Experts and Doctors on protein kinase c in London, England, United Kingdom


Locale: London, England, United Kingdom
Topic: protein kinase c

Top Publications

  1. Duggan S, Lindstrom T, Iglesias T, Bennett P, Mann G, Bartlett S. Role of atypical protein kinase C isozymes and NF-kappaB in IL-1beta-induced expression of cyclooxygenase-2 in human myometrial smooth muscle cells. J Cell Physiol. 2007;210:637-43 pubmed
  2. Devalia V, Thomas N, Roberts P, Jones H, Linch D. Down-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation. Blood. 1992;80:68-76 pubmed
    ..Therefore, the PK-C alpha isoform is specifically down-regulated during human neutrophil terminal differentiation. These data suggest that mature neutrophil functions do not require the PK-C alpha isoform. ..
  3. Chishty M, Reichel A, Begley D, Abbott N. Glial induction of blood-brain barrier-like L-system amino acid transport in the ECV304 cell line. Glia. 2002;39:99-104 pubmed
    ..Furthermore, it appears that L-system-mediated transport of amino acids can be modulated by several distinct pathways. ..
  4. Rodriguez Viciana P, Warne P, Khwaja A, Marte B, Pappin D, Das P, et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell. 1997;89:457-67 pubmed
    ..The ability of activated Ras to stimulate PI 3-kinase in addition to Raf is therefore important in Ras transformation of mammalian cells and essential in Ras-induced cytoskeletal reorganization. ..
  5. Goode N, Hughes K, Woodgett J, Parker P. Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes. J Biol Chem. 1992;267:16878-82 pubmed
    ..Phosphorylation of GSK-3 beta by PKC results in its specific inactivation. These results are consistent with a model in which activation of PKC stimulates c-Jun DNA binding by inhibiting its phosphorylation by GSK-3 beta. ..
  6. Quaderi N, Gianfrancesco F, Brown S, D Urso M, D ESPOSITO M. Genetic mapping of a gene encoding an atypical protein kinase C, protein kinase C lambda, to the proximal region of mouse chromosome 3. Genomics. 1995;29:815-6 pubmed
  7. Erusalimsky J, Brooks S, Herget T, Morris C, Rozengurt E. Molecular cloning and characterization of the acidic 80-kDa protein kinase C substrate from rat brain. Identification as a glycoprotein. J Biol Chem. 1991;266:7073-80 pubmed
    ..This is the first time that this major PKC substrate has been identified as a glycoprotein. ..
  8. Palmer R, Ridden J, Parker P. Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family. Eur J Biochem. 1995;227:344-51 pubmed
    ..PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. ..
  9. Mason J, Yarwood H, Tarnok A, Sugars K, Harrison A, Robinson P, et al. Human Thy-1 is cytokine-inducible on vascular endothelial cells and is a signaling molecule regulated by protein kinase C. J Immunol. 1996;157:874-83 pubmed
    ..The expression on EC, the inducibility by TNF, and the ability to transmit signals suggest that Thy-1 may have an important role in inflammatory responses. ..

