Genomes and Genes
Experts and Doctors on mice in London, England, United Kingdom
Locale: London, England, United Kingdom
Publications459 found, 100 shown here
- Smith D, Portier R, Woodman B, Hockly E, Mahal A, Klunk W, et al. Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles. Neurobiol Dis. 2001;8:1017-26 pubmed..Oral administration of creatine has been shown to delay the onset of all aspects of the phenotype and neuropathology in R6/2 mice. We show here that creatine can similarly inhibit aggregate formation in the slice culture assay. ..
- Jenner P. Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease. Neurology. 2004;63:S13-22 pubmed
- Nitcheu Tefit J, Dai M, Critchley Thorne R, Ramirez Jimenez F, Xu M, Conchon S, et al. Listeriolysin O expressed in a bacterial vaccine suppresses CD4+CD25high regulatory T cell function in vivo. J Immunol. 2007;179:1532-41 pubmed..These findings provide the first evidence that LLO expression affects Treg cell function and may have important implications for enhancing antitumor vaccination strategies in humans. ..
- Pinner S, Jordan P, Sharrock K, Bazley L, Collinson L, Marais R, et al. Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Res. 2009;69:7969-77 pubmed publisher..These data show reversible phenotype switching during melanoma metastasis. ..
- Stauber M, Sachidanandan C, Morgenstern C, Ish Horowicz D. Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis. PLoS ONE. 2009;4:e7996 pubmed publisher..We present evidence that Lfng controls dorsal-ventral axis specification in the tail, and also suggest that Lfng controls the expression or activity of a long-range signal that regulates axial extension...
- Ansari A, Temblay J, Alyahya S, Ashton Rickardt P. Serine protease inhibitor 6 protects iNKT cells from self-inflicted damage. J Immunol. 2010;185:877-83 pubmed publisher..Our findings demonstrate that Spi6 protects cytotoxic cells of the innate immune system from GrB-mediated self-inflicted triggered by the recognition of Ag. ..
- Zaher S, Germain C, Fu H, Larkin D, George A. 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2011;52:2640-8 pubmed publisher..These molecules have potential as specific agents for preventing allograft rejection in patients at high rejection risk. ..
- Mora J, Fenwick M, Castle L, Baithun M, Ryder T, Mobberley M, et al. Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles. Biol Reprod. 2012;86:153, 1-14 pubmed publisher..Lack of classic markers suggests that GCs are not epithelial. Identification of AJs during GC cuboidalization highlights the importance of AJs in regulating initiation of follicle growth. ..
- Luhmann U, Lange C, Robbie S, Munro P, Cowing J, Armer H, et al. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. PLoS ONE. 2012;7:e35551 pubmed publisher..These findings indicate that CCDKO mice are not a model of AMD, but a model for an inherited retinal degeneration that is differentially modulated by Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling. ..
- Mesquita F, Thomas M, Sachse M, Santos A, Figueira R, Holden D. The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates. PLoS Pathog. 2012;8:e1002743 pubmed publisher..Our data therefore show that there is a host selective autophagy response to intracellular Salmonella infection, which is counteracted by the deubiquitinase SseL...
- Tada M, Kai M. Planar cell polarity in coordinated and directed movements. Curr Top Dev Biol. 2012;101:77-110 pubmed publisher..In this review, we focus on how the planar cell polarity pathway is mediated by migrating cells to communicate with one another in different developmental processes. ..
- Hogan T, Shuvaev A, Commenges D, Yates A, Callard R, Thiebaut R, et al. Clonally diverse T cell homeostasis is maintained by a common program of cell-cycle control. J Immunol. 2013;190:3985-93 pubmed publisher..Our results show that diverse and heterogeneous clonal T cell responses can be accounted for by a single common model of homeostasis. ..
- Sisay S, Pryce G, Jackson S, Tanner C, Ross R, Michael G, et al. Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis. PLoS ONE. 2013;8:e76907 pubmed publisher..Importantly, it adds a note of caution for the translational value of some transgenic/gene knockout and other studies on low-EAE susceptibility backgrounds with inconsistent disease course and susceptibility. ..
