Genomes and Genes
Experts and Doctors on molecular sequence data in Cambridge, England, United Kingdom
Locale: Cambridge, England, United Kingdom
Topic: molecular sequence data
Publications115 found, 100 shown here
- Farooqi I, Keogh J, Yeo G, Lank E, Cheetham T, O Rahilly S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med. 2003;348:1085-95 pubmed..The correlation between the signaling properties of these mutant receptors and energy intake emphasizes the key role of this receptor in the control of eating behavior in humans. ..
- King V, Goodfellow P, Pearks Wilkerson A, Johnson W, O Brien S, Pecon Slattery J. Evolution of the male-determining gene SRY within the cat family Felidae. Genetics. 2007;175:1855-67 pubmed publisher..Thus, SRY evolution in cats likely reflects the different phylogeographic histories, selection pressures, and patterns of speciation in modern felids...
- Christie G, Lowe C. Role of chromosomal and plasmid-borne receptor homologues in the response of Bacillus megaterium QM B1551 spores to germinants. J Bacteriol. 2007;189:4375-83 pubmed..Wild-type spores carrying an insertion-deletion mutation in this cistron germinated normally; thus, the role of GrmA in spore germination needs to be reevaluated in this species...
- Camilloni C, Schaal D, Schweimer K, Schwarzinger S, De Simone A. Energy landscape of the prion protein helix 1 probed by metadynamics and NMR. Biophys J. 2012;102:158-67 pubmed publisher..The results underline the importance of adopting novel integrated approaches that take advantage of experiments and theory to achieve a comprehensive characterization of the structure and dynamics of biological macromolecules. ..
- Kato K. Novel GABAA receptor alpha subunit is expressed only in cerebellar granule cells. J Mol Biol. 1990;214:619-24 pubmed..This is the first demonstration of the exclusive presence of a neuroreceptor subtype in a single neuronal cell type. ..
- Harwood A, Plyte S, Woodgett J, Strutt H, Kay R. Glycogen synthase kinase 3 regulates cell fate in Dictyostelium. Cell. 1995;80:139-48 pubmed..We propose that cAMP acts through a common pathway that requires GSK-3 and determines the proportion of prespore and pstB cells. ..
- Warren A, Colledge W, Carlton M, Evans M, Smith A, Rabbitts T. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 1994;78:45-57 pubmed..This shows a pivotal role for a LIM domain protein in lineage specification during mammalian development and suggests that RBTN2 and GATA-1 are critical at similar stages of erythroid differentiation. ..
- Kent H, Clarkson W, Bullock T, Stewart M. Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2. J Struct Biol. 1996;116:326-9 pubmed..9 A; b = 56.7 A; c = 88.3 A and diffract past 2 A on laboratory X-ray sources. The asymmetric unit of these crystals contains two NTF2 polypeptide chains, consistent with the reported dimeric structure of the molecule. ..
- Edwards D, Murray J, Smith A. Multiple genes encoding the conserved CCAAT-box transcription factor complex are expressed in Arabidopsis. Plant Physiol. 1998;117:1015-22 pubmed..The unexpected presence of multiple forms of each HAP homolog in Arabidopsis, compared with the single genes in yeast and vertebrates, suggests that the HAP2,3,5 complex may play diverse roles in gene transcription in higher plants. ..
- Nicholson I, Zou X, Popov A, Cook G, Corps E, Humphries S, et al. Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes. J Immunol. 1999;163:6898-906 pubmed..These mice therefore allow the production of Ag-specific repertoires of both IgM,kappa and IgM,lambda Abs and should prove useful for the production of human mAbs for clinical use. ..
- Modha R, Campbell L, Nietlispach D, Buhecha H, Owen D, Mott H. The Rac1 polybasic region is required for interaction with its effector PRK1. J Biol Chem. 2008;283:1492-500 pubmed..This is the first structural demonstration that the C terminus of a G protein forms a novel recognition element for effector binding. ..
