Genomes and Genes
Experts and Doctors on amino acid sequence homology in New York, United States
Locale: New York, United States
Topic: amino acid sequence homology
Publications231 found, 100 shown here
- Chen X, Lufkin T. Linkage mapping of Sax2 to mouse chromosome 5. Mamm Genome. 1997;8:697-8 pubmed
- Yokoyama S, Radlwimmer F. The "five-sites" rule and the evolution of red and green color vision in mammals. Mol Biol Evol. 1998;15:560-7 pubmed publisher..The inferred amino acid sequences of ancestral organisms suggest that the extant mammalian red and green pigments appear to have evolved from a single ancestral green-red hybrid pigment by directed amino acid substitutions...
- Abdul Manan N, Aghazadeh B, Liu G, Majumdar A, Ouerfelli O, Siminovitch K, et al. Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature. 1999;399:379-83 pubmed..Structural and biochemical data suggest that GBD-sequence divergence outside the CRIB motif may reflect additional regulatory interactions with functional domains that are specific to individual effectors. ..
- Xiong J, Leahy A, Stuhlmann H. Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development. Mech Dev. 1999;86:183-91 pubmed..In summary, we report the first isolation of a novel full-length Sep3 cDNA and extensive characterization of its expression during mouse embryogenesis and in adult tissues. ..
- Taylor Clelland C, Levy B, McKie J, Duncan A, Hirschhorn K, Bancroft C. Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome. Mamm Genome. 2000;11:675-81 pubmed..We propose that PREB has a role during human development and that abnormal dosage of this transcription factor may be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. ..
- Losada A, Yokochi T, Kobayashi R, Hirano T. Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes. J Cell Biol. 2000;150:405-16 pubmed..These results shed light on the mechanism by which sister chromatid cohesion is partially dissolved in early mitosis, far before the onset of anaphase, in vertebrate cells. ..
- Chen I, Gotschlich E. ComE, a competence protein from Neisseria gonorrhoeae with DNA-binding activity. J Bacteriol. 2001;183:3160-8 pubmed publisher..Thus, we identified a novel gonococcal DNA-binding competence factor which is necessary for DNA uptake and does not affect pilus biogenesis or function...
- Melnick A, Carlile G, Ahmad K, Kiang C, Corcoran C, Bardwell V, et al. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Mol Cell Biol. 2002;22:1804-18 pubmed..Thus, the BTB pocket represents a molecular structure involved in recruitment of transcriptional repression complexes to target promoters. ..
- Li X, Li H, Amsler K, Hyink D, Wilson P, Burrow C. PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis. Proc Natl Acad Sci U S A. 2002;99:9260-5 pubmed
- Kljuic A, Christiano A. A novel mouse desmosomal cadherin family member, desmoglein 1 gamma. Exp Dermatol. 2003;12:20-9 pubmed..Interestingly, an orthologous Dsg1 gamma was not found in the human genome, suggesting that the desmosomal cadherin gene cluster contracted during mammalian evolution. ..
- Green J, Gardner C, Wharton R, Aggarwal A. RNA recognition via the SAM domain of Smaug. Mol Cell. 2003;11:1537-48 pubmed..Therefore, in addition to their previously characterized roles in protein-protein interactions, some SAM domains play crucial roles in RNA binding. ..
- Skowronek K, Guo F, Zheng Y, Nassar N. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. J Biol Chem. 2004;279:37895-907 pubmed..Our data suggest a role for the phosphoinositide 3-kinase, PI 3-kinase, in modulating the Trio/RhoG signaling pathway. ..
- Steinberg S. The cardiovascular actions of protease-activated receptors. Mol Pharmacol. 2005;67:2-11 pubmed..This review focuses on the cardiovascular actions of PARs that play a role in normal cardiovascular physiology and that are likely to contribute to cardiovascular diseases. ..
- Bartolini F, Tian G, Piehl M, Cassimeris L, Lewis S, Cowan N. Identification of a novel tubulin-destabilizing protein related to the chaperone cofactor E. J Cell Sci. 2005;118:1197-207 pubmed..These observations define E-like as a novel regulator of tubulin stability, and provide a link between tubulin turnover and vesicle transport. ..
- Mancia F, Shapiro L. ADAM and Eph: how Ephrin-signaling cells become detached. Cell. 2005;123:185-7 pubmed..In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease. ..