- Nikolova V, Papacleovoulou G, Bellafante E, Borges Manna L, Jansen E, Baron S, et al. Changes in LXR signaling influence early-pregnancy lipogenesis and protect against dysregulated fetoplacental lipid homeostasis. Am J Physiol Endocrinol Metab. 2017;313:E463-E472 pubmed publisher..Together, these data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis. ..
- Marais R, Wynne J, Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell. 1993;73:381-93 pubmed..These findings directly link transcriptional activation by the SRE to the growth factor-regulated phosphorylation of an SRE-binding protein. ..
- Blackman M, Dennis E, Hirst E, Kocken C, Scott Finnigan T, Thomas A. Plasmodium knowlesi: secondary processing of the malaria merozoite surface protein-1. Exp Parasitol. 1996;83:229-39 pubmed..Successful invasion is therefore associated with complete shedding of MSP-1(33) from the merozoite surface. The nucleotide sequence of the 3' domain of the P. knowlesi MSP-1 gene is also presented. ..
- Haley J, Delmas P, Offermanns S, Abogadie F, Simon M, Buckley N, et al. Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice. J Neurosci. 2000;20:3973-9 pubmed
- Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish Horowicz D. Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation. 2001;69:135-44 pubmed..These data implicate D14 and the Notch signalling pathway in angiogenesis and suggest possible new targets for antiangiogenic tumor therapy. ..
- Polley S, Tetteh K, Lloyd J, Akpogheneta O, Greenwood B, Bojang K, et al. Plasmodium falciparum merozoite surface protein 3 is a target of allele-specific immunity and alleles are maintained by natural selection. J Infect Dis. 2007;195:279-87 pubmed..A vaccine incorporating both major allelic types of this promising candidate antigen could be particularly useful for induction of protective immunity in infants and young children. ..
- Schalkwyk L, Fernandes C, Nash M, Kurrikoff K, Vasar E, Koks S. Interpretation of knockout experiments: the congenic footprint. Genes Brain Behav. 2007;6:299-303 pubmed..However, the impact of genetic background should not be simply viewed as a potential confound, but as a unique opportunity to study the broader responses of a system to a specific (genetic) perturbation...
- Hafalla J, Bauza K, Friesen J, Gonzalez Aseguinolaza G, Hill A, Matuschewski K. Identification of targets of CD8âº T cell responses to malaria liver stages by genome-wide epitope profiling. PLoS Pathog. 2013;9:e1003303 pubmed publisher..Our identification of antigen-specific CD8âº T cells will allow interrogation of the development of immune responses against malaria liver stages. ..
- Bridges L, Coulton G, Howard G, Moss J, Mason R. The neuromuscular basis of hereditary kyphoscoliosis in the mouse. Muscle Nerve. 1992;15:172-9 pubmed..Peripheral nerves and anterior horn cells were normal. The findings indicate a neuromuscular basis of hereditary kyphoscoliosis in the mouse. The animal may be useful as a model of human muscle disease and scoliosis. ..
- Nomura S, Wills A, Edwards D, Heath J, Hogan B. Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. J Cell Biol. 1988;106:441-50 pubmed..The temporal and spatial pattern of 2ar expression seen in vivo suggests that the protein plays a wider role than previously realized, in processes which are not confined to bone development. ..
- Garcia S, DiSanto J, Stockinger B. Following the development of a CD4 T cell response in vivo: from activation to memory formation. Immunity. 1999;11:163-71 pubmed..They differ qualitatively from naive T cells, suggesting that accelerated CD4 memory responses can occur without the need for increased frequencies of specific T cells. ..
- Lundberg A, Drexler S, Monaco C, Williams L, Sacre S, Feldmann M, et al. Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. Blood. 2007;110:3245-52 pubmed..This is the first report of such cell type- and species-specific response for any TLR stimulation and helps to explain important difficulties in correlating murine models of inflammatory diseases and human inflammation. ..
