mechanism of catalysis for this important enzyme. ..
  31. Rena G, Begg F, Ross A, MacKenzie C, McPhee I, Campbell L, et al. Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10. Mol Pharmacol. 2001;59:996-1011 pubmed
    ..We suggest that the unique N-terminal regions of PDE4A isoforms confer distinct properties upon them. ..
  32. Ambler R, Meyer T, Bartsch R, Cusanovich M. An alternative to the accepted phylogeny of purple bacteria based on 16S rRNA: analyses of the amino acid sequences of cytochromes C2 and C556 from Rhodobacter (Rhodovulum) sulfidophilus. Arch Biochem Biophys. 2001;388:25-33 pubmed
    ..Instead, the Rhodobacter cytochromes c2 are distinct from those of other genera and species of purple bacteria and show a different pattern of relationships among species than reported for 16S rRNA...
  33. Thomas C, Dowler S, Deak M, Alessi D, van Aalten D. Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity. Biochem J. 2001;358:287-94 pubmed
  34. Macrae J, Acosta Serrano A, Morrice N, Mehlert A, Ferguson M. Structural characterization of NETNES, a novel glycoconjugate in Trypanosoma cruzi epimastigotes. J Biol Chem. 2005;280:12201-11 pubmed
    ..cruzi genome data base. These genes are predicted to encode 65-amino acid proteins with cleavable 26-amino acid N-terminal signal peptides and 26-amino acid C-terminal GPI addition signal peptides. ..
  35. Arnaud F, Varela M, Spencer T, Palmarini M. Coevolution of endogenous betaretroviruses of sheep and their host. Cell Mol Life Sci. 2008;65:3422-32 pubmed publisher
    ..Thus, endogenization of these retroviruses may still be occurring today. Therefore, sheep provide an exciting and unique system to study retrovirus-host coevolution. (Part of a multi-author review)...
  36. Phelan M, Thai C, Soares D, Ogata R, Barlow P, Bramham J. Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement. J Biol Chem. 2009;284:19637-49 pubmed publisher
    ..Similar interfaces were predicted in a homology-based model of the C6-FIM pair. The C7-FIM structures also facilitated construction of a model of the single FIM of factor I. ..
  37. Fiskerstrand C, Roy D, Green I, Sargan D. Cloning, expression and characterization of ovine interleukins 1 alpha and beta. Cytokine. 1992;4:418-28 pubmed
    ..The presence of a Factor Xa cleavage site in the IL-1 alpha proprotein suggests that Factor Xa may be involved in the processing of ovine IL-1 alpha to its mature form. ..
  38. Jones D, Cowell I, Singh P. Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays. 2000;22:124-37 pubmed
    ..This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000. ..
  39. Thompson F, Britton C, Wheatley I, Maitland K, Walker G, Anant S, et al. Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans. Biochem J. 2002;365:99-107 pubmed
    ..RNA-interference (RNAi) assays were performed for both genes, either alone or in combination, but only cdd-2 RNAi produced a consistent visible phenotype. A proportion of eggs laid from these worms were swollen and distorted in shape. ..
  40. Dornan J, Taylor P, Walkinshaw M. Structures of immunophilins and their ligand complexes. Curr Top Med Chem. 2003;3:1392-409 pubmed
    ..For all structures discussed in the review a summary of the available biological data is also presented. ..
  41. McHugh B, Krause S, Yu B, Deans A, Heasman S, McLaughlin P, et al. Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration. J Cell Biol. 2004;167:673-86 pubmed
    ..Thus, invadolysin identifies a new family of conserved metalloproteases whose activity appears to be essential for the coordination of mitotic progression, but which also plays an unexpected role in cell migration. ..
  42. Warbrick E, Glover D. A Drosophila gene encoding a DEAD box RNA helicase can suppress loss of wee1/mik1 function in Schizosaccharomyces pombe. Mol Gen Genet. 1994;245:654-7 pubmed
    ..It is possible that the RNA helicase described here may regulate entry into mitosis by down regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis. ..