- Benarroch D, Shuman S. Characterization of mimivirus NAD+-dependent DNA ligase. Virology. 2006;353:133-43 pubmed..We speculate that the dissemination of NAD+-dependent ligase from bacterium to eukaryotic virus might have occurred within an amoebal host...
- Miller R, D Silva S, Moore J, Goodson H. The CLIP-170 orthologue Bik1p and positioning the mitotic spindle in yeast. Curr Top Dev Biol. 2006;76:49-87 pubmed..This chapter also highlights several recent findings, including the contribution of Bik1p to the yeast mating pathway. ..
- Chang J, Schwer B, Shuman S. Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing. RNA. 2010;16:1018-31 pubmed publisher..Mud2 mutational effects in the swm2Delta background paralleled those for mud1Delta. The requirements for Mud2 function are apparently more stringent when yeast cells lack TMG caps than when they lack Mud1 or Swm2. ..
- Goldman Wohl D, Chan E, Baird D, Heintz N. Kv3.3b: a novel Shaw type potassium channel expressed in terminally differentiated cerebellar Purkinje cells and deep cerebellar nuclei. J Neurosci. 1994;14:511-22 pubmed..3b K+ channel function is restricted to terminally differentiated Purkinje cells, and that analysis of the mechanisms governing its expression in vivo and in vitro can reveal molecular mechanisms governing Purkinje cell differentiation. ..
- Protopopov V, Govindan B, Novick P, Gerst J. Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell. 1993;74:855-61 pubmed..Our findings clearly place the Snc proteins on the late secretory pathway in S. cerevisiae and provide direct in vivo evidence that synaptobrevin-like proteins mediate the targeting and transport of secretory proteins. ..
- Londoño Vallejo J, Dubnau D. comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases. Mol Microbiol. 1993;9:119-31 pubmed..These observations allow us to hypothesize that the ComFORF1 late gene product plays an essential role during the binding and uptake events involved in Bacillus subtilis transformation. ..
- Zhao J, Lazzarini R, Pick L. Functional dissection of the mouse Hox-a5 gene. EMBO J. 1996;15:1313-22 pubmed..Our results suggest that this type of protein-protein interaction may be essential for the biological activities of Hox-a5 and Scr. ..
- Krachmarov C, Chepenik L, Barr Vagell S, Khalili K, Johnson E. Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha. Proc Natl Acad Sci U S A. 1996;93:14112-7 pubmed
- Kang J, Gao M, Feinleib J, Cotter P, Guadagno S, Krauss R. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J Cell Biol. 1997;138:203-13 pubmed..Taken together, these data suggest that loss of CDO function could play a role in oncogenesis. ..
- Yu J, Dong S, Rushmere N, Morgan B, Abagyan R, Tomlinson S. Mapping the regions of the complement inhibitor CD59 responsible for its species selective activity. Biochemistry. 1997;36:9423-8 pubmed..Analysis of a model of the molecular surface of human CD59 revealed that residues 40-66 mapped to a region in the three-dimensional structure that surrounds residues previously identified as important for CD59 function. ..
- Kao H, Porton B, Czernik A, Feng J, Yiu G, Haring M, et al. A third member of the synapsin gene family. Proc Natl Acad Sci U S A. 1998;95:4667-72 pubmed..On the basis of this localization and the well established neurobiological roles of the synapsins, synapsin III represents a candidate gene for schizophrenia. ..
- Miesel L, Weisbrod T, Marcinkeviciene J, Bittman R, Jacobs W. NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis. J Bacteriol. 1998;180:2459-67 pubmed..tuberculosis complex. The genetic data presented here indicate that defects in NADH oxidation cause all of the mutant traits and that an increase in the NADH/NAD+ ratio confers INH resistance...
- Yang Y, Yin G, Darnell R. The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. Proc Natl Acad Sci U S A. 1998;95:13254-9 pubmed..The expression pattern of the Nova-2 protein is likely to underlie the development of cognitive deficits in some POMA patients. ..
- Liou M, Liou H. The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis. J Biol Chem. 1999;274:10145-53 pubmed..Collectively, these observations highly suggest a role for DAP-1 in mediating TNF-induced cell death signaling pathways, presumably through the recruitment of FADD death effector. ..
- Barton R, Worman H. Prenylated prelamin A interacts with Narf, a novel nuclear protein. J Biol Chem. 1999;274:30008-18 pubmed..The prenyl-dependent binding of Narf to prelamin A is an important first step in understanding the functional significance of the lamin A precursor. ..