- Vaghjiani R, Talma S, Murphy C. Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells. Tissue Eng Part A. 2009;15:2073-83 pubmed publisher..Depletion of STEAP1 in human MSCs using RNAi resulted in decreased cell adhesion to tissue culture plastic. Further work is now needed to fully uncover its function in these cells, and to explore its potential as a marker of MSCs. ..
- Ali S, Heathcote D, Kroll S, Jogalekar A, Scheiper B, Patel H, et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009;69:6208-15 pubmed publisher..p. administration of 10 mg/kg. The same dose of drug inhibited the growth of MCF-7 human xenografts in nude mice. BS-181 therefore provides the first example of a potent and selective CDK7 inhibitor with potential as an anticancer agent. ..
- Bulgin R, Arbeloa A, Goulding D, Dougan G, Crepin V, Raymond B, et al. The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals. PLoS Pathog. 2009;5:e1000683 pubmed publisher..Moreover, our data breaks the dogma of EPEC as an extracellular pathogen and defines a new category of invasive EPEC. ..
- Collington S, Hallgren J, Pease J, Jones T, Rollins B, Westwick J, et al. The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo. J Immunol. 2010;184:6114-23 pubmed publisher..These experiments revealed a new function of SCF in chemokine receptor coupling, but they suggest a complex role of the CCL2/CCR2 axis in recruiting MCps during pulmonary inflammation. ..
- Carafoli F, Hussain S, Hohenester E. Crystal structures of the network-forming short-arm tips of the laminin ?1 and ?1 chains. PLoS ONE. 2012;7:e42473 pubmed publisher..Mutations in the laminin ?2 LN domain causing Pierson syndrome are likely to impair the folding of the ?2 chain or its ability to form network interactions. ..
- Figueira R, Watson K, Holden D, Helaine S. Identification of salmonella pathogenicity island-2 type III secretion system effectors involved in intramacrophage replication of S. enterica serovar typhimurium: implications for rational vaccine design. MBio. 2013;4:e00065 pubmed publisher..Moreover, we establish that a poly-effector mutant strain of S. Typhimurium can have a severe replication defect and maintain a functional SPI-2 T3SS, which can be exploited for delivery of heterologous antigens. ..
- Kabat A, Harrison O, Riffelmacher T, Moghaddam A, Pearson C, Laing A, et al. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. elife. 2016;5:e12444 pubmed publisher..These findings provide new insights into the reciprocal control of distinct intestinal TH cell responses by autophagy, with important implications for understanding and treatment of chronic inflammatory disorders. ..
- Stubbs L, Poustka A, Baron A, Lehrach H, Lonai P, Duboule D. The murine genes Hox-5.1 and Hox-4.1 belong to the same HOX complex on chromosome 2. Genomics. 1990;7:422-7 pubmed..Our results demonstrate that Hox-4.1 lies approximately 35 kb downstream of the Hox-5.1 gene and that the two loci do indeed thus constitute parts of the same HOX complex. ..
- Colville Nash P, Alam C, Appleton I, Brown J, Seed M, Willoughby D. The pharmacological modulation of angiogenesis in chronic granulomatous inflammation. J Pharmacol Exp Ther. 1995;274:1463-72 pubmed..I. These observations indicated the differential effects of angiostatic and anti-inflammatory steroid activity. The pharmacological modulation of angiogenesis in inflammation can therefore be quantified. ..
- Bhavsar P, Brand N, Yacoub M, Barton P. Isolation and characterization of the human cardiac troponin I gene (TNNI3). Genomics. 1996;35:11-23 pubmed..Following transfection, 2300 bp of 5' sequence is active in both cardiac myocytes and skeletal muscle cells but is inactive in fibroblasts, indicating that it can drive expression but is insufficient to confer cardiac specificity. ..