- Kingsley R, Kay S, Connor T, Barquist L, Sait L, Holt K, et al. Genome and transcriptome adaptation accompanying emergence of the definitive type 2 host-restricted Salmonella enterica serovar Typhimurium pathovar. MBio. 2013;4:e00565-13 pubmed publisher..Typhimurium isolates alongside phenotypic and transcriptome analyses, to identify genetic signatures linked to host adaptation within the DT2 lineage. ..
- Jiang Y, Xie M, Chen W, Talbot R, Maddox J, Faraut T, et al. The sheep genome illuminates biology of the rumen and lipid metabolism. Science. 2014;344:1168-1173 pubmed publisher..This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals. ..
- Cardona C, Rabbitts P, Spindel E, Ghatei M, Bleehen N, Bloom S, et al. Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines. Cancer Res. 1991;51:5205-11 pubmed..The antiserum used in the GRP radioimmunoassay failed to cross-react with NMB but showed some cross-reactivity with amphibian phyllolitorin raising the possibility that certain SCLC cell lines may produce a phyllolitorin-like peptide. ..
- Harris R, Bishop K, Sheehy A, Craig H, Petersen Mahrt S, Watt I, et al. DNA deamination mediates innate immunity to retroviral infection. Cell. 2003;113:803-9 pubmed..These findings imply that targeted DNA deamination is a major strategy of innate immunity to retroviruses and likely also contributes to the sequence variation observed in many viruses (including HIV)...
- Schwabe J, Chapman L, Finch J, Rhodes D. The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements. Cell. 1993;75:567-78 pubmed..Since all nuclear hormone receptors recognize one or the other of these two consensus half site sequences, this recognition mechanism applies generally to the whole receptor family. ..
- Wang Z, Kayikci M, Briese M, Zarnack K, Luscombe N, Rot G, et al. iCLIP predicts the dual splicing effects of TIA-RNA interactions. PLoS Biol. 2010;8:e1000530 pubmed publisher..Thus, our findings indicate that changes in splicing kinetics could mediate the distal regulation of alternative splicing. ..
- Aylett C, Lowe J. Superstructure of the centromeric complex of TubZRC plasmid partitioning systems. Proc Natl Acad Sci U S A. 2012;109:16522-7 pubmed publisher..The helical superstructure of this TubRC may indicate convergent evolution between the actin-containing ParMRC and tubulin-containing TubZRC systems. ..
- Serizawa A, Dando P, Barrett A. Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase. J Biol Chem. 1995;270:2092-8 pubmed..The biochemical properties of the mitochondrial oligopeptidase leave us in no doubt that it is neurolysin (EC 126.96.36.199), for which no sequence has previously been reported, and which has not been thought to be mitochondrial. ..
- Perisic O, Fong S, Lynch D, Bycroft M, Williams R. Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. J Biol Chem. 1998;273:1596-604 pubmed..Although hydrophobic interactions predominate for cPLA2, for other C2 domains such as in "conventional" protein kinase C and synaptotagmins, electrostatic forces prevail. ..
- Scott L, Tong W, Levine R, Scott M, Beer P, Stratton M, et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med. 2007;356:459-68 pubmed..JAK2 exon 12 mutations define a distinctive myeloproliferative syndrome that affects patients who currently receive a diagnosis of polycythemia vera or idiopathic erythrocytosis. ..
- Gordon A, Outram S, Keramatipour M, Goddard C, Colledge W, Metcalfe J, et al. Splenomegaly and modified erythropoiesis in KLF13-/- mice. J Biol Chem. 2008;283:11897-904 pubmed publisher..A higher proportion of the Ter119(med)CD71(hi) cells were proliferating, indicating that the mice were under a degree of erythropoietic stress. These data indicate that KLF13 is involved in the normal control of erythropoiesis. ..