  43. Naz N, Young H, Ahmed N, Gadd G. Cadmium accumulation and DNA homology with metal resistance genes in sulfate-reducing bacteria. Appl Environ Microbiol. 2005;71:4610-8 pubmed
  44. Stoddart L, Smith N, Jenkins L, Brown A, Milligan G. Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids. J Biol Chem. 2008;283:32913-24 pubmed publisher
    ..The development of small molecule ligands that interact selectively with these receptors will allow further details of the binding pockets to be elucidated. ..
  45. Thompson F, Martin S, Devaney E. Brugia pahangi: characterisation of a small heat shock protein cDNA clone. Exp Parasitol. 1996;83:259-66 pubmed
    ..The expression of the small heat shock protein cDNA appears to be controlled at the level of RNA synthesis and is highly stage specific and temperature dependent. ..
  46. Ireland L, Harrison D, Neal G, Hayes J. Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase. Biochem J. 1998;332 ( Pt 1):21-34 pubmed
    ..This hypothesis is supported in part by the finding that the major peak of 2-CBA reductase activity in human liver co-purifies with hAFAR protein. ..
  47. Rhind S, Hopkins J, Dutia B. Amino-terminal sequencing of sheep CD1 antigens and identification of a sheep CD1D gene. Immunogenetics. 1999;49:225-30 pubmed
    ..The predicted amino acid sequence of this gene shows that it is not identical to the SBU-T6 peptide, indicating that a different, CD1D-like gene was cloned. ..
  48. Nicoll G, Ni J, Liu D, Klenerman P, Munday J, Dubock S, et al. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. J Biol Chem. 1999;274:34089-95 pubmed
    ..Immunoprecipitation experiments indicated that siglec-7 is expressed as a monomer of approximately 65 kDa. ..
  49. Parkinson J, Everett R. Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 affect cellular structures and proteins. J Virol. 2000;74:10006-17 pubmed
  50. Oza S, Shaw M, Wyllie S, Fairlamb A. Trypanothione biosynthesis in Leishmania major. Mol Biochem Parasitol. 2005;139:107-16 pubmed
    ..fasciculata. It also appears that the L. major still harbours a redundant GSPS pseudogene that may be currently in the process of being lost from its genome...
  51. Conner S, Kular G, Peggie M, Shepherd S, Schuttelkopf A, Cohen P, et al. TAK1-binding protein 1 is a pseudophosphatase. Biochem J. 2006;399:427-34 pubmed
    ..Thus, it appears that TAB1 is a 'pseudophosphatase', possibly binding to and regulating accessibility of phosphorylated residues on substrates downstream of TAK1 or on the TAK1 complex itself. ..
  52. Doherty M, Young P, Cohen P. Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1. FEBS Lett. 1996;399:339-43 pubmed
    ..The amino acid sequence and properties of PPP1R5 indicate that it is not subject to the same modes of covalent and allosteric regulation by hormones as are G(M) and G(L). ..
  53. Thompson J, Doxakis E, Pinon L, Strachan P, Buj Bello A, Wyatt S, et al. GFRalpha-4, a new GDNF family receptor. Mol Cell Neurosci. 1998;11:117-26 pubmed
    ..Our findings extend the family of GFRalpha proteins and provide information about the tissues in which GFRalpha-4 may function during development. ..
  54. Argyle D, McGillivery C, Nicolson L, Onions D. Cloning, sequencing, and characterization of dog interleukin-18. Immunogenetics. 1999;49:541-3 pubmed
    ..The dog coding sequence shares 84% and 74% similarity to the human and mouse equivalents, respectively, at the nucleotide level. Based upon sequence analysis, we propose that this new gene is the dog equivalent of human IL-18. ..
  55. Taylor S, Hanlon L, McGillivray C, Gault E, Argyle D, Onions D, et al. Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides. DNA Seq. 2000;10:387-94 pubmed
    ..The predicted proteins are 410 and 404 amino acids in length respectively and are most closely related to caspase-1 sequences across the N-terminal 115 amino acids and to human caspase-13 across the C-terminal sequence. ..