- Williamson J, Bosher J, Skinner A, Sheer D, Williams T, Hurst H. Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. Genomics. 1996;35:262-4 pubmed..Tcfap2b and Tcfap2c map to mouse chromosomes 1A2-4 and 2H3-4, respectively, while TFAP2B and TFAP2C map to human chromosomes 6p12 and 20q13.2, the latter being a region that is frequently amplified in breast carcinoma. ..
- Selyanko A, Hadley J, Wood I, Abogadie F, Delmas P, Buckley N, et al. Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. J Neurosci. 1999;19:7742-56 pubmed..Thus, the channels generating M-like currents in different cells may be heterogeneous in molecular composition. ..
- Corrigall V, Bodman Smith M, Fife M, Canas B, Myers L, Wooley P, et al. The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J Immunol. 2001;166:1492-8 pubmed..These findings may stimulate the development of new immunotherapies for the treatment of RA. ..
- Harrington K, Rowlinson Busza G, Uster P, Vile R, Peters A, Stewart J. Single-fraction irradiation has no effect on uptake of radiolabeled pegylated liposomes in a tumor xenograft model. Int J Radiat Oncol Biol Phys. 2001;49:1141-8 pubmed..Single fraction doses of RT appear to have no effect on tumor or normal tissue biodistribution and pharmacokinetics of radiolabeled pegylated liposomes in this animal model. ..
- Chain B, Free P, Medd P, Swetman C, Tabor A, Terrazzini N. The expression and function of cathepsin E in dendritic cells. J Immunol. 2005;174:1791-800 pubmed..The data therefore support the hypothesis that cathepsin E has an important nonredundant role in the class II MHC Ag processing pathway within dendritic cells. ..
- Raguz S, De Bella M, Slade M, Higgins C, Coombes R, Yague E. Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis. Int J Cancer. 2005;117:934-41 pubmed..001). Therefore, activation of RPIP9 occurs during the malignant breast epithelial transformation and increases with progression toward an invasive phenotype. ..
- Crompton L, Du Roure C, Rodriguez T. Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues. Dev Dyn. 2007;236:3137-43 pubmed..Analysis of a gene-trap mutation in Testin indicates that this gene is not required for embryogenesis; therefore, other Prickle homologues may compensate for its function during development. ..
- Bystrom J, Evans I, Newson J, Stables M, Toor I, Van Rooijen N, et al. Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP. Blood. 2008;112:4117-27 pubmed publisher..Thus, rM macrophages are neither classically nor alternatively activated but a hybrid of both, with a role in mediating postresolution innate-lymphocyte repopulation and restoring tissue homeostasis. ..
- Jacquot C, Croft A, Prendergast M, Mulholland P, Shaw S, Little H. Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption. Alcohol Clin Exp Res. 2008;32:2107-16 pubmed publisher..The results suggest mifepristone may be of value in the treatment of alcoholics to reduce their cognitive deficits. ..
- Owen B, Milona A, van Mil S, Clements P, Holder J, Boudjelal M, et al. Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid. Drug Metab Dispos. 2010;38:143-9 pubmed publisher..Furthermore, the route of administration must be considered in the future planning and interpretation of experiments designed to assess hepatic responses to BAs, orally administered pharmaceuticals, and dietary toxins. ..
- Schmidt Hieber C, Bischofberger J. Fast sodium channel gating supports localized and efficient axonal action potential initiation. J Neurosci. 2010;30:10233-42 pubmed publisher..Thus, sodium channel gating and density in unmyelinated mossy fiber axons appear to be specialized for robust AP initiation and propagation with minimal current flow. ..
- Bassett J, Gogakos A, White J, Evans H, Jacques R, Van der Spek A, et al. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genet. 2012;8:e1002858 pubmed publisher..Application of the approach to diseases affecting other physiological systems will help to realize the full potential of the International Mouse Phenotyping Consortium. ..
- Reljic R, Sibley L, Huang J, Pepponi I, Hoppe A, Hong H, et al. Mucosal vaccination against tuberculosis using inert bioparticles. Infect Immun. 2013;81:4071-80 pubmed publisher..We conclude that this new vaccine delivery platform merits further development as a mucosal vaccine for TB and possibly also other respiratory pathogens. ..