- Klahre U, Friederich E, Kost B, Louvard D, Chua N. Villin-like actin-binding proteins are expressed ubiquitously in Arabidopsis. Plant Physiol. 2000;122:35-48 pubmed..Green fluorescent protein fused to full-length AtVLN and individual AtVLN headpiece domains can bind to both animal and plant actin filaments in vivo. ..
- Gershon A, Rudnick J, Kalam L, Zimmerman K. The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo. Development. 2000;127:2945-54 pubmed..One role of Xdbx during normal development may therefore be to restrict spatially neuronal differentiation within the neural plate, possibly by altering the neuronal differentiation function of Xash3. ..
- Xing F, Martzen M, Phizicky E. A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RNA. 2002;8:370-81 pubmed..Yeast extract from a dus1-A strain is completely defective in modification of yeast pre-tRNAPhe, and RNA isolated from dus1-delta and dus2-delta strains is significantly depleted in dihydrouridine content. ..
- Sahr K, Dias D, Sanchez R, Chen D, Chen S, Gudas L, et al. Structure, upstream promoter region, and functional domains of a mouse and human Mix paired-like homeobox gene. Gene. 2002;291:135-47 pubmed..These studies suggest that a number of features of paired-like protein structure and function are conserved across diverse species and provide a useful framework for studying the function and regulation of the mouse Mix gene. ..
- Guo Y, Philip F, Scarlata S. The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site. J Biol Chem. 2003;278:29995-30004 pubmed
- Padyana A, Burley S. Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution. Structure. 2003;11:1005-13 pubmed..The structure provides a framework for further investigation to discover and develop novel inhibitors targeting this essential enzyme...
- Jovine L, Qi H, Williams Z, Litscher E, Wassarman P. A duplicated motif controls assembly of zona pellucida domain proteins. Proc Natl Acad Sci U S A. 2004;101:5922-7 pubmed..Taken together, these findings suggest a general mechanism for assembly of ZP domain proteins. ..
- Khan J, Dunn B, Tong L. Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Structure. 2005;13:1443-52 pubmed..The structure unexpectedly showed the binding of a chloride ion in the active site, and our kinetic studies confirm that chlorides ions are inhibitors of this enzyme at physiologically relevant concentrations. ..
- Mitchell W, Li J, French D, Coller B. alphaIIbbeta3 biogenesis is controlled by engagement of alphaIIb in the calnexin cycle via the N15-linked glycan. Blood. 2006;107:2713-9 pubmed..Our findings suggest that pro-alphaIIb engages the calnexin cycle via the N15 glycan and that failure of pro-alphaIIb to complex normally with beta3 results in proteasomal degradation. ..
- Hao B, Oehlmann S, Sowa M, Harper J, Pavletich N. Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol Cell. 2007;26:131-43 pubmed
- Subedi A, Ubeda C, Adhikari R, PenadÃ©s J, Novick R. Sequence analysis reveals genetic exchanges and intraspecific spread of SaPI2, a pathogenicity island involved in menstrual toxic shock. Microbiology. 2007;153:3235-45 pubmed..We show additionally, that SaPIs are widespread among the staphylococci and that most TSS strains carry two or more, including SaPI2. ..
- Wu J, Jenny A, Mirkovic I, Mlodzik M. Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila. Mech Dev. 2008;125:30-42 pubmed..Our data suggest that Dgo sequesters Dsh to a functionally distinct Fz/PCP signaling compartment within the cell. ..
- Zhang J, Yang C, Brey C, Rodriguez M, Oksov Y, Gaugler R, et al. Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition. Exp Cell Res. 2009;315:2568-80 pubmed publisher..We present the first clear in vivo evidence supporting essential regulatory roles of KLF-3 in fat storage in C. elegans and shed light on the human equivalent in disease-gene association. ..
- Cortes P, Ye Z, Baltimore D. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A. 1994;91:7633-7 pubmed..Because this region of RAG-1 is not required for recombination and SRP1 appears to be bound to the nuclear envelope, we suggest that this interaction helps to localize RAG-1. ..
- Lois L, Lima C. Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J. 2005;24:439-51 pubmed..A mechanism for E2 recruitment to E1 is suggested by biochemical and genetic data, each of which supports a direct role for the E1 C-terminal ubiquitin-like domain for E2 recruitment during conjugation. ..