More Information


  1. Valverde A, Sinnett Smith J, van Lint J, Rozengurt E. Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain. Proc Natl Acad Sci U S A. 1994;91:8572-6 pubmed
    ..PKD may be an unusual component in the transduction of diacylglycerol and phorbol ester signals. ..
  2. Veale E, Kennard L, Sutton G, MacKenzie G, Sandu C, Mathie A. G(alpha)q-mediated regulation of TASK3 two-pore domain potassium channels: the role of protein kinase C. Mol Pharmacol. 2007;71:1666-75 pubmed
  3. Etienne Manneville S, Hall A. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell. 2001;106:489-98 pubmed
    ..Localized PKCzeta activity, acting through the microtubule motor protein dynein, is required for all aspects of induced polarity in these cells. ..
  4. Holmes D, Zachary I. Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2. Cell Signal. 2008;20:569-79 pubmed publisher
    ..These findings support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability. ..
  5. Van Lint J, Sinnett Smith J, Rozengurt E. Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase. J Biol Chem. 1995;270:1455-61 pubmed
    ..Taken together, these data unambiguously establish PKD as a phorbol ester receptor and as a novel phospholipid/diacylglycerol-stimulated protein kinase. ..
  6. Farzaneh F, Entwistle A, Zalin R. Protein kinase C mediates the hormonally regulated plasma membrane fusion of avian embryonic skeletal muscle. Exp Cell Res. 1989;181:298-304 pubmed
    ..These results implicate protein kinase C activation in prostaglandin E1-mediated myoblast fusion and add weight to the contention that inositol turnover is involved in the regulation of myoblast fusion. ..
  7. Erusalimsky J, Morris C, Perks K, Brown R, Brooks S, Rozengurt E. Internal amino acid sequence analysis of the 80 kDa protein kinase C substrate from rat brain: relationship to the 87 kDa substrate from bovine brain. FEBS Lett. 1989;255:149-53 pubmed
  8. Toda T, Dhut S, Superti Furga G, Gotoh Y, Nishida E, Sugiura R, et al. The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Mol Cell Biol. 1996;16:6752-64 pubmed
    ..pombe, Pmk1 may not act in a linear manner with respect to fission yeast protein kinase C homologs. Interestingly, however, these two pathways are not independent; instead, they regulate cell integrity in a coordinate manner. ..
  9. Lachmann S, Jevons A, De Rycker M, Casamassima A, Radtke S, Collazos A, et al. Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration. PLoS ONE. 2011;6:e21732 pubmed publisher
    ..It is concluded that intervention in PKNs may need to be directed at multiple isoforms to be effective in different cell types. ..
  10. Guedán A, Swieboda D, Charles M, Toussaint M, Johnston S, Asfor A, et al. Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication. J Virol. 2017;91: pubmed publisher
    ..Moreover, PKD inhibitors also block PV and FMDV replication. This is the first description that PKD may represent a target for antiviral drug discovery. ..
  11. McDowall A, Inwald D, Leitinger B, Jones A, Liesner R, Klein N, et al. A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. J Clin Invest. 2003;111:51-60 pubmed
  12. Cazaubon S, Parker P. Identification of the phosphorylated region responsible for the permissive activation of protein kinase C. J Biol Chem. 1993;268:17559-63 pubmed
    ..The location of this region and its phosphorylation in relation to PKC function are discussed. ..
  13. Coffer P, Woodgett J. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem. 1991;201:475-81 pubmed
    ..Column fractions containing PKB-immunoreactive protein exhibited elevated histone H1 kinase activity compared with similar fractions from control cells, demonstrating the enzymatic activity of this protein kinase. ..
  14. Herget T, Brooks S, Broad S, Rozengurt E. Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. Eur J Biochem. 1992;209:7-14 pubmed
    ..In contrast, the findings presented in this study indicate that rodent 80K and bovine and human MARCKS are not distinct members of a gene family, but represent the equivalent substrates in different species. ..
  15. Tan P, Sagoo P, Chan C, Yates J, Campbell J, Beutelspacher S, et al. Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J Immunol. 2005;174:7633-44 pubmed
    ..These data indicate that vitamin C- and E-treated DC might be useful for the induction of tolerance to allo- or autoantigens. ..
  16. Jovanovic J, Thomas P, Kittler J, Smart T, Moss S. Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability. J Neurosci. 2004;24:522-30 pubmed
    ..Thus, transient formation of GABA(A) receptor signaling complexes has the potential to provide a basis for acute changes in receptor function underlying GABAergic synaptic plasticity. ..
  17. O Toole E, van Koningsveld R, Chen M, Woodley D. Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway. J Cell Physiol. 2008;214:47-55 pubmed
    ..These data provide evidence that hypoxia-induced keratinocyte migration is mediated by increased cellular secretion of MMP-9 via the PKC pathway. ..
  18. Rosse C, Formstecher E, Boeckeler K, Zhao Y, Kremerskothen J, White M, et al. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol. 2009;7:e1000235 pubmed publisher