- Karagiannis S, Josephs D, Bax H, Spicer J. Therapeutic IgE Antibodies: Harnessing a Macrophage-Mediated Immune Surveillance Mechanism against Cancer. Cancer Res. 2017;77:2779-2783 pubmed publisher..i>Cancer Res; 77(11); 2779-83. Â©2017 AACR. ..
- Brace P, Tezera L, Bielecka M, Mellows T, Garay D, Tian S, et al. Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology. PLoS Pathog. 2017;13:e1006367 pubmed publisher..Therefore, Mtb disrupts negative regulatory pathways at multiple levels in macrophages to drive a tissue-destructive phenotype that facilitates transmission. ..
- Roy Chowdhury U, Rinkoski T, Bahler C, Millar J, Bertrand J, Holman B, et al. Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents. Invest Ophthalmol Vis Sci. 2017;58:5731-5742 pubmed publisher..To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination therapy with existing ocular hypotensive agents...
- Philpott K, Viney J, Kay G, Rastan S, Gardiner E, Chae S, et al. Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science. 1992;256:1448-52 pubmed..The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells. ..
- Simpson E, Scott D, Chandler P. The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning. Annu Rev Immunol. 1997;15:39-61 pubmed..Each of the Hya genes in mice is ubiquitously expressed but of unknown function. Their X chromosome homologues do not undergo X inactivation. ..
- Braga V, Machesky L, Hall A, Hotchin N. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol. 1997;137:1421-31 pubmed..Our results provide new insights into the role of the small GTPases in the cadherin-dependent cell- cell contact formation and the remodelling of actin filaments in epithelial cells. ..
- Yuan H, Suri C, Landon D, Yancopoulos G, Woolf A. Angiopoietin-2 is a site-specific factor in differentiation of mouse renal vasculature. J Am Soc Nephrol. 2000;11:1055-66 pubmed..Because Tie-2 is widely expressed by differentiating renal endothelia, this study is consistent with the hypothesis that Ang-2 has roles in kidney vascular maturation. ..
- Boyton R, Zaccai N, Jones E, Altmann D. CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3. J Immunol. 2002;168:1018-27 pubmed
- Patel N, Chatterjee P, Chatterjee B, Cuzzocrea S, Serraino I, Brown P, et al. TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney. Free Radic Biol Med. 2002;33:1575-89 pubmed
- Modarai B, Burnand K, Sawyer B, Smith A. Endothelial progenitor cells are recruited into resolving venous thrombi. Circulation. 2005;111:2645-53 pubmed..Many of these cells expressed a macrophage phenotype and may represent a population of plastic stem cells that orchestrate thrombus recanalization. ..
- Giles I, Pericleous C, Liu X, Ehsanullah J, Clarke L, Brogan P, et al. Thrombin binding predicts the effects of sequence changes in a human monoclonal antiphospholipid antibody on its in vivo biologic actions. J Immunol. 2009;182:4836-43 pubmed publisher..However, this finding did not hold true for the effects of these IgG on activation of cultured endothelial cells in vitro, where there was a less clear relationship between binding properties and biologic effects. ..
- Tudor C, Marchese F, Hitti E, Aubareda A, Rawlinson L, Gaestel M, et al. The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages. FEBS Lett. 2009;583:1933-8 pubmed publisher..TTP directly controls IL-10 mRNA stability, which is increased and insensitive to inhibition of p38 MAPK in TTP(-/-) macrophages. Furthermore, TTP enhances deadenylation of an IL-10 3'-untranslated region RNA in vitro. ..
- Prokopowicz Z, Arce F, Biedron R, Chiang C, Ciszek M, Katz D, et al. Hypochlorous acid: a natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity. J Immunol. 2010;184:824-35 pubmed publisher..A function of HOCl is therefore to target glycoprotein Ags to scavenger receptors on the APC surface. This additional mechanism linking innate and adaptive immunity suggests novel strategies to enhance immunity to vaccines...