  56. Vitari A, Deak M, Morrice N, Alessi D. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J. 2005;391:17-24 pubmed
    ..Our analysis also describes the first facile assay that can be employed to quantitatively assess WNK1 and WNK4 activity. ..
  57. Morgan H, Wear M, McNae I, Gallagher M, Walkinshaw M. Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:1240-5 pubmed publisher
    ..This first structure of a CSP from S. typhimurium provides new insight into the cold-shock response of this bacterium. ..
  58. Blakely G, May G, McCulloch R, Arciszewska L, Burke M, Lovett S, et al. Two related recombinases are required for site-specific recombination at dif and cer in E. coli K12. Cell. 1993;75:351-61 pubmed
    ..We predict that normal partition of most circular chromosomes requires the participation of site-specific recombination to convert any multimers (arising by homologous recombination) to monomers. ..
  59. Chang T, Milne K, Güther M, Smith T, Ferguson M. Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite. J Biol Chem. 2002;277:50176-82 pubmed
    ..These results suggest that the stabilities of other glycosylphosphatidylinositol pathway enzymes are not dependent on GlcNAc-PI de-N-acetylase levels. ..
  60. Tatham M, Kim S, Yu B, Jaffray E, Song J, Zheng J, et al. Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. Biochemistry. 2003;42:9959-69 pubmed
    ..The conservation of E2 enzymes across the ubiquitin and ubiquitin-like protein pathways indicates that analogous N-terminal sites of E2 enzymes are likely to have similar roles in general. ..
  61. McAleese S, Pemberton A, McGrath M, Huntley J, Miller H. Sheep mast-cell proteinases-1 and -3: cDNA cloning, primary structure and molecular modelling of the enzymes and further studies on substrate specificity. Biochem J. 1998;333 ( Pt 3):801-9 pubmed
    ..Using a peptide substrate representing residues 36-59 of the human thrombin receptor, increasing salt concentration favoured cleavage at Phe-43 rather than at Arg-41. ..
  62. Al Hakim A, Zagorska A, Chapman L, Deak M, Peggie M, Alessi D. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem J. 2008;411:249-60 pubmed publisher
    ..The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains. ..
  63. Holland Z, Prudent R, Reiser J, Cochet C, Doerig C. Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum. Eukaryot Cell. 2009;8:388-97 pubmed publisher
    ..falciparum CK2alpha enzymes to a small molecule inhibitor. Taken together, our data identify PfCK2alpha as a potential target for antimalarial chemotherapeutic intervention. ..
  64. Nisbet A, Knox D, McNair C, Meikle L, Smith S, Wildblood L, et al. Immune recognition of the surface associated antigen, Tc-SAA-1, from infective larvae of Teladorsagia circumcincta. Parasite Immunol. 2009;31:32-40 pubmed publisher
    ..IgA in abomasal mucus derived from sheep that had received a trickle infection of T. circumcincta bound recombinant Tc-SAA-1. ..
  65. Chanas S, Jiang Q, McMahon M, McWalter G, McLellan L, Elcombe C, et al. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem J. 2002;365:405-16 pubmed
    ..These data also indicate that attenuated induction of GSH-dependent enzymes in Nrf2(-/-) mice probably accounts for their failure to adapt to chronic exposure to chemical and oxidative stress. ..
  66. Palmer T, Stiles G. Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor. Mol Pharmacol. 2000;57:539-45 pubmed
  67. Van Hellemond J, Neuville P, Schwarz R, Matthews K, Mottram J. Isolation of Trypanosoma brucei CYC2 and CYC3 cyclin genes by rescue of a yeast G(1) cyclin mutant. Functional characterization of CYC2. J Biol Chem. 2000;275:8315-23 pubmed
    ..The CRK3 x CYC2ty complex, the first cyclin-dependent kinase complex identified in trypanosomes, was localized by immune fluorescence to the cytoplasm throughout the cell cycle...
  68. Gallagher G, Dickensheets H, Eskdale J, Izotova L, Mirochnitchenko O, Peat J, et al. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Genes Immun. 2000;1:442-50 pubmed
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