- Dobbelaere J, Josué F, Suijkerbuijk S, Baum B, Tapon N, Raff J. A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila. PLoS Biol. 2008;6:e224 pubmed publisher..Cnn is phosphorylated during mitosis in a Polo-dependent manner, suggesting that the Polo-dependent phosphorylation of Cnn initiates centrosome maturation in flies. ..
- Mazoyer S, Gayther S, Nagai M, Smith S, Dunning A, Van Rensburg E, et al. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A. Genomics. 1995;28:25-31 pubmed..No evidence for mutation was found, making it unlikely that DLG2 is involved in sporadic breast cancer. ..
- Hart K, Wilcox M. A Drosophila gene encoding an epithelial membrane protein with homology to CD36/LIMP II. J Mol Biol. 1993;234:249-53 pubmed..These expression patterns suggest a role of emp protein in the development or cellular function of epithelial cells. ..
- Newman A, Teigelkamp S, Beggs J. snRNA interactions at 5' and 3' splice sites monitored by photoactivated crosslinking in yeast spliceosomes. RNA. 1995;1:968-80 pubmed..These results constitute the first biochemical evidence for a direct interaction between the 3' splice site and U2 snRNA. ..
- Cabezon E, Butler P, Runswick M, Walker J. Modulation of the oligomerization state of the bovine F1-ATPase inhibitor protein, IF1, by pH. J Biol Chem. 2000;275:25460-4 pubmed
- Romanowski P, Madine M, Laskey R. XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication. Proc Natl Acad Sci U S A. 1996;93:10189-94 pubmed..We conclude that both proteins are present in the same complex in Xenopus egg extract throughout the cell cycle, that they remain together after binding to chromatin and during DNA replication, and that they perform similar functions. ..
- Sambrook J, Sehra H, Coggill P, Humphray S, Palmer S, Sims S, et al. Identification of a single killer immunoglobulin-like receptor (KIR) gene in the porcine leukocyte receptor complex on chromosome 6q. Immunogenetics. 2006;58:481-6 pubmed..Both the porcine KIR and LILR genes have diverged sufficiently to no longer be clearly orthologous with known human LRC family members. ..
- Miyadera K, Brierley I, Aguirre Hern ndez J, Mellersh C, Sargan D. Multiple mechanisms contribute to leakiness of a frameshift mutation in canine cone-rod dystrophy. PLoS ONE. 2012;7:e51598 pubmed publisher..This leakiness at the mutation site may allow escape from severe effects of the mutation for some dogs...
- Martin L, Calabi F, Lefebvre F, Bilsland C, Milstein C. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. Proc Natl Acad Sci U S A. 1987;84:9189-93 pubmed..The general relatedness to major histocompatibility complex class I and class II molecules is significant but low, with no section of higher homology to mouse Tla. ..
- Bogaert T, Brown N, Wilcox M. The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments. Cell. 1987;51:929-40 pubmed..We suggest that PS2, like vertebrate fibronectin receptors, mediates changes in cell shape and cell-extracellular matrix adhesion by binding to a basement membrane protein. ..
- Knauper V, Will H, Lopez Otin C, Smith B, Atkinson S, Stanton H, et al. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J Biol Chem. 1996;271:17124-31 pubmed..This new activation cascade may be significant in human breast cancer pathology, where all three enzymes have been implicated as playing important roles. ..
- Richards A, Al Imara L, Pope F. The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains. Eur J Biochem. 1996;238:813-21 pubmed..The gene is expressed in skin, placenta, heart, lung, skeletal muscle, and pancreas. We have also shown that the mRNA can be readily reverse transcribed and amplified from cultured dermal fibroblasts. ..
- Mason C, Lamers M, Henderson I, Monk T, Williams D. Baculoviral expression and characterization of rodent cathepsin S. Protein Expr Purif. 2001;23:45-54 pubmed..These reagents are vital for confirming inhibitor potency against the endogenous form of the enzyme prior to evaluation of drug candidates in rodent model systems. ..