- D Castro L, Wenborn A, Gros N, Joiner S, Cronier S, Collinge J, et al. Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid. PLoS ONE. 2010;5:e15679 pubmed publisher..This procedure now allows characterization of proteinase K-sensitive prions and investigation of their clinical relevance in human and animal prion disease without being confounded by contaminating PrP(C)...
- Portevin D, Gagneux S, Comas I, Young D. Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages. PLoS Pathog. 2011;7:e1001307 pubmed publisher..In addition to the lineage effects, the large strain-to-strain variation in innate immune responses elicited by MTBC will need to be considered in tuberculosis vaccine development. ..
- Kolatsi Joannou M, Price K, Winyard P, Long D. Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury. PLoS ONE. 2011;6:e18683 pubmed publisher..This raises the possibility that MCP may be a novel strategy to reduce renal injury in the long term, perhaps via carbohydrate binding-related functions of galectin-3. ..
- Laranjeira C, Sandgren K, Kessaris N, Richardson W, Potocnik A, Vanden Berghe P, et al. Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J Clin Invest. 2011;121:3412-24 pubmed publisher..Our results indicate that despite the absence of constitutive neurogenesis in the adult gut, enteric glia maintain limited neurogenic potential, which can be activated by tissue dissociation or injury. ..
- Tulone C, Sponaas A, Raiber E, Tabor A, Langhorne J, Chain B. Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1. PLoS ONE. 2011;6:e24886 pubmed publisher..The role of different proteinases in generating the CD4 T cell repertoire, therefore, depends on the context in which an antigen is introduced to the immune system. ..
- Maluquer de Motes C, Cooray S, Ren H, Almeida G, McGourty K, Bahar M, et al. Inhibition of apoptosis and NF-ÎºB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence. PLoS Pathog. 2011;7:e1002430 pubmed publisher..This indicates that anti-apoptotic activity of N1 does not drive virulence in these in vivo models, and highlights the importance of pro-inflammatory signalling in the immune response against viral infections. ..
- Boyle J, Christou I, Iqbal M, Nguyen A, Leung V, Evans P, et al. Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway. Am J Pathol. 2012;181:347-61 pubmed publisher..These observations indicate that solid-phase IgM and IgG can activate macrophages and destabilize vulnerable plaques. Solid-phase IgM activates macrophages via a novel SR-A pathway. ..
- Liu B, Barbosa Sampaio H, Jones P, Persaud S, Muller D. The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of ?-cells. PLoS ONE. 2012;7:e45711 pubmed publisher..Our results indicate that CaMK4 regulates ?-cell proliferation and apoptosis in a CREB-dependent manner and that CaMK4-induced IRS-2 expression is important in these processes. ..
- Murdoch C, Chaubey S, Zeng L, Yu B, Ivetic A, Walker S, et al. Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition. J Am Coll Cardiol. 2014;63:2734-41 pubmed publisher..Endothelial NOX2 enhances EMT and has proinflammatory effects. This may be an important mechanism underlying cardiac fibrosis and diastolic dysfunction during increased renin-angiotensin activation. ..
- Schlingmann K, Ruminska J, Kaufmann M, Dursun I, Patti M, Kranz B, et al. Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia. J Am Soc Nephrol. 2016;27:604-14 pubmed publisher..Therefore, early differentiation between SLC34A1 (NaPi-IIa) and CYP24A1 (24-hydroxylase) defects appears critical for targeted therapy in patients with IIH. ..
- Ashraf T, Collinson M, Fairhurst J, Wang R, Wilson L, Foulds N. Two further patients with the 1q24 deletion syndrome expand the phenotype: A possible role for the miR199-214 cluster in the skeletal features of the condition. Am J Med Genet A. 2015;167A:3153-60 pubmed publisher..The deletion in the second patient spans the previously reported critical region and indicates that the cognitive impairment may not always be as severe as previous reports suggest. ..