- Si K, Das K, Maitra U. Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5). J Biol Chem. 1996;271:16934-8 pubmed..Additionally, we demonstrate tissue-specific variations in eIF-5 mRNA expression as well as preference for polyadenylation sites. These results should lead to increased understanding of the regulation of eIF-5 gene expression. ..
- Lin R, Vera J, Chaganti R, Golde D. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998;273:28959-65 pubmed..These findings suggest that the two monocarboxylate transporters, MCT1 and MCT2, have distinct biological roles. ..
- Krasnoperov V, Lu Y, Buryanovsky L, Neubert T, Ichtchenko K, Petrenko A. Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS). J Biol Chem. 2002;277:46518-26 pubmed..We postulate that the proteolytic processing and two-subunit structure is a common characteristic feature in the family of GPS-containing adhesion GPCRs. ..
- Morcillo P, Rosen C, Baylies M, Dorsett D. Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila. Genes Dev. 1997;11:2729-40 pubmed..We suggest that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions. ..
- Wu S, Staudinger J, Olson E, Rubin C. Structure, expression, and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. PKC3 is required for the normal progression of embryogenesis and viability of the organism. J Biol Chem. 1998;273:1130-43 pubmed..A candidate anchoring/targeting protein, which binds PKC3 in vitro, has been identified. ..
- Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, et al. Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. J Biol Chem. 1998;273:4827-30 pubmed..Dok mRNAs were primarily expressed in tissues of hematopoietic origin. These findings strongly suggest that a family of Dok-related proteins exists that bind to RasGAP and may mediate the effects of p210(bcr-abl) in CML. ..
- Fabrega C, Shen V, Shuman S, Lima C. Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II. Mol Cell. 2003;11:1549-61 pubmed..A binding site for the RNA triphosphatase component of the capping apparatus was also uncovered within the Cgt1 OB domain. ..
- Ye K, Serganov A, Hu W, Garber M, Patel D. Ribosome-associated factor Y adopts a fold resembling a double-stranded RNA binding domain scaffold. Eur J Biochem. 2002;269:5182-91 pubmed..It appears probable that functional properties of pY are not identical to those of dsRBDs, as the postulated RNA-binding site in pY does not coincide with the RNA-binding surface of the dsRBDs...
- Jefferson J, Ciatto C, Shapiro L, Liem R. Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily. J Mol Biol. 2007;366:244-57 pubmed..Based on this structure and analysis of sequence conservation, we propose that the architecture of plakin domains is defined by two pairs of spectrin repeats interrupted by a putative Src-Homology 3 (SH3) domain. ..
- Parraga A, Bellsolell L, Ferré D Amaré A, Burley S. Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution. Structure. 1998;6:661-72 pubmed
- Reich Slotky R, Kabbash C, Della Latta P, Blanchard J, Feinmark S, Freeman S, et al. Gemfibrozil inhibits Legionella pneumophila and Mycobacterium tuberculosis enoyl coenzyme A reductases and blocks intracellular growth of these bacteria in macrophages. J Bacteriol. 2009;191:5262-71 pubmed publisher..coli strain sensitive to GFZ at the nonpermissive temperature. GFZ noncompetitively inhibited this L. pneumophila FabI homolog, as well as M. tuberculosis InhA and E. coli FabI. ..
- Vani K, Yang G, Mohler J. Isolation and cloning of a Drosophila homolog to the mammalian RACK1 gene, implicated in PKC-mediated signalling. Biochim Biophys Acta. 1997;1358:67-71 pubmed..The Drosophila rack1 gene has a dynamic pattern of expression during early embryogenesis with the highest expression in the mesodermal and endodermal lineages. ..
- Zaffran S, Das G, Frasch M. The NK-2 homeobox gene scarecrow (scro) is expressed in pharynx, ventral nerve cord and brain of Drosophila embryos. Mech Dev. 2000;94:237-41 pubmed..In larval stages, scro expression occurs in portions of the optic lobe regions. These observations indicate that scro and vertebrate Nkx2.1 share similarities both in terms of their sequence and their expression patterns. ..
- Grundy F, Waters D, Takova T, Henkin T. Identification of genes involved in utilization of acetate and acetoin in Bacillus subtilis. Mol Microbiol. 1993;10:259-71 pubmed..Two sequences resembling the amyO regulatory target site necessary for glucose repression of amyE were identified in the acsA-acuABC promoter regions. ..
- Pogo B, Holland J, Levine P. Human mammary tumor virus in inflammatory breast cancer. Cancer. 2010;116:2741-4 pubmed publisher..Because these conditions represent highly invasive malignancies, it is concluded that HMTV is sometimes associated with a particularly malignant phenotype...