- Woolfson A, Milstein C. Alternative splicing generates secretory isoforms of human CD1. Proc Natl Acad Sci U S A. 1994;91:6683-7 pubmed..CD1 gene expression is thus characterized by considerable splicing complexity, and the difference between the splicing patterns found in different environments suggests that this is tissue specific. ..
- Xian J, Aitchison A, Bobrow L, Corbett G, Pannell R, Rabbitts T, et al. Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Cancer Res. 2004;64:6432-7 pubmed..This suggests that Dutt1/Robo1 is a classic tumor suppressor gene requiring inactivation of both alleles to elicit tumorigenesis in these mice. ..
- Booth M, Shaw M, Carpenter D, Joseph S, Kabatereine N, Kariuki H, et al. Carriage of DRB1*13 is associated with increased posttreatment IgE levels against Schistosoma mansoni antigens and lower long-term reinfection levels. J Immunol. 2006;176:7112-8 pubmed..These results indicate that genetic background has a prominent influence on the posttreatment Th2 immune response to S. mansoni Ags, as well as a downstream association with long-term reinfection levels. ..
- Landry J, Kinston S, Knezevic K, de Bruijn M, Wilson N, Nottingham W, et al. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood. 2008;111:3005-14 pubmed publisher..Together, our data provide a key component of the transcriptional network of early hematopoiesis by identifying downstream targets of Scl that can explain key aspects of the early Scl(-/-) phenotype...
- Derry J, Barnard P. Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes. Genomics. 1992;12:632-8 pubmed..Analysis of the corresponding region of the human X chromosome indicates a similar arrangement and in addition shows that the properdin gene lies within 5 kb of the 5' end of the synapsin I gene. ..
- Goh P, Kilmartin J. NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae. J Cell Biol. 1993;121:503-12 pubmed..The staining pattern and the phenotype of ndc10-1 are consistent with Cbf2p/Ndc10p being a kinetochore protein, and provide in vivo evidence for its role in the attachment of chromosomes to the spindle. ..
- Creighton T, Charles I. Biosynthesis, processing, and evolution of bovine pancreatic trypsin inhibitor. Cold Spring Harb Symp Quant Biol. 1987;52:511-9 pubmed
- Clark I, Mitchell R, Powell L, Bigg H, Cawston T, O Hare M. Recombinant porcine collagenase: purification and autolysis. Arch Biochem Biophys. 1995;316:123-7 pubmed..The N-terminal fragment retains a reduced level of collagenolytic activity, along with that against casein and gelatin. ..
- Percipalle P, Clarkson W, Kent H, Rhodes D, Stewart M. Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import. J Mol Biol. 1997;266:722-32 pubmed..Our results are consistent with models for nuclear protein import in which Ran nucleotide exchange modulates the binding of the importin-substrate complexes during translocation through nuclear pore complexes. ..
- Owen D, Vallis Y, Noble M, Hunter J, Dafforn T, Evans P, et al. A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain. Cell. 1999;97:805-15 pubmed..A single site for binding multiple ligands would allow for temporal and spatial regulation in the recruitment of components of the endocytic machinery. ..
- Clayton E, McAdam S, Coadwell J, Chantry D, Turner M. Structural organization of the mouse phosphatidylinositol 3-kinase p110d gene. Biochem Biophys Res Commun. 2001;280:1328-32 pubmed..Comparison of the genomic structure with that of p110alpha, beta, and gamma demonstrates that the p110delta gene shares its exon structure with p110beta, the most closely related PI3K at the amino acid level. ..
- Blanco P, Sargent C, Boucher C, Howell G, Ross M, Affara N. A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. Genomics. 2001;74:1-11 pubmed publisher..The close proximity of this gene to translocation breakpoints associated with premature ovarian failure makes it a potential candidate for this condition...