- Shankley N, Welsh N, Black J. Histamine dependence of pentagastrin-stimulated gastric acid secretion in rats. Yale J Biol Med. 1992;65:613-9 pubmed..Potentiation was observed, however, between other combinations of stimuli, for example, between vagal nerve and pentagastrin stimulation. The physiological consequences of these results are discussed. ..
- Poirier F, Timmons P, Chan C, Guenet J, Rigby P. Expression of the L14 lectin during mouse embryogenesis suggests multiple roles during pre- and post-implantation development. Development. 1992;115:143-55 pubmed..Finally, within the nervous system expression of this gene is activated early during the differentiation of a particular subset of neurones. ..
- Parker A, Wheeler G, Arnemann J, Pidsley S, Ataliotis P, Thomas C, et al. Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing. J Biol Chem. 1991;266:10438-45 pubmed..The cadherin cell adhesion recognition sequence (His-Ala-Val) is replaced by Phe-Ala-Thr, suggesting that DGII/III may be adhesive molecules using a different mechanism. ..
- Brett S. Regulatory interactions between macrophages and T cells in Mycobacterium lepraemurium-specific T-cell activation. Cell Immunol. 1987;110:379-90 pubmed..Resident peritoneal macrophages from both C57BL and BALB/c mice infected subcutaneously with M. lepraemurium produced comparable or slightly elevated levels of IL-1 on stimulation with LPS or HK-MLM...
- Olsson P, Sutherland H, Nowicka U, Korn B, Poustka A, Frischauf A. The mouse homologue of the tuberin gene (TSC2) maps to a conserved synteny group between mouse chromosome 17 and human 16p13.3. Genomics. 1995;25:339-40 pubmed
- Yuan H, Gowan S, Kelly F, Bingle C. Cloning of guinea pig surfactant protein A defines a distinct cellular distribution pattern within the lung. Am J Physiol. 1997;273:L900-6 pubmed..This distinct expression pattern suggests that the guinea pig lung will be a useful model in which to study expression of transcription factors implicated in the regulation of SP genes. ..
- Skehel P, Fabian Fine R, Kandel E. Mouse VAP33 is associated with the endoplasmic reticulum and microtubules. Proc Natl Acad Sci U S A. 2000;97:1101-6 pubmed..Any functional interaction between mVAP33 and VAMP/synaptobrevin, therefore, most likely involves the delivery of components to synaptic terminals rather than a direct participation in synaptic vesicle exocytosis. ..
- Spencer J, Rice Evans C, Williams R. Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem. 2003;278:34783-93 pubmed
- Jomary C, Cullen J, Jones S. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Invest Ophthalmol Vis Sci. 2006;47:1620-9 pubmed
- Karagiannis S, Bracher M, Hunt J, McCloskey N, Beavil R, Beavil A, et al. IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells. J Immunol. 2007;179:2832-43 pubmed..These results demonstrate that IgE Abs can engage cell surface IgE receptors and activate effector cells against ovarian tumor cells. Our findings offer a framework for an improved immunotherapeutic strategy for combating solid tumors. ..
- Jarmin S, David R, Ma L, Chai J, Dewchand H, Takesono A, et al. T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice. J Clin Invest. 2008;118:1154-64 pubmed publisher..These observations suggest that pharmacological targeting of p110delta activity is a viable strategy for the therapy of T cell-mediated pathology. ..
- Weng L, Addey C, Warrens A, Dyson J, Chai J, Dazzi F. Dissection of effector pathways in the host-versus-graft response to bone marrow transplantation. Transplantation. 2008;86:1311-4 pubmed publisher..In the absence of both pathways, however, donor bone marrow engraftment was not fully restored identifying a role for an additional pathway(s) in the host-versus-graft response. ..
- Price K, Woolf A, Long D. Unraveling the genetic landscape of bladder development in mice. J Urol. 2009;181:2366-74 pubmed publisher..These data provide novel insights into molecules that orchestrate bladder development and highlight genes that may be involved in diseases associated with abnormal differentiation. ..
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