- Shi S, Chang B, Brunnert S. Identification and cloning of a truncated isoform of the cardiac sodium-calcium exchanger in the BALB/c mouse heart. Biochem Genet. 1998;36:119-35 pubmed..Using the mouse mapping gene panel BCB, the NCX1 gene was mapped to the distal end of mouse chromosome 17 (51.3 cM), confirming the data published from the rat probe. ..
- Tellinghuisen T, Marcotrigiano J, Gorbalenya A, Rice C. The NS5A protein of hepatitis C virus is a zinc metalloprotein. J Biol Chem. 2004;279:48576-87 pubmed..Collectively, these results indicate that NS5A is a zinc metalloprotein and that zinc coordination is likely required for NS5A function in the hepatitis C replicase. ..
- D Adamo D, Novick S, Kahn J, Leonardi P, Pellicer A. rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. Oncogene. 1997;14:1295-305 pubmed
- Collum R, Brutsaert S, Lee G, Schindler C. A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc Natl Acad Sci U S A. 2000;97:10120-5 pubmed..The ability of StIP1 to associate with several additional members of the signal transducer and activator of transcription family suggests that StIP1 may serve a broader role in cytokine-signaling events. ..
- Pan D, Chen F, Neimark E, Li X, Shneider B. FTF and LRH-1, two related but different transcription factors in human Caco-2 cells: their different roles in the regulation of bile acid transport. Biochim Biophys Acta. 2005;1732:31-7 pubmed..FTF is not involved directly in bile acid mediated negative feedback regulation of the ASBT. ..
- Crozat A, Aman P, Mandahl N, Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature. 1993;363:640-4 pubmed..In TLS-CHOP the RNA-binding domain of TLS is replaced by the DNA-binding and leucine zipper dimerization domain of CHOP. Targeting of a conserved effector domain of RNA-binding proteins to DNA may play a role in tumour formation. ..
- Weber U, Eroglu C, Mlodzik M. Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev Cell. 2003;5:559-70 pubmed..A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic. ..
- Jiang X, Dreano M, Buckler D, Cheng S, Ythier A, Wu H, et al. Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 1995;3:1341-53 pubmed..Averaging techniques used here to recognize the structural motif in these receptors should also apply to other proteins with repeated sequences. ..
- Reid M, Blobel C. Apexin, an acrosomal pentaxin. J Biol Chem. 1994;269:32615-20 pubmed..Apexin is distinct from the pentaxins serum amyloid protein and C-reactive protein and may have evolved to perform functions other than those performed by serum pentaxins, such as intracellular protein sorting to the acrosome...
- Smith J, Bollekens J, Inghirami G, Takeshita K. Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene. Genomics. 1997;43:99-103 pubmed..Whether this gene, which is leukemogenic in mice, also plays a leukemogenic role in humans will require further study. ..
- Schlegel A, Arvan P, Lisanti M. Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum. J Biol Chem. 2001;276:4398-408 pubmed..We conclude that caveolin-1 phosphorylation on invariant serine residue 80 is required for endoplasmic reticulum retention and entry into the regulated secretory pathway. ..
- Shi W, Sarver A, Wang C, Tanaka K, Almo S, Schramm V. Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration. J Biol Chem. 2002;277:39981-8 pubmed..1-A excursion of the ribosyl anomeric carbon, whereas the adenine ring and the 5-phosphoryl group remained fixed. G. lamblia APRTase therefore provides another example of nucleophilic displacement by electrophile migration. ..
- Stein E, Ghirlando R, Hubbard S. Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity. J Biol Chem. 2003;278:13257-64 pubmed..Moreover, the structure suggests the mechanism by which the Grb7 SH2 domain binds selectively to pTyr-1139 (pYVNQ) in Her2, which along with Grb7 is co-amplified in human breast cancers. ..
- Zhang Q, Chakravarty S, Ghersi D, Zeng L, Plotnikov A, Sanchez R, et al. Biochemical profiling of histone binding selectivity of the yeast bromodomain family. PLoS ONE. 2010;5:e8903 pubmed publisher..Finally, electrostatic interactions appear to be a primary determining factor that guides productive association between a bromodomain and a lysine-acetylated histone. ..