- González Muñoz A, Le Rolle A, Brun H, Hedrich H, Wedekind D, Powis S, et al. A novel instance of class I modification (cim) affecting two of three rat class I RT1-A molecules within one MHC haplotype. J Immunol. 2003;171:274-84 pubmed..Historically, this led to the misclassification of RT1(m) class Ia molecules as separate and distinct...
- Matilla M, Salmond G. Complete genome sequence of Serratia plymuthica bacteriophage ?MAM1. J Virol. 2012;86:13872-3 pubmed publisher..Genomic sequence analysis revealed a circular double-stranded DNA sequence of 157,834 bp, encoding 198 proteins and 3 tRNAs. The ?MAM1 genome shows high homology to previously reported ViI-like enterobacterial bacteriophage genomes...
- Shirakihara Y, Evans P. Crystal structure of the complex of phosphofructokinase from Escherichia coli with its reaction products. J Mol Biol. 1988;204:973-94 pubmed..However, this structure gives a clearer picture of the active site, and of the interactions between the enzyme and its reaction products. ..
- Mohun T, Garrett N, Stutz F, Sophr G. A third striated muscle actin gene is expressed during early development in the amphibian Xenopus laevis. J Mol Biol. 1988;202:67-76 pubmed..Comparison of the X. laevis and X. tropicalis alpha 3 gene promoters reveals extensive sequence homology, including several copies of a repeated motif that is common to other vertebrate striated-muscle actin gene promoters. ..
- Norman C, Runswick M, Pollock R, Treisman R. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell. 1988;55:989-1003 pubmed..SRF binds DNA as a dimer, and the DNA binding/dimerization domain of the protein exhibits striking homology to two yeast regulatory proteins. ..
- Falciani F, Hausdorf B, Schr der R, Akam M, Tautz D, Denell R, et al. Class 3 Hox genes in insects and the origin of zen. Proc Natl Acad Sci U S A. 1996;93:8479-84 pubmed..In the lineage leading to Drosophila, the zen genes have diverged particularly rapidly...
- Hopper N, Lee J, Sternberg P. ARK-1 inhibits EGFR signaling in C. elegans. Mol Cell. 2000;6:65-75 pubmed..We find that sem-5 also has a negative function in let-23-mediated ovulation and suggest that this negative function is mediated by the recruitment of inhibitors such as ARK-1. ..
- Thompson D, Easton D. Variation in cancer risks, by mutation position, in BRCA2 mutation carriers. Am J Hum Genet. 2001;68:410-9 pubmed..92% (95% CI = 1.20%-38.57%). Possible mechanisms for the variation in cancer risk are suggested by the coincidence of the OCCR with the RAD51-binding domain...
- Krugmann S, Anderson K, Ridley S, Risso N, McGregor A, Coadwell J, et al. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol Cell. 2002;9:95-108 pubmed
- Collins B, Watson P, Owen D. The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs. Dev Cell. 2003;4:321-32 pubmed
- Croucher N, Walker D, Romero P, Lennard N, Paterson G, Bason N, et al. Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81. J Bacteriol. 2009;191:1480-9 pubmed publisher..However, further sequencing of other pandemic clones will be required to establish whether there are any general attributes shared by these strains that are responsible for their international success...
- Lechtenberg B, Allen M, Rutherford T, Freund S, Bycroft M. Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2. Protein Sci. 2009;18:657-61 pubmed publisher..The structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs. ..
- Kelsh R, Weinzierl R, White R, Akam M. Homeotic gene expression in the locust Schistocerca: an antibody that detects conserved epitopes in Ultrabithorax and abdominal-A proteins. Dev Genet. 1994;15:19-31 pubmed
- Roberts R, Kendall E, Vetrie D, Bobrow M. Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene. Genomics. 1996;37:122-4 pubmed..The gene from which the transcript is derived maps to human chromosomal region Xq22 and therefore becomes a potential candidate for human X-linked disorders of gonadal development. ..
- Livesey F, Hunt S. Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests roles in retinal, striatal, nigral, and cerebellar development. Mol Cell Neurosci. 1997;8:417-29 pubmed
- Szeto I, Li L, Surani M. Ocat, a paternally expressed gene closely linked and transcribed in the opposite direction to Peg3. Genomics. 2000;67:221-7 pubmed..Like Peg3, Ocat is expressed exclusively from the paternal allele. Despite their proximity, Peg3 and Ocat showed dissimilar expression profiles, suggesting that they are regulated by independent genetic elements. ..
- Parker J, Mizuguchi K, Gay N. A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome. Proteins. 2001;45:71-80 pubmed..By contrast, Spz6 shows a complex spatial and temporally regulated expression pattern in the late embryo. Thus the new Toll/Spätzle families of signaling molecules may have important roles in other aspects of development and immunity. ..
- Pouchkina Stantcheva N, Tunnacliffe A. Spliced leader RNA-mediated trans-splicing in phylum Rotifera. Mol Biol Evol. 2005;22:1482-9 pubmed
- Zhao R, Oxley D, Smith T, Follows G, Green A, Alexander D. DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH. PLoS Biol. 2007;5:e1 pubmed..Our findings also suggest novel approaches to cancer therapy. ..
- Carter C, Dion C, Schnell S, Coadwell W, Graham M, Hepburn L, et al. A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1. J Immunol. 2007;179:1784-95 pubmed..Nevertheless, when wild rat DNA samples were studied the AT(+) allele was found at a high overall frequency ( approximately 30%). This suggests an adaptive significance for this hypomorphic allele...
- Sebaihia M, Bocsanczy A, Biehl B, Quail M, Perna N, Glasner J, et al. Complete genome sequence of the plant pathogen Erwinia amylovora strain ATCC 49946. J Bacteriol. 2010;192:2020-1 pubmed publisher..The analysis of the sequence and its comparison with sequenced genomes of closely related enterobacteria revealed signs of pathoadaptation to rosaceous hosts. ..
- Cvejic A, Haer Wigman L, Stephens J, Kostadima M, Smethurst P, Frontini M, et al. SMIM1 underlies the Vel blood group and influences red blood cell traits. Nat Genet. 2013;45:542-545 pubmed publisher..Our findings are of immediate relevance, as the homozygous presence of the deletion allows the unequivocal identification of Vel-negative blood donors. ..
- Kennedy M, Gonzalez Sarmiento R, Kees U, Lampert F, Dear N, Boehm T, et al. HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991;88:8900-4 pubmed..The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis. ..
- Robinson M. Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989;108:833-42 pubmed..Antipeptide antibodies are now being raised to find out whether the proteins are localized in functionally distinct populations of endocytic coated vesicles. ..
- Halter D, Urban J, Rickert C, Ner S, Ito K, Travers A, et al. The homeobox gene repo is required for the differentiation and maintenance of glia function in the embryonic nervous system of Drosophila melanogaster. Development. 1995;121:317-32 pubmed..By contrast, the expression of late glial-specific markers is either substantially reduced or absent. The specificity of expression is also observed in the locust Schistocerca gregaria and is thus evolutionarily conserved. ..
- Wunderle V, Critcher R, Ashworth A, Goodfellow P. Cloning and characterization of SOX5, a new member of the human SOX gene family. Genomics. 1996;36:354-8 pubmed..1. In contrast to the mouse gene, the human SOX5 gene is expressed in a variety of human tissues, and different size transcripts are observed in adult testis and fetal brain. ..
- Craxton M, Olsen A, Goedert M. Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location. Genomics. 1997;42:165-9 pubmed..4 by PCR analysis of somatic cell hybrid DNA and by DNA hybridization to arrayed cosmids of the chromosome 19 metric physical map. This provides the first report of linked synaptotagmin genes. ..
- Henderson B, Percipalle P. Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta. J Mol Biol. 1997;274:693-707 pubmed..The series of interactions we describe provide a novel pathway for the import of Rev across the nuclear pore complex, and a mechanism for its release into the nucleoplasm. ..