- Iourgenko V, Kliot B, Cann M, Levin L. Cloning and characterization of a Drosophila adenylyl cyclase homologous to mammalian type IX. FEBS Lett. 1997;413:104-8 pubmed
- Lawton L, Bonaldo M, Jelenc P, Qiu L, Baumes S, Marcelino R, et al. Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta. Gene. 1997;203:17-26 pubmed..9 kb that is predominant in adult skeletal muscle. Most importantly, the 1.2-kb PTGFB transcript was shown to be expressed in placenta at much higher levels than in any other human fetal or adult tissue surveyed. ..
- Lima C, Wang L, Shuman S. Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. Cell. 1999;99:533-43 pubmed..The structure and mechanism of fungal RNA triphosphatases are completely different from those of mammalian mRNA capping enzymes. Hence, RNA triphosphatase presents an ideal target for structure-based antifungal drug discovery. ..
- Che F, Yuan Q, Kalinina E, Fricker L. Peptidomics of Cpe fat/fat mouse hypothalamus: effect of food deprivation and exercise on peptide levels. J Biol Chem. 2005;280:4451-61 pubmed..Taken together, the differential regulation of these peptides in the two paradigms suggests that the regulation is not due to the lower body weight but to the manner in which the paradigms achieved this lower body weight. ..
- Kolappan S, Zwahlen J, Zhou R, Truglio J, Tonge P, Kisker C. Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family. Biochemistry. 2007;46:946-53 pubmed..The studies reported here extend the mechanism recently proposed for this enzyme family by He et al.: He, Z., Stigers Lavoie, K. D., Bartlett, P. A., and Toney, M. D. (2004) J. Am. Chem. Soc. 126, 2378-85. ..
- Takagaki Y, Manley J. A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein. Nature. 1994;372:471-4 pubmed..Our results thus also indicate that components of the complex polyadenylation machinery are conserved from yeast to man. ..
- Levy J, Canoll P, Silvennoinen O, Barnea G, Morse B, Honegger A, et al. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. J Biol Chem. 1993;268:10573-81 pubmed..The high level of expression of RPTP beta transcripts in the ventricular and subventricular zones of the embryonic mouse brain suggests the importance of this tyrosine phosphatase in the development of the central nervous system. ..
- Hoffmann A, Roeder R. Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation. J Biol Chem. 1996;271:18194-202 pubmed
- Kloss B, Price J, Saez L, Blau J, Rothenfluh A, Wesley C, et al. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell. 1998;94:97-107 pubmed..DBT is capable of binding to PER in vitro and in Drosophila cells, suggesting that a physical association of PER and DBT regulates PER phosphorylation and accumulation in vivo. ..
- Qiao X, Qiao J, Onodera S, Mindich L. Characterization of phi 13, a bacteriophage related to phi 6 and containing three dsRNA genomic segments. Virology. 2000;275:218-24 pubmed..Despite the differences in the structure of the membranes, the two viruses can successfully exchange the genes for host attachment proteins and thereby change their host specificities...
- Liu Z, Peng J, Mo R, Hui C, Huang C. Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals. J Biol Chem. 2001;276:1424-33 pubmed..Phylogenetic clustering, tissue-specific expression, and plasma membrane location suggest that RhBG homologous proteins are the long sought major ammonium transporters in mammalians. ..
- Fabrizi G, Sadlock J, Hirano M, Mita S, Koga Y, Rizzuto R, et al. Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase. Gene. 1992;119:307-12 pubmed..The cDNA specifying COX VIa-M is a prime candidate for use in investigations of Mendelian-inherited COX deficiencies with primary involvement of muscle. ..
- Lee J, Huberman J, Hurwitz J. Purification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1997;94:8427-32 pubmed..Based on its binding activity to centromeric DNA and homology to centromere proteins, we suggest that this protein may be a functional homologue of the mammalian CENP-B in S. pombe. ..
- Jovell R, Macario A, Conway De Macario E. An ABC-transporter system homolog in an organism of the phylogenetic domain Archaea. DNA Seq. 1997;7:193-7 pubmed..The proteins encoded by these genes were similar in structure, hydrophilicity-hydrophobicity profiles, and motifs to the equivalent components of homolog systems in bacteria and eucarya...
- Ahmad W, Irvine A, Lam H, Buckley C, Bingham E, Panteleyev A, et al. A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers. Am J Hum Genet. 1998;63:984-91 pubmed..The mutated arginine residue is conserved among human, mouse, and rat, suggesting that it is of significant importance to the function of the zinc-finger domain. ..