- Peterson K, Wang G, Horsley D, Richardson J, Sapienza C, Latham K, et al. The M31 gene has a complex developmentally regulated expression profile and may encode alternative protein products that possess diverse subcellular localisation patterns. J Exp Zool. 1998;280:288-303 pubmed..There are three protein products encoded by the M31 gene. Surprisingly, the two smaller products are found almost exclusively in the cytoplasm. ..
- Landry J, Kinston S, Knezevic K, Donaldson I, Green A, Gottgens B. Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells. Blood. 2005;106:2680-7 pubmed..Together, these results suggest that the conserved proximal promoter is central to LMO2 transcription in hematopoietic and endothelial cells, where it is regulated by Ets factors. ..
- Savage D, Zhai L, Ravikumar B, Choi C, Snaar J, McGuire A, et al. A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLoS Med. 2008;5:e27 pubmed publisher..The fact that it is present in approximately 1 in 70 UK whites increases the potential biomedical relevance of these observations. ..
- Funston G, Goh W, Wei S, Tng Q, Brown C, Jiah Tong L, et al. Binding of Translationally Controlled Tumour Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3. PLoS ONE. 2012;7:e42642 pubmed publisher..This result may provide an additional explanation of how Nutlin-derived compounds currently in clinical trials function to promote apoptosis in cancer cells. ..
- Baker K, Leggett R, Bexfield N, Alston M, Daly G, Todd S, et al. Metagenomic study of the viruses of African straw-coloured fruit bats: detection of a chiropteran poxvirus and isolation of a novel adenovirus. Virology. 2013;441:95-106 pubmed publisher..In sum, E. helvum display a wide variety of mammalian viruses, some of them genetically similar to known human pathogens, highlighting the possibility of zoonotic transmission...
- Dear T, Campbell K, Rabbitts T. Molecular cloning of putative odorant-binding and odorant-metabolizing proteins. Biochemistry. 1991;30:10376-82 pubmed..Its expression appears to be localized to the Bowman's glands, the site of several previously identified olfactory-specific biotransformation enzymes. ..
- Brand A, Manoukian A, Perrimon N. Ectopic expression in Drosophila. Methods Cell Biol. 1994;44:635-54 pubmed
- Goedert M, Hasegawa J, Craxton M, Leversha M, Clegg S. Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. Genomics. 1997;41:501-2 pubmed
- Buss F, Kendrick Jones J, Lionne C, Knight A, Cote G, Paul Luzio J. The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. J Cell Biol. 1998;143:1535-45 pubmed..These results strongly support a role for myosin VI in membrane traffic on secretory and endocytic pathways. ..
- Edwards Y, Cottage A. Bioinformatics methods to predict protein structure and function. A practical approach. Mol Biotechnol. 2003;23:139-66 pubmed..These methods, if used appropriately, can provide valuable indicators of protein structure and function. ..
- Piepenburg O, Williams C, Stemple D, Armes N. DNA detection using recombination proteins. PLoS Biol. 2006;4:e204 pubmed publisher..This unique combination of properties is a significant advance in the development of portable and widely accessible nucleic acid-based tests...
- Jones R, James P, Oxley D, Coadwell J, Suzuki Toyota F, Howes E. The equatorial subsegment in mammalian spermatozoa is enriched in tyrosine phosphorylated proteins. Biol Reprod. 2008;79:421-31 pubmed publisher..We speculate that the EqSS is an organizing center for assembly of multimolecular complexes that initiate fusion competence in this area of the plasma membrane following the acrosome reaction. ..
- Rajagopalan S, Andreeva A, Teufel D, Freund S, Fersht A. Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics. J Biol Chem. 2009;284:21728-37 pubmed publisher..The ubiquitous nature of the acidic transactivation domain of p53 in mediating interactions with several transcription cofactors is also manifested as a DNA mimetic. ..